Detailed information for compound 763662

Basic information

Technical information
  • TDR Targets ID: 763662
  • Name: 2-cyano-N-cyclohexyl-3-[2-(4-methoxyphenoxy)- 4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enami de
  • MW: 444.482 | Formula: C25H24N4O4
  • H donors: 1 H acceptors: 3 LogP: 3.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1c(Oc2ccc(cc2)OC)nc2n(c1=O)cccc2)C(=O)NC1CCCCC1
  • InChi: 1S/C25H24N4O4/c1-32-19-10-12-20(13-11-19)33-24-21(25(31)29-14-6-5-9-22(29)28-24)15-17(16-26)23(30)27-18-7-3-2-4-8-18/h5-6,9-15,18H,2-4,7-8H2,1H3,(H,27,30)/b17-15+
  • InChiKey: BDDFOXZYAQXHNR-BMRADRMJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-2-cyano-N-cyclohexyl-3-[2-(4-methoxyphenoxy)-4-oxopyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide
  • (E)-2-cyano-N-cyclohexyl-3-[2-(4-methoxyphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide
  • 2-cyano-N-cyclohexyl-3-[2-(4-methoxyphenoxy)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]prop-2-enamide
  • (E)-2-cyano-N-cyclohexyl-3-[2-(4-methoxyphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]prop-2-enamide
  • 2-cyano-N-cyclohexyl-3-[2-(4-methoxyphenoxy)-4-oxo-3-pyrido[1,2-a]pyrimidinyl]prop-2-enamide
  • 2-cyano-N-cyclohexyl-3-[4-keto-2-(4-methoxyphenoxy)pyrido[1,2-a]pyrimidin-3-yl]acrylamide
  • (E)-2-cyano-N-cyclohexyl-3-[4-keto-2-(4-methoxyphenoxy)pyrido[1,2-a]pyrimidin-3-yl]acrylamide
  • STOCK4S-42100

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0136 0.0603
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Echinococcus granulosus neuropeptide receptor A26 0.0447 0.489 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0268 0.1138
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0036
Brugia malayi major facilitator superfamily protein 0.003 0.0214 0.0527
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0136 0.0603
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0136 0.0279
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0136 0.0603
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0268 0.3666
Brugia malayi beta-lactamase family protein 0.0035 0.0268 0.0662
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.003 0.0214 0.2883
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Giardia lamblia Hexose transporter 0.003 0.0214 0.346
Onchocerca volvulus 0.0035 0.0268 0.0662
Echinococcus multilocularis synaptic vesicle 2 protein 0.003 0.0214 0.0437
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2263 0.4628
Loa Loa (eye worm) sugar transporter 0.003 0.0214 0.0527
Leishmania major hypothetical protein, conserved 0.0035 0.0268 0.3666
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0065 0.0609 0.0597
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0065 0.0609 0.0903
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0136 0.0336
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.003 0.0214 0.0201
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0065 0.0608 0.1501
Brugia malayi glycyl-tRNA synthetase 0.0012 0.0012 0.003
Trypanosoma brucei glucose transporter, putative 0.0066 0.0618 0.8653
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Chlamydia trachomatis proline--tRNA ligase 0.0023 0.0131 0.2978
Trypanosoma brucei glucose transporter, putative 0.0066 0.0618 0.8653
Schistosoma mansoni glucose transport protein 0.0213 0.2263 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0214 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0136 0.0336
Giardia lamblia Sugar-proton symporter 0.003 0.0214 0.346
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0344 0.3732 0.5632
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0012 0.0012 0.003
Onchocerca volvulus 0.003 0.0214 0.0527
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0012 0.0012 0.0021
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0213 0.2263 0.4628
Plasmodium vivax CDK-related protein kinase 6, putative 0.0902 1 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0268 0.6439
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0336
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0064 0.0594 0.1214
Entamoeba histolytica hypothetical protein 0.0047 0.041 0.6679
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0136 0.0279
Brugia malayi steroid hormone receptor 0.0023 0.0136 0.0336
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0344 0.3732 0.3724
Echinococcus granulosus synaptic vesicle 2 protein 0.003 0.0214 0.0437
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0136 0.0336
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0214 0.0527
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Onchocerca volvulus 0.003 0.0214 0.0527
Trichomonas vaginalis myo-inositol transporter, putative 0.003 0.0214 0.0894
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0336
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0136 0.0279
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0064 0.0594 0.9752
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.033 0.5469
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0012 0.0012 0.0021
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0136 0.0603
Schistosoma mansoni coup transcription factor 0.0023 0.0136 0.0603
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Mycobacterium tuberculosis Conserved protein 0.0035 0.0268 0.1085
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0618 0.269
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0618 0.269
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0268 0.1085
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0268 0.1085
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0618 0.8653
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0136 0.0336
Echinococcus granulosus solute carrier family 22 0.003 0.0214 0.0437
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.041 0.0399
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0015 0.003
Trypanosoma brucei glucose transporter 1E 0.0066 0.0618 0.8653
Brugia malayi hypothetical protein 0.0012 0.0015 0.0036
Brugia malayi beta-lactamase 0.0035 0.0268 0.0662
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Brugia malayi hypothetical protein 0.003 0.0214 0.0527
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0136 0.0336
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Loa Loa (eye worm) hypothetical protein 0.0064 0.0594 0.1464
Plasmodium falciparum calcium-dependent protein kinase 4 0.0065 0.0609 0.0597
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0064 0.0594 0.1464
Trichomonas vaginalis CAMK family protein kinase 0.0065 0.0608 0.2648
Leishmania major protein kinase, putative 0.0065 0.0608 0.8519
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Toxoplasma gondii ABC1 family protein 0.0035 0.0268 0.0388
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0012 0.0012 0.003
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0608 0.1244
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0015 0.003
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2263 0.4628
Leishmania major threonyl-tRNA synthetase, putative 0.0012 0.0012 0.0012
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.041 0.0399
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0065 0.0609 0.0903
Mycobacterium tuberculosis Conserved protein 0.0035 0.0268 0.1085
Loa Loa (eye worm) hypothetical protein 0.0035 0.0268 0.0662
Onchocerca volvulus 0.003 0.0214 0.0527
Trypanosoma cruzi hexose transporter, putative 0.003 0.0214 0.2883
Schistosoma mansoni sugar transporter 0.003 0.0214 0.0943
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2263 0.4628
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Loa Loa (eye worm) hypothetical protein 0.0065 0.0608 0.1501
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0136 0.0603
Plasmodium falciparum protein kinase 7 0.0601 0.6616 0.6612
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0136 0.0279
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0136 0.0279
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0065 0.0609 0.0903
Mycobacterium ulcerans sugar transporter 0.003 0.0214 0.5063
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0268 0.1085
Mycobacterium leprae Probable lipase LipE 0.0035 0.0268 0.4405
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0712 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0136 0.0603
Brugia malayi Cam kinase protein 1 0.0065 0.0608 0.1501
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0136 0.0336
Onchocerca volvulus 0.003 0.0214 0.0527
Loa Loa (eye worm) hypothetical protein 0.0035 0.0268 0.0662
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0136 0.0336
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0136 0.0336
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0011 0.0028
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0136 0.0336
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0136 0.0603
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0268 0.1085
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Schistosoma mansoni glucose transport protein 0.0213 0.2263 1
Treponema pallidum prolyl-tRNA synthetase 0.0023 0.0131 1
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0214 0.0894
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0036
Brugia malayi nuclear receptor RXR 0.0012 0.0015 0.0036
Brugia malayi Sugar transporter family protein 0.003 0.0214 0.0527
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.041 0.1814
Brugia malayi lysyl-tRNA synthetase 0.0047 0.041 0.1012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0268 0.0662
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0268 0.1186
Brugia malayi ecdysteroid receptor 0.0372 0.4055 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0268 0.0662
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0268 0.1138
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0172 0.0424
Schistosoma mansoni hypothetical protein 0.0213 0.2263 1
Onchocerca volvulus 0.003 0.0214 0.0527
Mycobacterium ulcerans lipase LipD 0.0035 0.0268 0.6439
Plasmodium falciparum hexose transporter 0.0213 0.2263 0.2253
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0214 0.0894
Echinococcus granulosus neuropeptide s receptor 0.0447 0.489 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0065 0.0608 0.1244
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0608 0.1244
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0214 0.0894
Plasmodium vivax proline--tRNA ligase, putative 0.0074 0.0712 0.0701
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.041 1
Leishmania major glucose transporter, lmgt2 0.0066 0.0618 0.8653
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0712 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0136 0.0279
Echinococcus granulosus Threonyl tRNA synthetase C 0.0012 0.0012 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0136 0.0603
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.041 0.0839
Loa Loa (eye worm) hypothetical protein 0.0047 0.041 0.1012
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.003 0.0214 0.0853
Schistosoma mansoni sugar transporter 0.003 0.0214 0.0943
Echinococcus multilocularis General substrate transporter 0.0183 0.1928 0.3942
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0608 0.1244
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0136 0.0336
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0336
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0268 0.1138
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0012 0.0012 0.003
Brugia malayi nuclear receptor NHR-88 0.0023 0.0136 0.0336
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0268 0.3666
Leishmania major hypothetical protein, conserved 0.003 0.0214 0.2883
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0618 0.269
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0712 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0065 0.0609 0.0597
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0336
Echinococcus multilocularis neuropeptide receptor A26 0.0447 0.489 1
Schistosoma mansoni serine/threonine protein kinase 0.0065 0.0608 0.2689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0136 0.0336
Trichomonas vaginalis esterase, putative 0.0035 0.0268 0.1138
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.041 0.1769
Onchocerca volvulus 0.003 0.0214 0.0527
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Schistosoma mansoni protein kinase 0.0065 0.0608 0.2689
Onchocerca volvulus 0.003 0.0214 0.0527
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0136 0.0279
Schistosoma mansoni sugar transporter 0.003 0.0214 0.0943
Mycobacterium ulcerans beta-lactamase 0.0035 0.0268 0.6439
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0136 0.0279
Loa Loa (eye worm) sugar transporter 0.0213 0.2263 0.5581
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0136 0.0603
Schistosoma mansoni glucose transporter 0.003 0.0214 0.0943
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.003
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.003 0.0214 0.0943
Echinococcus granulosus Sugar transporter ERD6 protein 0.003 0.0214 0.0437
Echinococcus multilocularis solute carrier family 22 0.003 0.0214 0.0437
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Trypanosoma brucei glucose transporter, putative 0.0066 0.0618 0.8653
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0268 0.3666
Onchocerca volvulus Putative transporter 0.003 0.0214 0.0527
Onchocerca volvulus 0.003 0.0214 0.0527
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0618 0.269
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.041 1
Toxoplasma gondii sugar transporter ST2 0.003 0.0214 0.0305
Schistosoma mansoni sugar transporter 0.003 0.0214 0.0943
Loa Loa (eye worm) hypothetical protein 0.0035 0.0268 0.0662
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.003 0.0214 0.0853
Brugia malayi beta-lactamase family protein 0.0035 0.0268 0.0662
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0136 0.0279
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0268 0.1138
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.003 0.0214 0.5063
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0608 0.1244
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.041 0.0839
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0268 0.1085
Trypanosoma cruzi sugar transporter, putative 0.003 0.0214 0.2883
Trichomonas vaginalis glucose transporter, putative 0.0066 0.0618 0.269
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0268 0.6439
Trypanosoma brucei glucose transporter, putative 0.0066 0.0618 0.8653
Leishmania major myo-inositol/proton symporter (MIT) 0.003 0.0214 0.2883
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0064 0.0594 0.1464
Trypanosoma brucei glucose transporter, putative 0.0066 0.0618 0.8653
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2263 0.4628
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0136 0.0603
Onchocerca volvulus 0.003 0.0214 0.0527
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.003 0.0214 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0136 0.0336
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.003 0.0214 0.5063
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0136 0.0336
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0268 0.1186
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.041 0.6849
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0074 0.0712 0.106
Leishmania major glucose transporter, lmgt3 0.0066 0.0618 0.8653
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Schistosoma mansoni protein kinase 0.0065 0.0608 0.2689
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0563 0.1152
Onchocerca volvulus 0.003 0.0214 0.0527
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0023 0.0131 0.2993
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.041 0.5694
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Brugia malayi Sugar transporter family protein 0.003 0.0214 0.0527
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0136 0.0279
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.041 0.5694
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0214 0.0527
Brugia malayi major facilitator superfamily protein 0.003 0.0214 0.0527
Plasmodium falciparum proline--tRNA ligase 0.0074 0.0712 0.0701
Toxoplasma gondii sugar transporter ST3 0.003 0.0214 0.0305
Trypanosoma brucei glucose transporter, putative 0.0066 0.0618 0.8653
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0268 0.1085
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0036
Trypanosoma brucei glucose transporter, putative 0.0066 0.0618 0.8653
Onchocerca volvulus 0.003 0.0214 0.0527
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0268 0.0549
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0136 0.0279
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0214 0.0527
Plasmodium falciparum calcium-dependent protein kinase 5 0.0065 0.0609 0.0597
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0012 0.0012 0.0012
Brugia malayi hypothetical protein 0.003 0.0214 0.0527
Trichomonas vaginalis sugar transport protein, putative 0.003 0.0214 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0214 0.0894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0136 0.0336
Loa Loa (eye worm) hypothetical protein 0.0035 0.0268 0.0662
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0015 0.0036
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Mycobacterium tuberculosis Conserved protein 0.0035 0.0268 0.1085
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0268 0.1085
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Echinococcus multilocularis solute carrier family 22 0.003 0.0214 0.0437
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0065 0.0608 0.8519
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0011 0.0028
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0268 0.1138
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0065 0.0609 0.0597
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0608 0.1244
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2263 0.4628
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0015 0.0065
Giardia lamblia Prolyl-tRNA synthetase 0.0064 0.0594 1
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.033 0.1348
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0594 0.2623
Loa Loa (eye worm) major facilitator superfamily transporter 0.003 0.0214 0.0527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0136 0.0336
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0268 0.0662
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0065 0.0608 0.1244
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0015 0.0036
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0136 0.0336
Echinococcus multilocularis glycyl tRNA synthetase 0.0012 0.0012 0.0025
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.041 1
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.041 0.6849
Brugia malayi Cytochrome P450 family protein 0.0012 0.0011 0.0028
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0136 0.0279
Brugia malayi Cytochrome P450 family protein 0.0012 0.0011 0.0028
Onchocerca volvulus 0.003 0.0214 0.0527
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0064 0.0594 0.2583
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.041 0.1814
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0036
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0012 0.0012 0.0012
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0136 0.0279
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0618 0.8653
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.2371 1
Schistosoma mansoni protein kinase 0.0065 0.0608 0.2689
Mycobacterium ulcerans integral membrane transport protein 0.003 0.0214 0.5063
Echinococcus multilocularis Sugar transporter ERD6 protein 0.003 0.0214 0.0437
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0268 0.0662
Loa Loa (eye worm) hypothetical protein 0.0052 0.0459 0.1133
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0065 0.0609 0.0597
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0012 0.0012 0.003
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0268 0.6439
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0015 0.0036
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0618 0.8653
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.041 0.0603
Brugia malayi Sugar transporter family protein 0.0213 0.2263 0.5581
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.033 0.1348
Loa Loa (eye worm) hypothetical protein 0.0012 0.0015 0.0036
Toxoplasma gondii transporter, major facilitator family protein 0.003 0.0214 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0136 0.0336
Onchocerca volvulus 0.0035 0.0268 0.0662
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0136 0.0336
Leishmania major glucose transporter, lmgt1 0.0066 0.0618 0.8653
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0012 0.0012 0.0012
Plasmodium falciparum calcium-dependent protein kinase 3 0.0065 0.0609 0.0597
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0136 0.0336
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0618 0.8653
Plasmodium falciparum mitogen-activated protein kinase 2 0.0344 0.3732 0.3724
Loa Loa (eye worm) hypothetical protein 0.0064 0.0594 0.1464
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0011 0.0028
Trichomonas vaginalis glucose transporter, putative 0.003 0.0214 0.0894
Echinococcus granulosus General substrate transporter 0.0183 0.1928 0.3942
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0136 0.0603
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0042 0.0345 0.1477
Onchocerca volvulus 0.003 0.0214 0.0527
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Onchocerca volvulus 0.0035 0.0268 0.0662
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0136 0.0279
Echinococcus granulosus solute carrier family 22 0.003 0.0214 0.0437
Loa Loa (eye worm) hypothetical protein 0.0372 0.4055 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0213 0.2263 0.3408
Trypanosoma cruzi hexose transporter 0.0066 0.0618 0.8653
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0074 0.0712 1
Echinococcus multilocularis solute carrier family 22 0.003 0.0214 0.0437
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0074 0.0712 1
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Onchocerca volvulus 0.003 0.0214 0.0527
Brugia malayi hypothetical protein 0.003 0.0214 0.0527
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0136 0.0279
Echinococcus granulosus solute carrier family 22 0.003 0.0214 0.0437
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0136 0.0336
Trichomonas vaginalis sugar transporter, putative 0.0066 0.0618 0.269
Onchocerca volvulus Bile acid receptor homolog 0.0372 0.4055 1
Toxoplasma gondii protein kinase, putative 0.0601 0.6616 1
Onchocerca volvulus 0.0023 0.0136 0.0336
Trypanosoma brucei glucose transporter, putative 0.0066 0.0618 0.8653
Leishmania major glucose transporter/membrane transporter D2, putative 0.0066 0.0618 0.8653
Echinococcus granulosus glycyl tRNA synthetase 0.0012 0.0012 0.0025
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0136 0.0279
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0065 0.0608 0.1501
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0064 0.0594 0.2623
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0336
Plasmodium falciparum calcium-dependent protein kinase 1 0.0065 0.0609 0.0597
Echinococcus multilocularis solute carrier family 22 0.003 0.0214 0.0437
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0065 0.0608 0.1244
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0065 0.0608 0.1501
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0064 0.0594 0.1214
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0213 0.2263 0.4628
Trypanosoma cruzi hexose transporter, putative 0.0066 0.0618 0.8653
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0282 0.3867
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0136 0.0279
Loa Loa (eye worm) hypothetical protein 0.0035 0.0268 0.0662
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Schistosoma mansoni glucose transport protein 0.0213 0.2263 1
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0136 0.0336
Trypanosoma cruzi glucose transporter, putative 0.003 0.0214 0.2883
Brugia malayi Major Facilitator Superfamily protein 0.003 0.0214 0.0527
Plasmodium falciparum calcium-dependent protein kinase 2 0.0065 0.0609 0.0597
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0336
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0136 0.0279
Entamoeba histolytica protein kinase, putative 0.0065 0.0608 1
Schistosoma mansoni glycyl-tRNA synthetase 0.0012 0.0012 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0213 0.2263 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0136 0.0603
Trypanosoma brucei THT1 - hexose transporter, putative 0.0066 0.0618 0.8653
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0336
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0015 0.0065
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0563 0.1152
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.0618 0.269
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0268 0.0549
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0213 0.2263 0.4628
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0136 0.0336
Trichomonas vaginalis sugar transporter, putative 0.003 0.0214 0.0894
Toxoplasma gondii sugar transporter ST1 0.003 0.0214 0.0305
Plasmodium vivax hexose transporter 0.0213 0.2263 0.2253
Echinococcus granulosus solute carrier family 22 0.003 0.0214 0.0437
Brugia malayi nuclear hormone receptor 0.0023 0.0136 0.0336
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0268 0.0256
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0136 0.0336
Onchocerca volvulus 0.003 0.0214 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0136 0.0336
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0012 0.0012 0.0025
Trypanosoma brucei sugar transporter, putative 0.003 0.0214 0.2883
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0064 0.0594 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.041 0.5694
Plasmodium vivax sugar transporter, putative 0.003 0.0214 0.0201
Brugia malayi hypothetical protein 0.0012 0.0015 0.0036
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0268 0.4405
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0527
Onchocerca volvulus 0.003 0.0214 0.0527
Trypanosoma brucei glucose transporter 2A 0.0066 0.0618 0.8653
Echinococcus multilocularis neuropeptide s receptor 0.0447 0.489 1
Entamoeba histolytica protein kinase, putative 0.0065 0.0608 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0136 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0136 0.0336

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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