TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 402.964 | Formula: C19H19ClN4S2
H donors: 1 H acceptors: 0 LogP: 4.41 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CS/C(=N\c1cccc(c1)C1N=C2N(C1)CCS2)/Nc1ccccc1Cl
InChi: 1S/C19H19ClN4S2/c1-25-18(22-16-8-3-2-7-15(16)20)21-14-6-4-5-13(11-14)17-12-24-9-10-26-19(24)23-17/h2-8,11,17H,9-10,12H2,1H3,(H,21,22)
InChiKey: RHXWEURZMNLVPU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	laminin gamma-3 chain	0.0018	0.0525	0.0346
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0018	0.0525	0.0346
Echinococcus granulosus	fibropellin Ia	0.0018	0.0525	0.1068
Brugia malayi	EGF-like domain containing protein	0.0018	0.0525	0.0525
Schistosoma mansoni	notch	0.0018	0.0525	0.0346
Onchocerca volvulus		0.0018	0.0525	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Brugia malayi	endoprotease bli-4 precursor	0.0009	0.0186	0.0186
Brugia malayi	Membrane-bound transcription factor site-1 protease precursor	0.0009	0.0186	0.0186
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0186	0.0186
Echinococcus multilocularis	membrane bound transcription factor site 1	0.0009	0.0186	0.0378
Brugia malayi	EGF-like domain containing protein	0.0018	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Giardia lamblia	High cysteine protein	0.0018	0.0525	0.5
Echinococcus multilocularis		0.0009	0.0186	0.0378
Schistosoma mansoni	notch	0.0018	0.0525	0.0346
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Brugia malayi	Calcium binding EGF domain containing protein	0.0018	0.0525	0.0525
Echinococcus granulosus	peroxidasin	0.0141	0.492	1
Brugia malayi	POT family protein	0.0083	0.283	0.283
Echinococcus granulosus	protein jagged 1	0.0018	0.0525	0.1068
Echinococcus multilocularis	Peptidase S8 S53, subtilisin kexin sedolisin	0.0106	0.3665	0.7448
Loa Loa (eye worm)	notch protein	0.0018	0.0525	0.0525
Schistosoma mansoni	peroxidasin	0.0141	0.492	0.4824
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0018	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Schistosoma mansoni	cell polarity protein	0.0018	0.0525	0.0346
Schistosoma mansoni	peroxidasin	0.0141	0.492	0.4824
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0186	0.5
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0009	0.0186	0.5
Loa Loa (eye worm)	endoprotease bli-4	0.0009	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0186	0.0186
Schistosoma mansoni	notch	0.0018	0.0525	0.0346
Brugia malayi	Blistered cuticle protein 3	0.0141	0.492	0.492
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Echinococcus granulosus	neurogenic locus notch protein 4	0.0018	0.0525	0.1068
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0018	0.0525	0.1068
Echinococcus multilocularis	neurogenic locus protein delta	0.0018	0.0525	0.1068
Echinococcus multilocularis	neurogenic locus protein delta	0.0018	0.0525	0.1068
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Schistosoma mansoni	notch	0.0018	0.0525	0.0346
Echinococcus granulosus	membrane bound transcription factor site 1	0.0009	0.0186	0.0378
Brugia malayi	Calcium binding EGF domain containing protein	0.0018	0.0525	0.0525
Echinococcus multilocularis	fibropellin Ia	0.0018	0.0525	0.1068
Brugia malayi	Animal haem peroxidase family protein	0.0141	0.492	0.492
Echinococcus multilocularis	neural cadherin	0.0018	0.0525	0.1068
Schistosoma mansoni	hypothetical protein	0.0018	0.0525	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Schistosoma mansoni	tripeptidyl-peptidase II (S08 family)	0.0283	1	1
Onchocerca volvulus	Neurogenic locus notch homolog	0.0018	0.0534	0.0736
Mycobacterium ulcerans	proline rich membrane-anchored mycosin MycP5	0.0009	0.0186	0.5
Schistosoma mansoni	hypothetical protein	0.0018	0.0525	0.0346
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Echinococcus granulosus	notch	0.0018	0.0525	0.1068
Echinococcus granulosus	neurogenic locus notch protein	0.0018	0.0525	0.1068
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Onchocerca volvulus		0.0141	0.492	1
Plasmodium falciparum	subtilisin-like protease 3	0.0009	0.0186	0.5
Brugia malayi	celfurPC protein	0.0009	0.0186	0.0186
Plasmodium vivax	subtilisin-like protease 1	0.0009	0.0186	0.5
Onchocerca volvulus		0.0018	0.0525	0.0717
Echinococcus granulosus	protein jagged 2	0.0018	0.0525	0.1068
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0018	0.0525	0.0717
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4)	0.0009	0.0186	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Schistosoma mansoni	hypothetical protein	0.0018	0.0525	0.0346
Mycobacterium leprae	Possible secreted protease	0.0009	0.0186	0.5
Echinococcus granulosus	delta-like protein 1	0.0018	0.0525	0.1068
Onchocerca volvulus		0.0018	0.0525	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Echinococcus granulosus	peptidase s8 s53 subtilisin kexin sedolisin	0.0106	0.3665	0.7448
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0009	0.0186	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Brugia malayi	Animal haem peroxidase family protein	0.0141	0.492	0.492
Onchocerca volvulus	Chorion peroxidase homolog	0.0141	0.492	1
Onchocerca volvulus		0.0018	0.0525	0.0717
Plasmodium vivax	subtilisin-like protease 2, putative	0.0009	0.0186	0.5
Loa Loa (eye worm)	proprotein convertase 2	0.0009	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Onchocerca volvulus		0.0141	0.492	1
Loa Loa (eye worm)	animal heme peroxidase	0.0141	0.492	0.492
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Brugia malayi	Calcium binding EGF domain containing protein	0.0018	0.0525	0.0525
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0009	0.0186	0.0378
Echinococcus multilocularis	Furin 1	0.0009	0.0186	0.0378
Echinococcus granulosus	protein jagged 1	0.0018	0.0525	0.1068
Onchocerca volvulus	Dual oxidase homolog	0.0141	0.492	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0009	0.0186	0.0378
Schistosoma mansoni	hypothetical protein	0.0018	0.0525	0.0346
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0186	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Onchocerca volvulus	Peroxidase homolog	0.0141	0.492	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Brugia malayi	proprotein convertase 2	0.0009	0.0186	0.0186
Brugia malayi	EGF-like domain containing protein	0.0018	0.0525	0.0525
Brugia malayi	Animal haem peroxidase family protein	0.0141	0.492	0.492
Onchocerca volvulus		0.0141	0.492	1
Echinococcus granulosus	neurogenic locus protein delta	0.0018	0.0525	0.1068
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Brugia malayi	Muscle positioning protein 4	0.0018	0.0525	0.0525
Onchocerca volvulus		0.0018	0.0525	0.0717
Brugia malayi	Animal haem peroxidase family protein	0.0141	0.492	0.492
Echinococcus granulosus	protein jagged 2	0.0018	0.0525	0.1068
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Brugia malayi	EGF-like domain containing protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Plasmodium vivax	subtilisin-like serine protease, putative	0.0009	0.0186	0.5
Plasmodium falciparum	subtilisin-like protease 2	0.0009	0.0186	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Loa Loa (eye worm)	blistered cuticle protein 3	0.0141	0.492	0.492
Echinococcus granulosus	slit 2 protein	0.0018	0.0525	0.1068
Brugia malayi	Cadherin domain containing protein	0.0018	0.0525	0.0525
Loa Loa (eye worm)	Notch2	0.0018	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Schistosoma mansoni	notch	0.0018	0.0525	0.0346
Brugia malayi	EGF-like domain containing protein	0.0018	0.0525	0.0525
Schistosoma mansoni	hypothetical protein	0.0018	0.0525	0.0346
Onchocerca volvulus	Peroxidasin homolog	0.0141	0.492	1
Echinococcus granulosus	neuroendocrine convertase 2	0.0009	0.0186	0.0378
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0009	0.0186	0.5
Brugia malayi	notch-like transmembrane receptor	0.0018	0.0525	0.0525
Schistosoma mansoni	septate junction protein	0.0018	0.0525	0.0346
Onchocerca volvulus	Slit protein homolog	0.0018	0.0525	0.0717
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0212	1
Brugia malayi	GCC2 and GCC3 family protein	0.0018	0.0525	0.0525
Brugia malayi	EGF-like domain containing protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Schistosoma mansoni	hypothetical protein	0.0018	0.0525	0.0346
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Echinococcus multilocularis	neurogenic locus notch protein	0.0018	0.0525	0.1068
Brugia malayi	EGF-like domain containing protein	0.0018	0.0525	0.0525
Loa Loa (eye worm)	subtilase	0.0283	1	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Brugia malayi	neuroendocrine convertase 1 precursor	0.0009	0.0186	0.0186
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0186	0.5
Loa Loa (eye worm)	animal heme peroxidase	0.0141	0.492	0.492
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0186	0.5
Onchocerca volvulus	Peroxidasin homolog	0.0141	0.492	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Trypanosoma brucei	subtilisin peptidase	0.0009	0.0186	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Echinococcus multilocularis	protein jagged 1	0.0018	0.0525	0.1068
Schistosoma mansoni	slit	0.0018	0.0525	0.0346
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0009	0.0186	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Mycobacterium ulcerans	membrane-anchored serine protease (mycosin), MycP4	0.0009	0.0186	0.5
Echinococcus granulosus	Furin 1	0.0009	0.0186	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Brugia malayi	Delta serrate ligand family protein	0.0018	0.0525	0.0525
Brugia malayi	hypothetical protein	0.0141	0.492	0.492
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Echinococcus granulosus	neural cadherin	0.0018	0.0525	0.1068
Mycobacterium tuberculosis	Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5)	0.0009	0.0186	0.5
Onchocerca volvulus	Putative cubilin	0.0018	0.0525	0.0717
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Loa Loa (eye worm)	animal heme peroxidase	0.0141	0.492	0.492
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Echinococcus multilocularis	neurogenic locus notch protein	0.0018	0.0525	0.1068
Mycobacterium tuberculosis	Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like)	0.0009	0.0186	0.5
Leishmania major	hypothetical protein, conserved	0.0009	0.0212	1
Onchocerca volvulus	Peroxidase homolog	0.0141	0.492	1
Echinococcus granulosus	neurogenic locus notch protein	0.0018	0.0525	0.1068
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Loa Loa (eye worm)	POT family protein	0.0083	0.283	0.283
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Brugia malayi	Hypothetical subtilase-type proteinase F21H12.6 in chromosome II	0.0009	0.0186	0.0186
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0018	0.0525	0.1068
Echinococcus multilocularis	protein jagged 1	0.0018	0.0525	0.1068
Echinococcus multilocularis	peroxidasin	0.0141	0.492	1
Echinococcus multilocularis	protein jagged 2	0.0018	0.0525	0.1068
Brugia malayi	Peroxidasin	0.0141	0.492	0.492
Brugia malayi	Animal haem peroxidase family protein	0.0141	0.492	0.492
Schistosoma mansoni	notch	0.0018	0.0534	0.0355
Echinococcus multilocularis	notch	0.0018	0.0525	0.1068
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Brugia malayi	Cadherin domain containing protein	0.0018	0.0525	0.0525
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Mycobacterium tuberculosis	Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3)	0.0009	0.0186	0.5
Echinococcus multilocularis	neuroendocrine convertase 2	0.0009	0.0186	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0141	0.492	0.492
Plasmodium falciparum	subtilisin-like protease 1	0.0009	0.0186	0.5
Toxoplasma gondii	EGF family domain-containing protein	0.0018	0.0525	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0525	0.0525
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Echinococcus multilocularis	slit 2 protein	0.0018	0.0525	0.1068
Mycobacterium ulcerans	membrane-anchored mycosin MycP3	0.0009	0.0186	0.5
Trypanosoma cruzi	hypothetical protein, conserved	0.0009	0.0212	1
Loa Loa (eye worm)	animal heme peroxidase	0.0141	0.492	0.492
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0009	0.0186	0.5
Schistosoma mansoni	hypothetical protein	0.0018	0.0525	0.0346
Echinococcus granulosus	furin	0.0009	0.0186	0.0378

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	NA 0 %	Anthelmintic activity against adult liver fluke (Fasciola hepatica) in sheep, after peroral administration of 30 mg/kg of the compound was determined ; I means no effect on sheep fecal fluke egg output	ChEMBL.	3116256
Activity (functional)	0 %	Anthelmintic activity against adult liver fluke (Fasciola hepatica) in sheep following 20 mg/kg p.o.; No data	ChEMBL.	3116256
Activity (functional)	0 %	Anthelmintic activity against adult liver fluke (Fasciola hepatica) in sheep, after peroral administration of 15 mg/kg of the compound was determined; ND means no data	ChEMBL.	3116256
Reduction (functional)	%	Nematocidal activity against N. dubius induced necropsy in mouse, after oral administration of 50 mg/kg of the compound ; ND means nodata	ChEMBL.	3116256
Reduction (functional)	%	Nematocidal activity against N. dubius induced necropsy in mouse, after oral administration of 100 mg/kg of the compound ; ND means no data	ChEMBL.	3116256
Reduction (functional)	0 %	Nematocidal activity against N. dubius induced necropsy in mouse, after oral administration of 100 mg/kg of the compound ; ND means no data	ChEMBL.	3116256
Reduction (functional)	ND 0 %	Nematocidal activity against N. dubius induced necropsy in mouse, after oral administration of 50 mg/kg of the compound ; ND means nodata	ChEMBL.	3116256
Reduction (functional)	= 23 %	Nematocidal activity against Nematospiroides dubius induced necropsy in mouse, oral administration 200 mg/kg	ChEMBL.	3116256

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL52143

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 78726