Detailed information for compound 797506

Basic information

Technical information
  • TDR Targets ID: 797506
  • Name: 3-[(1,1-dioxo-1,2-benzothiazol-3-yl)-[(4-meth oxyphenyl)methylideneamino]amino]-N,N-diethyl propanamide
  • MW: 442.531 | Formula: C22H26N4O4S
  • H donors: 0 H acceptors: 3 LogP: 2.43 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)CCN(C1=NS(=O)(=O)c2c1cccc2)N=Cc1ccc(cc1)OC)CC
  • InChi: 1S/C22H26N4O4S/c1-4-25(5-2)21(27)14-15-26(23-16-17-10-12-18(30-3)13-11-17)22-19-8-6-7-9-20(19)31(28,29)24-22/h6-13,16H,4-5,14-15H2,1-3H3/b23-16+
  • InChiKey: CWAMEOUKENTTDE-XQNSMLJCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(1,1-dioxo-1,2-benzothiazol-3-yl)-[(4-methoxyphenyl)methyleneamino]amino]-N,N-diethyl-propanamide
  • 3-[(1,1-dioxo-1,2-benzothiazol-3-yl)-[(4-methoxyphenyl)methyleneamino]amino]-N,N-diethylpropanamide
  • 3-[(1,1-diketo-1,2-benzothiazol-3-yl)-[(4-methoxybenzylidene)amino]amino]-N,N-diethyl-propionamide
  • 3-[(1,1-dioxo-1,2-benzothiazol-3-yl)-[(4-methoxyphenyl)methylideneamino]amino]-N,N-diethyl-propanamide
  • A2205/0092856

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Loa Loa (eye worm) hypothetical protein 0.0035 0.0562 0.2012
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0015 0.0137 0.0323
Brugia malayi casein kinase II, putaitve 0.0022 0.0293 0.0949
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.028 0.0518
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.028 0.0518
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Echinococcus multilocularis Mastin 0.0015 0.0137 0.0122
Brugia malayi PAN domain containing protein 0.0035 0.0562 0.2021
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Plasmodium falciparum cysteine repeat modular protein 1 0.0054 0.0957 0.2425
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0312
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.028 0.0518
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0293 0.0805
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0054 0.0957 0.2425
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0076 0.1396 1
Trichomonas vaginalis hypothetical protein 0.0185 0.3645 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0963 0.3618
Loa Loa (eye worm) hypothetical protein 0.0055 0.0963 0.3618
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.119 0.169
Toxoplasma gondii subtilisin SUB12 0.0035 0.0562 0.0719
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.1343 0.959
Brugia malayi PAN domain containing protein 0.0035 0.0562 0.2021
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.028 0.0518
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.1343 0.3513
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0312
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0963 0.2441
Onchocerca volvulus 0.0035 0.0562 0.3579
Brugia malayi AMP-binding enzyme family protein 0.0021 0.028 0.0896
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.028 0.0518
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.028 0.0518
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0312
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.028 0.0768
Trichomonas vaginalis protein kinase ck2-beta, putative 0.0022 0.0293 0.0805
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.028 0.0518
Giardia lamblia Casein kinase II beta chain 0.0076 0.1396 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.1343 0.3513
Loa Loa (eye worm) hypothetical protein 0.0013 0.0096 0.0149
Loa Loa (eye worm) casein kinase II 0.0022 0.0293 0.0939
Brugia malayi AMP-binding enzyme family protein 0.0021 0.028 0.0896
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0562 0.0719
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0013 0.0096 0.0081
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0901 0.2268
Toxoplasma gondii propionate-CoA ligase 0.0021 0.028 0.0284
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0014 0.0129 0.028
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.028 0.0518
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0975 0.0961
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0185 0.3645 0.5483
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0019 0.0233 0.0217
Loa Loa (eye worm) hypothetical protein 0.0019 0.0233 0.0695
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Brugia malayi PAN domain containing protein 0.0035 0.0562 0.2021
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0312
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0562 0.2012
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.028 0.0518
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0129 0.0051
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.028 0.0896
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.028 0.0518
Echinococcus granulosus Mastin 0.0015 0.0137 0.0122
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0219 0.0345
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.028 0.0518
Loa Loa (eye worm) hypothetical protein 0.0054 0.0957 0.3595
Onchocerca volvulus 0.0015 0.0137 0.0313
Onchocerca volvulus 0.0015 0.0137 0.0313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0901 0.2268
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.028 0.0768
Trypanosoma cruzi phosphoinositide-specific phospholipase C, putative 0.0019 0.0233 0.1049
Onchocerca volvulus 0.0035 0.0562 0.3579
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0076 0.1396 1
Schistosoma mansoni hypothetical protein 0.0054 0.0957 0.0943
Brugia malayi PAN domain containing protein 0.0035 0.0562 0.2021
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.028 0.0518
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.028 0.1415
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.028 0.0896
Onchocerca volvulus 0.0035 0.0552 0.3504
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.028 0.0518
Schistosoma mansoni hypothetical protein 0.0015 0.0137 0.0122
Onchocerca volvulus 0.0021 0.028 0.1415
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0562 0.0719
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Loa Loa (eye worm) hypothetical protein 0.0035 0.0562 0.2012
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.028 0.0518
Loa Loa (eye worm) hypothetical protein 0.0035 0.0562 0.2012
Loa Loa (eye worm) hypothetical protein 0.0073 0.1343 0.5142
Schistosoma mansoni casein kinase II beta subunit 0.0076 0.1396 0.1383
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0013 0.0096 0.0081
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.028 0.0265
Loa Loa (eye worm) hypothetical protein 0.0021 0.028 0.0885
Loa Loa (eye worm) hypothetical protein 0.0055 0.0963 0.3618
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Loa Loa (eye worm) hypothetical protein 0.0073 0.1343 0.5142
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0562 0.2012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0901 0.2268
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0975 0.0961
Onchocerca volvulus 0.0035 0.0562 0.3579
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0975 0.0961
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.1396 1
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0185 0.3645 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.028 0.0518
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.1343 0.3513
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.028 0.1415
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Onchocerca volvulus 0.0015 0.0137 0.0313
Echinococcus multilocularis casein kinase ii subunit beta 0.0076 0.1396 0.1383
Plasmodium falciparum phosphoinositide-specific phospholipase C 0.0018 0.021 0.0321
Leishmania major phosphoinositide-specific phospholipase C, putative 0.0018 0.021 0.0877
Onchocerca volvulus 0.0015 0.0137 0.0313
Brugia malayi AMP-binding enzyme family protein 0.0073 0.1343 0.5147
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.028
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0076 0.1396 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.028 0.0518
Toxoplasma gondii PAN domain-containing protein 0.0327 0.6569 1
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.021 0.0616
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.028
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0975 0.3674
Echinococcus multilocularis glycoprotein Antigen 5 0.0015 0.0137 0.0122
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0963 0.2441
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.028 0.1415
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.028 0.0518
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0312
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.028
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0021 0.028 0.0518
Brugia malayi Kringle domain containing protein 0.0054 0.0957 0.3602
Loa Loa (eye worm) hypothetical protein 0.0035 0.0562 0.2012
Brugia malayi CXXC zinc finger family protein 0.0035 0.0552 0.1982
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0013 0.0096 0.0149
Echinococcus granulosus Tolloid protein 1 0.0014 0.0129 0.0114
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.1343 0.3513
Mycobacterium ulcerans hypothetical protein 0.0015 0.0137 0.0115
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0552 0.1973
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0015 0.0137 0.0122
Onchocerca volvulus 0.0021 0.028 0.1415
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.1343 0.3513
Brugia malayi AMP-binding enzyme family protein 0.0073 0.1343 0.5147
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0019 0.0233 0.0695
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0059 0.0044
Onchocerca volvulus 0.0054 0.0957 0.6619
Plasmodium vivax casein kinase II beta chain, putative 0.0076 0.1396 0.3663
Schistosoma mansoni cpg binding protein 0.0037 0.0593 0.0578
Loa Loa (eye worm) TK/ROR protein kinase 0.0054 0.0957 0.3595
Plasmodium falciparum casein kinase II beta chain 0.0076 0.1396 0.3663
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.028 0.0518
Brugia malayi PAN domain containing protein 0.0035 0.0562 0.2021
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0132 0.2556 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.028 0.1415
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0963 0.2441
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0015 0.0137 0.0122
Echinococcus multilocularis laminin 0.0014 0.0129 0.0114
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0185 0.3645 1
Brugia malayi Variant SH3 domain containing protein 0.0132 0.2556 1
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.028 0.0518
Brugia malayi hypothetical protein 0.0015 0.0137 0.0323
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Schistosoma mansoni egf-like domain protein 0.0014 0.0129 0.0114
Brugia malayi AMP-binding enzyme family protein 0.0021 0.028 0.0896
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0137 0.0122
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.1343 0.959
Plasmodium vivax phospholipase C-like, putative 0.0018 0.021 0.0321
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.028 0.0518
Brugia malayi Trypsin family protein 0.0015 0.0137 0.0323
Schistosoma mansoni hypothetical protein 0.0494 1 1
Brugia malayi phospholipase C homolog 0.0012 0.0076 0.0079
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.028 0.0885
Onchocerca volvulus 0.0021 0.028 0.1415
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.1343 0.959
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0018 0.021 0.0616
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.028 0.0885
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.028 0.0518
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0312
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0013 0.0096 0.0081
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.1343 0.959
Onchocerca volvulus 0.0035 0.0562 0.3579
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.028 0.1415
Onchocerca volvulus 0.0019 0.0233 0.1049
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0963 0.2441
Onchocerca volvulus 0.0035 0.0562 0.3579
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.028 0.0518
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0562 0.0719
Onchocerca volvulus 0.0035 0.0562 0.3579
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.1396 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0137 0.0122
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0019 0.0233 0.0705
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0076 0.1396 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0059 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0073 0.1343 0.5147
Toxoplasma gondii phosphoinositide phospholipase PIPLC 0.0019 0.0233 0.0211
Onchocerca volvulus 0.0035 0.0562 0.3579
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Loa Loa (eye worm) hypothetical protein 0.0018 0.021 0.0605
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.028 0.0518
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0076 0.1396 1
Loa Loa (eye worm) hypothetical protein 0.0073 0.1343 0.5142
Onchocerca volvulus 0.0015 0.0137 0.0313
Brugia malayi Csnk2b protein 0.0076 0.1396 0.536
Onchocerca volvulus 0.0015 0.0137 0.0313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.1343 0.3513
Onchocerca volvulus 0.0035 0.0562 0.3579
Brugia malayi PAN domain containing protein 0.0035 0.0562 0.2021
Loa Loa (eye worm) hypothetical protein 0.0055 0.0963 0.3618
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.028 0.0518
Loa Loa (eye worm) hypothetical protein 0.0021 0.028 0.0885
Toxoplasma gondii microneme protein MIC17C 0.0035 0.0562 0.0719
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0076 0.1396 1
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0019 0.0233 0.0217
Toxoplasma gondii calcium binding egf domain-containing protein 0.0014 0.0129 0.0051
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0129 0.0291
Loa Loa (eye worm) hypothetical protein 0.0035 0.0562 0.2012
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0129 0.0291
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0137 0.0122
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Echinococcus multilocularis Tolloid protein 1 0.0014 0.0129 0.0114
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0015 0.0137 0.0122
Loa Loa (eye worm) oxidoreductase 0.0013 0.0096 0.0149
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.1343 0.3513
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.028 0.0518
Echinococcus multilocularis tissue type plasminogen activator 0.0054 0.0957 0.0943
Echinococcus multilocularis enteropeptidase 0.0015 0.0137 0.0122
Plasmodium vivax casein kinase II beta chain, putative 0.0076 0.1396 0.3663
Brugia malayi Trypsin family protein 0.0015 0.0137 0.0323
Echinococcus granulosus tissue type plasminogen activator 0.0054 0.0957 0.0943
Echinococcus granulosus casein kinase ii subunit beta 0.0076 0.1396 0.1383
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0957 0.6619
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.028 0.0265
Onchocerca volvulus 0.0073 0.1343 0.959
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Brugia malayi PAN domain containing protein 0.0035 0.0562 0.2021
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0076 0.1396 0.2009
Loa Loa (eye worm) oxidoreductase 0.0021 0.028 0.0885
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0076 0.1396 1
Echinococcus granulosus cpg binding protein 0.0037 0.0593 0.0578
Loa Loa (eye worm) hypothetical protein 0.0015 0.0137 0.0312
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0096 0.016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.1343 0.3513
Loa Loa (eye worm) Plcb4 protein 0.0018 0.021 0.0605
Onchocerca volvulus 0.0035 0.0562 0.3579
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0185 0.3645 1
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0014 0.0129 0.028
Brugia malayi PAN domain containing protein 0.0035 0.0562 0.2021
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0562 0.2012
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0185 0.3645 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0137 0.0122
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0129 0.028
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.028 0.1415
Toxoplasma gondii PAN domain-containing protein 0.0327 0.6569 1
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.028 0.1415
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0975 0.0961
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.028 0.0518
Loa Loa (eye worm) hypothetical protein 0.0014 0.0129 0.028
Toxoplasma gondii microneme protein MIC4 0.0035 0.0562 0.0719
Brugia malayi PAN domain containing protein 0.0035 0.0562 0.2021
Toxoplasma gondii PAN/Apple domain-containing protein 0.0035 0.0562 0.0719
Echinococcus multilocularis transmembrane protease serine 3 0.0015 0.0137 0.0122
Toxoplasma gondii hypothetical protein 0.0035 0.0562 0.0719
Toxoplasma gondii microneme protein, putative 0.0035 0.0562 0.0719
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Schistosoma mansoni dihydropteridine reductase 0.0013 0.0096 0.0081
Toxoplasma gondii PAN domain-containing protein 0.0035 0.0562 0.0719
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0096 0.016
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0137 0.0122
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.1343 0.3513
Onchocerca volvulus 0.0035 0.0562 0.3579
Toxoplasma gondii kringle domain-containing protein 0.0054 0.0957 0.133
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.1343 0.3513
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.028 0.0518
Brugia malayi Trypsin family protein 0.0015 0.0137 0.0323
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.028 0.1415
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0015 0.0137 0.0122
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0185 0.3645 1
Brugia malayi PAN domain containing protein 0.0035 0.0562 0.2021
Loa Loa (eye worm) Csnk2b protein 0.0076 0.1396 0.5355
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0562 0.2012
Toxoplasma gondii microneme protein MIC17A 0.0035 0.0562 0.0719
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.028 0.0518
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.028 0.0518
Schistosoma mansoni cpg binding protein 0.0037 0.0593 0.0578
Loa Loa (eye worm) hypothetical protein 0.0019 0.0233 0.0695
Onchocerca volvulus 0.0019 0.0233 0.1049
Onchocerca volvulus Arrow homolog 0.0014 0.0129 0.0253
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.0293 0.1517
Echinococcus granulosus laminin 0.0014 0.0129 0.0114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0975 0.0961
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0185 0.3645 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0562 0.2012
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0137 0.0122
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0019 0.0233 0.1049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0901 0.2268
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Brugia malayi Protein kinase domain containing protein 0.0054 0.0957 0.3602
Toxoplasma gondii microneme protein MIC17B 0.0035 0.0562 0.0719
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.028 0.0518
Leishmania major phospholipase c-like protein 0.0019 0.0233 0.1049
Schistosoma mansoni hypothetical protein 0.0015 0.0137 0.0122
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.028 0.0518
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.028 0.0265
Echinococcus multilocularis fibrillin 1 0.0014 0.0129 0.0114
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0975 0.0961
Schistosoma mansoni cercarial elastase (S01 family) 0.0015 0.0137 0.0122
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Trichomonas vaginalis casein kinase II beta chain, putative 0.0022 0.0293 0.0805
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0035 0.0562 0.0719
Schistosoma mansoni phospholipase C-like protein 2 plc-L2 0.0012 0.0076 0.006
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.028 0.0284
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.028 0.0284
Loa Loa (eye worm) trypsin family protein 0.0015 0.0137 0.0312
Loa Loa (eye worm) retinol dehydrogenase 12 0.0013 0.0096 0.0149
Onchocerca volvulus 0.0021 0.028 0.1415
Echinococcus granulosus enteropeptidase 0.0015 0.0137 0.0122
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0562 0.2012
Brugia malayi Trypsin family protein 0.0015 0.0137 0.0323
Brugia malayi AMP-binding enzyme family protein 0.0021 0.028 0.0896
Brugia malayi Trypsin-like protease protein 5 0.0015 0.0137 0.0323
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0137 0.0122
Loa Loa (eye worm) hypothetical protein 0.0055 0.0963 0.3618
Plasmodium falciparum casein kinase II beta chain 0.0076 0.1396 0.3663
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0975 0.3667
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0022 0.0293 0.1517
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.028 0.1415
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0975 0.0961
Onchocerca volvulus 0.0035 0.0562 0.3579
Echinococcus granulosus transmembrane protease serine 3 0.0015 0.0137 0.0122
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1352 0.1338
Loa Loa (eye worm) PAN domain-containing protein 0.0035 0.0562 0.2012
Echinococcus granulosus glycoprotein Antigen 5 0.0015 0.0137 0.0122
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.028 0.0518
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.1343 0.3513
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0014 0.0129 0.0114
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.1343 0.959
Plasmodium falciparum enoyl-acyl carrier reductase 0.0185 0.3645 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Mycobacterium ulcerans hypothetical protein 0.0073 0.1343 0.3513
Brugia malayi Fibulin-1 precursor 0.0014 0.0129 0.0291
Toxoplasma gondii hypothetical protein 0.0035 0.0562 0.0719
Schistosoma mansoni phospholipase C beta 0.0018 0.021 0.0195
Leishmania major phosphatidylinositol-specific phospholipase-like protein 0.0018 0.021 0.0877
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0963 0.2441
Toxoplasma gondii ck2 beta subunit 0.0076 0.1396 0.2009
Schistosoma mansoni cpg binding protein 0.0035 0.0552 0.0537
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0015 0.0137 0.0122
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.028 0.1415
Echinococcus multilocularis cpg binding protein 0.0037 0.0593 0.0578
Trichomonas vaginalis casein kinase II beta chain, putative 0.0076 0.1396 0.383
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.1343 0.959
Leishmania major hypothetical protein, conserved 0.0054 0.0957 0.6619

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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