Detailed information for compound 784790

Basic information

Technical information
  • TDR Targets ID: 784790
  • Name: N-[2-[(2E)-2-[(4-methoxyphenyl)methylidene]hy drazinyl]-2-oxoethyl]-2,2-di(phenyl)acetamide
  • MW: 401.458 | Formula: C24H23N3O3
  • H donors: 2 H acceptors: 2 LogP: 3.78 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C=NNC(=O)CNC(=O)C(c1ccccc1)c1ccccc1
  • InChi: 1S/C24H23N3O3/c1-30-21-14-12-18(13-15-21)16-26-27-22(28)17-25-24(29)23(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-16,23H,17H2,1H3,(H,25,29)(H,27,28)/b26-16+
  • InChiKey: XPSDLRANZPFAFI-WGOQTCKBSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-[2-[(4-methoxyphenyl)methylidene]hydrazinyl]-2-oxoethyl]-2,2-di(phenyl)acetamide
  • N-[2-[(N'E)-N'-[(4-methoxyphenyl)methylene]hydrazino]-2-oxo-ethyl]-2,2-di(phenyl)acetamide
  • N-[2-[N'-[(4-methoxyphenyl)methylene]hydrazino]-2-oxo-ethyl]-2,2-di(phenyl)acetamide
  • N-[2-[(N'E)-N'-[(4-methoxyphenyl)methylene]hydrazino]-2-oxoethyl]-2,2-di(phenyl)acetamide
  • N-[2-[N'-[(4-methoxyphenyl)methylene]hydrazino]-2-oxoethyl]-2,2-di(phenyl)acetamide
  • N-[2-keto-2-[N'-(4-methoxybenzylidene)hydrazino]ethyl]-2,2-di(phenyl)acetamide
  • N-[2-keto-2-[(N'E)-N'-(4-methoxybenzylidene)hydrazino]ethyl]-2,2-di(phenyl)acetamide
  • N-[2-[2-[(4-methoxyphenyl)methylidene]hydrazinyl]-2-oxo-ethyl]-2,2-di(phenyl)ethanamide
  • N-[2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazinyl]-2-oxo-ethyl]-2,2-di(phenyl)ethanamide
  • A0668/0031102

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi trypanothione reductase, putative 0.0186 0.0338 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0425 0.0815 0.1795
Echinococcus multilocularis tar DNA binding protein 0.0067 0.0099 0.0082
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0065 0.0095 0.2547
Toxoplasma gondii thioredoxin reductase 0.0186 0.0338 1
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0048 0.0081
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0048 0.0262
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0026 0.0017 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0017 0.0121
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0065 0.039
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0065 0.0095 0.0078
Schistosoma mansoni hypothetical protein 0.005 0.0065 0.0049
Schistosoma mansoni hypothetical protein 0.005 0.0065 0.0049
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0079 0.0063
Echinococcus granulosus expressed conserved protein 0.009 0.0145 0.0128
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0136 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0136 0.0119
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0472 0.0909 0.2011
Echinococcus multilocularis tumor protein p63 0.1425 0.2813 0.2801
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0077 0.0147
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0113 0.0096
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0048 0.0343
Schistosoma mansoni hypothetical protein 0.0133 0.0231 0.0214
Mycobacterium tuberculosis Probable dehydrogenase 0.0425 0.0815 0.1799
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.0079 0.0063
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0048 0.0905
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0048 0.0053
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0065 0.0049
Brugia malayi beta-lactamase 0.0041 0.0048 0.0343
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0048 0.0053
Mycobacterium ulcerans lipase LipD 0.0041 0.0048 0.0081
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0095 0.2378
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0136 0.3676
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0012 0.0083
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.0156 0.0139
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0048 0.0053
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0186 0.0338 0.0731
Trichomonas vaginalis mercuric reductase, putative 0.0065 0.0095 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0181 0.1229
Schistosoma mansoni patched 1 0.0041 0.0047 0.0031
Brugia malayi TAR-binding protein 0.0067 0.0099 0.0713
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0077 0.0147
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0077 0.0061
Brugia malayi jmjC domain containing protein 0.0057 0.0079 0.0571
Loa Loa (eye worm) hypothetical protein 0.0041 0.0048 0.0262
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0065 0.0095 0.2547
Loa Loa (eye worm) hypothetical protein 0.0209 0.0383 0.269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0026 0.0017 0.0038
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0017 0.0121
Brugia malayi nuclear hormone receptor 0.0026 0.0017 0.0121
Echinococcus granulosus tumor protein p63 0.1425 0.2813 0.2801
Brugia malayi glutathione reductase 0.0186 0.0338 0.243
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0136 1
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0048 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0099 0.0082
Brugia malayi ecdysteroid receptor 0.0026 0.0017 0.0121
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0065 0.047
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0048 0.0262
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0047 0.006 0.0435
Echinococcus multilocularis protein patched 0.0041 0.0047 0.0031
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0065 0.0095 0.2378
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0048 0.0031
Trypanosoma cruzi trypanothione reductase, putative 0.0065 0.0095 0.2378
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0048 0.0905
Loa Loa (eye worm) hypothetical protein 0.0041 0.0048 0.0262
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0048 0.0905
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0065 0.0095 0.2378
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.0099 0.0635
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0425 0.0815 0.1799
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0024 0.0176
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0065 0.0095 0.0186
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0047 0.026
Loa Loa (eye worm) TAR-binding protein 0.0067 0.0099 0.0635
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0038
Loa Loa (eye worm) hypothetical protein 0.0041 0.0047 0.026
Echinococcus granulosus geminin 0.0164 0.0293 0.0277
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.0156 0.1123
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0065 0.0095 0.2378
Echinococcus granulosus GPCR family 2 0.005 0.0065 0.0049
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0065 0.0095 0.0186
Echinococcus multilocularis GPCR, family 2 0.005 0.0065 0.0049
Schistosoma mansoni hypothetical protein 0.0164 0.0293 0.0277
Echinococcus multilocularis microtubule associated protein 2 0.5023 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0048 0.0081
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0083 0.016
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.0231 0.0214
Schistosoma mansoni hypothetical protein 0.0074 0.0113 0.0096
Brugia malayi beta-lactamase family protein 0.0041 0.0048 0.0343
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0199 0.1361
Mycobacterium leprae Probable lipase LipE 0.0041 0.0048 0.0081
Echinococcus granulosus survival motor neuron protein 1 0.0713 0.139 0.1376
Plasmodium falciparum thioredoxin reductase 0.0186 0.0338 1
Loa Loa (eye worm) thioredoxin reductase 0.0186 0.0338 0.2367
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0136 0.0278
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0095 0.2378
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0136 0.0119
Brugia malayi RNA binding protein 0.0067 0.0099 0.0713
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0065 0.0095 0.0681
Brugia malayi photoreceptor-specific nuclear receptor 0.0026 0.0017 0.0121
Mycobacterium ulcerans TetR family transcriptional regulator 0.2262 0.4485 1
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0048 0.0081
Plasmodium vivax glutathione reductase, putative 0.0186 0.0338 1
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.0238 0.0221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0026 0.0017 0.0038
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0026 0.0017 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0026 0.0017 0.0038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0038
Plasmodium falciparum glutathione reductase 0.0186 0.0338 1
Loa Loa (eye worm) hypothetical protein 0.0158 0.0281 0.1951
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0048 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0017 0.0121
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0048 0.0081
Leishmania major hypothetical protein, conserved 0.0041 0.0048 0.1106
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0048 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0026 0.0017 0.0121
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0136 0.0278
Entamoeba histolytica hypothetical protein 0.0074 0.0113 0.7011
Brugia malayi nuclear receptor NHR-88 0.0026 0.0017 0.0121
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0079 0.0063
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.0238 0.0221
Toxoplasma gondii NADPH-glutathione reductase 0.0065 0.0095 0.2378
Plasmodium falciparum glutathione reductase 0.0065 0.0095 0.2378
Entamoeba histolytica hypothetical protein 0.0074 0.0113 0.7011
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0472 0.0909 0.2007
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0065 0.0095 0.2378
Schistosoma mansoni hypothetical protein 0.0039 0.0044 0.0028
Echinococcus multilocularis geminin 0.0164 0.0293 0.0277
Entamoeba histolytica hypothetical protein 0.0074 0.0113 0.7011
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.0099 0.0713
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0472 0.0909 0.2011
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0099 0.0082
Brugia malayi hypothetical protein 0.0027 0.0019 0.0135
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.0281 0.1951
Schistosoma mansoni hypothetical protein 0.0145 0.0256 0.024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0065 0.0049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0026 0.0017 0.0038
Loa Loa (eye worm) hypothetical protein 0.005 0.0065 0.039
Mycobacterium tuberculosis Conserved protein 0.0041 0.0048 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0026 0.0017 0.0121
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0079 0.0492
Mycobacterium tuberculosis Conserved protein 0.0041 0.0048 0.0081
Brugia malayi hypothetical protein 0.0713 0.139 1
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 0.2258 0.4476 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0136 1
Toxoplasma gondii ABC1 family protein 0.0041 0.0048 0.0905
Loa Loa (eye worm) hypothetical protein 0.0095 0.0156 0.1048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0065 0.0049
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0047 0.0031
Schistosoma mansoni thyroid hormone receptor 0.0158 0.0282 0.0266
Schistosoma mansoni microtubule-associated protein tau 0.5023 1 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0038
Schistosoma mansoni hypothetical protein 0.0039 0.0044 0.0028
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0038
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.0181 0.1302
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0083 0.0066
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0048 0.0081
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0065 0.0095 0.2378
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0136 1
Toxoplasma gondii hypothetical protein 0.0029 0.0024 0.0176
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0065 0.0095 0.2378
Onchocerca volvulus 0.0041 0.0048 0.0973
Schistosoma mansoni hypothetical protein 0.0108 0.0181 0.0164
Brugia malayi CHE-14 protein 0.0041 0.0047 0.0341
Onchocerca volvulus 0.0041 0.0048 0.0973
Loa Loa (eye worm) steroid hormone receptor 0.0026 0.0017 0.0038
Schistosoma mansoni thyroid hormone receptor 0.0158 0.0282 0.0266
Onchocerca volvulus Bile acid receptor homolog 0.0026 0.0017 0.0143
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0095 0.2378
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.0281 0.2018
Schistosoma mansoni hypothetical protein 0.0164 0.0293 0.0277
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0024 0.0176
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0065 0.0095 0.2547
Echinococcus granulosus thioredoxin glutathione reductase 0.0187 0.0339 0.0323
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0065 0.0095 0.2378
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0065 0.0095 0.2378
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0199 0.1361
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0026 0.0017 0.0121
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0262 0.0489 0.107
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0026 0.0017 0.0121
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.0159 0.0142
Schistosoma mansoni cellular tumor antigen P53 0.0209 0.0383 0.0366
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0026 0.0017 0.0143
Brugia malayi beta-lactamase family protein 0.0041 0.0048 0.0343
Mycobacterium tuberculosis Probable oxidoreductase 0.0472 0.0909 0.2011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0083 0.016
Trichomonas vaginalis esterase, putative 0.0041 0.0048 0.0053
Mycobacterium ulcerans beta-lactamase 0.0041 0.0048 0.0081
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0136 0.0119
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0012 0.0083
Leishmania major trypanothione reductase 0.0186 0.0338 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0012 0.0083
Schistosoma mansoni hypothetical protein 0.005 0.0065 0.0049
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0083 0.0066
Schistosoma mansoni hypothetical protein 0.0039 0.0044 0.0028
Mycobacterium ulcerans hypothetical protein 0.0041 0.0048 0.0081
Mycobacterium tuberculosis Probable reductase 0.0425 0.0815 0.1799
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.0079 0.0063
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0065 0.0095 0.2378
Brugia malayi MH2 domain containing protein 0.0117 0.0199 0.1433
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0047 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0026 0.0017 0.0121
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0425 0.0815 0.1799
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0099 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0099 0.0082
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0425 0.0815 0.1799
Entamoeba histolytica hypothetical protein 0.0074 0.0113 0.7011
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.0017 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0048 0.0053
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0145 0.0256 0.1843
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0095 0.2378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0026 0.0017 0.0038
Onchocerca volvulus 0.0145 0.0256 0.6598
Echinococcus granulosus tar DNA binding protein 0.0067 0.0099 0.0082
Brugia malayi Thioredoxin reductase 0.0186 0.0338 0.243
Mycobacterium ulcerans transcriptional regulator 0.2262 0.4485 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0048 0.0031
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0038
Mycobacterium leprae Probable transcriptional regulatory repressor protein (TetR-family) EthR 0.2262 0.4485 1
Onchocerca volvulus 0.0041 0.0048 0.0973
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0095 0.2378
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0065 0.0095 0.2378
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0785 0.1534 0.1519
Onchocerca volvulus 0.0209 0.0383 1
Brugia malayi jmjC domain containing protein 0.0057 0.0079 0.0571
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.0079 0.0063
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0083 0.016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0026 0.0017 0.0121
Trichomonas vaginalis glutathione reductase, putative 0.0065 0.0095 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0083 0.0066
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0113 0.0096
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0047 0.006 0.0435
Brugia malayi hypothetical protein 0.0074 0.0113 0.0812
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.0231 0.0214
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0095 0.2378
Schistosoma mansoni survival motor neuron protein 0.0145 0.0256 0.024
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.0079 0.0063
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0065 0.0095 0.2547
Loa Loa (eye worm) hypothetical protein 0.0713 0.139 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0026 0.0017 0.0121
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0048 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0048 0.0905
Mycobacterium ulcerans AcrR family transcriptional regulator 0.2262 0.4485 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0136 0.3676
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0077 0.0061
Schistosoma mansoni hypothetical protein 0.0039 0.0044 0.0028
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0065 0.0095 0.0078
Loa Loa (eye worm) hypothetical protein 0.0027 0.0019 0.0053
Schistosoma mansoni hypothetical protein 0.005 0.0065 0.0049
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0048 0.0081
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0083 0.016
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0083 0.2016
Echinococcus multilocularis thioredoxin glutathione reductase 0.0187 0.0339 0.0323
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0136 0.3676
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.0079 0.0063
Loa Loa (eye worm) hypothetical protein 0.0041 0.0048 0.0262
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0083 0.0066
Loa Loa (eye worm) beta-lactamase 0.0041 0.0048 0.0262
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0047 0.0031
Leishmania major hypothetical protein, conserved 0.0027 0.0019 0.0222
Loa Loa (eye worm) RNA binding protein 0.0067 0.0099 0.0635
Brugia malayi Latrophilin receptor protein 2 0.005 0.0065 0.047
Schistosoma mansoni tar DNA-binding protein 0.0067 0.0099 0.0082
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0024 0.0029
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0065 0.0095 0.0186
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0038
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0048 0.0031
Mycobacterium tuberculosis Conserved protein 0.0041 0.0048 0.0081
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0083 0.2193
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0065 0.0049
Loa Loa (eye worm) hypothetical protein 0.005 0.0066 0.0393
Brugia malayi Steroid receptor seven-up type 2 0.0026 0.0017 0.0121
Loa Loa (eye worm) hypothetical protein 0.0041 0.0048 0.0262
Treponema pallidum NADH oxidase 0.0065 0.0095 0.6291
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.0281 0.2018
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0026 0.0017 0.0121
Loa Loa (eye worm) hypothetical protein 0.0085 0.0136 0.0903
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0065 0.0095 0.2378
Loa Loa (eye worm) hypothetical protein 0.0041 0.0048 0.0262
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0077 0.0147
Trypanosoma brucei trypanothione reductase 0.0186 0.0338 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0136 0.0278
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0136 0.3676
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0026 0.0017 0.0121
Loa Loa (eye worm) hypothetical protein 0.0026 0.0017 0.0038
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0048 0.0031
Brugia malayi steroid hormone receptor 0.0026 0.0017 0.0121
Giardia lamblia NADH oxidase lateral transfer candidate 0.0065 0.0095 0.5
Echinococcus multilocularis protein dispatched 1 0.0047 0.0059 0.0042
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0113 0.0096
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.0156 1
Loa Loa (eye worm) glutathione reductase 0.0186 0.0338 0.2367
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0065 0.0095 0.0078
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0048 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0026 0.0017 0.0038
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0425 0.0815 0.1799
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0065 0.0095 0.0186
Brugia malayi Probable ClpP-like protease 0.0085 0.0136 0.0979
Onchocerca volvulus 0.0026 0.0017 0.0143
Onchocerca volvulus Protein ultraspiracle homolog 0.0026 0.0017 0.0143
Plasmodium falciparum thioredoxin reductase 0.0065 0.0095 0.2378
Echinococcus multilocularis thyroid hormone receptor alpha 0.0158 0.0282 0.0266
Echinococcus multilocularis survival motor neuron protein 1 0.0713 0.139 0.1376
Plasmodium vivax thioredoxin reductase, putative 0.0186 0.0338 1
Echinococcus multilocularis expressed conserved protein 0.009 0.0145 0.0128
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.0156 0.0139

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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