TDR Targets

Basic information

Technical information

TDR Targets ID: 794838
Name: 4-bromo-N-(3-chloro-2-methylphenyl)benzenesul fonamide
MW: 360.654 | Formula: C13H11BrClNO2S
H donors: 1 H acceptors: 2 LogP: 4.13 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Brc1ccc(cc1)S(=O)(=O)Nc1cccc(c1C)Cl
InChi: 1S/C13H11BrClNO2S/c1-9-12(15)3-2-4-13(9)16-19(17,18)11-7-5-10(14)6-8-11/h2-8,16H,1H3
InChiKey: HKOUIPZCTZESCA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-bromo-N-(3-chloro-2-methyl-phenyl)benzenesulfonamide
AG-205/36813014
ZINC00713399
A1306/0059418

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0124	0.0311
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0124	0.0448
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Plasmodium falciparum	hexose transporter	0.0109	0.2253	0.2253
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0201	0.58
Onchocerca volvulus		0.0015	0.0201	1
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0399	0.1436
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0124	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0009
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.5689
Echinococcus multilocularis	General substrate transporter	0.0093	0.1918	0.48
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0701	1
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0726
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0597	0.8517
Schistosoma mansoni	hypothetical protein	0.0078	0.1569	0.3926
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0124	0.0448
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0064	0.016
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1494
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0582	0.1457
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0201	0.0504
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0124	0.0448
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	hypothetical protein	0.0036	0.0654	0.1637
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0504
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0124	0.0448
Schistosoma mansoni	hypothetical protein	0.0109	0.2253	0.564
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0124	0.0311
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0597	0.0903
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0124	0.0448
Schistosoma mansoni	hypothetical protein	0.0188	0.3995	1
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1569	0.5653
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.142	0.3555
Onchocerca volvulus		0.0015	0.0201	1
Entamoeba histolytica	protein kinase, putative	0.0033	0.0597	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0504
Echinococcus multilocularis	GPCR, family 2	0.0036	0.0654	0.1637
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0124	0.0448
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0399	0.0603
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.0124	0.0311
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0399	0.0998
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	hypothetical protein	0.0036	0.0654	0.1637
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0124	0.0448
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0124	0.0311
Plasmodium falciparum	protein kinase 7	0.0307	0.6612	0.6612
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0124	0.0448
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0124	0.0448
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.8651
Brugia malayi	latrophilin 2 splice variant baaae	0.0078	0.1569	0.5653
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0002	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0582	0.1457
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0347	0.2444
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0201	0.2874
Brugia malayi	Cam kinase protein 1	0.0033	0.0597	0.2151
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0399	0.1436
Schistosoma mansoni	glucose transport protein	0.0109	0.2253	0.564
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.0347	0.5818
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0176	0.3724	0.5632
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0036	0.0654	0.2356
Schistosoma mansoni	hypothetical protein	0.0188	0.3995	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0109	0.2253	0.564
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0726
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0347	0.1251
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0033	0.0582	1
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0124	0.0311
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0124	0.0311
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0109	0.2253	0.564
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.0124	0.0311
Brugia malayi	Sugar transporter family protein	0.0015	0.0201	0.0726
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.0124	0.0311
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0064	0.016
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1494
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0597	0.2151
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0201	0.1418
Onchocerca volvulus		0.0015	0.0201	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0033	0.0582	1
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0064	0.016
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.0124	0.0311
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0064	0.016
Onchocerca volvulus		0.0015	0.0201	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0347	0.0347
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0399	1
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0033	0.0582	0.1457
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0064	0.016
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.0002	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0654	0.2356
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0597	0.2151
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0124	0.0311
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0201	0.0504
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0033	0.0582	0.2097
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0124	0.0311
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0124	0.0311
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0124	0.0448
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0201	0.1418
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0347	0.4955
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0124	0.0311
Schistosoma mansoni	coup transcription factor	0.0012	0.0124	0.0311
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.098	0.3533
Schistosoma mansoni	ap endonuclease	0.0022	0.0347	0.0869
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0597	0.0903
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0201	0.0305
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0347	0.1251
Toxoplasma gondii	aldehyde dehydrogenase	0.0071	0.142	0.2148
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0399	0.2806
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0504
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.098	0.2454
Schistosoma mansoni	Smad4	0.0009	0.0064	0.016
Brugia malayi	Sugar transporter family protein	0.0109	0.2253	0.812
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0597	0.2648
Echinococcus multilocularis	smad	0.0009	0.0064	0.016
Brugia malayi	hypothetical protein	0.0006	0.0002	0.0009
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0109	0.2253	0.564
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0201	0.2874
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0124	0.0448
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0347	1
Trypanosoma brucei	glucose transporter 1E	0.0034	0.0606	0.8651
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0347	0.0347
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.8651
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0399	0.2806
Schistosoma mansoni	glucose transporter	0.0015	0.0201	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Schistosoma mansoni	ap endonuclease	0.0022	0.0347	0.0869
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0726
Brugia malayi	Smad1	0.0009	0.0064	0.023
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0597	0.0597
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0606	0.8651
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0347	0.1541
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0113	0.2357	0.8493
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	hexose transporter, putative	0.0034	0.0606	0.8651
Brugia malayi	major facilitator superfamily protein	0.0015	0.0201	0.0726
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0036	0.0654	0.1637
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0124	0.0311
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0124	0.0448
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.098	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0124	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0399	0.6849
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0036	0.0654	0.1637
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0597	0.0597
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0124	0.0448
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	geminin	0.0188	0.3995	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0448	0.1613
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.2806
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0318	0.2241
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.0002	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.0124	0.0311
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0124	0.0311
Onchocerca volvulus		0.0015	0.0201	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0124	0.0448
Brugia malayi	steroid hormone receptor	0.0012	0.0124	0.0448
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0606	0.269
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1494
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0124	0.0448
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0124	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0201	0.0504
Onchocerca volvulus	Putative transporter	0.0015	0.0201	1
Mycobacterium ulcerans	sugar transporter	0.0015	0.0201	0.1418
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0201	0.2874
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0124	0.0448
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0124	0.0448
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.2775	1
Onchocerca volvulus		0.0015	0.0201	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.0124	0.0311
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.098	0.2454
Toxoplasma gondii	facilitative glucose transporter GT1	0.0109	0.2253	0.3408
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0109	0.2253	0.564
Onchocerca volvulus		0.0015	0.0201	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.0124	0.0311
Onchocerca volvulus		0.0015	0.0201	1
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0399	0.0998
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0461	1	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Onchocerca volvulus		0.0015	0.0201	1
Echinococcus multilocularis	Smad4	0.0009	0.0064	0.016
Loa Loa (eye worm)	sugar transporter	0.0015	0.0201	0.0726
Brugia malayi	MH2 domain containing protein	0.0132	0.2775	1
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0201	0.2874
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0124	0.0448
Onchocerca volvulus		0.0015	0.0201	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0109	0.2253	0.564
Brugia malayi	nuclear hormone receptor	0.0012	0.0124	0.0448
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0597	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0347	0.0869
Schistosoma mansoni	hypothetical protein	0.0036	0.0654	0.1637
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0504
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0109	0.2253	0.564
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0124	0.0311
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.0124	0.0311
Leishmania major	glucose transporter, lmgt1	0.0034	0.0606	0.4268
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.0124	0.0311
Brugia malayi	MH2 domain containing protein	0.0009	0.0064	0.023
Trichomonas vaginalis	sugar transporter, putative	0.0034	0.0606	0.269
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0124	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0606	0.269
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0124	0.0448
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.8651
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0033	0.0582	0.1457
Trichomonas vaginalis	glucose transporter, putative	0.0034	0.0606	0.269
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0036	0.0654	0.1637
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0038	0.0701	0.106
Schistosoma mansoni	glucose transport protein	0.0109	0.2253	0.564
Brugia malayi	hypothetical protein	0.0006	0.0002	0.0009
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	Smad1	0.0009	0.0064	0.023
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Entamoeba histolytica	hypothetical protein	0.0024	0.0399	0.6679
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0504
Echinococcus granulosus	geminin	0.0188	0.3995	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.142	1
Brugia malayi	ecdysteroid receptor	0.0012	0.0124	0.0448
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.8651
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0124	0.0311
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	solute carrier family 22	0.0015	0.0201	0.0504
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0109	0.2253	0.564
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0201	0.0726
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0201	0.2874
Schistosoma mansoni	glucose transport protein	0.0109	0.2253	0.564
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.1769
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0071	0.142	0.3555
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0582	0.2097
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1494
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0597	0.2151
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0124	0.0448
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0201	0.1418
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0124	0.0448
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.0347	1
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0012	0.0119	0.0836
Brugia malayi	MH1 domain containing protein	0.0009	0.0064	0.023
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0113	0.2357	0.8493
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0064	0.016
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0597	0.0597
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0124	0.0448
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1494
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0036	0.0654	0.1637
Toxoplasma gondii	exonuclease III APE	0.0022	0.0347	0.0525
Onchocerca volvulus		0.0015	0.0201	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0124	0.0448
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0701	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0034	0.0606	0.4268
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.0002	0.0006
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.0124	0.0311
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0201	0.1418
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0124	0.0311
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0552	0.1381
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0038	0.0701	1
Echinococcus granulosus	GPCR family 2	0.0036	0.0654	0.1637
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0113	0.2357	0.8493
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0201	0.0201
Brugia malayi	MH1 domain containing protein	0.0009	0.0064	0.023
Brugia malayi	Latrophilin receptor protein 2	0.0036	0.0654	0.2356
Brugia malayi	Sugar transporter family protein	0.0015	0.0201	0.0726
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0033	0.0582	0.2097
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0064	0.016
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0552	0.1381
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	protein kinase	0.0033	0.0597	0.1494
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0504
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0124	0.0448
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0124	0.0448
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.142	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0701	0.4933
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0176	0.3724	0.3724
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0109	0.2253	0.564
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	General substrate transporter	0.0093	0.1918	0.48
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.0347	0.4955
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.027	0.386
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.016	0.0576
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0176	0.3724	0.3724
Toxoplasma gondii	protein kinase, putative	0.0307	0.6612	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0071	0.142	0.3555
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.0002	0.0009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.098	0.2454
Giardia lamblia	Sugar-proton symporter	0.0015	0.0201	0.346
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0071	0.142	1
Chlamydia trachomatis	proline--tRNA ligase	0.0012	0.0119	0.2978
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Plasmodium falciparum	proline--tRNA ligase	0.0038	0.0701	0.0701
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0124	0.0448
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0606	0.8651
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.2775	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0201	0.0504
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.0347	0.5966
Brugia malayi	nuclear receptor RXR	0.0006	0.0002	0.0009
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0597	0.0597
Loa Loa (eye worm)	sugar transporter	0.0109	0.2253	0.812
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0124	0.0311
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0504
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.8651
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0201	0.0305
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0347	0.0869
Schistosoma mansoni	smad	0.0009	0.0064	0.016
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0597	0.0597
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0333	0.1477
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0399	0.0399
Trypanosoma cruzi	hexose transporter	0.0034	0.0606	0.8651
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0113	0.2357	0.8493
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0036	0.0654	0.2356
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0201	0.0305
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0124	0.0311
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0504
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0038	0.0701	0.4933
Echinococcus granulosus	Smad4	0.0009	0.0064	0.016
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Onchocerca volvulus		0.0015	0.0201	1
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0597	0.0597
Onchocerca volvulus		0.0015	0.0201	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0071	0.142	0.3555
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0399	0.6849
Onchocerca volvulus		0.0015	0.0201	1
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0347	0.2444
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0124	0.0311
Trypanosoma brucei	glucose transporter, putative	0.0034	0.0606	0.8651
Brugia malayi	MH2 domain containing protein	0.0009	0.0064	0.023
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0009
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0201	0.0504
Treponema pallidum	prolyl-tRNA synthetase	0.0012	0.0119	0.3418
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0201	0.1418
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0002	0.0009
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0124	0.0311
Leishmania major	protein kinase, putative	0.0033	0.0597	0.4202
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0597	0.0597
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.0002	0.0006
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0033	0.0582	0.9752
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0064	0.023
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Leishmania major	glucose transporter, lmgt3	0.0034	0.0606	0.4268
Onchocerca volvulus		0.0015	0.0201	1
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0597	0.2151
Schistosoma mansoni	protein kinase	0.0033	0.0597	0.1494
Echinococcus granulosus	smad	0.0009	0.0064	0.016
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.0347	0.1541
Trypanosoma brucei	glucose transporter 2A	0.0034	0.0606	0.8651
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0064	0.016
Schistosoma mansoni	sugar transporter	0.0015	0.0201	0.0504
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0034	0.0606	0.8651
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0124	0.0448
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0124	0.0448
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0399	0.0998
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0399	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Entamoeba histolytica	protein kinase, putative	0.0033	0.0597	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0033	0.0582	0.2583
Leishmania major	glucose transporter, lmgt2	0.0034	0.0606	0.4268
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0201	0.0894
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0071	0.142	1
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0124	0.0448
Plasmodium vivax	hexose transporter	0.0109	0.2253	0.2253
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.0347	0.4955
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.098	0.2454
Schistosoma mansoni	protein kinase	0.0033	0.0597	0.1494
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.098	0.2454
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.098	0.2454
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0399	0.5689
Brugia malayi	major facilitator superfamily protein	0.0015	0.0201	0.0726
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0064	0.023
Leishmania major	hypothetical protein, conserved	0.0015	0.0201	0.1418
Onchocerca volvulus		0.0015	0.0201	1
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0201	0.0305
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0201	0.0726
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1494
Plasmodium vivax	sugar transporter, putative	0.0015	0.0201	0.0201
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0399	0.0998
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.098	0.3533
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.0124	0.0311
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0597	0.1494
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0201	0.1418
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0597	0.1494
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0201	0.0894
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0726
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0201	0.0504
Trichomonas vaginalis	conserved hypothetical protein	0.0109	0.2253	1
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0201	0.0894
Giardia lamblia	Hexose transporter	0.0015	0.0201	0.346
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0201	0.0726
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0597	0.1494
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0071	0.142	1
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0318	0.5469
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.0347	0.2444
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0201	0.0726
Brugia malayi	hypothetical protein	0.0015	0.0201	0.0726
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0124	0.0311
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.0002	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0582	0.2097
Plasmodium vivax	proline--tRNA ligase, putative	0.0038	0.0701	0.0701
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0318	0.2241
Schistosoma mansoni	hypothetical protein	0.0036	0.0654	0.1637

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 794838