Detailed information for compound 731409

Basic information

Technical information
  • TDR Targets ID: 731409
  • Name: 2-(methyl-phenylsulfonylamino)-N-(4-propan-2- ylphenyl)acetamide
  • MW: 346.444 | Formula: C18H22N2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.1 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1ccc(cc1)NC(=O)CN(S(=O)(=O)c1ccccc1)C)C
  • InChi: 1S/C18H22N2O3S/c1-14(2)15-9-11-16(12-10-15)19-18(21)13-20(3)24(22,23)17-7-5-4-6-8-17/h4-12,14H,13H2,1-3H3,(H,19,21)
  • InChiKey: KJLMATWBJNIDBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-isopropylphenyl)-2-(methyl-phenylsulfonyl-amino)acetamide
  • N-(4-isopropylphenyl)-2-(methyl-phenylsulfonylamino)acetamide
  • 2-(methyl-phenylsulfonyl-amino)-N-(4-propan-2-ylphenyl)ethanamide
  • ZINC00465001
  • CBKinase1_002891
  • CBKinase1_015291
  • STK154876

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.1373 0.1342
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0372 0.0337
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.239 0.5365
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2701 0.347
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0372 0.0739
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0372 0.0864
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0062 0.0699 0.4786
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0123 0.0544
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0433 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0566 0.127
Mycobacterium ulcerans bacterioferritin BfrB 0.0051 0.0533 0.1092
Leishmania major GTP-binding protein, putative 0.0021 0.0091 0.0087
Plasmodium vivax importin-beta 2, putative 0.0029 0.0205 0.1162
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0033 0.0267 0.1448
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0717 0.0872
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0062 0.0699 0.7638
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0091 0.0034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0532 0.1195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0699 0.1568
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0205 0.0535
Loa Loa (eye worm) hypothetical protein 0.0064 0.0717 0.1534
Onchocerca volvulus 0.0108 0.1373 0.5468
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.008 0.0179
Echinococcus multilocularis dna polymerase kappa 0.0021 0.008 0.0037
Echinococcus multilocularis ferritin 0.0051 0.0533 0.063
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0185
Loa Loa (eye worm) hypothetical protein 0.0108 0.1373 0.3045
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0045 0.0438 0.0403
Entamoeba histolytica hypothetical protein 0.0076 0.0899 1
Echinococcus granulosus ferritin 0.0051 0.0533 0.063
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2701 0.347
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.239 0.5365
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.008 0.0214
Echinococcus multilocularis geminin 0.0534 0.7687 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0112 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0185
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0372 0.0728
Schistosoma mansoni hypothetical protein 0.0138 0.1814 0.2309
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0045 0.0438 0.1042
Schistosoma mansoni cpg binding protein 0.0098 0.1219 0.1529
Echinococcus granulosus geminin 0.0534 0.7687 1
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0062 0.0699 0.0848
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0185
Brugia malayi beta-lactamase family protein 0.0108 0.1373 0.3562
Echinococcus multilocularis GPCR, family 2 0.0064 0.0717 0.0872
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0001
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0045 0.0438 0.0403
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.239 0.5365
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0045 0.0438 0.1556
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0267 0.0599
Schistosoma mansoni DNA polymerase eta 0.0021 0.008 0.0037
Onchocerca volvulus 0.0108 0.1373 0.5468
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0062 0.0699 0.1745
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0146 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0382 0.0858
Schistosoma mansoni hypothetical protein 0.0534 0.7687 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0205 0.0971
Plasmodium vivax hypothetical protein, conserved 0.0108 0.1373 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0052 0.0015
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0284 0.0305
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.1373 0.1342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0267 0.0599
Treponema pallidum bacterioferrin (TpF1) 0.0051 0.0533 1
Schistosoma mansoni ap endonuclease 0.004 0.0372 0.042
Loa Loa (eye worm) TAR-binding protein 0.0197 0.2701 0.6104
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0196 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.035 0.0786
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.008 0.0179
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.1373 0.3082
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.008 0.0037
Trichomonas vaginalis ran, putative 0.0021 0.0091 0.0204
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0112 0.008
Loa Loa (eye worm) phosphatidylinositol 3 0.0062 0.0699 0.1492
Brugia malayi RNA, U transporter 1 0.0083 0.1003 0.2565
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0205 0.0201
Brugia malayi hypothetical protein 0.0076 0.0899 0.2284
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0717 0.0872
Loa Loa (eye worm) hypothetical protein 0.0077 0.0914 0.1986
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0051 0.0533 0.0498
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1166 0.3004
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.4392 1
Echinococcus granulosus serine protein kinase ATM 0.0034 0.0275 0.0293
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0275 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.04 0.0898
Loa Loa (eye worm) hypothetical protein 0.0029 0.0205 0.0354
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0091 0.0091
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0045 0.0438 0.0403
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0062 0.0699 0.0848
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0267 0.0599
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0372 0.2426
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0054 0.0566 0.3763
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0717 0.1795
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.008 0.0065
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0034 0.0275 0.0293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0399 0.0896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0317 0.0711
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0532 0.1195
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2531 0.5681
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.1373 0.1731
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0532 0.1195
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0045 0.0438 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0185
Echinococcus multilocularis expressed protein 0.0051 0.0533 0.063
Echinococcus multilocularis cpg binding protein 0.0098 0.1219 0.1529
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0146 0.0214
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0185
Entamoeba histolytica hypothetical protein 0.0076 0.0899 1
Echinococcus multilocularis serine protein kinase ATM 0.0034 0.0275 0.0293
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0372 0.0835
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0717 0.1795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0267 0.0599
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.2759 0.7297
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.008 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3762 0.8444
Trypanosoma brucei PAB1-binding protein , putative 0.0077 0.0914 0.6446
Brugia malayi beta-lactamase family protein 0.0108 0.1373 0.3562
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0914 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0532 0.1195
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.008 0.0214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1166 0.146
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0185
Loa Loa (eye worm) hypothetical protein 0.0108 0.1373 0.3045
Plasmodium falciparum ornithine aminotransferase 0.0045 0.0438 0.4485
Loa Loa (eye worm) hypothetical protein 0.0108 0.1373 0.3045
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0091 0.0183
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0001
Schistosoma mansoni ap endonuclease 0.004 0.0372 0.042
Schistosoma mansoni hypothetical protein 0.0064 0.0717 0.0872
Loa Loa (eye worm) hypothetical protein 0.0021 0.0083 0.0073
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.008 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0051 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0483 0.1084
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0091 0.0107
Echinococcus granulosus dna polymerase kappa 0.0021 0.008 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0566 0.127
Loa Loa (eye worm) hypothetical protein 0.0027 0.018 0.0297
Plasmodium vivax ataxin-2 like protein, putative 0.0077 0.0914 0.6522
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0062 0.0699 0.4898
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.239 0.5365
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0899 0.111
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0123 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0185
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0033 0.0267 0.1448
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0001
Trichomonas vaginalis esterase, putative 0.0108 0.1373 0.3082
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.2531 0.5681
Plasmodium vivax ornithine aminotransferase, putative 0.0045 0.0438 0.2925
Echinococcus multilocularis ornithine aminotransferase 0.0045 0.0438 0.0507
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0146 0.0255
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3762 0.8444
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0146 0.0513
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0372 0.2261
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0372 0.042
Brugia malayi RNA binding protein 0.0197 0.2701 0.714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0317 0.0711
Toxoplasma gondii LsmAD domain-containing protein 0.0077 0.0914 0.3639
Entamoeba histolytica hypothetical protein 0.0034 0.0275 0.2642
Loa Loa (eye worm) hypothetical protein 0.0138 0.1814 0.4061
Brugia malayi Importin beta-1 subunit 0.0029 0.0205 0.0415
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.239 0.5365
Loa Loa (eye worm) hypothetical protein 0.0021 0.008 0.0065
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0146 0.0214
Leishmania major phosphatidylinositol kinase related protein, putative 0.0022 0.0092 0.0092
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0091 0.0298
Leishmania major hypothetical protein, conserved 0.0108 0.1373 1
Brugia malayi hypothetical protein 0.0077 0.0914 0.2323
Echinococcus granulosus GPCR family 2 0.0064 0.0717 0.0872
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.1373 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.1373 0.1342
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0146 0.0214
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0205 0.0971
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.1373 1
Schistosoma mansoni ferritin 0.0051 0.0533 0.063
Trypanosoma cruzi target of rapamycin kinase 3 0.0054 0.0566 0.3896
Loa Loa (eye worm) hypothetical protein 0.0019 0.0052 0.0001
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0034 0.0275 0.1694
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.003 0.0216 0.1055
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0372 0.3719
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.1373 0.3082
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0372 0.2426
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0196 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0399 0.0896
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0717 0.1534
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.008 0.0333
Entamoeba histolytica hypothetical protein 0.0076 0.0899 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0146 0.0214
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0062 0.0699 0.4786
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.1373 0.1342
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2701 0.347
Leishmania major phosphatidylinositol 3-kinase, putative 0.0033 0.0267 0.1448
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0045 0.0438 0.0878
Mycobacterium leprae Probable lipase LipE 0.0108 0.1373 0.2848
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.239 0.5365
Schistosoma mansoni ferritin 0.0051 0.0533 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0532 0.1195
Schistosoma mansoni hypothetical protein 0.0076 0.0899 0.111
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.1373 0.1342
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0914 0.6522
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0082 0.0185
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0146 0.1117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0267 0.0599
Echinococcus granulosus tar DNA binding protein 0.0197 0.2701 0.347
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0146 0.1117
Schistosoma mansoni importin beta-1 0.0029 0.0205 0.0201
Mycobacterium ulcerans hypothetical protein 0.0025 0.0146 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.04 0.0898
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0092 0.0304
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0112 0.008
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0091 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.1373 0.3082
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0062 0.0699 0.4786
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.1373 0.1731
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.1373 0.1342
Schistosoma mansoni hypothetical protein 0.0312 0.4392 0.5685
Echinococcus multilocularis tar DNA binding protein 0.0197 0.2701 0.347
Loa Loa (eye worm) hypothetical protein 0.0025 0.0146 0.0218
Echinococcus granulosus ornithine aminotransferase 0.0045 0.0438 0.0507
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3762 0.8444
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0372 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0433 0.0973
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0091 0.0052
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0033 0.0267 0.0282
Brugia malayi RNA recognition motif domain containing protein 0.0197 0.2701 0.714
Entamoeba histolytica hypothetical protein 0.0024 0.0123 0.0849
Schistosoma mansoni apoferritin-2 0.0051 0.0533 0.063
Schistosoma mansoni hypothetical protein 0.0064 0.0717 0.0872
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0316 0.4456 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0317 0.0711
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.018 0.0975
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0185
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0033 0.0267 0.1631
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0717 0.0872
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0062 0.0699 0.0848
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1166 0.146
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.1373 0.1731
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0185
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0112 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.1373 1
Schistosoma mansoni hypothetical protein 0.0534 0.7687 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0091 0.0456
Mycobacterium ulcerans lipase LipD 0.0108 0.1373 0.3001
Mycobacterium ulcerans beta-lactamase 0.0108 0.1373 0.3001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.1373 0.3045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0051 0.0115
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0372 0.2261
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0316 0.4456 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0717 0.0872
Loa Loa (eye worm) hypothetical protein 0.0025 0.0146 0.0218
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.008 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1166 0.146
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.008 0.0076
Echinococcus granulosus snurportin 1 0.0312 0.4392 0.5685
Leishmania major hypothetical protein, conserved 0.0077 0.0914 0.6446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0532 0.1195
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0146 0.011
Mycobacterium leprae conserved hypothetical protein 0.0108 0.1373 0.2848
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0372 0.2425
Schistosoma mansoni cpg binding protein 0.0098 0.1219 0.1529
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0699 0.1568
Mycobacterium ulcerans hypothetical protein 0.0316 0.4456 1
Entamoeba histolytica hypothetical protein 0.0076 0.0899 1
Schistosoma mansoni ferritin 0.0051 0.0533 0.063
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0372 0.3784
Echinococcus multilocularis Aminotransferase class III 0.0045 0.0438 0.0507
Schistosoma mansoni ferritin 0.0051 0.0533 0.063
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.1373 0.3001
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0091 0.0087
Schistosoma mansoni cpg binding protein 0.0092 0.1141 0.1427
Toxoplasma gondii histone lysine methyltransferase SET1 0.0175 0.2365 1
Schistosoma mansoni ferritin light chain 0.0051 0.0533 0.063
Loa Loa (eye worm) beta-lactamase 0.0108 0.1373 0.3045
Giardia lamblia GTOR 0.0062 0.0699 1
Schistosoma mansoni ferritin light chain 0.0051 0.0533 0.063
Onchocerca volvulus Glucosylceramidase homolog 0.0177 0.239 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0146 0.0513
Loa Loa (eye worm) RNA binding protein 0.0197 0.2701 0.6104
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0146 0.0255
Schistosoma mansoni hypothetical protein 0.0035 0.0284 0.0305
Toxoplasma gondii exonuclease III APE 0.004 0.0372 0.1266
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0123 0.0277
Onchocerca volvulus 0.0092 0.1141 0.4432
Mycobacterium ulcerans bacterioferritin BfrA 0.0051 0.0533 0.1092
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0033 0.0267 0.1448
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.239 0.5365
Brugia malayi TAR-binding protein 0.0197 0.2701 0.714
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0372 0.0835
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.1373 0.1342
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0185
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0532 0.1195
Mycobacterium tuberculosis Conserved protein 0.0108 0.1373 0.1342
Mycobacterium ulcerans acetylornithine aminotransferase 0.0045 0.0438 0.0878
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0033 0.0267 0.0282
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0062 0.0699 0.7638
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0034 0.0275 0.1513
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.1373 0.3082
Loa Loa (eye worm) hypothetical protein 0.0201 0.2759 0.6238
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.1814 0.475
Brugia malayi beta-lactamase 0.0108 0.1373 0.3562
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0123 0.0277
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0185
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0091 0.0299
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0112 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0185
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3762 0.8444
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0054 0.0566 0.3763
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0051 0.0533 1
Echinococcus granulosus cpg binding protein 0.0098 0.1219 0.1529
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0316 0.4456 0.4435
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2701 0.347
Echinococcus granulosus importin subunit beta 1 0.0029 0.0205 0.0201
Echinococcus granulosus Aminotransferase class III 0.0045 0.0438 0.0507
Brugia malayi CXXC zinc finger family protein 0.0092 0.1141 0.2936
Plasmodium falciparum ataxin-2 like protein, putative 0.0077 0.0914 1
Leishmania major importin beta-1 subunit, putative 0.0024 0.0123 0.0338
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0269 0.3762 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0275 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0566 0.127
Trypanosoma cruzi PAB1-binding protein , putative 0.0077 0.0914 0.6522
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0083 0.0187
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.008 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0196 0.2675 0.3436
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.1373 0.1731
Loa Loa (eye worm) hypothetical protein 0.0108 0.1373 0.3045
Mycobacterium tuberculosis Conserved protein 0.0108 0.1373 0.1342
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0033 0.0267 0.0282
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0899 0.111
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0316 0.4456 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0399 0.0896
Toxoplasma gondii FATC domain-containing protein 0.0034 0.0275 0.0842
Entamoeba histolytica Ran family GTPase 0.0021 0.0091 0.0467
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0045 0.0438 0.0507
Mycobacterium tuberculosis Probable aminotransferase 0.0316 0.4456 0.4435
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3762 0.8444
Loa Loa (eye worm) hypothetical protein 0.0108 0.1373 0.3045
Toxoplasma gondii ABC1 family protein 0.0108 0.1373 0.5654
Trichomonas vaginalis ferritin, putative 0.0051 0.0533 0.1195
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0566 0.127
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0062 0.0699 0.4898
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0146 0.1117
Mycobacterium ulcerans L-lysine aminotransferase 0.0045 0.0438 0.0878
Schistosoma mansoni tar DNA-binding protein 0.0197 0.2701 0.347
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0045 0.0438 0.0878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0566 0.127
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.008 0.0214
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0045 0.0438 0.0878
Loa Loa (eye worm) hypothetical protein 0.0108 0.1373 0.3045
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0091 0.0299
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0146 0.0513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0062 0.0699 0.1568
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.008 0.0043
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0051 0.0533 0.0897
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0033 0.0267 0.1631
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.2759 0.7297
Mycobacterium tuberculosis Conserved protein 0.0108 0.1373 0.1342
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.008 0.0214
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0045 0.0438 0.4118
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0045 0.0438 0.0678
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.04 0.0898
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.0082 0.0185
Echinococcus granulosus dna polymerase eta 0.0021 0.008 0.0037
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0146 0.011
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0045 0.0438 0.0678
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0024 0.0133 0.0412
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0082 0.0185
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.1373 0.3001
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.008 0.0064
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0146 0.0214
Echinococcus multilocularis ornithine aminotransferase 0.0045 0.0438 0.0507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.04 0.0898
Schistosoma mansoni hypothetical protein 0.0064 0.0717 0.0872
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0899 0.111
Loa Loa (eye worm) hypothetical protein 0.0025 0.0146 0.0218
Trichomonas vaginalis glucosylceramidase, putative 0.0269 0.3762 0.8444
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0372 0.4724
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0284 0.0305
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0146 0.0214
Plasmodium falciparum importin beta, putative 0.0029 0.0205 0.1782
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0197 0.2701 0.6104
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.1373 0.3082
Schistosoma mansoni ran 0.0021 0.0091 0.0052
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.1373 0.3562
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.008 0.0076
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.2759 0.6238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1166 0.146
Brugia malayi hypothetical protein 0.005 0.0509 0.1234
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0269 0.3762 0.8549
Toxoplasma gondii target of rapamycin (TOR), putative 0.0051 0.0532 0.1968
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0196 0.0189
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0033 0.0267 0.0581
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1166 0.2568
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1166 0.146
Schistosoma mansoni ran 0.0021 0.0091 0.0052
Schistosoma mansoni hypothetical protein 0.0064 0.0717 0.0872
Loa Loa (eye worm) CXXC zinc finger family protein 0.0092 0.1141 0.251
Onchocerca volvulus 0.0108 0.1373 0.5468
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1166 0.146
Echinococcus multilocularis snurportin 1 0.0312 0.4392 0.5685
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.008 0.0037
Echinococcus granulosus expressed protein 0.0051 0.0533 0.063
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0062 0.0699 0.4786
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.008 0.0214
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0045 0.0438 0.0878
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0051 0.0533 0.0498
Trichomonas vaginalis helicase, putative 0.0021 0.0082 0.0185
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0146 0.0214
Echinococcus multilocularis dna polymerase eta 0.0021 0.008 0.0037
Mycobacterium ulcerans hypothetical protein 0.0108 0.1373 0.3001
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.019 0.0375
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0045 0.0438 0.0678
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.0185
Loa Loa (eye worm) phosphatidylinositol 3 0.0033 0.0267 0.0497
Schistosoma mansoni apoferritin-2 0.0051 0.0533 0.063
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1166 0.146
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0045 0.0438 0.0403

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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