Detailed information for compound 770665

Basic information

Technical information
  • TDR Targets ID: 770665
  • Name: 2-cyano-3-[2-(4-ethylphenoxy)-9-methyl-4-oxop yrido[1,2-a]pyrimidin-3-yl]-N-(phenylmethyl)p rop-2-enamide
  • MW: 464.515 | Formula: C28H24N4O3
  • H donors: 1 H acceptors: 3 LogP: 4.17 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=Cc1c(Oc2ccc(cc2)CC)nc2n(c1=O)cccc2C)C(=O)NCc1ccccc1
  • InChi: 1S/C28H24N4O3/c1-3-20-11-13-23(14-12-20)35-27-24(28(34)32-15-7-8-19(2)25(32)31-27)16-22(17-29)26(33)30-18-21-9-5-4-6-10-21/h4-16H,3,18H2,1-2H3,(H,30,33)/b22-16+
  • InChiKey: HHLUNPAABMADKV-CJLVFECKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-2-cyano-3-[2-(4-ethylphenoxy)-9-methyl-4-oxopyrido[1,2-a]pyrimidin-3-yl]-N-(phenylmethyl)prop-2-enamide
  • 2-cyano-3-[2-(4-ethylphenoxy)-9-methyl-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(phenylmethyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(4-ethylphenoxy)-9-methyl-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]-N-(phenylmethyl)prop-2-enamide
  • (E)-2-cyano-3-[2-(4-ethylphenoxy)-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(phenylmethyl)prop-2-enamide
  • 2-cyano-3-[2-(4-ethylphenoxy)-9-methyl-4-oxo-3-pyrido[1,2-a]pyrimidinyl]-N-(phenylmethyl)prop-2-enamide
  • (E)-N-(benzyl)-2-cyano-3-[2-(4-ethylphenoxy)-4-keto-9-methyl-pyrido[1,2-a]pyrimidin-3-yl]acrylamide
  • N-(benzyl)-2-cyano-3-[2-(4-ethylphenoxy)-4-keto-9-methyl-pyrido[1,2-a]pyrimidin-3-yl]acrylamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0115 0.0457 0.0515
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0344 0.0329
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0115 0.0457 0.1286
Schistosoma mansoni coup transcription factor 0.0243 0.107 0.1056
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0047 0.0135 0.3157
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0115 0.0457 0.0443
Echinococcus granulosus lamin 0.003 0.0056 0.0046
Loa Loa (eye worm) intermediate filament protein 0.003 0.0056 0.0072
Entamoeba histolytica hypothetical protein 0.0108 0.0424 1
Loa Loa (eye worm) T-complex protein 1 0.0047 0.0135 0.0173
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0104 0.01
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.1649 0.7776 1
Brugia malayi nuclear receptor NHR-88 0.0243 0.107 0.1253
Brugia malayi orphan nuclear receptor NR2E1 0.0115 0.0457 0.0515
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0108
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0115 0.0457 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0243 0.107 0.1253
Echinococcus multilocularis ecdysone induced protein 78C 0.0243 0.107 0.1056
Loa Loa (eye worm) hypothetical protein 0.0101 0.0392 0.0504
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0243 0.107 0.1056
Schistosoma mansoni nuclear receptor 0.0115 0.0457 0.0443
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0244 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0243 0.107 0.1056
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0084 0.2436
Onchocerca volvulus 0.0243 0.107 0.313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0243 0.107 0.1056
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.0505 0.065
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0047 0.0135 0.2649
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0243 0.107 0.1253
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0144 0.3762
Brugia malayi ecdysteroid receptor 0.0243 0.107 0.1253
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0039
Brugia malayi beta-lactamase family protein 0.0036 0.0084 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0115 0.0457 0.0443
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Schistosoma mansoni nuclear hormone receptor 0.0243 0.107 0.1056
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0084 0.0069
Toxoplasma gondii t-complex protein beta subunit 0.0047 0.0135 0.1947
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0244 1
Plasmodium vivax SET domain protein, putative 0.0091 0.0344 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.003 0.0297
Onchocerca volvulus 0.0115 0.0457 0.1286
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0084 0.0824
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0047 0.0135 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0243 0.107 0.1253
Trichomonas vaginalis set domain proteins, putative 0.0722 0.3351 1
Giardia lamblia TCP-1 chaperonin subunit beta 0.0047 0.0135 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0063 0.0081
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0128 0.0523 0.0508
Brugia malayi MH2 domain containing protein 0.0125 0.0505 0.0573
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0069
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0084 0.0065
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0128 0.0523 0.0575
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0243 0.107 0.1376
Loa Loa (eye worm) hypothetical protein 0.0049 0.0144 0.0186
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.003 0.3604
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0336 0.0321
Mycobacterium ulcerans hypothetical protein 0.0036 0.0084 1
Brugia malayi Nuclear hormone receptor E75 0.0115 0.0457 0.0515
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0336 0.0321
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0063 0.0039
Onchocerca volvulus 0.003 0.0056 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0243 0.107 0.1253
Schistosoma mansoni nuclear hormone receptor 0.0115 0.0457 0.0443
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0063 0.0039
Brugia malayi nuclear receptor NHR-88 0.0115 0.0457 0.0515
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0115 0.0457 0.0443
Brugia malayi steroid hormone receptor 0.0243 0.107 0.1253
Brugia malayi nuclear receptor RXR 0.0128 0.0523 0.0594
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0244 0.0258
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0128 0.0523 0.0508
Brugia malayi hypothetical protein 0.0108 0.0424 0.0475
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0243 0.107 0.1056
Leishmania major hypothetical protein, conserved 0.0049 0.0144 0.5323
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0424 0.0409
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0047 0.0135 0.3157
Entamoeba histolytica hypothetical protein 0.0108 0.0424 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0084 0.0078
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0144 0.3762
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.024 0.0252
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0243 0.107 0.1253
Schistosoma mansoni hypothetical protein 0.1873 0.8841 0.8839
Onchocerca volvulus 0.0722 0.3351 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0115 0.0457 0.0501
Leishmania major hypothetical protein, conserved 0.0036 0.0084 0.2503
Echinococcus granulosus thyroid hormone receptor alpha 0.0115 0.0457 0.0501
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0108
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0056 0.0072
Schistosoma mansoni lamin 0.003 0.0056 0.0041
Brugia malayi hypothetical protein 0.0128 0.0523 0.0594
Onchocerca volvulus 0.0115 0.0457 0.1286
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Mycobacterium tuberculosis Conserved protein 0.0036 0.0084 0.0824
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.003 0.3604
Brugia malayi hypothetical protein 0.0032 0.0061 0.0038
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.003 0.3604
Schistosoma mansoni nuclear receptor nhr-48 0.0115 0.0457 0.0443
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0108
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0056 0.0031
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0243 0.107 0.1195
Mycobacterium ulcerans lipase LipD 0.0036 0.0084 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0336 0.0432
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Brugia malayi tailless protein 0.0115 0.0457 0.0515
Schistosoma mansoni thyroid hormone receptor 0.2116 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0243 0.107 0.1056
Brugia malayi Nuclear hormone receptor-like 1 0.1764 0.8323 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0243 0.107 0.1195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0243 0.107 0.1376
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0243 0.107 0.1056
Brugia malayi nuclear receptor NHR-67 0.0115 0.0457 0.0515
Brugia malayi hypothetical protein 0.0115 0.0457 0.0515
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.1017 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0344 0.0329
Loa Loa (eye worm) hypothetical protein 0.0243 0.107 0.1376
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0243 0.107 0.1195
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0115 0.0457 0.0443
Plasmodium falciparum T-complex protein 1 subunit beta 0.0047 0.0135 0.9326
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0084 0.0824
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0084 0.0824
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.003 0.3604
Echinococcus granulosus FTZ F1 alpha 0.0243 0.107 0.1195
Brugia malayi T-complex protein 1, beta subunit 0.0047 0.0135 0.0126
Brugia malayi nuclear hormone receptor family member odr-7 0.0115 0.0457 0.0515
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0144 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1873 0.8841 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0108
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0243 0.107 0.1056
Loa Loa (eye worm) hypothetical protein 0.0243 0.107 0.1376
Loa Loa (eye worm) hypothetical protein 0.0069 0.024 0.0308
Loa Loa (eye worm) nuclear hormone receptor 0.0115 0.0457 0.0588
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0392 0.0504
Loa Loa (eye worm) DR-78 0.0115 0.0457 0.0588
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0144 0.4191
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0243 0.107 0.1376
Schistosoma mansoni retinoic acid receptor RXR 0.0243 0.107 0.1056
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0048
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0144 0.232
Mycobacterium tuberculosis Conserved protein 0.0036 0.0084 0.0824
Leishmania major T-complex protein 1, beta subunit, putative 0.0047 0.0135 0.4869
Entamoeba histolytica hypothetical protein 0.0108 0.0424 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0115 0.0457 0.0501
Echinococcus granulosus histone lysine methyltransferase setb 0.0091 0.0344 0.0373
Loa Loa (eye worm) steroid hormone receptor 0.0243 0.107 0.1376
Loa Loa (eye worm) hypothetical protein 0.1636 0.7711 0.9916
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0243 0.107 0.1253
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0063 0.0048
Brugia malayi hypothetical protein 0.0049 0.0144 0.0138
Brugia malayi hypothetical protein 0.0115 0.0457 0.0515
Echinococcus granulosus Nuclear hormone receptor HR96 0.0115 0.0457 0.0501
Brugia malayi Steroid receptor seven-up type 2 0.0243 0.107 0.1253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0243 0.107 0.1376
Brugia malayi nuclear hormone receptor family member nhr-6 0.0115 0.0457 0.0515
Brugia malayi intermediate filament protein 0.003 0.0056 0.0031
Trichomonas vaginalis chaperonin, putative 0.0047 0.0135 0.0155
Loa Loa (eye worm) hypothetical protein 0.0128 0.0523 0.0673
Loa Loa (eye worm) hypothetical protein 0.0128 0.0523 0.0673
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0243 0.107 0.313
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0063 0.0048
Echinococcus granulosus GPCR family 2 0.0032 0.0063 0.0054
Onchocerca volvulus 0.0036 0.0084 0.0161
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0115 0.0457 0.0443
Loa Loa (eye worm) hypothetical protein 0.0243 0.107 0.1376
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0244 0.544
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0039
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0084 0.0824
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0244 0.0314
Mycobacterium leprae Probable lipase LipE 0.0036 0.0084 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0344 0.0443
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0047 0.0135 0.3909
Brugia malayi nuclear hormone receptor 0.0115 0.0457 0.0515
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0084 0.0069
Echinococcus multilocularis GPCR, family 2 0.0032 0.0063 0.0048
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.003 0.3604
Loa Loa (eye worm) nuclear receptor NHR-67 0.0115 0.0457 0.0588
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Loa Loa (eye worm) hypothetical protein 0.0128 0.0523 0.0673
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0243 0.107 0.1253
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0244 1
Brugia malayi Pre-SET motif family protein 0.0634 0.2934 0.3501
Onchocerca volvulus Bile acid receptor homolog 0.0243 0.107 0.313
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0243 0.107 0.1253
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.003 0.0297
Echinococcus granulosus Nuclear hormone receptor HR96 0.0115 0.0457 0.0501
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0108
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.003 0.3604
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0424 0.0463
Echinococcus granulosus lamin dm0 0.003 0.0056 0.0046
Brugia malayi beta-lactamase 0.0036 0.0084 0.0065
Echinococcus granulosus intermediate filament protein 0.003 0.0056 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0056 0.0072
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Brugia malayi photoreceptor-specific nuclear receptor 0.0243 0.107 0.1253
Schistosoma mansoni thyroid hormone receptor 0.2116 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0243 0.107 0.1195
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0115 0.0457 0.0588
Entamoeba histolytica hypothetical protein 0.0108 0.0424 1
Schistosoma mansoni nuclear receptor 0.0115 0.0457 0.0443
Schistosoma mansoni RAR-like nuclear receptor 0.0243 0.107 0.1056
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0047 0.0135 0.0119
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0244 0.0229
Onchocerca volvulus 0.003 0.0056 0.0077
Loa Loa (eye worm) hypothetical protein 0.0128 0.0523 0.0673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0243 0.107 0.1376
Brugia malayi Nuclear hormone receptor-like 1 0.1649 0.7776 0.9341
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0047 0.0135 0.0135
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0084 0.0069
Loa Loa (eye worm) hypothetical protein 0.0036 0.0084 0.0108
Mycobacterium ulcerans beta-lactamase 0.0036 0.0084 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0244 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0336 0.0321
Brugia malayi T-complex protein 1, beta subunit 0.0047 0.0135 0.0126
Onchocerca volvulus 0.0091 0.0344 0.0946
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0084 0.0824
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0047 0.0135 0.0119
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0128 0.0523 0.0508
Echinococcus multilocularis lamin 0.003 0.0056 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0243 0.107 0.1253
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0063 0.0054
Brugia malayi hypothetical protein 0.0128 0.0523 0.0594
Brugia malayi conserved hypotetical protein 0.0115 0.0457 0.0515
Brugia malayi ecdysone receptor 0.0115 0.0457 0.0515
Loa Loa (eye worm) hypothetical protein 0.0243 0.107 0.1376
Echinococcus granulosus nuclear receptor nhr 48 0.0115 0.0457 0.0501
Onchocerca volvulus Protein ultraspiracle homolog 0.0243 0.107 0.313
Brugia malayi Nuclear hormone receptor-like 1 0.1649 0.7776 0.9341
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0063 0.0081
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0243 0.107 0.1056
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0243 0.107 0.1195
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0243 0.107 0.1376
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0392 0.0436
Loa Loa (eye worm) hypothetical protein 0.0243 0.107 0.1376
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0 0.5
Schistosoma mansoni steroid hormone receptor ad4bp 0.0243 0.107 0.1056
Echinococcus multilocularis nuclear receptor nhr 48 0.0115 0.0457 0.0443
Loa Loa (eye worm) hypothetical protein 0.0243 0.107 0.1376
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0243 0.107 0.1195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0243 0.107 0.1376
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0243 0.107 0.1195
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0243 0.107 0.1056
Brugia malayi beta-lactamase family protein 0.0036 0.0084 0.0065
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0091 0.0344 0.0329
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0244 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0091 0.0344 0.0329
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0634 0.2934 0.3773
Loa Loa (eye worm) hypothetical protein 0.0115 0.0457 0.0588
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0244 0.026
Onchocerca volvulus 0.0036 0.0084 0.0161
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0104 0.0089
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0084 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0243 0.107 0.1056
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0115 0.0457 0.0443
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0243 0.107 0.1056
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0047 0.0135 0.0155
Brugia malayi Pre-SET motif family protein 0.0091 0.0344 0.0379
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0084 0.0824
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0047 0.0135 0.0119
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0336 0.0369
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0424 0.0409
Brugia malayi nuclear receptor RXR 0.0115 0.0457 0.0515
Schistosoma mansoni hypothetical protein 0.0032 0.0063 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0336 0.0321
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0084 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0243 0.107 0.1056
Echinococcus granulosus ecdysone induced protein 78C 0.0243 0.107 0.1195
Mycobacterium ulcerans hypothetical protein 0.0025 0.003 0.3604
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0336 0.0363
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0091 0.0344 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0243 0.107 0.1253
Loa Loa (eye worm) hypothetical protein 0.0243 0.107 0.1376
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0091 0.0344 0.0329
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1873 0.8841 0.8839
Schistosoma mansoni nuclear hormone receptor 0.0115 0.0457 0.0443
Schistosoma mansoni lamin 0.003 0.0056 0.0041
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0039
Loa Loa (eye worm) hypothetical protein 0.0128 0.0523 0.0673
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.003 0.3604
Mycobacterium tuberculosis Conserved protein 0.0036 0.0084 0.0824
Loa Loa (eye worm) hypothetical protein 0.0243 0.107 0.1376
Loa Loa (eye worm) beta-lactamase 0.0036 0.0084 0.0108
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0084 0.0108
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0336 0.0321
Schistosoma mansoni intermediate filament proteins 0.003 0.0056 0.0041
Brugia malayi Nuclear hormone receptor E75 0.0115 0.0457 0.0515
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0084 0.0824
Schistosoma mansoni hypothetical protein 0.0108 0.0424 0.0409
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0144 1
Echinococcus multilocularis lamin dm0 0.003 0.0056 0.0041
Echinococcus multilocularis FTZ F1 alpha 0.0243 0.107 0.1056
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.0505 0.065
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0144 0.3762
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0243 0.107 0.1253
Schistosoma mansoni hypothetical protein 0.0069 0.024 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0243 0.107 0.1253
Onchocerca volvulus 0.0036 0.0084 0.0161
Schistosoma mansoni zinc finger protein 0.0115 0.0457 0.0443
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0243 0.107 0.1253
Echinococcus multilocularis musashi 0.003 0.0056 0.0041
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0091 0.0344 0.0329
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0088 0.0328 0.0355
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0336 0.0363
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0115 0.0457 0.1286
Brugia malayi nuclear hormone receptor 0.0243 0.107 0.1253
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0063 0.0054
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0392 0.0436

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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