TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 486.488 | Formula: C19H17F3N4O4S2
H donors: 2 H acceptors: 3 LogP: 3.79 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1sc2c(c1C)c(=O)n(c(n2)SCC(=O)Nc1ccccc1C(F)(F)F)N
InChi: 1S/C19H17F3N4O4S2/c1-3-30-17(29)14-9(2)13-15(32-14)25-18(26(23)16(13)28)31-8-12(27)24-11-7-5-4-6-10(11)19(20,21)22/h4-7H,3,8,23H2,1-2H3,(H,24,27)
InChiKey: HWPUMELOSWXOBJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	lysyl tRNA synthetase	0.0018	0.0399	0.1769
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0024	0.0582	0.1157
Schistosoma mansoni	sugar transporter	0.0011	0.0201	0.0894
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0005	0.0023	0.0101
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Trichomonas vaginalis	myo-inositol transporter, putative	0.0011	0.0201	0.0894
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0005	0.0023	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0201	0.0894
Plasmodium falciparum	hexose transporter	0.0081	0.2253	0.2253
Giardia lamblia	Sugar-proton symporter	0.0011	0.0201	0.346
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.012	0.0238
Loa Loa (eye worm)	hypothetical protein	0.0009	0.012	0.0238
Schistosoma mansoni	hypothetical protein	0.0081	0.2253	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Schistosoma mansoni	lysyl-tRNA synthetase	0.0018	0.0399	0.1769
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0025	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0009	0.012	0.0238
Echinococcus granulosus	rap guanine nucleotide exchange factor 1	0.0006	0.0047	0.0208
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0024	0.0582	0.1157
Schistosoma mansoni	ras GTP exchange factor	0.0006	0.0047	0.0208
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0025	0.0597	0.0597
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0131	0.3724	0.5632
Brugia malayi	major facilitator superfamily protein	0.0011	0.0201	0.04
Brugia malayi	Sugar transporter family protein	0.0011	0.0201	0.04
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0011	0.0201	0.04
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0028	0.0701	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0025	0.0597	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0582	0.1157
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0025	0.0597	0.2648
Echinococcus granulosus	lysyl tRNA synthetase	0.0018	0.0399	0.1769
Echinococcus granulosus	Pleckstrin G protein interacting region	0.0009	0.012	0.0532
Schistosoma mansoni	serine/threonine protein kinase	0.0005	0.0023	0.0101
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0025	0.0606	0.8651
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0024	0.0582	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0024	0.0582	0.2583
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0047	0.0093
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0081	0.2253	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Trypanosoma brucei	glucose transporter, putative	0.0025	0.0606	0.8651
Brugia malayi	RasGEF domain containing protein	0.0006	0.0047	0.0093
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0025	0.0606	0.8651
Leishmania major	glucose transporter, lmgt1	0.0025	0.0606	0.8651
Schistosoma mansoni	serine/threonine protein kinase	0.0005	0.0023	0.0101
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0028	0.0701	0.106
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0006	0.0047	0.0208
Mycobacterium ulcerans	sugar transporter	0.0011	0.0201	0.5052
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Onchocerca volvulus		0.0011	0.0201	0.031
Schistosoma mansoni	sugar transporter	0.0011	0.0201	0.0894
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0318	0.141
Trypanosoma cruzi	guanine nucleotide releasing protein, putative	0.0006	0.0047	0.067
Onchocerca volvulus		0.0011	0.0201	0.031
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0028	0.0701	1
Echinococcus granulosus	Protein son of sevenless	0.0006	0.0047	0.0208
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0318	0.0632
Leishmania major	hypothetical protein, conserved	0.0011	0.0201	0.2874
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0024	0.0582	0.9752
Plasmodium vivax	hexose transporter	0.0081	0.2253	0.2253
Trypanosoma cruzi	hypothetical protein	0.0006	0.0047	0.067
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0025	0.0597	0.2648
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Echinococcus multilocularis	solute carrier family 22	0.0011	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Echinococcus multilocularis	son of sevenless 1	0.0006	0.0047	0.0208
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0025	0.0597	0.0903
Trichomonas vaginalis	CAMK family protein kinase	0.0025	0.0597	0.2648
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0025	0.0597	0.0597
Plasmodium falciparum	protein kinase 7	0.0229	0.6612	0.6612
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0131	0.3724	0.3724
Echinococcus multilocularis	rap guanine nucleotide exchange factor 6	0.0006	0.0047	0.0208
Brugia malayi	major facilitator superfamily protein	0.0011	0.0201	0.04
Trichomonas vaginalis	ras GTP exchange factor, putative	0.0006	0.0047	0.0208
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Plasmodium vivax	proline--tRNA ligase, putative	0.0028	0.0701	0.0701
Brugia malayi	hypothetical protein	0.0011	0.0201	0.04
Treponema pallidum	prolyl-tRNA synthetase	0.0009	0.0119	1
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0131	0.3724	0.3724
Toxoplasma gondii	facilitative glucose transporter GT1	0.0081	0.2253	0.3408
Schistosoma mansoni	dep domain containing protein	0.0009	0.012	0.0532
Schistosoma mansoni	protein kinase	0.0025	0.0597	0.2648
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0025	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0318	0.0632
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0025	0.0597	0.2648
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0009	0.0119	0.2978
Schistosoma mansoni	lysyl-tRNA synthetase	0.0018	0.0399	0.1769
Echinococcus granulosus	solute carrier family 22	0.0011	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0318	0.141
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0081	0.2253	1
Trypanosoma brucei	glucose transporter, putative	0.0025	0.0606	0.8651
Entamoeba histolytica	protein kinase, putative	0.0025	0.0597	1
Schistosoma mansoni	guanine-nucleotide-exchange-factor	0.0006	0.0047	0.0208
Trypanosoma brucei	glucose transporter, putative	0.0025	0.0606	0.8651
Echinococcus granulosus	cGMP dependent protein kinase	0.0005	0.0023	0.0101
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0025	0.0597	0.1186
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0318	0.141
Trypanosoma cruzi	glucose transporter, putative	0.0011	0.0201	0.2874
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0015	0.0318	0.4536
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0081	0.2253	1
Onchocerca volvulus		0.0011	0.0201	0.031
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Trypanosoma brucei	glucose transporter, putative	0.0025	0.0606	0.8651
Plasmodium vivax	lysine--tRNA ligase, putative	0.0018	0.0399	0.0399
Trypanosoma brucei	glucose transporter, putative	0.0025	0.0606	0.8651
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0201	0.0894
Giardia lamblia	Prolyl-tRNA synthetase	0.0024	0.0582	1
Brugia malayi	DIX domain containing protein	0.0009	0.012	0.0238
Echinococcus granulosus	calcium dependent protein kinase	0.0023	0.0552	0.2448
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0318	0.4536
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.012	0.0532
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0015	0.0318	0.4536
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.012	0.0532
Onchocerca volvulus		0.0011	0.0201	0.031
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0024	0.0582	0.2583
Trypanosoma cruzi	sugar transporter, putative	0.0011	0.0201	0.2874
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0016	0.0333	0.1477
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0018	0.0399	0.5689
Schistosoma mansoni	serine/threonine protein kinase	0.0005	0.0023	0.0101
Onchocerca volvulus		0.0011	0.0201	0.031
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0024	0.0582	0.2583
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0015	0.0318	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Loa Loa (eye worm)	DIX domain-containing protein	0.0009	0.012	0.0238
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0025	0.0597	0.2648
Schistosoma mansoni	sugar transporter	0.0011	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0597	0.2648
Echinococcus granulosus	solute carrier family 22	0.0011	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0025	0.0606	0.8651
Schistosoma mansoni	glucose transport protein	0.0081	0.2253	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0025	0.0597	0.2648
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0011	0.0201	0.5052
Toxoplasma gondii	hypothetical protein	0.0009	0.012	0.0181
Schistosoma mansoni	dishevelled	0.0009	0.012	0.0532
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0024	0.0582	0.2583
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0011	0.0201	0.0201
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0011	0.0201	0.2874
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0015	0.0318	0.0318
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0015	0.0318	0.5469
Onchocerca volvulus		0.0011	0.0201	0.031
Leishmania major	lysyl-tRNA synthetase, putative	0.0018	0.0399	0.5689
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Trypanosoma brucei	glucose transporter, putative	0.0025	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0597	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Onchocerca volvulus		0.0011	0.0201	0.031
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0018	0.0399	1
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0606	0.269
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0011	0.0201	0.0894
Echinococcus multilocularis	rap guanine nucleotide exchange factor 1	0.0006	0.0047	0.0208
Echinococcus granulosus	solute carrier family 22	0.0011	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Plasmodium falciparum	proline--tRNA ligase	0.0028	0.0701	0.0701
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Brugia malayi	Major Facilitator Superfamily protein	0.0011	0.0201	0.04
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0018	0.0399	0.5689
Leishmania major	protein kinase, putative	0.0005	0.0023	0.0326
Echinococcus granulosus	regulator of G protein signaling 7	0.0009	0.012	0.0532
Entamoeba histolytica	hypothetical protein	0.0006	0.0047	0.0787
Chlamydia trachomatis	lysine--tRNA ligase	0.0018	0.0399	1
Echinococcus multilocularis	segment polarity protein dishevelled	0.0009	0.012	0.0532
Brugia malayi	Major Facilitator Superfamily protein	0.0011	0.0201	0.04
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Onchocerca volvulus		0.0011	0.0201	0.031
Plasmodium falciparum	lysine--tRNA ligase	0.0018	0.0399	0.0399
Trypanosoma cruzi	hexose transporter, putative	0.0011	0.0201	0.2874
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0011	0.0201	1
Entamoeba histolytica	protein kinase, putative	0.0025	0.0597	1
Schistosoma mansoni	sugar transporter	0.0011	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trichomonas vaginalis	glucose transporter, putative	0.0025	0.0606	0.269
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.001	0.016	0.0317
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.012	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0081	0.2253	1
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0006	0.0038	0.0169
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0025	0.0597	0.0903
Trichomonas vaginalis	sugar transporter, putative	0.0025	0.0606	0.269
Brugia malayi	regulator of G-protein signaling egl-10	0.0009	0.012	0.0238
Loa Loa (eye worm)	hypothetical protein	0.002	0.0448	0.089
Trypanosoma brucei	glucose transporter 1E	0.0025	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0011	0.0201	0.6328
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0025	0.0597	0.0597
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0015	0.0318	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0318	0.141
Schistosoma mansoni	glucose transporter	0.0011	0.0201	0.0894
Brugia malayi	RasGEF domain containing protein	0.0006	0.0047	0.0093
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0011	0.0201	0.0894
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0318	0.4536
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0005	0.0023	0.0101
Trypanosoma brucei	glucose transporter 2A	0.0025	0.0606	0.8651
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0175	0.5032	1
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Schistosoma mansoni	protein kinase	0.0025	0.0597	0.2648
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0025	0.0597	0.0903
Trypanosoma cruzi	hexose transporter, putative	0.0025	0.0606	0.8651
Schistosoma mansoni	glucose transport protein	0.0081	0.2253	1
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0047	0.0093
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0201	0.0894
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0318	0.141
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trichomonas vaginalis	ras GTP exchange factor, son of sevenless, putative	0.0006	0.0047	0.0208
Toxoplasma gondii	sugar transporter ST3	0.0011	0.0201	0.0305
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0025	0.0597	0.2648
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0011	0.0201	0.04
Brugia malayi	lysyl-tRNA synthetase	0.0018	0.0399	0.0792
Giardia lamblia	Lysyl-tRNA synthetase	0.0018	0.0399	0.6849
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0047	0.0208
Brugia malayi	RasGEF domain containing protein	0.0006	0.0047	0.0093
Trichomonas vaginalis	sugar transporter, putative	0.0025	0.0606	0.269
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0028	0.0701	1
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0025	0.0597	0.1186
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0399	0.0792
Schistosoma mansoni	regulator of G protein signaling	0.0009	0.012	0.0532
Brugia malayi	Egg laying defective protein 4	0.0005	0.0023	0.0045
Mycobacterium ulcerans	integral membrane transport protein	0.0011	0.0201	0.5052
Onchocerca volvulus		0.0011	0.0201	0.031
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0025	0.0597	0.8517
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0047	0.0208
Leishmania major	myo-inositol/proton symporter (MIT)	0.0011	0.0201	0.2874
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0028	0.0701	1
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0318	0.0632
Toxoplasma gondii	lysine-tRNA ligase	0.0018	0.0399	0.0603
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0011	0.0201	0.5052
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0018	0.0399	0.6849
Onchocerca volvulus	Segment polarity protein dishevelled homolog	0.0009	0.012	0.0146
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0005	0.0023	0.0045
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0011	0.0201	0.6328
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0081	0.2253	1
Echinococcus multilocularis	expressed conserved protein	0.0005	0.0023	0.0101
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0015	0.0318	0.0318
Echinococcus multilocularis	Protein son of sevenless	0.0006	0.0047	0.0208
Onchocerca volvulus		0.0011	0.0201	0.031
Leishmania major	protein kinase, putative	0.0005	0.0023	0.0326
Schistosoma mansoni	dishevelled	0.0009	0.012	0.0532
Leishmania major	protein kinase, putative	0.0025	0.0597	0.8517
Brugia malayi	N-terminal motif family protein	0.0175	0.5032	1
Schistosoma mansoni	z-protein (S1r protein)	0.0009	0.012	0.0532
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0028	0.0701	1
Trypanosoma brucei	glucose transporter, putative	0.0025	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Brugia malayi	Sugar transporter family protein	0.0081	0.2253	0.4478
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0318	0.0481
Brugia malayi	Domain found in Dishevelled, Egl-10, and Pleckstrin family protein	0.0009	0.012	0.0238
Trichomonas vaginalis	glucose transporter, putative	0.0011	0.0201	0.0894
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.2253	1
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Schistosoma mansoni	protein kinase	0.0025	0.0597	0.2648
Onchocerca volvulus		0.0011	0.0201	0.031
Toxoplasma gondii	sugar transporter ST1	0.0011	0.0201	0.0305
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0015	0.0318	0.9985
Trypanosoma cruzi	hexose transporter	0.0025	0.0606	0.8651
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Toxoplasma gondii	protein kinase, putative	0.0229	0.6612	1
Chlamydia trachomatis	proline--tRNA ligase	0.0009	0.0119	0.2978
Echinococcus granulosus	ras GTP exchange factor	0.0006	0.0047	0.0208
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0025	0.0597	0.2648
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0025	0.0597	0.0597
Onchocerca volvulus		0.0009	0.012	0.0146
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0025	0.0597	0.0597
Leishmania major	glucose transporter, lmgt2	0.0025	0.0606	0.8651
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0024	0.0582	0.2583
Trichomonas vaginalis	sugar transport protein, putative	0.0011	0.0201	0.0894
Leishmania major	glucose transporter, lmgt3	0.0025	0.0606	0.8651
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0006	0.0047	0.0093
Giardia lamblia	Hexose transporter	0.0011	0.0201	0.346
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Loa Loa (eye worm)	sugar transporter	0.0081	0.2253	0.4478
Trichomonas vaginalis	conserved hypothetical protein	0.0011	0.0201	0.0894
Echinococcus granulosus	synaptic vesicle 2 protein	0.0011	0.0201	0.0894
Onchocerca volvulus		0.0011	0.0201	0.031
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0025	0.0597	0.0597
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0015	0.0318	0.4536
Echinococcus granulosus	General substrate transporter	0.007	0.1918	0.851
Echinococcus multilocularis	Pleckstrin G protein, interacting region	0.0009	0.012	0.0532
Onchocerca volvulus		0.0011	0.0201	0.031
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0318	0.141
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0606	0.269
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0005	0.0023	0.0101
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0025	0.0606	0.8651
Echinococcus multilocularis	regulator of G protein signaling 7	0.0009	0.012	0.0532
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0025	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Schistosoma mansoni	ras GTP exchange factor son of sevenless	0.0006	0.0047	0.0208
Echinococcus multilocularis	ras GTP exchange factor	0.0006	0.0047	0.0208
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0318	0.141
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0011	0.0201	0.04
Brugia malayi	N-terminal motif family protein	0.0006	0.0047	0.0093
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0018	0.0399	1
Onchocerca volvulus	Putative transporter	0.0011	0.0201	0.031
Brugia malayi	N-terminal motif family protein	0.0006	0.0047	0.0093
Echinococcus multilocularis	calcium dependent protein kinase	0.0023	0.0552	0.2448
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0025	0.0606	0.8651
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0009	0.012	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Trypanosoma brucei	glucose transporter, putative	0.0025	0.0606	0.8651
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0018	0.0399	0.1769
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0344	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Trypanosoma brucei	sugar transporter, putative	0.0011	0.0201	0.2874
Echinococcus multilocularis	General substrate transporter	0.007	0.1918	0.851
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0011	0.0201	0.0894
Brugia malayi	Sugar transporter family protein	0.0011	0.0201	0.04
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0081	0.2253	1
Echinococcus multilocularis	solute carrier family 22	0.0011	0.0201	0.0894
Schistosoma mansoni	fyve finger-containing phosphoinositide kinase fyv1	0.0009	0.012	0.0532
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0081	0.2253	1
Trichomonas vaginalis	glucose transporter, putative	0.0025	0.0606	0.269
Echinococcus multilocularis	solute carrier family 22	0.0011	0.0201	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0011	0.0201	0.04
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Loa Loa (eye worm)	sugar transporter	0.0011	0.0201	0.04
Toxoplasma gondii	sugar transporter ST2	0.0011	0.0201	0.0305
Trypanosoma cruzi	hypothetical protein	0.0006	0.0047	0.067
Plasmodium vivax	sugar transporter, putative	0.0011	0.0201	0.0201
Schistosoma mansoni	glucose transport protein	0.0081	0.2253	1
Plasmodium falciparum	cGMP-dependent protein kinase	0.0005	0.0023	0.0023
Trichomonas vaginalis	guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0582	0.1157
Entamoeba histolytica	hypothetical protein	0.0018	0.0399	0.6679
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0011	0.0201	0.0894
Onchocerca volvulus		0.0011	0.0201	0.031
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.027	0.386
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.012	0.0532
Echinococcus granulosus	son of sevenless 1	0.0006	0.0047	0.0208
Entamoeba histolytica	Ras guanine nucleotide exchange factor, putative	0.0006	0.0047	0.0787
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0047	0.0093
Onchocerca volvulus		0.0011	0.0201	0.031
Echinococcus multilocularis	solute carrier family 22	0.0011	0.0201	0.0894
Toxoplasma gondii	isocitrate dehydrogenase	0.0015	0.0318	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0175	0.5032	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0201	0.04
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0047	0.0093
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0005	0.0023	0.0035
Brugia malayi	hypothetical protein	0.0011	0.0201	0.04
Trichomonas vaginalis	sugar transporter, putative	0.0025	0.0606	0.269
Brugia malayi	Cam kinase protein 1	0.0025	0.0597	0.1186
Echinococcus granulosus	rap guanine nucleotide exchange factor 6	0.0006	0.0047	0.0208
Toxoplasma gondii	transporter, major facilitator family protein	0.0011	0.0201	0.0305
Trypanosoma cruzi	hexose transporter, putative	0.0025	0.0606	0.8651
Brugia malayi	hypothetical protein	0.0009	0.012	0.0238
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0025	0.0597	0.2648
Brugia malayi	hypothetical protein	0.0009	0.012	0.0238
Trichomonas vaginalis	sugar transporter, putative	0.0011	0.0201	0.0894
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0011	0.0201	0.0894
Echinococcus granulosus	segment polarity protein dishevelled	0.0009	0.012	0.0532
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0081	0.2253	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.012	0.0238
Onchocerca volvulus		0.0011	0.0201	0.031

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 783864