Detailed information for compound 797353

Basic information

Technical information
  • TDR Targets ID: 797353
  • Name: 3-(4-amino-1,2,5-oxadiazol-3-yl)-1,2,4-oxadia zol-5-amine
  • MW: 168.114 | Formula: C4H4N6O2
  • H donors: 2 H acceptors: 4 LogP: -1.03 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1onc(n1)c1nonc1N
  • InChi: 1S/C4H4N6O2/c5-2-1(8-12-9-2)3-7-4(6)11-10-3/h(H2,5,9)(H2,6,7,10)
  • InChiKey: OXXKTGRIPAUKMA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-(5-amino-1,2,4-oxadiazol-3-yl)furazan-3-yl]amine
  • ZINC01066115
  • MLS000728257
  • SMR000306950
  • Oprea1_192706
  • ZERO/001233

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0364
Loa Loa (eye worm) hypothetical protein 0.0019 0.0093 0.0356
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.019 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0142 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0009 0.0009
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0149 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0133 0.107
Schistosoma mansoni ap endonuclease 0.002 0.0102 0.0118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0188
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0149 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0102 0.0102
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0123 0.0991
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0364
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0149 1
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0102 0.0822
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0178 0.143
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0143
Loa Loa (eye worm) hypothetical protein 0.0024 0.0133 0.0507
Schistosoma mansoni Smad4 0.0009 0.0009 0.001
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0252 0.0252
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0093 0.0093
Onchocerca volvulus 0.0029 0.0178 1
Schistosoma mansoni DNA helicase recq5 0.0024 0.0133 0.0153
Loa Loa (eye worm) transcription factor SMAD2 0.0128 0.0981 0.3734
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0102 0.6864
Echinococcus granulosus lamin 0.0029 0.0178 0.0178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0087 0.5844
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0102 0.0822
Echinococcus multilocularis smad 0.0009 0.0009 0.0009
Loa Loa (eye worm) MH2 domain-containing protein 0.0128 0.0981 0.3734
Entamoeba histolytica recQ family helicase, putative 0.0024 0.0133 0.107
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0038 0.2639
Brugia malayi MH1 domain containing protein 0.0009 0.0009 0.0073
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0133 0.9366
Loa Loa (eye worm) kinesin-like protein KLP2 0.016 0.1245 0.4741
Onchocerca volvulus 0.0029 0.0178 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0149 0.1197
Schistosoma mansoni intermediate filament proteins 0.0029 0.0178 0.0205
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0038 0.0301
Loa Loa (eye worm) Smad1 0.0009 0.0009 0.0035
Entamoeba histolytica hypothetical protein 0.0039 0.0252 0.2026
Toxoplasma gondii exonuclease III APE 0.002 0.0102 0.0822
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0149 1
Echinococcus granulosus Smad4 0.0009 0.0009 0.0009
Schistosoma mansoni smad1 5 8 and 0.0009 0.0009 0.001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0102 0.5388
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.0133 0.0507
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0102 0.7192
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0149 0.1197
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0034 0.0039
Plasmodium vivax importin-beta 2, putative 0.0031 0.019 0.1525
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0149 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0133 0.107
Leishmania major importin beta-1 subunit, putative 0.0025 0.0142 0.9545
Echinococcus multilocularis GPCR, family 2 0.0019 0.0093 0.0093
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0102 1
Brugia malayi Kinesin motor domain containing protein 0.016 0.1245 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0123 0.0991
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0133 0.9366
Schistosoma mansoni ap endonuclease 0.002 0.0102 0.0118
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0123 0.0991
Loa Loa (eye worm) RecQ helicase 0.0024 0.0133 0.0507
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0067 0.0535
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0034 0.0271
Schistosoma mansoni lamin 0.0029 0.0178 0.0205
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0149 0.1197
Brugia malayi MH1 domain containing protein 0.0009 0.0009 0.0073
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0149 1
Schistosoma mansoni hypothetical protein 0.0039 0.0252 0.029
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0102 0.6864
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0096 0.5
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0102 0.7192
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0123 0.0991
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0133 0.0133
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0102 0.5
Echinococcus multilocularis importin subunit beta 1 0.0031 0.019 0.019
Schistosoma mansoni DNA helicase recq1 0.0024 0.0133 0.0153
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0149 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0093 0.0356
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.019 0.1525
Echinococcus granulosus bloom syndrome protein 0.0024 0.0133 0.0133
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0188
Plasmodium falciparum kinesin-5 0.016 0.1245 1
Schistosoma mansoni ran 0.0023 0.0123 0.0142
Schistosoma mansoni hypothetical protein 0.0019 0.0093 0.0107
Schistosoma mansoni kinesin eg-5 0.016 0.1245 0.1432
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0133 0.7017
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0252 0.029
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.0133 0.0133
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0123 0.047
Entamoeba histolytica hypothetical protein 0.0039 0.0252 0.2026
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.0133 0.0133
Brugia malayi Smad1 0.0009 0.0009 0.0073
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0178 0.0678
Schistosoma mansoni hypothetical protein 0.0019 0.0093 0.0107
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0038 0.2639
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0149 0.1197
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0142 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0133 0.9366
Entamoeba histolytica kinesin, putative 0.016 0.1245 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0087 0.5844
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0133 0.107
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0102 0.7192
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0054 0.0054
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0364
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0087 0.5844
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0009 0.0009
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0102 0.0822
Echinococcus granulosus lamin dm0 0.0029 0.0178 0.0178
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0149 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0054 0.0054
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0133 0.9366
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0567
Echinococcus granulosus importin subunit beta 1 0.0031 0.019 0.019
Echinococcus granulosus snurportin 1 0.033 0.2626 0.2626
Echinococcus multilocularis lamin dm0 0.0029 0.0178 0.0178
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0142 1
Echinococcus multilocularis snurportin 1 0.033 0.2626 0.2626
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0274 0.2198
Entamoeba histolytica hypothetical protein 0.0025 0.0142 0.1142
Plasmodium falciparum importin beta, putative 0.0031 0.019 0.1525
Schistosoma mansoni importin beta-1 0.0031 0.019 0.0218
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0093 0.0093
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0178 0.0678
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0093 0.075
Entamoeba histolytica hypothetical protein 0.0039 0.0252 0.2026
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0149 0.1197
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0009 0.0035
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0133 0.107
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0102 0.6864
Giardia lamblia Kinesin-5 0.016 0.1245 1
Schistosoma mansoni hypothetical protein 0.1074 0.8693 1
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0093 0.075
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.2626 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0009 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0567
Schistosoma mansoni hypothetical protein 0.0019 0.0093 0.0107
Echinococcus multilocularis Smad4 0.0009 0.0009 0.0009
Brugia malayi MH2 domain containing protein 0.0128 0.0981 0.7875
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0123 0.8674
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0123 0.0123
Plasmodium vivax kinesin-5 0.016 0.1245 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.0133 0.0271
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.0133 0.0133
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0038 0.0043
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0012 0.0034 0.0271
Loa Loa (eye worm) hypothetical protein 0.0029 0.0178 0.0678
Schistosoma mansoni smad1 5 8 and 0.0009 0.0009 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0364
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0096 0.0769
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0038 0.0301
Schistosoma mansoni hypothetical protein 0.0041 0.0274 0.0315
Echinococcus granulosus GPCR family 2 0.0019 0.0093 0.0093
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.0133 0.107
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0123 0.0123
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0067 0.0254
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0009 0.001
Brugia malayi MH2 domain containing protein 0.0009 0.0009 0.0073
Loa Loa (eye worm) hypothetical protein 0.0012 0.0038 0.0143
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0149 1
Schistosoma mansoni lamin 0.0029 0.0178 0.0205
Entamoeba histolytica Ran family GTPase 0.0023 0.0123 0.0991
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0142 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0096 0.6421
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0429 0.3445
Schistosoma mansoni hypothetical protein 0.0019 0.0093 0.0107
Brugia malayi RNA, U transporter 1 0.0088 0.0654 0.5253
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0102 0.0102
Schistosoma mansoni smad1 5 8 and 0.0009 0.0009 0.001
Toxoplasma gondii kinesin motor domain-containing protein 0.016 0.1245 1
Brugia malayi hypothetical protein 0.0039 0.0252 0.2026
Loa Loa (eye worm) hypothetical protein 0.0041 0.0274 0.1042
Mycobacterium ulcerans hypothetical protein 0.0026 0.0149 1
Echinococcus multilocularis musashi 0.0029 0.0178 0.0178
Echinococcus multilocularis lamin 0.0029 0.0178 0.0178
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0093 0.0093
Schistosoma mansoni smad 0.0009 0.0009 0.001
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0429 0.1633
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0102 0.7192
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0149 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.019 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0009 0.0009
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0149 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0429 0.3445
Loa Loa (eye worm) hypothetical protein 0.006 0.0429 0.1633
Loa Loa (eye worm) hypothetical protein 0.0031 0.019 0.0723
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0102 0.039
Echinococcus granulosus smad 0.0009 0.0009 0.0009
Brugia malayi intermediate filament protein 0.0029 0.0178 0.143
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0093 0.0093
Echinococcus multilocularis kinesin family 1 0.1234 1 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0096 0.6421
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0087 0.5844
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0102 0.0822
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0123 0.0185
Trichomonas vaginalis ran, putative 0.0023 0.0123 0.8674
Schistosoma mansoni hypothetical protein 0.033 0.2626 0.3021
Loa Loa (eye worm) hypothetical protein 0.0029 0.0174 0.0661
Loa Loa (eye worm) hypothetical protein 0.0026 0.0149 0.0567
Brugia malayi MH2 domain containing protein 0.0009 0.0009 0.0073
Echinococcus granulosus intermediate filament protein 0.0029 0.0178 0.0178
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0123 0.8674
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0149 0.1197
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0034 0.0271
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0123 0.6498
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0149 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0149 1
Leishmania major GTP-binding protein, putative 0.0023 0.0123 0.8279
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0364
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0252 0.0252
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0133 0.894
Schistosoma mansoni ran 0.0023 0.0123 0.0142
Entamoeba histolytica hypothetical protein 0.0039 0.0252 0.2026
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0096 0.0769
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.0133 0.107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0149 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.0133 0.0133
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0133 0.107
Onchocerca volvulus 0.0026 0.0149 0.8371
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0038 0.0301
Loa Loa (eye worm) hypothetical protein 0.0014 0.0054 0.0205
Brugia malayi Importin beta-1 subunit 0.0031 0.019 0.1525

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.631 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 70.7946 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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