TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 383.502 | Formula: C23H30FN3O
H donors: 0 H acceptors: 0 LogP: 4.01 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)N1CCN(CC1)C1CCCN(C1)Cc1ccccc1F
InChi: 1S/C23H30FN3O/c1-28-22-10-8-20(9-11-22)26-13-15-27(16-14-26)21-6-4-12-25(18-21)17-19-5-2-3-7-23(19)24/h2-3,5,7-11,21H,4,6,12-18H2,1H3
InChiKey: PNRHJDVXRCZVRA-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	beta-lactamase family protein	0.0041	0.029	0.1017
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0062	0.0537	0.9677
Echinococcus granulosus	lysyl tRNA synthetase	0.0046	0.0353	0.0416
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0039	0.0272	0.4049
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0551	0.0649
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0353	0.1238
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0046	0.0353	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0092	0.0322
Leishmania major	myo-inositol/proton symporter (MIT)	0.0029	0.0155	0.1113
Loa Loa (eye worm)	sugar transporter	0.0206	0.2217	0.7777
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0072	0.0656	1
Schistosoma mansoni	sugar transporter	0.0029	0.0155	0.0182
Brugia malayi	TAR-binding protein	0.0063	0.0551	0.1933
Trypanosoma brucei	glucose transporter 1E	0.0064	0.0561	0.8107
Mycobacterium tuberculosis	Probable esterase LipL	0.0041	0.029	0.0986
Trichomonas vaginalis	glucose transporter, putative	0.0064	0.0561	0.1542
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0561	0.8107
Mycobacterium ulcerans	hypothetical protein	0.0041	0.029	0.8096
Brugia malayi	Pre-SET motif family protein	0.0032	0.0192	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Trypanosoma brucei	hypothetical protein, conserved	0.0041	0.029	0.2696
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0155	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0041	0.029	0.1017
Onchocerca volvulus		0.0029	0.0155	0.0233
Brugia malayi	major facilitator superfamily protein	0.0029	0.0155	0.0543
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0062	0.0537	0.0633
Trichomonas vaginalis	glucose transporter, putative	0.0064	0.0561	0.1542
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0029	0.0155	0.5
Brugia malayi	major facilitator superfamily protein	0.0029	0.0155	0.0543
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0062	0.0537	1
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0029	0.0155	0.0182
Schistosoma mansoni	glucose transporter	0.0029	0.0155	0.0182
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0062	0.0537	0.145
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0092	0.0322
Onchocerca volvulus		0.0029	0.0155	0.0233
Brugia malayi	hypothetical protein	0.004	0.0279	0.0978
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.2217	0.2613
Onchocerca volvulus		0.0029	0.0155	0.0233
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0072	0.0656	0.0779
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0552	0.0651
Mycobacterium ulcerans	esterase/lipase LipP	0.0041	0.029	0.8096
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.029	0.2696
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0092	0.21
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0155	0.0543
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0029	0.0155	0.0508
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0192	0.0227
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0063	0.0552	0.0531
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0561	0.8107
Mycobacterium tuberculosis	Conserved protein	0.0041	0.029	0.0986
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0561	0.8107
Leishmania major	protein kinase, putative	0.0063	0.0552	0.8151
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0039	0.0272	0.0923
Onchocerca volvulus		0.0049	0.039	0.1104
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0046	0.0353	1
Brugia malayi	beta-lactamase	0.0041	0.029	0.1017
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.029	0.0513
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0063	0.0552	0.1937
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0551	0.0649
Onchocerca volvulus		0.0255	0.2791	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0032	0.0192	0.0058
Leishmania major	lysyl-tRNA synthetase, putative	0.0046	0.0353	0.4623
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Schistosoma mansoni	sugar transporter	0.0029	0.0155	0.0182
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0092	0.21
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0046	0.0353	0.0752
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0155	0.0182
Leishmania major	glucose transporter, lmgt1	0.0064	0.0561	0.8317
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0072	0.0656	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.029	0.0513
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0155	0.0182
Toxoplasma gondii	ABC1 family protein	0.0041	0.029	0.021
Schistosoma mansoni	hypothetical protein	0.004	0.0279	0.0329
Onchocerca volvulus		0.0029	0.0155	0.0233
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0552	0.0651
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0092	0.21
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0063	0.0552	0.0531
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0062	0.0537	0.0633
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0029	0.0155	0.4002
Brugia malayi	hypothetical protein	0.0029	0.0155	0.0543
Echinococcus granulosus	calcium dependent protein kinase	0.0059	0.0507	0.0597
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0552	0.0651
Entamoeba histolytica	hypothetical protein	0.004	0.0279	0.4062
Brugia malayi	hypothetical protein	0.0029	0.0155	0.0543
Brugia malayi	Cam kinase protein 1	0.0063	0.0552	0.1937
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0053	0.0436	0.153
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0552	0.0651
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.029	0.0513
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0155	0.0543
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0063	0.0552	0.0531
Loa Loa (eye worm)	hypothetical protein	0.005	0.0402	0.1411
Loa Loa (eye worm)	hypothetical protein	0.026	0.285	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0062	0.0537	0.1885
Trypanosoma cruzi	hexose transporter	0.0064	0.0561	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0041	0.029	0.1017
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0212	0.0744
Echinococcus granulosus	tar DNA binding protein	0.0063	0.0551	0.0649
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0561	0.8107
Chlamydia trachomatis	lysine--tRNA ligase	0.0046	0.0353	1
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0029	0.0155	0.0182
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0064	0.0561	0.8317
Brugia malayi	hypothetical protein	0.026	0.285	1
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0561	0.8107
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0092	0.21
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0041	0.029	0.1017
Giardia lamblia	Lysyl-tRNA synthetase	0.0046	0.0353	0.5182
Leishmania major	glucose transporter, lmgt2	0.0064	0.0561	0.8317
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0552	0.0651
Echinococcus multilocularis	lysyl tRNA synthetase	0.0046	0.0353	0.0416
Schistosoma mansoni	hypothetical protein	0.0034	0.0212	0.025
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0032	0.0192	0.0227
Onchocerca volvulus		0.0029	0.0155	0.0233
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0.0072	0.5
Echinococcus granulosus	solute carrier family 22	0.0029	0.0155	0.0182
Onchocerca volvulus		0.0041	0.029	0.0734
Plasmodium falciparum	hexose transporter	0.0206	0.2217	0.2199
Leishmania major	hypothetical protein, conserved	0.0029	0.0155	0.1113
Plasmodium falciparum	proline--tRNA ligase	0.0072	0.0656	0.0635
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0561	0.8107
Echinococcus granulosus	solute carrier family 22	0.0029	0.0155	0.0182
Brugia malayi	Pre-SET motif family protein	0.0224	0.243	0.8527
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0332	0.3694	0.368
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0092	0.0322
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.029	0.0342
Mycobacterium tuberculosis	Conserved protein	0.0041	0.029	0.0986
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0561	0.1542
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0092	0.0322
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0656	1
Echinococcus granulosus	tumor protein p63	0.0335	0.373	0.4397
Schistosoma mansoni	microtubule-associated protein tau	0.0743	0.8482	1
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0656	1
Brugia malayi	hypothetical protein	0.0029	0.0155	0.0543
Echinococcus multilocularis	tar DNA binding protein	0.0063	0.0551	0.0649
Echinococcus multilocularis	survival motor neuron protein 1	0.026	0.285	0.336
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0561	0.8107
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0092	0.0285
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0029	0.0155	0.0133
Mycobacterium tuberculosis	Probable hydrolase	0.0041	0.029	0.0986
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0039	0.0272	0.0923
Onchocerca volvulus		0.0029	0.0155	0.0233
Schistosoma mansoni	hypothetical protein	0.0053	0.0436	0.0514
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.2217	0.782
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Mycobacterium leprae	Probable lipase LipE	0.0041	0.029	0.4449
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0022	0.004
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.2217	0.2613
Echinococcus granulosus	histone lysine methyltransferase setb	0.0032	0.0192	0.0227
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0041	0.029	0.1017
Loa Loa (eye worm)	hypothetical protein	0.0049	0.039	0.1368
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0092	0.21
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0561	0.8107
Schistosoma mansoni	glucose transport protein	0.0206	0.2217	0.2613
Trichomonas vaginalis	CAMK family protein kinase	0.0063	0.0552	0.1507
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0079
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0063	0.0552	0.0531
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0063	0.0552	0.0651
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0063	0.0552	0.1937
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0551	0.0649
Trypanosoma brucei	glucose transporter 2A	0.0064	0.0561	0.8107
Schistosoma mansoni	glucose transport protein	0.0206	0.2217	0.2613
Brugia malayi	RNA binding protein	0.0063	0.0551	0.1933
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0552	0.0651
Schistosoma mansoni	protein kinase	0.0063	0.0552	0.0651
Echinococcus granulosus	solute carrier family 22	0.0029	0.0155	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0041	0.029	0.1017
Brugia malayi	Sugar transporter family protein	0.0029	0.0155	0.0543
Onchocerca volvulus		0.0029	0.0155	0.0233
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0063	0.0552	0.7919
Echinococcus multilocularis	tumor protein p63	0.0335	0.373	0.4397
Plasmodium vivax	proline--tRNA ligase, putative	0.0072	0.0656	0.0635
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0029	0.0155	0.4002
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0206	0.2217	0.2613
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0155	0.0543
Plasmodium vivax	sugar transporter, putative	0.0029	0.0155	0.0133
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0092	0.0285
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0224	0.243	0.8527
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0561	0.1542
Schistosoma mansoni	lysyl-tRNA synthetase	0.0046	0.0353	0.0416
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0063	0.0552	0.0531
Brugia malayi	Major Facilitator Superfamily protein	0.0029	0.0155	0.0543
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0063	0.0552	0.0531
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0063	0.0552	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0192	0.0674
Onchocerca volvulus		0.0029	0.0155	0.0233
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0092	0.0322
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0041	0.029	0.0342
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0032	0.0192	0.0227
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0259	0.2837	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Brugia malayi	Sugar transporter family protein	0.0029	0.0155	0.0543
Loa Loa (eye worm)	beta-lactamase	0.0041	0.029	0.1017
Onchocerca volvulus		0.0032	0.0192	0.0372
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0561	0.1542
Entamoeba histolytica	protein kinase, putative	0.0063	0.0552	1
Onchocerca volvulus		0.0029	0.0155	0.0233
Schistosoma mansoni	protein kinase	0.0063	0.0552	0.0651
Echinococcus granulosus	synaptic vesicle 2 protein	0.0029	0.0155	0.0182
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0063	0.0552	0.1937
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0046	0.0353	0.395
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0395	0.1384
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.004	0.0287	0.0501
Plasmodium falciparum	protein kinase 7	0.0581	0.6596	0.6588
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0041	0.029	0.0986
Echinococcus granulosus	solute carrier family 22	0.0029	0.0155	0.0182
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0046	0.0353	0.5862
Plasmodium vivax	lysine--tRNA ligase, putative	0.0046	0.0353	0.0331
Entamoeba histolytica	hypothetical protein	0.004	0.0279	0.4062
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0092	0.21
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0224	0.1383
Schistosoma mansoni	protein kinase	0.0063	0.0552	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0537	0.1885
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0178	0.021
Brugia malayi	beta-lactamase family protein	0.0041	0.029	0.1017
Onchocerca volvulus		0.0029	0.0155	0.0233
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0192	0.0227
Onchocerca volvulus		0.0029	0.0155	0.0233
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0332	0.3694	0.5495
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0079
Mycobacterium tuberculosis	Probable lipase LipE	0.0041	0.029	0.0986
Schistosoma mansoni	glucose transport protein	0.0206	0.2217	0.2613
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0561	0.8107
Mycobacterium ulcerans	beta-lactamase	0.0041	0.029	0.8096
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0873	1	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0206	0.2217	0.3201
Plasmodium vivax	hypothetical protein, conserved	0.0041	0.029	0.0268
Entamoeba histolytica	hypothetical protein	0.004	0.0279	0.4062
Plasmodium vivax	SET domain protein, putative	0.0032	0.0192	0.017
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0032	0.0192	0.0227
Echinococcus granulosus	survival motor neuron protein 1	0.026	0.285	0.336
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0279	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0041	0.029	0.1017
Trypanosoma cruzi	hypothetical protein, conserved	0.0041	0.029	0.2696
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0064	0.0561	0.8107
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0062	0.0537	0.0633
Loa Loa (eye worm)	TAR-binding protein	0.0063	0.0551	0.1933
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0063	0.0552	0.0617
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0029	0.0155	0.0182
Schistosoma mansoni	survival motor neuron protein	0.0053	0.0436	0.0514
Echinococcus granulosus	beta LACTamase domain containing family member	0.0041	0.029	0.0342
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0063	0.0552	0.0617
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0212	0.0744
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0079
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0025	0.0113	0.0396
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Trichomonas vaginalis	D-aminoacylase, putative	0.0041	0.029	0.0513
Trichomonas vaginalis	esterase, putative	0.0041	0.029	0.0513
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0395	0.1384
Trichomonas vaginalis	sugar transporter, putative	0.0064	0.0561	0.1542
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0561	0.8107
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0656	1
Onchocerca volvulus		0.0041	0.029	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Echinococcus multilocularis	calcium dependent protein kinase	0.0059	0.0507	0.0597
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0206	0.2217	0.2613
Loa Loa (eye worm)	hypothetical protein	0.0041	0.029	0.1017
Entamoeba histolytica	protein kinase, putative	0.0063	0.0552	1
Entamoeba histolytica	hypothetical protein	0.004	0.0279	0.4062
Brugia malayi	Sugar transporter family protein	0.0206	0.2217	0.7777
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0032	0.0192	0.0227
Onchocerca volvulus		0.0029	0.0155	0.0233
Mycobacterium tuberculosis	Conserved protein	0.0041	0.029	0.0986
Toxoplasma gondii	lysine-tRNA ligase	0.0046	0.0353	0.0308
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0552	0.0651
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0041	0.029	0.8096
Schistosoma mansoni	sugar transporter	0.0029	0.0155	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0552	0.1937
Loa Loa (eye worm)	RNA binding protein	0.0063	0.0551	0.1933
Brugia malayi	RNA recognition motif domain containing protein	0.0063	0.0551	0.1933
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0041	0.029	0.0986
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0063	0.0552	0.0531
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0029	0.0155	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0041	0.029	0.1017
Trypanosoma cruzi	hexose transporter, putative	0.0064	0.0561	0.8107
Chlamydia trachomatis	proline--tRNA ligase	0.0022	0.0072	0.1487
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0029	0.0155	0.0543
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0063	0.0551	0.1933
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0022	0.0072	0.1487
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0079
Echinococcus multilocularis	microtubule associated protein 2	0.0743	0.8482	1
Echinococcus multilocularis	General substrate transporter	0.0177	0.1879	0.2216
Mycobacterium ulcerans	lipase LipD	0.0041	0.029	0.8096
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0395	0.1384
Mycobacterium ulcerans	sugar transporter	0.0029	0.0155	0.4002
Plasmodium vivax	hexose transporter	0.0206	0.2217	0.2199
Brugia malayi	lysyl-tRNA synthetase	0.0046	0.0353	0.1238
Plasmodium falciparum	lysine--tRNA ligase	0.0046	0.0353	0.0331
Mycobacterium ulcerans	integral membrane transport protein	0.0029	0.0155	0.4002
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0332	0.3694	0.368
Mycobacterium tuberculosis	Probable lipase LipD	0.0041	0.029	0.0986
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0063	0.0552	0.0531
Toxoplasma gondii	protein kinase, putative	0.0581	0.6596	1
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0561	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0206	0.2217	0.2613
Onchocerca volvulus		0.0029	0.0155	0.0233
Onchocerca volvulus		0.0041	0.029	0.0734
Schistosoma mansoni	hypothetical protein	0.0206	0.2217	0.2613
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0041	0.029	0.0342
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.039	0.046
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0279	0.0329
Schistosoma mansoni	sugar transporter	0.0029	0.0155	0.0182
Entamoeba histolytica	hypothetical protein	0.0046	0.0353	0.5672
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0062	0.0537	0.0633
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0041	0.029	0.0986
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0537	0.1885
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0155	0.0543
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0063	0.0552	0.0531
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.2217	0.2613
Onchocerca volvulus		0.0029	0.0155	0.0233
Onchocerca volvulus		0.0029	0.0155	0.0233
Mycobacterium leprae	conserved hypothetical protein	0.0041	0.029	0.4449
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0046	0.0353	0.395
Schistosoma mansoni	lysyl-tRNA synthetase	0.0046	0.0353	0.0416
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0206	0.2217	0.2613
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.0561	0.1542
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0062	0.0537	0.1885
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0206	0.2217	0.2613
Loa Loa (eye worm)	sugar transporter	0.0029	0.0155	0.0543
Giardia lamblia	Prolyl-tRNA synthetase	0.0062	0.0537	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0552	0.0651
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0092	0.21
Onchocerca volvulus	Putative transporter	0.0029	0.0155	0.0233
Echinococcus multilocularis	solute carrier family 22	0.0029	0.0155	0.0182
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0092	0.21
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0551	0.0649
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0279	0.0329
Onchocerca volvulus		0.0029	0.0155	0.0233
Trichomonas vaginalis	set domain proteins, putative	0.0255	0.2791	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0022	0.0079
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0395	0.1384
Echinococcus granulosus	microtubule associated protein 2	0.0743	0.8482	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0092	0.0322
Schistosoma mansoni	tar DNA-binding protein	0.0063	0.0551	0.0649
Echinococcus granulosus	General substrate transporter	0.0177	0.1879	0.2216
Trypanosoma brucei	glucose transporter, putative	0.0064	0.0561	0.8107
Leishmania major	hypothetical protein, conserved	0.0041	0.029	0.3509
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0029	0.0155	0.0182
Onchocerca volvulus		0.0053	0.0436	0.1275
Trichomonas vaginalis	penicillin-binding protein, putative	0.0041	0.029	0.0513
Leishmania major	glucose transporter, lmgt3	0.0064	0.0561	0.8317

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 732267