Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0151 | 0.1409 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1572 | 0.2949 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.0158 | 0.0296 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0245 | 0.2587 | 0.2587 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Loa Loa (eye worm) | thiamine pyrophosphate enzyme | 0.0267 | 0.2859 | 0.9385 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0151 | 0.1409 | 0.5 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0466 | 0.5333 | 1 |
Loa Loa (eye worm) | ILVBL protein | 0.0282 | 0.3046 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0303 | 0.3299 | 0.5896 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0267 | 0.2853 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.1572 | 0.2949 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0466 | 0.5333 | 1 |
Trypanosoma cruzi | phosphonopyruvate decarboxylase, putative | 0.0151 | 0.1409 | 0.5 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0466 | 0.5333 | 1 |
Mycobacterium ulcerans | pyruvate or indole-3-pyruvate decarboxylase Pdc | 0.0267 | 0.2853 | 0.4994 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.1572 | 0.5163 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1572 | 0.6078 |
Mycobacterium ulcerans | acetolactate synthase | 0.0267 | 0.2853 | 0.4994 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1572 | 0.1572 |
Brugia malayi | Thiamine pyrophosphate enzyme, central domain containing protein | 0.0466 | 0.5333 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1572 | 0.5163 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0267 | 0.2853 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0398 | 0.449 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.1572 | 0.1572 |
Schistosoma mansoni | acetolactate synthase | 0.0398 | 0.449 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.1572 | 0.5163 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0151 | 0.1409 | 0.208 |
Loa Loa (eye worm) | hypothetical protein | 0.0245 | 0.2587 | 0.8493 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0303 | 0.3299 | 0.5734 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0267 | 0.2853 | 0.5 |
Mycobacterium tuberculosis | Acetolactate synthase (large subunit) IlvB1 (acetohydroxy-acid synthase) | 0.0199 | 0.2015 | 0.3304 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.0158 | 0.0351 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.0158 | 0.0351 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.1572 | 0.6078 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0466 | 0.5333 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0245 | 0.2587 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0303 | 0.3299 | 0.5896 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.1572 | 0.6078 |
Brugia malayi | hypothetical protein | 0.0245 | 0.2587 | 0.4851 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0619 | 0.7241 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.1572 | 0.5163 |
Mycobacterium ulcerans | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | 0.0083 | 0.0566 | 0.0378 |
Mycobacterium ulcerans | acetolactate synthase large subunit IlvB | 0.0267 | 0.2853 | 0.4994 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.1572 | 0.1572 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0466 | 0.5333 | 1 |
Onchocerca volvulus | 0.005 | 0.0158 | 1 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.1572 | 0.3502 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0466 | 0.5333 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0466 | 0.5333 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Trypanosoma brucei | phosphonopyruvate decarboxylase-like protein, putative | 0.0151 | 0.1409 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0619 | 0.7241 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0619 | 0.7241 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 30 nM | Inhibition of equine (Eq) Butyrylcholinesterase | ChEMBL. | 11425559 |
Ki (binding) | = 30 nM | Inhibition of equine (Eq) Butyrylcholinesterase | ChEMBL. | 11425559 |
Ki (binding) | = 100 nM | Inhibition of acetylcholinesterase (AChE) of fetal bovine serum (FBS) | ChEMBL. | 11425559 |
Ki (binding) | = 100 nM | Inhibition of acetylcholinesterase (AChE) of fetal bovine serum (FBS) | ChEMBL. | 11425559 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.