Detailed information for compound 784248

Basic information

Technical information
  • TDR Targets ID: 784248
  • Name: 3-(4-propan-2-ylphenyl)spiro[1,3-thiazolidine -2,3'-1H-indole]-2',4-dione
  • MW: 338.423 | Formula: C19H18N2O2S
  • H donors: 1 H acceptors: 2 LogP: 3.46 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CSC2(N1c1ccc(cc1)C(C)C)C(=O)Nc1c2cccc1
  • InChi: 1S/C19H18N2O2S/c1-12(2)13-7-9-14(10-8-13)21-17(22)11-24-19(21)15-5-3-4-6-16(15)20-18(19)23/h3-10,12H,11H2,1-2H3,(H,20,23)
  • InChiKey: YKOSLKGEHSNDGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3'-(4-isopropylphenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione
  • 3'-(4-isopropylphenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-quinone
  • ChemDiv1_011808
  • AG-205/12909023
  • BIM-0009807.P001
  • Oprea1_578178
  • A2058/0086581
  • CBMicro_009915

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.2082 0.3098
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0399 0.8049
Brugia malayi Sugar transporter family protein 0.0101 0.2082 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0289 0.0288
Loa Loa (eye worm) hypothetical protein 0.003 0.0374 0.1672
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.2561
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.039 0.0287
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0872 0.4099
Trypanosoma brucei glucose transporter, putative 0.0031 0.0399 0.8049
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0125 0.0458
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0081
Echinococcus granulosus peregrin 0.0031 0.038 0.092
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0596 0.2753
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0626 0.0815
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0556 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0289 0.0288
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0187 0.028
Trypanosoma brucei glucose transporter, putative 0.0031 0.0399 0.8049
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0374 0.0978
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0399 0.8049
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1273 0.183
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0592 0.1479
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0495 1
Entamoeba histolytica protein kinase, putative 0.0031 0.0389 0.0444
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.0374 0.1672
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0483 0.2202
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0187 0.0285
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0399 0.0459
Schistosoma mansoni chromobox protein 0.0068 0.1273 0.333
Loa Loa (eye worm) hypothetical protein 0.003 0.0374 0.1672
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.0374 0.0905
Echinococcus multilocularis peregrin 0.0031 0.038 0.092
Schistosoma mansoni transient receptor potential channel 0.0094 0.1915 0.5008
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.1878 0.487
Loa Loa (eye worm) hypothetical protein 0.0035 0.0487 0.2223
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0389 0.0944
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0119 0.0021
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0041 0.0027
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0041 0.0027
Plasmodium falciparum phd finger protein, putative 0.0028 0.0324 0.0221
Schistosoma mansoni zinc finger protein 0.0019 0.01 0.0262
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6485 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0324 0.0774
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.2985 1
Brugia malayi Bromodomain containing protein 0.0073 0.1398 0.6664
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2082 0.541
Giardia lamblia PHD finger protein 15 0.0028 0.0324 0.0343
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0187 0.0758
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0399 0.8049
Plasmodium vivax CDK-related protein kinase 6, putative 0.043 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0187 0.0758
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.6485 1
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.017 0.0366
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0187 0.0126
Trypanosoma brucei glucose transporter, putative 0.0031 0.0399 0.8049
Echinococcus granulosus geminin 0.0174 0.3823 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0556 0.0706
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0872 0.4099
Loa Loa (eye worm) hypothetical protein 0.0069 0.1298 0.6175
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0106 0.2137
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0389 0.0944
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.104 0.266
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0399 0.0459
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6485 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0187 0.028
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0389 0.7856
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0389 0.0944
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0343 0.0823
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0187 0.3766
Brugia malayi PHD-finger family protein 0.0024 0.0225 0.0946
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0187 0.0125
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1051 0.4974
Schistosoma mansoni hypothetical protein 0.0174 0.3823 1
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0389 0.0444
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6485 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.1878 0.487
Loa Loa (eye worm) hypothetical protein 0.0041 0.064 0.2971
Plasmodium vivax hexose transporter 0.0101 0.2082 0.1998
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0324 0.034
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0389 0.1746
Echinococcus granulosus zinc finger protein 0.0019 0.01 0.0182
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.1145 0.2938
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.039 0.0287
Brugia malayi chromobox protein homolog 3 0.0038 0.0556 0.2561
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0041 0.0107
Schistosoma mansoni glucose transport protein 0.0101 0.2082 0.5447
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0389 0.0944
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0324 0.0849
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.039 0.0287
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.2082 0.541
Echinococcus multilocularis chromobox protein 1 0.0068 0.1273 0.3276
Trypanosoma brucei glucose transporter, putative 0.0031 0.0399 0.8049
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2082 0.541
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.039 0.0287
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0468 0.1153
Schistosoma mansoni protein kinase 0.0031 0.0389 0.1018
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.039 0.0287
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2082 0.541
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6485 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0389 0.0944
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.6485 1
Echinococcus granulosus short transient receptor potential channel 6 0.0062 0.1145 0.2938
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2082 0.541
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0556 0.7695
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0081
Trypanosoma brucei glucose transporter, putative 0.0031 0.0399 0.8049
Leishmania major glucose transporter, lmgt2 0.0031 0.0399 0.8049
Schistosoma mansoni hypothetical protein 0.0028 0.0324 0.0849
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0164 0.3585 0.3517
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0187 0.0082
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0389 0.1746
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0389 0.0944
Loa Loa (eye worm) hypothetical protein 0.0028 0.0324 0.1431
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0389 0.1746
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.039 0.0441
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0081
Schistosoma mansoni transient receptor potential channel 0.0062 0.1145 0.2995
Toxoplasma gondii protein kinase, putative 0.0286 0.6537 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0812 0.3808
Schistosoma mansoni hypothetical protein 0.0101 0.2082 0.5447
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0106 0.0005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0389 0.0944
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.0374 0.0905
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0399 0.0459
Entamoeba histolytica protein kinase, putative 0.0031 0.0389 0.0444
Brugia malayi Cam kinase protein 1 0.0031 0.0389 0.1746
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0106 0.0197
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0483 0.1192
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0187 0.0488
Brugia malayi Bromodomain containing protein 0.0031 0.038 0.1701
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0487 0.1203
Trypanosoma brucei glucose transporter 2A 0.0031 0.0399 0.8049
Brugia malayi Bromodomain containing protein 0.0037 0.0539 0.2474
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0495 1
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0487 0.1203
Loa Loa (eye worm) hypothetical protein 0.003 0.0359 0.1598
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0187 0.0126
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0399 0.8049
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0399 0.0459
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.0374 0.042
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0187 0.0488
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0389 0.0944
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0626 0.0815
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0872 0.4099
Schistosoma mansoni hypothetical protein 0.0174 0.3823 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0106 0.0197
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1273 0.183
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.039 0.0441
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0106 0.2137
Echinococcus granulosus transient receptor potential gamma protein 0.0094 0.1915 0.4967
Trypanosoma brucei glucose transporter, putative 0.0031 0.0399 0.8049
Loa Loa (eye worm) hypothetical protein 0.0025 0.0237 0.1003
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.0374 0.042
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0513 0.1341
Loa Loa (eye worm) hypothetical protein 0.0017 0.0041 0.0049
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0399 0.0459
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0041 0.0107
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0399 0.8049
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0041 0.0027
Schistosoma mansoni glucose transport protein 0.0101 0.2082 0.5447
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0187 0.041
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0106 0.5
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0495 0.0606
Loa Loa (eye worm) sugar transporter 0.0101 0.2082 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.0374 0.1672
Onchocerca volvulus 0.003 0.0359 0.1137
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.017 0.0444
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0495 0.0394
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1273 0.6055
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.1145 0.2938
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.0374 0.0978
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0324 0.0774
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.039 0.0287
Schistosoma mansoni protein kinase 0.0031 0.0389 0.1018
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0041 0.0107
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0399 0.0459
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0389 0.1018
Loa Loa (eye worm) hypothetical protein 0.0051 0.0872 0.4099
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0187 0.0082
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2082 0.541
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.2985 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0399 0.8049
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.1839 0.4767
Loa Loa (eye worm) hypothetical protein 0.0035 0.0483 0.2202
Echinococcus granulosus General substrate transporter 0.0087 0.1739 0.4505
Entamoeba histolytica hypothetical protein 0.0023 0.0187 0.0126
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0399 0.8049
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1418 0.3709
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0324 0.1431
Schistosoma mansoni ap endonuclease 0.0019 0.0106 0.0277
Trypanosoma cruzi hexose transporter 0.0031 0.0399 0.8049
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0081
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.039 0.0441
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.1839 0.4767
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0106 0.2137
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0106 0.2137
Leishmania major protein kinase, putative 0.0031 0.0389 0.7856
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0106 0.0365
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6485 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0094 0.1915 0.4967
Brugia malayi jmjC domain containing protein 0.0036 0.0513 0.2349
Schistosoma mansoni ap endonuclease 0.0019 0.0106 0.0277
Echinococcus multilocularis geminin 0.0174 0.3823 1
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0164 0.3585 0.541
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.039 0.0287
Brugia malayi jmjC domain containing protein 0.0093 0.1878 0.9002
Schistosoma mansoni hypothetical protein 0.0035 0.0483 0.1262
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0411 0.1854
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0055 0.0119
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0399 0.8049
Schistosoma mansoni hypothetical protein 0.002 0.0125 0.0327
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0324 0.034
Schistosoma mansoni glucose transport protein 0.0101 0.2082 0.5447
Leishmania major glucose transporter, lmgt1 0.0031 0.0399 0.8049
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0187 0.5
Trypanosoma brucei glucose transporter 1E 0.0031 0.0399 0.8049
Schistosoma mansoni bromodomain containing protein 0.0062 0.1124 0.2939
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.2985 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0626 1
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0592 0.1479
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0495 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.054 0.2483
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0513 0.1271
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0483 0.1192
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0513 0.1341
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.104 0.266
Echinococcus multilocularis chromobox protein 1 0.0068 0.1273 0.3276
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.2082 0.541
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0056 0.1121
Echinococcus granulosus chromobox protein 1 0.0068 0.1273 0.3276
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.2082 0.541
Plasmodium falciparum mitogen-activated protein kinase 2 0.0164 0.3585 0.3517
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.6485 1
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.0374 0.042
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.2082 0.3073
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0041 0.0027
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0343 0.0823
Brugia malayi PHD-finger family protein 0.0028 0.0324 0.1431
Plasmodium falciparum protein kinase 7 0.0286 0.6537 0.65
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6485 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.1915 0.9182
Echinococcus multilocularis General substrate transporter 0.0087 0.1739 0.4505
Schistosoma mansoni transient receptor potential channel 4 0.0094 0.1915 0.5008
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0106 0.0365
Echinococcus granulosus chromobox protein 1 0.0068 0.1273 0.3276
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0487 0.2223
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.6485 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0041 0.0107
Trypanosoma brucei glucose transporter, putative 0.0031 0.0399 0.8049
Loa Loa (eye worm) hypothetical protein 0.0031 0.0389 0.1746
Plasmodium falciparum hexose transporter 0.0101 0.2082 0.1998
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0187 0.3766
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6485 1
Leishmania major glucose transporter, lmgt3 0.0031 0.0399 0.8049
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0399 0.0459
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.0374 0.0936
Schistosoma mansoni transient receptor potential channel 0.0062 0.1145 0.2995
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0187 0.3766
Schistosoma mansoni chromobox protein 0.0068 0.1273 0.333
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0513 0.2349
Echinococcus multilocularis zinc finger protein 0.0019 0.01 0.0182
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.039 0.0287
Brugia malayi Heterochromatin protein 1 0.0068 0.1273 0.6055
Echinococcus multilocularis short transient receptor potential channel 6 0.0062 0.1145 0.2938
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.6485 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1069 0.5061
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0324 0.0221
Schistosoma mansoni protein kinase 0.0031 0.0389 0.1018
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.039 0.0287
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.017 0.0366
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0187 0.041
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0495 0.0394

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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