Detailed information for compound 783037

Basic information

Technical information
  • TDR Targets ID: 783037
  • Name: N-(4-chlorophenyl)-2-ethyl-7-methyl-5-oxo-[1, 3,4]thiadiazolo[3,2-a]pyrimidine-6-sulfonamid e
  • MW: 384.861 | Formula: C14H13ClN4O3S2
  • H donors: 1 H acceptors: 3 LogP: 2.43 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1sc2n(n1)c(=O)c(c(n2)C)S(=O)(=O)Nc1ccc(cc1)Cl
  • InChi: 1S/C14H13ClN4O3S2/c1-3-11-17-19-13(20)12(8(2)16-14(19)23-11)24(21,22)18-10-6-4-9(15)5-7-10/h4-7,18H,3H2,1-2H3
  • InChiKey: RNUPAOQUHZGTLB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-chlorophenyl)-2-ethyl-5-keto-7-methyl-[1,3,4]thiadiazolo[3,2-a]pyrimidine-6-sulfonamide
  • C301-4016
  • NCGC00107329-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0097 0.2483 0.4774
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.041 0.0756
Echinococcus multilocularis geminin 0.0174 0.5699 0.7873
Brugia malayi RNA binding protein 0.0076 0.1634 0.3014
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0261 0.8483
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0261 0.8483
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0261 0.0438
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1634 0.2737
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0308 1
Brugia malayi beta-lactamase family protein 0.0043 0.0261 0.0482
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0261 0.022
Mycobacterium ulcerans lipase LipD 0.0043 0.0261 0.8244
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0261 0.0438
Mycobacterium tuberculosis Conserved protein 0.0043 0.0261 0.022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.041 0.0756
Mycobacterium ulcerans beta-lactamase 0.0043 0.0261 0.8244
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0038 0.0042 0.5
Brugia malayi Muscleblind-like protein 0.0156 0.4934 0.9102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.041 0.0566
Mycobacterium tuberculosis Conserved protein 0.0043 0.0261 0.022
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0261 0.8483
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0308 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0308 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0482
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.059 0.1089
Echinococcus granulosus muscleblind protein 0.0156 0.4934 0.6815
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0308 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.059 0.1089
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1634 0.2737
Mycobacterium leprae Probable lipase LipE 0.0043 0.0261 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.059 0.1089
Schistosoma mansoni alpha-glucosidase 0.0144 0.445 0.7456
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0482
Schistosoma mansoni inositol monophosphatase 0.0045 0.0308 0.0516
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0261 0.8483
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.542 0.7487
Loa Loa (eye worm) hypothetical protein 0.0156 0.4934 0.9102
Brugia malayi beta-lactamase 0.0043 0.0261 0.0482
Echinococcus granulosus geminin 0.0174 0.5699 0.7873
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.542 1
Schistosoma mansoni glutamate receptor NMDA 0.0181 0.5969 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0261 0.8483
Schistosoma mansoni hypothetical protein 0.0174 0.5699 0.9548
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0308 1
Mycobacterium ulcerans hypothetical protein 0.0043 0.0261 0.8244
Echinococcus granulosus nmda type glutamate receptor 0.0211 0.7239 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0261 0.8244
Loa Loa (eye worm) hypothetical protein 0.0155 0.4915 0.9068
Schistosoma mansoni hypothetical protein 0.0174 0.5699 0.9548
Echinococcus multilocularis nmda type glutamate receptor 0.0211 0.7239 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0482
Echinococcus granulosus glutamate receptor NMDA 0.0158 0.5032 0.6951
Chlamydia trachomatis glutamine binding protein 0.0038 0.0042 0.5
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0308 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.1634 0.3014
Echinococcus multilocularis muscleblind protein 1 0.0156 0.4934 0.6815
Mycobacterium tuberculosis Conserved protein 0.0043 0.0261 0.022
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0261 0.022
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0261 0.8483
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1634 0.2257
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0308 0.0426
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0261 0.022
Loa Loa (eye worm) inositol-1 0.0045 0.0308 0.0568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.041 0.0566
Trichomonas vaginalis esterase, putative 0.0043 0.0261 0.8483
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0308 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1634 0.2737
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.041 0.0566
Echinococcus granulosus nmda type glutamate receptor 0.0166 0.535 0.739
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0261 0.022
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1634 0.3014
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1634 0.2737
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0261 0.8483
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.542 1
Brugia malayi Inositol-1 0.0045 0.0308 0.0568
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1634 0.3014
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0308 1
Echinococcus multilocularis glutamate receptor NMDA 0.0158 0.5032 0.6951
Brugia malayi hypothetical protein 0.0155 0.4915 0.9068
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0308 1
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0261 1
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0261 0.022
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.542 0.7487
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0482
Onchocerca volvulus 0.0155 0.4915 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0053 0.0661 0.0914
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0038 0.0042 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.041 0.0566
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0482
Loa Loa (eye worm) hypothetical protein 0.0156 0.4934 0.9102
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.041 0.0687
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0482
Echinococcus granulosus tar DNA binding protein 0.0076 0.1634 0.2257
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1634 0.3014
Echinococcus multilocularis nmda type glutamate receptor 0.0166 0.535 0.739
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.041 0.0687
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0261 0.0361
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0261 0.022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0261 0.0482
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0261 0.022
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0308 0.5
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0308 1
Toxoplasma gondii ABC1 family protein 0.0043 0.0261 0.8483
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0261 0.8483
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0261 0.0482
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0261 0.8244
Loa Loa (eye worm) beta-lactamase 0.0043 0.0261 0.0482
Schistosoma mansoni inositol monophosphatase 0.0045 0.0308 0.0516
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.059 0.1089
Brugia malayi beta-lactamase family protein 0.0043 0.0261 0.0482
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1634 0.2737
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0261 0.0361
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.542 0.7487
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0261 0.5
Echinococcus multilocularis muscleblind protein 0.0156 0.4934 0.6815
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0038 0.0042 0.5
Leishmania major hypothetical protein, conserved 0.0043 0.0261 0.8483
Brugia malayi TAR-binding protein 0.0076 0.1634 0.3014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.041 0.0687
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.0114 0.0072
Schistosoma mansoni alpha-glucosidase 0.0144 0.445 0.7456
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0308 0.0426

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2512 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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