TDR Targets

Basic information

Technical information

TDR Targets ID: 773165
Name: 6-(4-ethoxyphenyl)-3-phenyl-N-propyl-6,7-dihy dro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazi ne-7-carboxamide
MW: 423.531 | Formula: C22H25N5O2S
H donors: 2 H acceptors: 3 LogP: 4.26 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCNC(=O)C1Sc2nnc(n2NC1c1ccc(cc1)OCC)c1ccccc1
InChi: 1S/C22H25N5O2S/c1-3-14-23-21(28)19-18(15-10-12-17(13-11-15)29-4-2)26-27-20(24-25-22(27)30-19)16-8-6-5-7-9-16/h5-13,18-19,26H,3-4,14H2,1-2H3,(H,23,28)
InChiKey: GJQRZDKMNMILDH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	epsilon tubulin	0.0141	0.1316	0.4019
Trichomonas vaginalis	tubulin beta chain, putative	0.0198	0.2242	0.6847
Echinococcus multilocularis	tubulin alpha chain	0.0198	0.2242	0.2242
Loa Loa (eye worm)	beta-tubulin	0.0261	0.3275	1
Echinococcus multilocularis	beta tubulin	0.0261	0.3275	0.3275
Leishmania major	beta tubulin	0.0261	0.3275	1
Loa Loa (eye worm)	tubulin alpha chain	0.0198	0.2242	0.6847
Plasmodium falciparum	tubulin gamma chain	0.0141	0.1316	0.4019
Echinococcus granulosus	tubulin alpha chain	0.0198	0.2242	0.2242
Echinococcus multilocularis	tubulin alpha chain	0.0198	0.2242	0.2242
Mycobacterium ulcerans	cell division protein FtsZ	0.0061	0	0.5
Echinococcus multilocularis	tubulin subunit beta	0.0261	0.3275	0.3275
Loa Loa (eye worm)	BEN-1 protein	0.0261	0.3275	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0198	0.2242	0.2242
Schistosoma mansoni	alpha tubulin	0.0198	0.2242	0.2242
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0895	0.2732
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0136	0.1232	0.3763
Echinococcus multilocularis	tubulin alpha chain	0.0198	0.2242	0.2242
Echinococcus multilocularis	Tubulin beta 2C chain	0.0261	0.3275	0.3275
Leishmania major	beta tubulin	0.0261	0.3275	1
Schistosoma mansoni	tubulin subunit alpha	0.0198	0.2242	0.2242
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0198	0.2242	0.6847
Leishmania major	beta tubulin	0.0261	0.3275	1
Echinococcus granulosus	tubulin alpha chain	0.0198	0.2242	0.2242
Giardia lamblia	Alpha-tubulin	0.0198	0.2242	0.6847
Echinococcus granulosus	Tubulin beta 2C chain	0.0261	0.3275	0.3275
Leishmania major	beta tubulin	0.0261	0.3275	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0141	0.1316	0.4019
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0061	0	0.5
Entamoeba histolytica	tubulin family protein	0.0261	0.3275	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0141	0.1316	0.4019
Echinococcus multilocularis	peroxisome assembly protein 26	0.0198	0.2242	0.2242
Leishmania major	gamma-tubulin	0.0141	0.1316	0.4019
Schistosoma mansoni	tubulin subunit alpha	0.0198	0.2242	0.2242
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Brugia malayi	tubulin alpha chain - mouse	0.0198	0.2242	0.6847
Brugia malayi	Tubulin alpha-2 chain	0.0198	0.2242	0.6847
Trypanosoma brucei	beta tubulin	0.0141	0.1316	0.4019
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0061	0	0.5
Leishmania major	beta tubulin	0.0261	0.3275	1
Trypanosoma brucei	alpha tubulin	0.0198	0.2242	0.6847
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Entamoeba histolytica	tubulin alpha chain, putative	0.0198	0.2242	0.4728
Echinococcus granulosus	Tubulin beta 2C chain	0.0261	0.3275	0.3275
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Trypanosoma brucei	beta tubulin	0.0261	0.3275	1
Trypanosoma brucei	alpha tubulin	0.0198	0.2242	0.6847
Brugia malayi	alpha-tubulin	0.0198	0.2242	0.6847
Schistosoma mansoni	tubulin subunit beta	0.0261	0.3275	0.3275
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Trichomonas vaginalis	tubulin beta chain, putative	0.0198	0.2242	0.6847
Toxoplasma gondii	alpha tubulin TUBA1	0.0198	0.2242	0.6847
Leishmania major	beta tubulin	0.0261	0.3275	1
Schistosoma mansoni	tubulin subunit beta	0.0261	0.3275	0.3275
Loa Loa (eye worm)	hypothetical protein	0.0118	0.0926	0.2828
Treponema pallidum	cell division protein FtsZ	0.0061	0	0.5
Schistosoma mansoni	tubulin subunit beta	0.0261	0.3275	0.3275
Entamoeba histolytica	tubulin family protein	0.0261	0.3275	1
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Echinococcus granulosus	tubulin alpha chain	0.0198	0.2242	0.2242
Trypanosoma cruzi	beta tubulin, putative	0.0261	0.3275	1
Trichomonas vaginalis	tubulin, putative	0.0261	0.3275	1
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Trichomonas vaginalis	tubulin beta chain, putative	0.0261	0.3275	1
Trypanosoma cruzi	tubulin gamma chain	0.0141	0.1316	0.4019
Echinococcus multilocularis	Tubulin beta 2C chain	0.0261	0.3275	0.3275
Echinococcus multilocularis	Tubulin beta 2C chain	0.0261	0.3275	0.3275
Leishmania major	beta tubulin	0.0261	0.3275	1
Trypanosoma brucei	beta tubulin	0.0261	0.3275	1
Toxoplasma gondii	alpha-tubulin I, putative	0.0198	0.2242	0.6847
Giardia lamblia	Beta tubulin	0.0261	0.3275	1
Leishmania major	beta tubulin	0.0261	0.3275	1
Schistosoma mansoni	tubulin subunit beta	0.0261	0.3275	0.3275
Echinococcus granulosus	Tubulin beta 2C chain	0.0261	0.3275	0.3275
Plasmodium falciparum	tubulin beta chain	0.0261	0.3275	1
Trypanosoma brucei	alpha tubulin, putative	0.008	0.0306	0.0935
Echinococcus granulosus	alpha tubulin	0.0198	0.2242	0.2242
Echinococcus multilocularis	tubulin gamma 1 chain	0.0141	0.1316	0.1316
Trypanosoma brucei	tubulin gamma chain	0.0141	0.1316	0.4019
Trichomonas vaginalis	tubulin, putative	0.008	0.0306	0.0935
Schistosoma mansoni	alpha tubulin	0.0198	0.2242	0.2242
Echinococcus multilocularis	tubulin beta 1 chain	0.0261	0.3275	0.3275
Loa Loa (eye worm)	tubulin beta chain	0.0261	0.3275	1
Echinococcus granulosus	tubulin alpha chain	0.0198	0.2242	0.2242
Echinococcus multilocularis	tubulin alpha chain	0.0198	0.2242	0.2242
Echinococcus multilocularis	microtubule associated protein 2	0.067	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0198	0.2242	0.6847
Leishmania major	beta tubulin	0.0261	0.3275	1
Schistosoma mansoni	tubulin subunit alpha	0.0198	0.2242	0.2242
Echinococcus multilocularis	Tubulin beta 2C chain	0.0261	0.3275	0.3275
Leishmania major	beta tubulin	0.0261	0.3275	1
Trypanosoma brucei	beta tubulin	0.0261	0.3275	1
Echinococcus multilocularis	tubulin subunit TubB	0.0198	0.2242	0.2242
Echinococcus granulosus	Tubulin beta 2C chain	0.0261	0.3275	0.3275
Loa Loa (eye worm)	tubulin gamma chain	0.0141	0.1316	0.4019
Toxoplasma gondii	beta-1 tubulin, putative	0.0261	0.3275	1
Loa Loa (eye worm)	alpha-tubulin	0.0198	0.2242	0.6847
Leishmania major	beta tubulin	0.0261	0.3275	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0141	0.1316	0.4019
Echinococcus granulosus	beta tubulin	0.0261	0.3275	0.3275
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.008	0.0306	0.0935
Plasmodium vivax	tubulin alpha chain, putative	0.0198	0.2242	0.6847
Schistosoma mansoni	tubulin subunit gamma	0.0141	0.1316	0.1316
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0895	0.2732
Toxoplasma gondii	beta-tubulin, putative	0.0261	0.3275	1
Loa Loa (eye worm)	alpha-tubulin	0.0198	0.2242	0.6847
Mycobacterium leprae	cell division protein FtsZ	0.0061	0	0.5
Loa Loa (eye worm)	tubulin beta-2A chain	0.0261	0.3275	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.008	0.0306	0.0935
Echinococcus granulosus	tubulin alpha 3 chain	0.0198	0.2242	0.2242
Echinococcus granulosus	Tubulin alpha 1 chain	0.0198	0.2242	0.2242
Schistosoma mansoni	tubulin subunit beta	0.0261	0.3275	0.3275
Brugia malayi	Tubulin beta-1 chain	0.0261	0.3275	1
Echinococcus granulosus	tubulin beta 1 chain	0.0261	0.3275	0.3275
Echinococcus multilocularis	tubulin alpha	0.0141	0.1316	0.1316
Echinococcus granulosus	Tubulin beta 2C chain	0.0261	0.3275	0.3275
Trichomonas vaginalis	tubulin alpha chain, putative	0.0261	0.3275	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0261	0.3275	0.3275
Trypanosoma brucei	epsilon tubulin	0.0141	0.1316	0.4019
Echinococcus granulosus	Tubulin alpha 1 chain	0.0198	0.2242	0.2242
Trichomonas vaginalis	tubulin beta chain, putative	0.0198	0.2242	0.6847
Loa Loa (eye worm)	tubulin beta-4 chain	0.0261	0.3275	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0261	0.3275	1
Giardia lamblia	Gamma tubulin	0.0141	0.1316	0.4019
Leishmania major	beta tubulin	0.0261	0.3275	1
Echinococcus multilocularis	hypothetical protein	0.0198	0.2242	0.2242
Echinococcus granulosus	tubulin alpha chain	0.0198	0.2242	0.2242
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0261	0.3275	1
Onchocerca volvulus		0.008	0.0306	0.5
Leishmania major	beta tubulin	0.0261	0.3275	1
Leishmania major	beta tubulin	0.0261	0.3275	1
Plasmodium vivax	tubulin alpha chain, putative	0.0198	0.2242	0.6847
Plasmodium vivax	tubulin gamma chain, putative	0.0141	0.1316	0.4019
Schistosoma mansoni	tubulin subunit epsilon	0.0141	0.1316	0.1316
Echinococcus multilocularis	tubulin alpha chain	0.0198	0.2242	0.2242
Brugia malayi	tubulin alpha-2 chain	0.0198	0.2242	0.6847
Echinococcus granulosus	peroxisome assembly protein 26	0.0198	0.2242	0.2242
Echinococcus multilocularis	tubulin alpha 3 chain	0.0198	0.2242	0.2242
Plasmodium falciparum	alpha tubulin 1	0.0198	0.2242	0.6847
Trichomonas vaginalis	tubulin alpha chain, putative	0.008	0.0306	0.0935
Trichomonas vaginalis	tubulin beta chain, putative	0.008	0.0306	0.0935
Schistosoma mansoni	alpha tubulin	0.0198	0.2242	0.2242
Leishmania major	beta tubulin	0.0261	0.3275	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0198	0.2242	0.4728
Loa Loa (eye worm)	tubulin beta-1 chain	0.0261	0.3275	1
Plasmodium falciparum	alpha tubulin 2	0.0198	0.2242	0.6847
Loa Loa (eye worm)	BEN-1 protein	0.0261	0.3275	1
Trypanosoma brucei	beta tubulin	0.0261	0.3275	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0198	0.2242	0.6847
Leishmania major	beta tubulin	0.0261	0.3275	1
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Trichomonas vaginalis	tubulin beta chain, putative	0.0198	0.2242	0.6847
Echinococcus granulosus	tubulin gamma 1 chain	0.0141	0.1316	0.1316
Trichomonas vaginalis	tubulin alpha chain, putative	0.008	0.0306	0.0935
Brugia malayi	Tubulin alpha-2 chain	0.0198	0.2242	0.6847
Giardia lamblia	Beta tubulin	0.0261	0.3275	1
Loa Loa (eye worm)	hypothetical protein	0.0198	0.2242	0.6847
Echinococcus granulosus	tubulin beta 4A class IVa	0.0261	0.3275	0.3275
Trichomonas vaginalis	tubulin beta chain, putative	0.0198	0.2242	0.6847
Giardia lamblia	Alpha-tubulin	0.0198	0.2242	0.6847
Trypanosoma brucei	alpha tubulin	0.0198	0.2242	0.6847
Trypanosoma cruzi	alpha tubulin, putative	0.0198	0.2242	0.6847
Brugia malayi	MH2 domain containing protein	0.0116	0.0895	0.2732
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Plasmodium vivax	tubulin epsilon chain, putative	0.0141	0.1316	0.4019
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0136	0.1232	0.3763
Trichomonas vaginalis	tubulin beta chain, putative	0.0198	0.2242	0.6847
Giardia lamblia	Beta tubulin	0.0261	0.3275	1
Loa Loa (eye worm)	tubulin alpha 2	0.0136	0.1232	0.3763
Trypanosoma brucei	epsilon tubulin	0.0141	0.1316	0.4019
Trypanosoma cruzi	epsilon tubulin, putative	0.0141	0.1316	0.4019
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0141	0.1316	0.4019
Trichomonas vaginalis	tubulin gamma chain, putative	0.0141	0.1316	0.4019
Echinococcus granulosus	tubulin epsilon chain	0.0141	0.1316	0.1316
Echinococcus granulosus	tubulin subunit TubB	0.0198	0.2242	0.2242
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0261	0.3275	0.3275
Trichomonas vaginalis	tubulin, putative	0.008	0.0306	0.0935
Plasmodium vivax	tubulin beta chain, putative	0.0261	0.3275	1
Echinococcus multilocularis	beta tubulin	0.0261	0.3275	0.3275
Echinococcus granulosus	tubulin alpha 1C chain	0.0198	0.2242	0.2242
Leishmania major	beta tubulin	0.0261	0.3275	1
Brugia malayi	Tubulin beta chain	0.008	0.0306	0.0935
Leishmania major	beta tubulin	0.0261	0.3275	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0118	0.0926	0.2828
Echinococcus granulosus	tubulin alpha 1C chain	0.0198	0.2242	0.2242
Echinococcus granulosus	tubulin alpha	0.0141	0.1316	0.1316
Brugia malayi	Tubulin gamma chain	0.0141	0.1316	0.4019
Echinococcus granulosus	beta tubulin	0.0261	0.3275	0.3275
Brugia malayi	Tubulin alpha chain	0.0198	0.2242	0.6847
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0198	0.2242	0.6847
Echinococcus granulosus	tubulin subunit beta	0.0261	0.3275	0.3275
Loa Loa (eye worm)	tubulin alpha 2	0.0136	0.1232	0.3763
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0198	0.2242	0.2242
Echinococcus multilocularis	tubulin epsilon chain	0.0141	0.1316	0.1316
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0118	0.0926	0.2828
Leishmania major	epsilon tubulin, putative	0.0141	0.1316	0.4019
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0198	0.2242	0.2242
Echinococcus multilocularis	tubulin alpha 3 chain	0.0198	0.2242	0.2242
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1232	0.3763
Schistosoma mansoni	tubulin subunit beta	0.0261	0.3275	0.3275
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0198	0.2242	0.2242
Echinococcus granulosus	tubulin alpha 3 chain	0.0198	0.2242	0.2242
Trypanosoma brucei	alpha tubulin	0.0198	0.2242	0.6847
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Toxoplasma gondii	beta tubulin	0.0261	0.3275	1
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Echinococcus granulosus	Tubulin alpha 1 chain	0.0198	0.2242	0.2242
Leishmania major	alpha tubulin	0.0198	0.2242	0.6847
Schistosoma mansoni	microtubule-associated protein tau	0.067	1	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0141	0.1316	0.4019
Echinococcus multilocularis	tubulin alpha 1C chain	0.0198	0.2242	0.2242
Brugia malayi	beta-tubulin, identical	0.0261	0.3275	1
Loa Loa (eye worm)	tubulin alpha chain	0.0198	0.2242	0.6847
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0261	0.3275	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 773165