TDR Targets

Basic information

Technical information

TDR Targets ID: 794377
Name: 1,3-dimethyl-7-(2-oxopropyl)-8-piperidin-1-yl purine-2,6-dione
MW: 319.359 | Formula: C15H21N5O3
H donors: 0 H acceptors: 4 LogP: 0.72 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Cn1c(nc2c1c(=O)n(c(=O)n2C)C)N1CCCCC1
InChi: 1S/C15H21N5O3/c1-10(21)9-20-11-12(17(2)15(23)18(3)13(11)22)16-14(20)19-7-5-4-6-8-19/h4-9H2,1-3H3
InChiKey: KIOWFXZVDXMYGQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-acetonyl-1,3-dimethyl-8-(1-piperidyl)purine-2,6-dione
7-acetonyl-1,3-dimethyl-8-piperidino-xanthine
1,3-dimethyl-7-(2-oxopropyl)-8-piperidin-1-yl-purine-2,6-dione
ZINC00099738
A2937/0123670

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	vesicular acetylcholine transporter	0.0605	0.7645	1
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0042	0.0055
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0387	0.1242
Echinococcus multilocularis	smad	0.0008	0.0042	0.0042
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0508	0.0665
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0066	0.0087
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0387	0.1034
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1461	0.1911
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0605	0.7645	0.7645
Schistosoma mansoni	Smad4	0.0008	0.0042	0.0055
Echinococcus multilocularis	expressed protein	0.0008	0.0046	0.0046
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0508	0.0657
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0066	0.0087
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0066	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0066	0.0086
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0066	0.0087
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0387	0.0281
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0066	0.0066
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0066	0.0066
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0508	0.0665
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0728	0.094
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0086
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0042	0.0055
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0508	0.0665
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0007	0.0009
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0508	0.0657
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0605	0.7645	1
Brugia malayi	beta-lactamase	0.0035	0.0387	0.05
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0728	0.0952
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0728	0.0728
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0066	0.0086
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0605	0.7645	0.9874
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0086
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0387	0.1242
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0387	1
Trichomonas vaginalis	glutaminase, putative	0.0268	0.3348	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0728	0.0952
Onchocerca volvulus		0.0035	0.0387	0.0507
Brugia malayi	nuclear receptor RXR	0.0005	0.0007	0.0009
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0387	0.0507
Onchocerca volvulus		0.001	0.0066	0.0087
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0728	0.0952
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0066	0.0087
Loa Loa (eye worm)	glutaminase 2	0.0268	0.3348	0.4325
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0009
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0066	0.0086
Mycobacterium ulcerans	lipase LipD	0.0035	0.0387	0.1034
Brugia malayi	ecdysteroid receptor	0.001	0.0066	0.0086
Schistosoma mansoni	hypothetical protein	0.0165	0.2043	0.2672
Brugia malayi	glutaminase DH11.1	0.0268	0.3348	0.4325
Schistosoma mansoni	ferritin light chain	0.0008	0.0046	0.006
Loa Loa (eye worm)	glutaminase	0.0268	0.3348	0.4325
Schistosoma mansoni	apoferritin-2	0.0008	0.0046	0.006
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0387	0.1242
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0086
Schistosoma mansoni	ferritin	0.0008	0.0046	0.006
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0007	0.0009
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0066	0.0086
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0066	0.0087
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0387	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1461	0.1887
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0066	0.0066
Schistosoma mansoni	ferritin	0.0008	0.0046	0.006
Brugia malayi	MH1 domain containing protein	0.0008	0.0042	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0313	0.3928	0.5074
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0008	0.0042	0.0042
Schistosoma mansoni	smad1 5 8 and	0.0008	0.0042	0.0055
Brugia malayi	Smad1	0.0008	0.0042	0.0054
Echinococcus granulosus	Smad4	0.0008	0.0042	0.0055
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0175	1
Brugia malayi	MH1 domain containing protein	0.0008	0.0042	0.0054
Schistosoma mansoni	hypothetical protein	0.0165	0.2043	0.2672
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0086
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0066	0.0086
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0066	0.0086
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0066	0.0066
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0728	0.0952
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0387	0.05
Echinococcus multilocularis	neuropeptide receptor A26	0.0451	0.5677	0.5677
Echinococcus granulosus	neuropeptide s receptor	0.0451	0.5677	0.7426
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0066	0.0087
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0066	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0387	0.05
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0008	0.0042	0.0042
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0066	0.0087
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0387	0.1242
Trichomonas vaginalis	esterase, putative	0.0035	0.0387	0.1034
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0387	0.05
Schistosoma mansoni	apoferritin-2	0.0008	0.0046	0.006
Schistosoma mansoni	ferritin	0.0008	0.0046	0.006
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0387	0.0507
Brugia malayi	hypothetical protein	0.0005	0.0007	0.0009
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0066	0.0087
Echinococcus multilocularis	geminin	0.0165	0.2043	0.2043
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0613	0.7742	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0387	0.1034
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0613	0.7742	1
Echinococcus granulosus	expressed protein	0.0008	0.0046	0.006
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0066	0.0087
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0175	0.0229
Brugia malayi	TAR-binding protein	0.0062	0.0728	0.094
Leishmania major	hypothetical protein, conserved	0.0035	0.0387	0.0281
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0175	0.047
Loa Loa (eye worm)	MH2 domain-containing protein	0.0008	0.0042	0.0054
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0066	0.0087
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0066	0.0086
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0066	0.0086
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0066	0.0087
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0007	0.0009
Brugia malayi	RNA binding protein	0.0062	0.0728	0.094
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0066	0.0086
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0008	0.0042	0.0055
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0387	0.1242
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1461	0.1887
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0508	0.0508
Brugia malayi	MH2 domain containing protein	0.0008	0.0042	0.0054
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1461	0.1911
Schistosoma mansoni	ap endonuclease	0.0018	0.0175	0.0229
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0008	0.0042	0.0055
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0086
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0066	0.0087
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0508	0.0508
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0066	0.0087
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0605	0.7645	0.9874
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0387	0.1242
Brugia malayi	hypothetical protein	0.0119	0.1461	0.1887
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0066	0.0087
Echinococcus granulosus	ferritin	0.0008	0.0046	0.006
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0387	0.1034
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0066	0.0086
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0066	0.0086
Onchocerca volvulus		0.0035	0.0387	0.0507
Brugia malayi	MH2 domain containing protein	0.0116	0.1422	0.1836
Toxoplasma gondii	ABC1 family protein	0.0035	0.0387	1
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0387	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0066	0.0086
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0175	1
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0728	0.094
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0175	0.5
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0387	0.05
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0387	0.05
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0387	0.05
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0066	0.0086
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0066	0.0087
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0066	0.0086
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0387	0.1242
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0175	0.0391
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0066	0.0086
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0066	0.0066
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0007	0.0009
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0387	0.1034
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0066	0.0087
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0066	0.0087
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0175	0.0391
Loa Loa (eye worm)	Smad1	0.0008	0.0042	0.0054
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0175	0.0391
Schistosoma mansoni	ferritin	0.0008	0.0046	0.006
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0066	0.0086
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0387	0.1242
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0387	0.0281
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0066	0.0086
Mycobacterium ulcerans	glutaminase	0.0268	0.3348	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0066	0.0087
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0508	0.0665
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0066	0.0087
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0387	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0066	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0066	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0009
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0175	0.0175
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0175	0.0226
Schistosoma mansoni	ap endonuclease	0.0018	0.0175	0.0229
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0175	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0387	0.1034
Onchocerca volvulus		0.0035	0.0387	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0613	0.7742	1
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0613	0.7742	1
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0387	0.1034
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0387	0.1242
Brugia malayi	nuclear receptor NHR-88	0.001	0.0066	0.0086
Schistosoma mansoni	smad	0.0008	0.0042	0.0055
Brugia malayi	hypothetical protein	0.0005	0.0007	0.0009
Loa Loa (eye worm)	MH1 domain-containing protein	0.0008	0.0042	0.0054
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0066	0.0066
Brugia malayi	nuclear hormone receptor	0.001	0.0066	0.0086
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0728	0.094
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0728	0.094
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0175	0.5
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0007	0.0009
Echinococcus granulosus	smad	0.0008	0.0042	0.0055
Echinococcus granulosus	neuropeptide receptor A26	0.0451	0.5677	0.7426
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0066	0.0087
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.2794	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.1422	0.1836
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0728	0.0952
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0508	0.0665
Brugia malayi	steroid hormone receptor	0.001	0.0066	0.0086
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0066	0.0066
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0728	0.0952
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0009
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0066	0.0087
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0086
Echinococcus granulosus	geminin	0.0165	0.2043	0.2672
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0175	0.0226
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0387	0.1034
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0387	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0009
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0066	0.0066
Echinococcus multilocularis	ferritin	0.0008	0.0046	0.0046
Brugia malayi	beta-lactamase family protein	0.0035	0.0387	0.05
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.1422	0.1836
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0066	0.0087
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0387	0.05
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0066	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0387	0.05
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0387	0.1242
Schistosoma mansoni	glutaminase	0.0268	0.3348	0.438
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0387	0.1034
Brugia malayi	MH2 domain containing protein	0.0008	0.0042	0.0054
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0066	0.0086
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0007	0.0009
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0387	0.05
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0066	0.0086
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0387	0.0281
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0066	0.0087
Schistosoma mansoni	ferritin light chain	0.0008	0.0046	0.006
Schistosoma mansoni	coup transcription factor	0.001	0.0066	0.0087
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0387	0.0387
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0007	0.0007
Leishmania major	C-8 sterol isomerase-like protein	0.0613	0.7742	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0008	0.0042	0.0055
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0066	0.0066
Echinococcus multilocularis	Smad4	0.0008	0.0042	0.0042
Echinococcus multilocularis	neuropeptide s receptor	0.0451	0.5677	0.5677
Brugia malayi	beta-lactamase family protein	0.0035	0.0387	0.05
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0007	0.0009
Loa Loa (eye worm)	hypothetical protein	0.001	0.0066	0.0086
Schistosoma mansoni	vesicular acetylcholine transporter	0.0605	0.7645	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0066	0.0086

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 794377