Detailed information for compound 737871

Basic information

Technical information
  • TDR Targets ID: 737871
  • Name: 2-(methyl-methylsulfonylamino)-N-[2-(morpholi ne-4-carbonyl)phenyl]benzamide
  • MW: 417.479 | Formula: C20H23N3O5S
  • H donors: 1 H acceptors: 4 LogP: 1.54 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1NC(=O)c1ccccc1N(S(=O)(=O)C)C)N1CCOCC1
  • InChi: 1S/C20H23N3O5S/c1-22(29(2,26)27)18-10-6-4-8-16(18)19(24)21-17-9-5-3-7-15(17)20(25)23-11-13-28-14-12-23/h3-10H,11-14H2,1-2H3,(H,21,24)
  • InChiKey: NAKYZKIXVNUNTH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(methyl-methylsulfonyl-amino)-N-[2-(morpholine-4-carbonyl)phenyl]benzamide
  • 2-(methyl-methylsulfonylamino)-N-[2-(morpholino-oxomethyl)phenyl]benzamide
  • 2-(mesyl-methyl-amino)-N-[2-(morpholine-4-carbonyl)phenyl]benzamide
  • 2-(methyl-methylsulfonyl-amino)-N-(2-morpholin-4-ylcarbonylphenyl)benzamide
  • AH-487/42662591
  • ZINC00667417
  • CBKinase1_007256
  • CBKinase1_019656

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis sugar transporter, putative 0.014 0.0585 0.25
Schistosoma mansoni protein kinase 0.0138 0.0576 0.0767
Echinococcus granulosus Niemann Pick C1 protein 0.0159 0.0687 0.0915
Onchocerca volvulus 0.0063 0.0179 0.1643
Echinococcus granulosus microtubule associated protein 2 0.1444 0.7504 1
Brugia malayi beta-lactamase 0.0036 0.0034 0.0154
Brugia malayi hypothetical protein 0.0071 0.0219 0.0982
Trypanosoma brucei glucose transporter, putative 0.014 0.0585 0.8532
Schistosoma mansoni sugar transporter 0.0063 0.0179 0.0239
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0424 0.1897
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0138 0.0576 0.0576
Mycobacterium ulcerans sugar transporter 0.0063 0.0179 0.4227
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0179 0.0658
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Brugia malayi beta-lactamase family protein 0.0036 0.0034 0.0154
Schistosoma mansoni hypothetical protein 0.0035 0.0027 0.0036
Giardia lamblia Lysyl-tRNA synthetase 0.0101 0.0377 0.5182
Echinococcus granulosus solute carrier family 22 0.0063 0.0179 0.0239
Schistosoma mansoni glucose transport protein 0.0451 0.2236 0.298
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.0433 0.1938
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.0939 0.4201
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.1068 1
Trypanosoma cruzi hexose transporter, putative 0.014 0.0585 0.8532
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0154
Loa Loa (eye worm) hypothetical protein 0.0111 0.0433 0.1938
Giardia lamblia Prolyl-tRNA synthetase 0.0135 0.0561 1
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1075 0.1433
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0576 0.0767
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0085 0.0296 0.4977
Onchocerca volvulus 0.0063 0.0179 0.1643
Schistosoma mansoni hypothetical protein 0.0075 0.024 0.032
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0063 0.0179 0.1401
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0056 0.0137 0.0615
Onchocerca volvulus Putative transporter 0.0063 0.0179 0.1643
Schistosoma mansoni glucose transport protein 0.0451 0.2236 0.298
Echinococcus multilocularis lysyl tRNA synthetase 0.0101 0.0377 0.0502
Onchocerca volvulus 0.0063 0.0179 0.1643
Echinococcus granulosus calcium dependent protein kinase 0.013 0.053 0.0707
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0096 0.043
Plasmodium falciparum lysine--tRNA ligase 0.0101 0.0377 0.0201
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.0433 0.6009
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.2236 0.298
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Plasmodium falciparum hexose transporter 0.0451 0.2236 0.2094
Leishmania major lysyl-tRNA synthetase, putative 0.0101 0.0377 0.5307
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0034 0.0046
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0085 0.0296 0.2535
Echinococcus granulosus solute carrier family 22 0.0063 0.0179 0.0239
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0576 0.0767
Loa Loa (eye worm) hypothetical protein 0.0059 0.0153 0.0685
Toxoplasma gondii protein kinase, putative 0.1274 0.6604 1
Onchocerca volvulus 0.0235 0.1091 1
Trypanosoma brucei glucose transporter, putative 0.014 0.0585 0.8532
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0154
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0138 0.0576 0.0767
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0119
Schistosoma mansoni microtubule-associated protein tau 0.1444 0.7504 1
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Chlamydia trachomatis lysine--tRNA ligase 0.0101 0.0377 1
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Echinococcus multilocularis Niemann Pick C1 protein 0.0159 0.0687 0.0915
Trypanosoma brucei THT1 - hexose transporter, putative 0.014 0.0585 0.8532
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0034 0.0154
Trichomonas vaginalis sugar transport protein, putative 0.0063 0.0179 0.0658
Loa Loa (eye worm) sugar transporter 0.0063 0.0179 0.0801
Schistosoma mansoni hypothetical protein 0.0035 0.0027 0.0036
Schistosoma mansoni hypothetical protein 0.0047 0.0094 0.0125
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0576 0.0767
Trichomonas vaginalis CAMK family protein kinase 0.0138 0.0576 0.2458
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0135 0.0561 0.0747
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Toxoplasma gondii transporter, major facilitator family protein 0.0063 0.0179 0.0271
Onchocerca volvulus 0.0063 0.0179 0.1643
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0138 0.0576 0.2574
Loa Loa (eye worm) hypothetical protein 0.011 0.0426 0.1905
Echinococcus multilocularis General substrate transporter 0.0388 0.1899 0.2531
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Schistosoma mansoni sugar transporter 0.0063 0.0179 0.0239
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0179 0.0801
Entamoeba histolytica protein kinase, putative 0.0138 0.0576 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0219 0.0292
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0576 0.0767
Brugia malayi Sugar transporter family protein 0.0063 0.0179 0.0801
Loa Loa (eye worm) sugar transporter 0.0451 0.2236 1
Onchocerca volvulus 0.0063 0.0179 0.1643
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0135 0.0561 0.9583
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0027 0.0036
Leishmania major myo-inositol/proton symporter (MIT) 0.0063 0.0179 0.2244
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0154
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0027 0.0036
Echinococcus multilocularis expressed conserved protein 0.0105 0.0398 0.053
Trypanosoma cruzi hexose transporter 0.014 0.0585 0.8532
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0158 0.068 0.1029
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0219 0.0292
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Schistosoma mansoni sugar transporter 0.0063 0.0179 0.0239
Brugia malayi hypothetical protein 0.0063 0.0179 0.0801
Toxoplasma gondii sugar transporter ST3 0.0063 0.0179 0.0271
Loa Loa (eye worm) hypothetical protein 0.0101 0.0377 0.1686
Trypanosoma cruzi hexose transporter, putative 0.014 0.0585 0.8532
Trypanosoma brucei glucose transporter, putative 0.014 0.0585 0.8532
Brugia malayi MH2 domain containing protein 0.012 0.0479 0.2143
Echinococcus multilocularis solute carrier family 22 0.0063 0.0179 0.0239
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Schistosoma mansoni hypothetical protein 0.0071 0.0219 0.0292
Schistosoma mansoni sugar transporter 0.0063 0.0179 0.0239
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0138 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0135 0.0561 0.2508
Onchocerca volvulus 0.0063 0.0179 0.1643
Leishmania major glucose transporter, lmgt3 0.014 0.0585 0.8532
Schistosoma mansoni hypothetical protein 0.0451 0.2236 0.298
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0063 0.0179 0.2244
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0451 0.2236 0.298
Toxoplasma gondii sugar transporter ST2 0.0063 0.0179 0.0271
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0063 0.0179 0.4227
Plasmodium vivax CDK-related protein kinase 6, putative 0.1914 1 1
Onchocerca volvulus 0.0063 0.0179 0.1643
Echinococcus granulosus General substrate transporter 0.0388 0.1899 0.2531
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0063 0.0179 0.1401
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0138 0.0576 0.0872
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.0443 0.059
Plasmodium vivax hexose transporter 0.0451 0.2236 0.2236
Echinococcus granulosus GPCR family 2 0.0035 0.0027 0.0036
Onchocerca volvulus 0.0063 0.0179 0.1643
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0027 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Plasmodium falciparum protein kinase 7 0.1274 0.6604 0.6542
Echinococcus multilocularis solute carrier family 22 0.0063 0.0179 0.0239
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0101 0.0377 0.1556
Onchocerca volvulus 0.0063 0.0179 0.1643
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0034 0.0046
Trypanosoma cruzi sugar transporter, putative 0.0063 0.0179 0.2244
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0179 0.0801
Schistosoma mansoni survival motor neuron protein 0.0047 0.0094 0.0125
Toxoplasma gondii lysine-tRNA ligase 0.0101 0.0377 0.0571
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0088 0.0311 0.1256
Brugia malayi Sugar transporter family protein 0.0451 0.2236 1
Schistosoma mansoni hypothetical protein 0.0046 0.0087 0.0116
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Schistosoma mansoni hypothetical protein 0.0046 0.0087 0.0116
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Schistosoma mansoni patched 1 0.0048 0.0096 0.0128
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0576 0.0767
Echinococcus multilocularis protein patched 0.0048 0.0096 0.0128
Loa Loa (eye worm) hypothetical protein 0.0075 0.024 0.1074
Trypanosoma brucei glucose transporter, putative 0.014 0.0585 0.8532
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Loa Loa (eye worm) hypothetical protein 0.0138 0.0576 0.2574
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0138 0.0576 0.0767
Schistosoma mansoni hypothetical protein 0.0035 0.0027 0.0036
Trichomonas vaginalis glucose transporter, putative 0.014 0.0585 0.25
Brugia malayi lysyl-tRNA synthetase 0.0101 0.0377 0.1686
Loa Loa (eye worm) hypothetical protein 0.0135 0.0561 0.2508
Schistosoma mansoni hypothetical protein 0.0046 0.0087 0.0116
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0048 0.0096 0.1807
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0451 0.2236 0.298
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Onchocerca volvulus 0.0036 0.0034 0.0316
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0451 0.2236 0.298
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0179 0.0658
Echinococcus granulosus solute carrier family 22 0.0063 0.0179 0.0239
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0063 0.0179 0.4227
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0154
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0135 0.0561 1
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0138 0.0576 0.8386
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Mycobacterium ulcerans integral membrane transport protein 0.0063 0.0179 0.4227
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0063 0.0179 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0027 0.0119
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0027 0.0119
Plasmodium falciparum calcium-dependent protein kinase 4 0.0138 0.0576 0.0404
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0729 0.371 0.5617
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.068 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0138 0.0576 0.2574
Brugia malayi Cam kinase protein 1 0.0138 0.0576 0.2574
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0138 0.0576 0.0872
Loa Loa (eye worm) hypothetical protein 0.0048 0.0096 0.043
Leishmania major glucose transporter, lmgt2 0.014 0.0585 0.8532
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1091 0.4799
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0135 0.0561 0.239
Leishmania major protein kinase, putative 0.0138 0.0576 0.8386
Plasmodium falciparum calcium-dependent protein kinase 2 0.0138 0.0576 0.0404
Onchocerca volvulus 0.0063 0.0179 0.1643
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Entamoeba histolytica hypothetical protein 0.0101 0.0377 0.4421
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Onchocerca volvulus 0.0063 0.0179 0.1643
Brugia malayi hypothetical protein 0.0232 0.1075 0.4808
Echinococcus multilocularis GPCR, family 2 0.0035 0.0027 0.0036
Plasmodium vivax calcium-dependent protein kinase, putative 0.0138 0.0576 0.0576
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0027 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0138 0.0576 0.0767
Trypanosoma brucei glucose transporter 2A 0.014 0.0585 0.8532
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0034 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.2236 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0451 0.2236 0.3386
Schistosoma mansoni protein kinase 0.0138 0.0576 0.0767
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0027 0.0119
Trypanosoma brucei glucose transporter, putative 0.014 0.0585 0.8532
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0179 0.0658
Echinococcus multilocularis synaptic vesicle 2 protein 0.0063 0.0179 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Echinococcus granulosus expressed conserved protein 0.0105 0.0398 0.053
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1075 0.1433
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0034 0.0046
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0094 0.0421
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Brugia malayi Pre-SET motif family protein 0.0207 0.0939 0.4201
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0096 0.0281
Trypanosoma brucei glucose transporter 1E 0.014 0.0585 0.8532
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.068 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.2236 0.298
Plasmodium falciparum mitogen-activated protein kinase 2 0.0729 0.371 0.3595
Toxoplasma gondii ABC1 family protein 0.0036 0.0034 0.0052
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Schistosoma mansoni hypothetical protein 0.0035 0.0027 0.0036
Trichomonas vaginalis sugar transporter, putative 0.014 0.0585 0.25
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0154
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0158 0.068 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0729 0.371 0.371
Echinococcus multilocularis microtubule associated protein 2 0.1444 0.7504 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.068 1
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0034 0.0034
Onchocerca volvulus 0.0063 0.0179 0.1643
Brugia malayi major facilitator superfamily protein 0.0063 0.0179 0.0801
Brugia malayi beta-lactamase family protein 0.0036 0.0034 0.0154
Trypanosoma brucei glucose transporter, putative 0.014 0.0585 0.8532
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.2236 0.298
Trypanosoma cruzi hexose transporter, putative 0.014 0.0585 0.8532
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0135 0.0561 0.2508
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0101 0.0377 0.6507
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0179 0.2244
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0101 0.0377 0.5307
Onchocerca volvulus 0.0063 0.0179 0.1643
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Trypanosoma brucei glucose transporter, putative 0.014 0.0585 0.8532
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.0433 0.0578
Trypanosoma brucei THT1 - hexose transporter, putative 0.014 0.0585 0.8532
Leishmania major hypothetical protein, conserved 0.0063 0.0179 0.2244
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Schistosoma mansoni lysyl-tRNA synthetase 0.0101 0.0377 0.0502
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.2236 0.298
Plasmodium vivax lysine--tRNA ligase, putative 0.0101 0.0377 0.0377
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0138 0.0576 0.0767
Trypanosoma brucei glucose transporter, putative 0.014 0.0585 0.8532
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0101 0.0377 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0135 0.0561 0.0747
Echinococcus granulosus Sugar transporter ERD6 protein 0.0063 0.0179 0.0239
Plasmodium falciparum calcium-dependent protein kinase 3 0.0138 0.0576 0.0404
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0138 0.0576 0.2574
Brugia malayi Sugar transporter family protein 0.0063 0.0179 0.0801
Echinococcus multilocularis calcium dependent protein kinase 0.013 0.053 0.0707
Loa Loa (eye worm) hypothetical protein 0.011 0.0424 0.1897
Loa Loa (eye worm) hypothetical protein 0.0036 0.0034 0.0154
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0138 0.0576 0.0872
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0063 0.0179 0.5
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Treponema pallidum prolyl-tRNA synthetase 0.0048 0.0096 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0424 0.1897
Onchocerca volvulus 0.0047 0.0094 0.0862
Plasmodium falciparum proline--tRNA ligase 0.0158 0.068 0.051
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0219 0.0292
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Onchocerca volvulus 0.0036 0.0034 0.0316
Schistosoma mansoni hypothetical protein 0.0046 0.0087 0.0116
Schistosoma mansoni lysyl-tRNA synthetase 0.0101 0.0377 0.0502
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Leishmania major glucose transporter/membrane transporter D2, putative 0.014 0.0585 0.8532
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Plasmodium falciparum calcium-dependent protein kinase 5 0.0138 0.0576 0.0404
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Onchocerca volvulus 0.0063 0.0179 0.1643
Echinococcus granulosus lysyl tRNA synthetase 0.0101 0.0377 0.0502
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0101 0.0377 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Loa Loa (eye worm) major facilitator superfamily transporter 0.0063 0.0179 0.0801
Echinococcus multilocularis protein dispatched 1 0.0055 0.0132 0.0176
Plasmodium falciparum calcium-dependent protein kinase 1 0.0138 0.0576 0.0404
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0096 0.0128
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0138 0.0576 0.0576
Schistosoma mansoni protein kinase 0.0138 0.0576 0.0767
Schistosoma mansoni glucose transport protein 0.0451 0.2236 0.298
Echinococcus multilocularis solute carrier family 22 0.0063 0.0179 0.0239
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0085 0.0296 0.2535
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0179 0.0658
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0158 0.068 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0135 0.0561 0.2508
Trypanosoma brucei sugar transporter, putative 0.0063 0.0179 0.2244
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0179 0.0801
Onchocerca volvulus 0.0036 0.0034 0.0316
Brugia malayi hypothetical protein 0.0063 0.0179 0.0801
Trypanosoma brucei THT1 - hexose transporter, putative 0.014 0.0585 0.8532
Loa Loa (eye worm) major facilitator superfamily transporter 0.0063 0.0179 0.0801
Leishmania major glucose transporter, lmgt1 0.014 0.0585 0.8532
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0135 0.0561 0.0747
Trichomonas vaginalis myo-inositol transporter, putative 0.0063 0.0179 0.0658
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0479 0.2143
Loa Loa (eye worm) beta-lactamase 0.0036 0.0034 0.0154
Brugia malayi major facilitator superfamily protein 0.0063 0.0179 0.0801
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0479 0.2143
Brugia malayi CHE-14 protein 0.0048 0.0096 0.043
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0063 0.0179 0.0239
Loa Loa (eye worm) hypothetical protein 0.0232 0.1075 0.4808
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0179 0.0658
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0096 0.0128
Onchocerca volvulus 0.0063 0.0179 0.1643
Toxoplasma gondii sugar transporter ST1 0.0063 0.0179 0.0271
Echinococcus granulosus synaptic vesicle 2 protein 0.0063 0.0179 0.0239
Trichomonas vaginalis glucose transporter, putative 0.014 0.0585 0.25
Brugia malayi hypothetical protein 0.0063 0.0179 0.0801
Echinococcus multilocularis solute carrier family 22 0.0063 0.0179 0.0239
Trichomonas vaginalis sugar transporter, putative 0.014 0.0585 0.25
Plasmodium vivax sugar transporter, putative 0.0063 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0179 0.0658
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Echinococcus granulosus solute carrier family 22 0.0063 0.0179 0.0239
Schistosoma mansoni glucose transporter 0.0063 0.0179 0.0239
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.0433 0.0578
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0101 0.0377 0.5307
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0424 0.1897
Entamoeba histolytica protein kinase, putative 0.0138 0.0576 1
Trypanosoma cruzi glucose transporter, putative 0.0063 0.0179 0.2244
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0034 0.0046
Trypanosoma cruzi hexose transporter, putative 0.0076 0.0248 0.3316
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.024 0.1074
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0179 0.0658
Onchocerca volvulus 0.0063 0.0179 0.1643
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0135 0.0561 0.0747
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0096 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0585 0.25
Loa Loa (eye worm) hypothetical protein 0.0063 0.0179 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0585 0.25
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0451 0.2236 0.298
Plasmodium vivax proline--tRNA ligase, putative 0.0158 0.068 0.068

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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