Detailed information for compound 779111

Basic information

Technical information
  • TDR Targets ID: 779111
  • Name: 3-hydroxy-3-(2-oxo-2-pyridin-2-ylethyl)-1-pro p-2-enylindol-2-one
  • MW: 308.331 | Formula: C18H16N2O3
  • H donors: 1 H acceptors: 4 LogP: 2 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCN1c2ccccc2C(C1=O)(O)CC(=O)c1ccccn1
  • InChi: 1S/C18H16N2O3/c1-2-11-20-15-9-4-3-7-13(15)18(23,17(20)22)12-16(21)14-8-5-6-10-19-14/h2-10,23H,1,11-12H2
  • InChiKey: CVOMAUKCVNNUFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-allyl-3-hydroxy-3-[2-oxo-2-(2-pyridyl)ethyl]indolin-2-one
  • 1-allyl-3-hydroxy-3-[2-oxo-2-(2-pyridyl)ethyl]-2-indolinone
  • 1-allyl-3-hydroxy-3-[2-keto-2-(2-pyridyl)ethyl]oxindole
  • 3-hydroxy-3-(2-oxo-2-pyridin-2-yl-ethyl)-1-prop-2-enyl-indol-2-one
  • STK215181
  • 1-allyl-3-hydroxy-3-[2-oxo-2-(2-pyridinyl)ethyl]-1,3-dihydro-2H-indol-2-one
  • Oprea1_472923
  • MLS000663725
  • SMR000293021

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis inositol monophosphatase 1 0.0073 0.1774 0.1981
Brugia malayi Choline O-acetyltransferase 0.0039 0.0855 0.0855
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0716 0.0716
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0855 0.1531
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0855 0.1531
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0025 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.0025
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0039 0.0855 0.0855
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.0025
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1144 0.1144
Loa Loa (eye worm) hypothetical protein 0.0016 0.022 0.022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1771 0.9983
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.0025
Brugia malayi Inositol-1 0.0073 0.1774 0.1774
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.022 0.022
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1283 0.1433
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0004 0.0025
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1283 0.1283
Echinococcus granulosus cpg binding protein 0.0037 0.0781 0.0873
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0073 0.1774 1
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0215 0.5589 0.6242
Onchocerca volvulus 0.0035 0.0728 0.6425
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1283 0.1433
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1144 0.1144
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0039 0.0855 0.0855
Brugia malayi Choline O-acetyltransferase 0.0039 0.0855 0.0855
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1771 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.022 0.0246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0855 0.1531
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0073 0.1774 1
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.0039 0.0855 0.1531
Loa Loa (eye worm) hypothetical protein 0.0034 0.0716 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.0025
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.0039 0.0855 0.4823
Schistosoma mansoni hypothetical protein 0.0034 0.0716 0.167
Schistosoma mansoni hypothetical protein 0.0167 0.4288 1
Trichomonas vaginalis helicase, putative 0.0008 0.0004 0.0025
Echinococcus granulosus GPCR family 2 0.0016 0.022 0.0246
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.022 0.0246
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0039 0.0855 0.1531
Loa Loa (eye worm) hypothetical protein 0.005 0.1144 0.1144
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0039 0.0855 0.1531
Echinococcus granulosus inositol monophosphatase 1 0.0073 0.1774 0.1981
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.0025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.022 0.0246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.0025
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1771 0.9983
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0082 0.0082
Echinococcus multilocularis GPCR, family 2 0.0016 0.022 0.0246
Schistosoma mansoni choline o-acyltransferase 0.0039 0.0855 0.1995
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.1566 1
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0039 0.0855 0.4823
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0025 0.0028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1777 0.4144
Trichomonas vaginalis inositol monophosphatase, putative 0.0073 0.1774 1
Echinococcus multilocularis cpg binding protein 0.0037 0.0781 0.0873
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1771 0.9983
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0025 0.0028
Schistosoma mansoni cpg binding protein 0.0037 0.0781 0.1822
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1771 0.1978
Brugia malayi Latrophilin receptor protein 2 0.0016 0.022 0.022
Echinococcus multilocularis choline O acetyltransferase 0.0039 0.0855 0.0955
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0855 0.1531
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0855 0.4823
Schistosoma mansoni hypothetical protein 0.0167 0.4288 1
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.0039 0.0855 0.4823
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.0025
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.022 0.022
Chlamydia trachomatis 3'(2'),5'-bisphosphate nucleotidase CysQ 0.0008 0 0.5
Schistosoma mansoni cellular tumor antigen P53 0.005 0.1133 0.2643
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0039 0.0855 0.1531
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0039 0.0855 0.0855
Brugia malayi CXXC zinc finger family protein 0.0035 0.0728 0.0728
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0215 0.5589 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1283 0.1433
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1771 0.3168
Leishmania major carnitine palmitoyltransferase-like protein 0.0039 0.0855 0.1531
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0039 0.0855 0.0955
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1774 0.3174
Schistosoma mansoni inositol monophosphatase 0.0073 0.1774 0.4136
Echinococcus multilocularis tumor protein p63 0.034 0.8953 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1283 0.2991
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1144 0.1144
Leishmania major carnitine/choline acetyltransferase, putative 0.0039 0.0855 0.1531
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1774 0.3174
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.022 0.0246
Echinococcus granulosus tumor protein p63 0.034 0.8953 1
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0215 0.5589 0.6242
Onchocerca volvulus 0.0039 0.0855 0.7549
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0215 0.5589 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1771 0.4129
Schistosoma mansoni hypothetical protein 0.0016 0.022 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.0025
Echinococcus granulosus geminin 0.0167 0.4288 0.4789
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0728 0.0728
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0039 0.0855 0.4823
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1283 0.1283
Schistosoma mansoni inositol monophosphatase 0.0073 0.1774 0.4136
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0025 0.0058
Schistosoma mansoni hypothetical protein 0.0016 0.022 0.0513
Giardia lamblia Hypothetical protein 0.0008 0 0.5
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.0039 0.0855 0.1531
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1283 0.2991
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.1774 1
Schistosoma mansoni choline o-acyltransferase 0.0039 0.0855 0.1995
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1771 0.4129
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.0025
Echinococcus multilocularis geminin 0.0167 0.4288 0.4789
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1771 0.9983
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1283 0.1433
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1771 0.1978
Loa Loa (eye worm) choline O-acetyltransferase 0.0039 0.0855 0.0855
Loa Loa (eye worm) inositol-1 0.0073 0.1774 0.1774
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1283 0.2991
Loa Loa (eye worm) hypothetical protein 0.0039 0.0855 0.0855
Echinococcus granulosus choline O acetyltransferase 0.0039 0.0855 0.0955
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1774 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0073 0.1774 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.1566 0.8844
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.0025
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0073 0.1774 1
Onchocerca volvulus 0.005 0.1133 1
Loa Loa (eye worm) hypothetical protein 0.0378 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0008 0.0004 0.0025
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0025 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0004 0.0025
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0215 0.5589 1
Onchocerca volvulus 0.0039 0.0855 0.7549
Onchocerca volvulus 0.0039 0.0855 0.7549
Loa Loa (eye worm) hypothetical protein 0.005 0.1133 0.1133
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0078 0.0078
Onchocerca volvulus 0.0039 0.0855 0.7549
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0004 0.0025
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0039 0.0855 0.0955
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0855 0.1531
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0082 0.0091
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0073 0.1774 0.3174
Schistosoma mansoni cpg binding protein 0.0035 0.0728 0.1698
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0082 0.0091
Schistosoma mansoni hypothetical protein 0.0016 0.022 0.0513
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0073 0.1774 0.5
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0039 0.0855 0.0855
Schistosoma mansoni hypothetical protein 0.0016 0.022 0.0513
Schistosoma mansoni cpg binding protein 0.0037 0.0781 0.1822
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.0039 0.0855 0.1531
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1565 0.8824

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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