TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 379.538 | Formula: C24H33N3O
H donors: 0 H acceptors: 0 LogP: 4.28 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1N1CCN(CC1)C1CCCN(C1)Cc1ccccc1C
InChi: 1S/C24H33N3O/c1-20-8-3-4-9-21(20)18-25-13-7-10-22(19-25)26-14-16-27(17-15-26)23-11-5-6-12-24(23)28-2/h3-6,8-9,11-12,22H,7,10,13-19H2,1-2H3
InChiKey: SKOCAYYXIZTJJO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	phd finger protein, putative	0.003	0.0234	0.2811
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	0.3348	1
Giardia lamblia	Flap structure-specific endonuclease	0.0026	0.0197	0.0226
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Loa Loa (eye worm)	hexokinase	0.0081	0.0831	0.225
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0236	0.0236
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0234	0.2811
Onchocerca volvulus		0.0081	0.0831	0.2609
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0046	0.0555
Echinococcus multilocularis	geminin	0.0172	0.1894	0.1894
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.006	0.0161
Leishmania major	hexokinase, putative	0.0081	0.0831	1
Schistosoma mansoni	hypothetical protein	0.0172	0.1894	0.2351
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0117	0.1408
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0111	0.0301
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.1019	0.1265
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0111	0.1338
Brugia malayi	Bromodomain containing protein	0.003	0.0234	0.0632
Echinococcus granulosus	hexokinase	0.0081	0.0831	0.1032
Loa Loa (eye worm)	hypothetical protein	0.0105	0.1114	0.3014
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1657	0.4484
Echinococcus granulosus	peregrin	0.003	0.0234	0.029
Brugia malayi	PHD-finger family protein	0.003	0.0234	0.0632
Loa Loa (eye worm)	flap endonuclease-1	0.0026	0.0197	0.0533
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0236	0.0294
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0492	0.5915
Echinococcus multilocularis	dna polymerase eta	0.002	0.0117	0.0117
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0117	0.1408
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0236	0.0236
Echinococcus multilocularis	hexokinase type 2	0.0081	0.0831	0.0831
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0187	0.2249
Brugia malayi	hypothetical protein	0.0026	0.0187	0.0506
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0111	0.0111
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.0117	0.0117
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0345	0.3896	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.002	0.0117	0.1408
Plasmodium vivax	hypothetical protein, conserved	0.0011	0.0022	0.0266
Brugia malayi	tumor suppressor.	0.0327	0.3695	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.0306	0.0306
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.0234	0.0632
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0297	0.3348	0.8551
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0236	0.0294
Schistosoma mansoni	ap endonuclease	0.0019	0.0111	0.0138
Echinococcus granulosus	hexokinase type 2	0.0081	0.0831	0.1032
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.041	0.041
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0145	0.1578	0.5
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0187	0.2249
Echinococcus granulosus	geminin	0.0172	0.1894	0.2351
Echinococcus granulosus	protein quaking	0.0028	0.0211	0.0261
Loa Loa (eye worm)	hypothetical protein	0.003	0.0234	0.0632
Onchocerca volvulus		0.0081	0.0831	0.2609
Echinococcus granulosus	flap endonuclease 1	0.0026	0.0197	0.0244
Brugia malayi	cytoplasmic intermediate filament protein	0.0015	0.006	0.0161
Onchocerca volvulus	Hexokinase homolog	0.0051	0.048	0.1139
Brugia malayi	Pre-SET motif family protein	0.0205	0.227	0.6142
Loa Loa (eye worm)	hexokinase	0.0051	0.048	0.1299
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	0.3348	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0052	0.0492	0.5915
Schistosoma mansoni	hypothetical protein	0.0012	0.0022	0.0028
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Loa Loa (eye worm)	hexokinase	0.0081	0.0831	0.225
Brugia malayi	AF-10 protein	0.001	0.0001	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1339	0.3623
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0.0001	0.0017
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.001	0.0001	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0202	0.0547
Plasmodium vivax	hypothetical protein, conserved	0.003	0.0234	0.2811
Schistosoma mansoni	DNA polymerase eta	0.002	0.0117	0.0145
Giardia lamblia	DNA repair protein RAD52	0.0345	0.3896	1
Trypanosoma cruzi	hexokinase, putative	0.0081	0.0831	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0208	0.0562
Brugia malayi	F/Y-rich N-terminus family protein	0.002	0.0118	0.0319
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.041	0.111
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0188	0.051
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0117	0.004
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0229	0.0619
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0229	0.0619
Echinococcus granulosus	muscleblind protein	0.0152	0.1657	0.2056
Giardia lamblia	PHD finger protein 15	0.003	0.0234	0.0324
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	0.3348	1
Schistosoma mansoni	hypothetical protein	0.001	0.0001	0.0002
Giardia lamblia	DINP protein human, muc B family	0.002	0.0117	0.0015
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0187	0.2249
Entamoeba histolytica	hexokinase 2	0.0081	0.0831	0.1903
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0492	0.1176
Brugia malayi	Hexokinase family protein	0.0081	0.0831	0.225
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.0234	0.029
Echinococcus multilocularis	protein quaking	0.0028	0.0211	0.0211
Echinococcus multilocularis	muscleblind protein 1	0.0152	0.1657	0.1657
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0217	0.0269
Brugia malayi	Temporarily assigned gene name protein 44	0.0028	0.0211	0.057
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0043	0.0043
Plasmodium vivax	SET domain protein, putative	0.003	0.0236	0.2845
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0326	0.0404
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.0234	0.029
Echinococcus granulosus	mitogen activated protein kinase 3	0.0052	0.0492	0.061
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0187	0.2249
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0052	0.0492	0.5915
Trypanosoma brucei	hexokinase	0.0081	0.0831	1
Onchocerca volvulus	Huntingtin homolog	0.0125	0.1339	0.4732
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.041	0.0509
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.002	0.0117	0.004
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0006	0.0006
Brugia malayi	jmjC domain containing protein	0.0038	0.0326	0.0881
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.227	0.6142
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.0786	0.0976
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0111	0.1338
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0038	0.0326	0.0404
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0111	0.0301
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	0.3348	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0145	0.1578	1
Echinococcus granulosus	hexokinase	0.0081	0.0831	0.1032
Onchocerca volvulus		0.0081	0.0831	0.2609
Echinococcus multilocularis	hexokinase	0.0081	0.0831	0.0831
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.041	0.0509
Echinococcus granulosus	hexokinase	0.0081	0.0831	0.1032
Brugia malayi	PHD-finger family protein	0.0011	0.0021	0.0056
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.0234	0.2811
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0545	0.6557
Trypanosoma brucei	DNA polymerase IV, putative	0.002	0.0117	0.1408
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0211	0.057
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.0622	0.0772
Echinococcus multilocularis	transcription factor eb	0.0106	0.112	0.112
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0011	0.0019	0.0019
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.0601	0.1627
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0043	0.0053
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0022	0.0028
Echinococcus granulosus	dna polymerase kappa	0.002	0.0117	0.0145
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.041	0.0509
Echinococcus multilocularis	flap endonuclease 1	0.0026	0.0197	0.0197
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.0011	0.0022	0.0266
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.0117	0.0145
Mycobacterium ulcerans	DNA polymerase IV	0.002	0.0117	0.004
Schistosoma mansoni	hypothetical protein	0.003	0.0234	0.029
Echinococcus granulosus	lamin dm0	0.0027	0.0208	0.0258
Echinococcus granulosus	lamin	0.0027	0.0208	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0056
Brugia malayi	hexokinase	0.0081	0.0831	0.225
Schistosoma mansoni	hypothetical protein	0.0028	0.0211	0.0261
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0236	0.0294
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.002	0.0117	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0188	0.051
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.0492	0.5915
Schistosoma mansoni	lamin	0.0027	0.0208	0.0258
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0117	0.0317
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.041	0.0509
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0006	0.0008
Loa Loa (eye worm)	jmjC domain-containing protein	0.0038	0.0326	0.0881
Loa Loa (eye worm)	hypothetical protein	0.002	0.0117	0.0317
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.041	0.0509
Brugia malayi	intermediate filament protein	0.0027	0.0208	0.0562
Echinococcus multilocularis	musashi	0.0027	0.0208	0.0208
Schistosoma mansoni	cpg binding protein	0.0029	0.0229	0.0284
Entamoeba histolytica	deoxycytidyl transferase, putative	0.002	0.0117	0.0015
Plasmodium vivax	hexokinase, putative	0.0081	0.0831	1
Echinococcus granulosus	hypothetical protein	0.0028	0.0211	0.0261
Onchocerca volvulus		0.0233	0.2597	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0187	0.2249
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Schistosoma mansoni	lamin	0.0027	0.0208	0.0258
Trypanosoma brucei	DNA polymerase eta, putative	0.002	0.0117	0.1408
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Entamoeba histolytica	Flap nuclease, putative	0.0026	0.0197	0.0226
Brugia malayi	Pre-SET motif family protein	0.003	0.0236	0.064
Echinococcus multilocularis	mitogen activated protein kinase	0.0052	0.0492	0.0492
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0.0001	0.0017
Leishmania major	hexokinase, putative	0.0081	0.0831	1
Trypanosoma brucei	unspecified product	0.002	0.0117	0.1408
Plasmodium falciparum	hexokinase	0.0081	0.0831	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.0234	0.0234
Brugia malayi	hypothetical protein	0.0125	0.1339	0.3623
Schistosoma mansoni	hypothetical protein	0.0028	0.0211	0.0261
Trypanosoma cruzi	hexokinase, putative	0.0081	0.0831	1
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0052	0.0492	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0532	0.1439
Treponema pallidum	fructose-bisphosphate aldolase	0.0297	0.3348	1
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0297	0.3348	0.8551
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0208	0.0258
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0492	0.1176
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0026	0.0197	0.2368
Loa Loa (eye worm)	hypothetical protein	0.0125	0.1339	0.3623
Trichomonas vaginalis	set domain proteins, putative	0.0233	0.2597	0.7681
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0492	0.1176
Loa Loa (eye worm)	hypothetical protein	0.003	0.0236	0.064
Onchocerca volvulus	Huntingtin homolog	0.0125	0.1339	0.4732
Echinococcus multilocularis	dna polymerase kappa	0.002	0.0117	0.0117
Plasmodium falciparum	flap endonuclease 1	0.0026	0.0197	0.2368
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0037	0.01
Echinococcus multilocularis	lamin	0.0027	0.0208	0.0208
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0046	0.0555
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.0369	0.0369
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0208	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0208	0.0562
Trichomonas vaginalis	flap endonuclease-1, putative	0.0026	0.0197	0.0265
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0098	0.1029	0.2425
Echinococcus multilocularis	hexokinase	0.0081	0.0831	0.0831
Echinococcus granulosus	cpg binding protein	0.0031	0.0248	0.0308
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.0369	0.0458
Echinococcus granulosus	intermediate filament protein	0.0027	0.0208	0.0258
Brugia malayi	Flap endonuclease-1	0.0026	0.0197	0.0533
Entamoeba histolytica	hypothetical protein	0.0098	0.1029	0.2425
Echinococcus multilocularis	microtubule associated protein 2	0.0702	0.8056	0.8056
Loa Loa (eye worm)	hexokinase	0.0025	0.018	0.0488
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0236	0.2845
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0187	0.2249
Onchocerca volvulus		0.003	0.0236	0.012
Leishmania major	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.0117	0.0317
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0236	0.0294
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.0492	0.1176
Schistosoma mansoni	hypothetical protein	0.0172	0.1894	0.2351
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Schistosoma mansoni	cpg binding protein	0.0031	0.0248	0.0308
Trichomonas vaginalis	DNA polymerase eta, putative	0.002	0.0117	0.0018
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0111	0.1338
Brugia malayi	Hexokinase family protein	0.0051	0.048	0.1299
Trypanosoma brucei	DNA polymerase kappa, putative	0.0014	0.0046	0.0555
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0052	0.0492	0.5915
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0026	0.0197	0.2368
Schistosoma mansoni	ap endonuclease	0.0019	0.0111	0.0138
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0026	0.0197	0.2368
Trypanosoma brucei	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0026	0.0197	0.2368
Schistosoma mansoni	cpg binding protein	0.0031	0.0248	0.0308
Onchocerca volvulus	Alhambra homolog	0.003	0.0234	0.0108
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0011	0.0019	0.0024
Echinococcus multilocularis	muscleblind protein	0.0152	0.1657	0.1657
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0111	0.1338
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0111	0.1338
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	0.3348	1
Brugia malayi	Helix-loop-helix DNA-binding domain containing protein	0.0106	0.112	0.303
Giardia lamblia	Kinase, CMGC MAPK	0.0052	0.0492	0.1005
Schistosoma mansoni	flap endonuclease-1	0.0024	0.0167	0.0208
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Brugia malayi	hexokinase type II	0.0026	0.0188	0.051
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.002	0.0117	0.1408
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0052	0.0492	0.5915
Trypanosoma brucei	unspecified product	0.0014	0.0046	0.0555
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0052	0.0492	0.5915
Toxoplasma gondii	exonuclease III APE	0.0019	0.0111	0.1338
Schistosoma mansoni	microtubule-associated protein tau	0.0702	0.8056	1
Plasmodium vivax	flap endonuclease 1, putative	0.0026	0.0197	0.2368
Loa Loa (eye worm)	hypothetical protein	0.0152	0.1657	0.4484
Treponema pallidum	hexokinase (hxk)	0.0081	0.0831	0.2225
Brugia malayi	hypothetical protein	0.0017	0.0081	0.022
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0111	0.0138
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0111	0.1338
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0145	0.1578	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0018	0.0098	0.0122
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.1019	0.1019
Leishmania major	DNA polymerase eta, putative	0.002	0.0117	0.1408
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0006	0.0017
Toxoplasma gondii	hexokinase	0.0081	0.0831	1
Brugia malayi	Hexokinase family protein	0.0025	0.018	0.0488
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	0.3348	1
Brugia malayi	Muscleblind-like protein	0.0152	0.1657	0.4484
Echinococcus granulosus	transcription factor eb	0.0106	0.112	0.139
Brugia malayi	MAP kinase sur-1	0.0052	0.0492	0.1331
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0236	0.0294
Echinococcus granulosus	mitogen activated protein kinase	0.0052	0.0492	0.061
Loa Loa (eye worm)	hypothetical protein	0.0051	0.048	0.13
Echinococcus granulosus	lysine specific demethylase 5A	0.0038	0.0326	0.0404
Entamoeba histolytica	hexokinase 1	0.0081	0.0831	0.1903
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0492	0.061
Leishmania major	hypothetical protein, conserved	0.0026	0.0187	0.2249
Trypanosoma brucei	hexokinase	0.0081	0.0831	1
Echinococcus multilocularis	lamin dm0	0.0027	0.0208	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0187	0.0506
Brugia malayi	jmjC domain containing protein	0.0097	0.1019	0.2757
Echinococcus granulosus	microtubule associated protein 2	0.0702	0.8056	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0037	0.01
Mycobacterium tuberculosis	Conserved hypothetical protein	0.002	0.0117	0.004
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0111	0.5
Echinococcus multilocularis	hexokinase	0.0081	0.0831	0.0831
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0022	0.0022
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.0117	0.0145
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0208	0.0562
Trypanosoma brucei	unspecified product	0.0014	0.0046	0.0555
Brugia malayi	hypothetical protein	0.0028	0.0211	0.057
Echinococcus granulosus	dna polymerase eta	0.002	0.0117	0.0145
Giardia lamblia	Fructose-bisphosphate aldolase	0.0297	0.3348	0.8551
Loa Loa (eye worm)	tumor suppressor	0.0327	0.3695	1
Trypanosoma brucei	protein kinase, putative	0.0052	0.0492	0.5915
Trypanosoma cruzi	DNA polymerase kappa, putative	0.002	0.0117	0.1408
Toxoplasma gondii	PHD-finger domain-containing protein	0.001	0.0001	0.0017
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	0.3348	1
Echinococcus multilocularis	peregrin	0.003	0.0234	0.0234
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.0117	0.0145
Loa Loa (eye worm)	helix-loop-helix DNA-binding domain-containing protein	0.0105	0.1114	0.3014
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0052	0.0492	0.5915
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.041	0.111
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0297	0.3348	1
Onchocerca volvulus		0.0051	0.048	0.1139
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.0117	0.0317
Schistosoma mansoni	hexokinase	0.0081	0.0831	0.1032
Loa Loa (eye worm)	hexokinase type II	0.0081	0.0831	0.225
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0187	0.2249
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0043	0.0115
Onchocerca volvulus		0.0029	0.0229	0.0087
Trypanosoma brucei	hexokinase, putative	0.0081	0.0831	1
Echinococcus multilocularis	cpg binding protein	0.0031	0.0248	0.0248
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.041	0.041
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0052	0.0492	0.1331

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 770332