Detailed information for compound 806386

Basic information

Technical information
  • TDR Targets ID: 806386
  • Name: 1,4-dimethyl-2,3-dioxo-N-[4-(trifluoromethoxy )phenyl]quinoxaline-6-sulfonamide
  • MW: 429.37 | Formula: C17H14F3N3O5S
  • H donors: 1 H acceptors: 4 LogP: 2.51 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1n(C)c2ccc(cc2n(c1=O)C)S(=O)(=O)Nc1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C17H14F3N3O5S/c1-22-13-8-7-12(9-14(13)23(2)16(25)15(22)24)29(26,27)21-10-3-5-11(6-4-10)28-17(18,19)20/h3-9,21H,1-2H3
  • InChiKey: OJBJXNNPHKHPBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,4-dimethyl-2,3-dioxo-N-[4-(trifluoromethoxy)phenyl]-6-quinoxalinesulfonamide
  • 2,3-diketo-1,4-dimethyl-N-[4-(trifluoromethoxy)phenyl]quinoxaline-6-sulfonamide
  • MLS000521871
  • SMR000132279

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0042 0.0074 0.0068
Echinococcus granulosus tyrosine protein kinase Fyn 0.0122 0.1582 0.1576
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0105 0.1264 0.1258
Schistosoma mansoni tyrosine kinase 0.0232 0.3675 0.6394
Schistosoma mansoni tyrosine kinase 0.0178 0.2642 0.459
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0058 0.0372 0.0623
Echinococcus granulosus tyrosine protein kinase Src42A 0.0122 0.1582 0.1576
Echinococcus multilocularis neuroglian 0.007 0.0614 0.0774
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0249 0.3988 0.507
Echinococcus multilocularis epidermal growth factor receptor 0.0341 0.5738 0.7297
Schistosoma mansoni ephrin receptor 0.0079 0.0776 0.1328
Echinococcus granulosus tyrosine protein kinase Src42A 0.0079 0.0779 0.0774
Echinococcus granulosus plexin a4 0.0137 0.1871 0.1866
Schistosoma mansoni tyrosine kinase 0.0274 0.4459 0.7764
Schistosoma mansoni tyrosine kinase 0.0064 0.05 0.0847
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.0685 0.0969
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0059 0.0391 0.2271
Onchocerca volvulus 0.0053 0.0277 0.0931
Echinococcus granulosus c src tyrosine kinase 0.0064 0.05 0.0494
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1099 0.1893
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0016 0.0013
Loa Loa (eye worm) AUR protein kinase 0.0059 0.0391 0.0494
Loa Loa (eye worm) hypothetical protein 0.0039 0.0016 0.0012
Loa Loa (eye worm) SRC-1 0.0122 0.1582 0.2025
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0183 0.0227
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0047 0.0168 0.0565
Echinococcus multilocularis tyrosine protein kinase HCK 0.0083 0.0845 0.1068
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0074 0.0097
Echinococcus granulosus mitogen activated protein kinase 14 0.0127 0.168 0.1675
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0046 0.0148 0.0182
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.018 0.2684 0.3409
Onchocerca volvulus 0.0048 0.0183 0.0614
Onchocerca volvulus 0.0053 0.0291 0.0979
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.168 0.213
Echinococcus multilocularis tyrosine protein kinase Blk 0.0105 0.1264 0.1601
Entamoeba histolytica protein kinase domain containing protein 0.0049 0.0201 0.02
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0105 0.1264 0.1601
Echinococcus multilocularis hemicentin 1 0.0047 0.0168 0.0206
Loa Loa (eye worm) hypothetical protein 0.0053 0.0277 0.0348
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1099 1
Brugia malayi Protein kinase domain containing protein 0.0409 0.7016 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0122 0.1582 0.2005
Echinococcus granulosus protein kinase shaggy 0.0051 0.0236 0.023
Entamoeba histolytica protein kinase, putative 0.0059 0.0391 0.2271
Echinococcus multilocularis plexin a4 0.0137 0.1871 0.2374
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0122 0.1582 0.1576
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0039 0.0016 0.0012
Echinococcus granulosus aurora kinase A 0.0059 0.0391 0.0385
Brugia malayi Protein kinase domain containing protein 0.0048 0.0183 0.0252
Loa Loa (eye worm) hypothetical protein 0.0114 0.1434 0.1835
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0074 0.0097
Onchocerca volvulus 0.0048 0.0183 0.0614
Entamoeba histolytica tyrosin kinase, putative 0.0049 0.0201 0.02
Onchocerca volvulus 0.0051 0.0236 0.0793
Loa Loa (eye worm) hypothetical protein 0.0061 0.0436 0.0553
Loa Loa (eye worm) hypothetical protein 0.0053 0.0277 0.0348
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.1099 0.1559
Brugia malayi Sex muscle abnormal protein 5 0.0039 0.0016 0.0013
Brugia malayi SH2 domain containing protein 0.0048 0.0183 0.0252
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0127 0.168 1
Brugia malayi Serine/threonine-protein kinase Pim-3 0.016 0.23 0.3272
Brugia malayi intracellular kinase 0.0051 0.0236 0.0327
Brugia malayi P38 map kinase family protein 2 0.0127 0.168 0.2387
Schistosoma mansoni tyrosine kinase 0.0122 0.1582 0.2736
Echinococcus multilocularis tyrosine kinase 0.0048 0.0183 0.0225
Schistosoma mansoni cell adhesion molecule 0.0087 0.0924 0.1588
Brugia malayi Sema domain containing protein 0.0053 0.0277 0.0386
Echinococcus granulosus MAP kinase activated protein kinase 2 0.018 0.2684 0.2679
Trypanosoma brucei aurora B kinase 0.0059 0.0391 0.1074
Echinococcus granulosus semaphorin 5B 0.0053 0.0277 0.0271
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.016 0.23 0.292
Echinococcus multilocularis protein kinase shaggy 0.0051 0.0236 0.0292
Echinococcus granulosus tyrosine protein kinase Blk 0.0105 0.1264 0.1258
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1099 1
Schistosoma mansoni serine/threonine protein kinase 0.018 0.2684 0.4663
Onchocerca volvulus 0.0114 0.1434 0.4824
Brugia malayi protein-tyrosine kinase 0.0105 0.1264 0.1794
Echinococcus multilocularis tyrosine protein kinase Abl 0.0064 0.05 0.0629
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0042 0.0074 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1099 1
Brugia malayi serine/threonine-protein kinase 6 0.0059 0.0391 0.0549
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1099 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.0183 0.0252
Brugia malayi Protein kinase domain containing protein 0.0095 0.1088 0.1543
Loa Loa (eye worm) hypothetical protein 0.0058 0.0372 0.047
Brugia malayi ephrin receptor 1 precursor 0.0051 0.0241 0.0335
Brugia malayi SH2 domain containing protein 0.0048 0.0183 0.0252
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0122 0.1582 0.2005
Echinococcus multilocularis roundabout 2 0.01 0.1167 0.1477
Echinococcus multilocularis 0.0175 0.2592 0.3292
Schistosoma mansoni tyrosine kinase 0.0274 0.4459 0.7764
Brugia malayi Protein kinase domain containing protein 0.0232 0.3675 0.5233
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0042 0.0074 0.0087
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0236 0.0295
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0382 0.0536
Loa Loa (eye worm) TK/INSR protein kinase 0.0232 0.3675 0.4715
Schistosoma mansoni survival motor neuron protein 0.0058 0.0382 0.0641
Echinococcus multilocularis epidermal growth factor receptor 0.0274 0.4459 0.5668
Loa Loa (eye worm) hypothetical protein 0.0053 0.0291 0.0366
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0391 0.2271
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0122 0.1582 0.2005
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0183 0.0227
Echinococcus granulosus tyrosine kinase 0.0048 0.0183 0.0177
Schistosoma mansoni tyrosine kinase 0.0341 0.5738 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0277 0.0348
Echinococcus multilocularis growth factor receptor bound protein 2 0.0039 0.0016 0.0012
Brugia malayi Immunoglobulin I-set domain containing protein 0.0042 0.0074 0.0097
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0048 0.0183 0.0177
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0059 0.0391 0.2271
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.1099 0.5979
Giardia lamblia Kinase, PLK 0.0096 0.1099 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0064 0.05 0.0847
Brugia malayi hypothetical protein 0.0286 0.4687 0.6677
Echinococcus granulosus hemicentin 1 0.0047 0.0168 0.0162
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0122 0.1582 0.2005
Entamoeba histolytica protein kinase , putative 0.0059 0.0391 0.2271
Loa Loa (eye worm) TK protein kinase 0.0105 0.1264 0.1616
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0236 0.0239
Brugia malayi hypothetical protein 0.0053 0.0277 0.0386
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0039 0.0016 0.0012
Echinococcus granulosus epidermal growth factor receptor 0.0274 0.4459 0.4455
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0391 0.1992
Brugia malayi map kinase activated protein kinase protein 2 0.018 0.2684 0.382
Schistosoma mansoni serine/threonine protein kinase 0.016 0.23 0.3992
Schistosoma mansoni nephrin 0.0042 0.0074 0.0102
Echinococcus granulosus roundabout 2 0.0042 0.0074 0.0068
Loa Loa (eye worm) hypothetical protein 0.0286 0.4687 0.6015
Echinococcus granulosus tyrosine protein kinase HCK 0.0083 0.0845 0.0839
Echinococcus multilocularis aurora kinase A 0.0059 0.0391 0.049
Loa Loa (eye worm) hypothetical protein 0.0083 0.0853 0.1089
Loa Loa (eye worm) CAMK/PIM protein kinase 0.016 0.23 0.2948
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0122 0.1582 0.2005
Echinococcus granulosus tyrosine kinase 0.0105 0.1264 0.1258
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.4687 0.4683
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0236 0.0579
Echinococcus granulosus neuroglian 0.0042 0.0074 0.0068
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0127 0.168 1
Entamoeba histolytica protein kinase, putative 0.0083 0.0845 0.723
Loa Loa (eye worm) hypothetical protein 0.0042 0.007 0.0081
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0042 0.0074 0.0102
Schistosoma mansoni tyrosine kinase 0.0051 0.0245 0.0401
Echinococcus granulosus NCK adaptor protein 0.0039 0.0016 0.0009
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0059 0.0391 0.049
Brugia malayi Protein kinase domain containing protein 0.016 0.23 0.3272
Loa Loa (eye worm) AUR protein kinase 0.0059 0.0391 0.0494
Loa Loa (eye worm) hypothetical protein 0.007 0.0603 0.0767
Echinococcus granulosus mitogen activated protein kinase 11 0.0127 0.168 0.1675
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0183 0.0227
Loa Loa (eye worm) TK protein kinase 0.0083 0.0845 0.1078
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.0453 0.7861 1
Echinococcus granulosus tyrosine protein kinase shark 0.0048 0.0183 0.0177
Schistosoma mansoni tyrosine kinase 0.0048 0.0183 0.0292
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.007 0.0611 0.0605
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0042 0.0074 0.0086
Echinococcus multilocularis mitogen activated protein kinase 14 0.0127 0.168 0.213
Schistosoma mansoni protein kinase 0.0059 0.0391 0.0656
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0059 0.0391 1
Schistosoma mansoni tyrosine kinase 0.0122 0.1582 0.2736
Loa Loa (eye worm) hypothetical protein 0.0058 0.0376 0.0475
Echinococcus granulosus epidermal growth factor receptor 0.0341 0.5738 0.5736
Giardia lamblia Aurora kinase 0.0059 0.0391 0.1796
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0183 0.0227
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0183 0.0227
Loa Loa (eye worm) hypothetical protein 0.0105 0.126 0.1612
Echinococcus multilocularis roundabout 2 0.0042 0.0074 0.0086
Brugia malayi hypothetical protein 0.0053 0.0277 0.0386
Schistosoma mansoni hypothetical protein 0.0053 0.0277 0.0457
Echinococcus granulosus roundabout 2 0.01 0.1167 0.1161
Echinococcus multilocularis Immunoglobulin 0.0058 0.0372 0.0465
Echinococcus multilocularis hypothetical protein 0.0053 0.0277 0.0345
Echinococcus multilocularis NCK adaptor protein 0.0039 0.0016 0.0012
Loa Loa (eye worm) hypothetical protein 0.007 0.0611 0.0777
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0048 0.0183 0.0225
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0391 0.1992
Echinococcus granulosus tyrosine protein kinase Fyn 0.0122 0.1582 0.1576
Echinococcus granulosus contactin 0.0063 0.0481 0.0475
Plasmodium falciparum serine/threonine protein kinase, putative 0.0059 0.0391 1
Echinococcus granulosus ephrin type A receptor 4 A 0.0092 0.1017 0.1011
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0409 0.7016 0.9009
Brugia malayi hypothetical protein 0.0074 0.0685 0.0969
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.168 0.213
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0183 0.0227
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0183 0.0227
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0058 0.0372 0.0465
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0122 0.1582 0.2005
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.016 0.23 0.2295
Schistosoma mansoni nephrin 0.0087 0.0928 0.1594
Onchocerca volvulus 0.0048 0.0183 0.0614
Brugia malayi Fibronectin type III domain containing protein 0.0074 0.0685 0.0969
Loa Loa (eye worm) CAMK/PIM protein kinase 0.016 0.23 0.2948
Schistosoma mansoni tyrosine kinase 0.0248 0.3974 0.6917
Entamoeba histolytica protein kinase domain containing protein 0.0051 0.0236 0.0579
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1099 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.0183 0.0252
Loa Loa (eye worm) plexin A 0.0137 0.1871 0.2397
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1099 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0051 0.0236 0.0295
Onchocerca volvulus 0.0048 0.0183 0.0614
Brugia malayi Furin-like cysteine rich region family protein 0.0341 0.5738 0.8177
Loa Loa (eye worm) hypothetical protein 0.0449 0.7787 1
Onchocerca volvulus 0.0048 0.0183 0.0614
Echinococcus granulosus neuroglian 0.007 0.0614 0.0608
Schistosoma mansoni hypothetical protein 0.0058 0.0382 0.0641
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0194 0.296 0.376
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0081 0.0115
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0391 0.1992
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0236 0.0239
Schistosoma mansoni tyrosine kinase 0.0064 0.05 0.0847
Echinococcus granulosus semaphorin 1A 0.0053 0.0277 0.0271
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.168 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0048 0.0183 0.0227
Echinococcus multilocularis mitogen activated protein kinase 11 0.0127 0.168 0.213
Echinococcus granulosus insulin receptor 0.0232 0.3675 0.3671
Brugia malayi Tyrosine-protein kinase abl-1 0.0064 0.05 0.0705
Brugia malayi Protein kinase domain containing protein 0.016 0.2301 0.3273
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.1099 0.1391
Schistosoma mansoni kinase 0.0051 0.0238 0.0388
Echinococcus granulosus twitchin 0.0074 0.0688 0.0682
Brugia malayi Protein kinase domain containing protein 0.0048 0.0183 0.0252
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0183 0.0227
Schistosoma mansoni protein kinase 0.016 0.2301 0.3993
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1099 0.5979
Echinococcus multilocularis roundabout 2 0.0042 0.0074 0.0086
Loa Loa (eye worm) hypothetical protein 0.0048 0.0183 0.0227
Echinococcus granulosus STE20 serine:threonine protein kinase 0.0453 0.7861 0.786
Schistosoma mansoni cell adhesion molecule 0.0042 0.0074 0.0102
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0058 0.0372 0.0623
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0051 0.0236 0.0385
Loa Loa (eye worm) hypothetical protein 0.0053 0.0277 0.0348
Brugia malayi plexin A 0.0137 0.1871 0.266
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.018 0.2684 0.3441
Loa Loa (eye worm) TK/EPH protein kinase 0.0094 0.1053 0.1345
Echinococcus multilocularis ephrin type A receptor 4 A 0.0092 0.1017 0.1286
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0274 0.4459 0.4455
Echinococcus granulosus tyrosine protein kinase Srms 0.0048 0.0183 0.0177
Echinococcus granulosus defective proboscis extension response 0.0058 0.0372 0.0366
Loa Loa (eye worm) hypothetical protein 0.0053 0.0277 0.0348
Echinococcus multilocularis neuroglian 0.0042 0.0074 0.0086
Loa Loa (eye worm) hypothetical protein 0.0074 0.0685 0.0873
Brugia malayi hypothetical protein 0.0048 0.0183 0.0252
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0249 0.3988 0.3985
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0122 0.1582 0.1576
Brugia malayi serine/threonine protein kinase 6 0.0059 0.0391 0.0549
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0122 0.1582 0.2005
Toxoplasma gondii aurora kinase 0.0059 0.0391 1
Schistosoma mansoni tyrosine kinase 0.0248 0.3974 0.6917
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0048 0.0183 0.0225
Schistosoma mansoni vesicular amine transporter 0.0058 0.0372 0.0623
Loa Loa (eye worm) hypothetical protein 0.0074 0.0685 0.0873
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1099 0.5979
Brugia malayi Sema domain containing protein 0.0053 0.0277 0.0386
Echinococcus granulosus Immunoglobulin 0.0058 0.0372 0.0366
Brugia malayi Plexin repeat family protein 0.0114 0.1434 0.2037
Loa Loa (eye worm) hypothetical protein 0.0058 0.0372 0.047
Onchocerca volvulus Tyrosine kinase homolog 0.0195 0.2972 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0194 0.296 0.2955
Loa Loa (eye worm) hypothetical protein 0.0053 0.0277 0.0348
Onchocerca volvulus 0.0048 0.0183 0.0614
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0127 0.168 1
Schistosoma mansoni ephrin receptor 0.0042 0.0077 0.0108
Echinococcus granulosus tyrosine protein kinase Src64B 0.0122 0.1582 0.1576
Trypanosoma cruzi aurora B kinase, putative 0.0059 0.0391 0.1074
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0059 0.0391 0.0385
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1099 1
Loa Loa (eye worm) AUR protein kinase 0.0059 0.0391 0.0494
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0122 0.1582 0.2005
Schistosoma mansoni hypothetical protein 0.0053 0.0277 0.0457
Loa Loa (eye worm) TK/EGFR protein kinase 0.0341 0.5738 0.7367
Brugia malayi Protein kinase domain containing protein 0.0048 0.0183 0.0252
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.1099 1
Echinococcus multilocularis Immunoglobulin 0.0058 0.0372 0.0465
Loa Loa (eye worm) hypothetical protein 0.0042 0.0074 0.0087
Echinococcus multilocularis tyrosine protein kinase shark 0.0048 0.0183 0.0225
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.1099 0.1094
Schistosoma mansoni hypothetical protein 0.0051 0.0242 0.0396
Loa Loa (eye worm) sema domain-containing protein 0.0053 0.0277 0.0348
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0051 0.0236 0.0292
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.4687 0.5959
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0127 0.168 0.2151
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0231 0.3655 0.4689
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0183 0.0227
Onchocerca volvulus 0.0058 0.0382 0.1286
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0391 0.0656
Brugia malayi Immunoglobulin I-set domain containing protein 0.0231 0.3655 0.5204
Entamoeba histolytica protein kinase, putative 0.0059 0.0391 0.2271
Echinococcus granulosus roundabout 2 0.0042 0.0074 0.0068
Echinococcus multilocularis c src tyrosine kinase 0.0064 0.05 0.0629
Loa Loa (eye worm) hypothetical protein 0.0074 0.0685 0.0873
Schistosoma mansoni tyrosine kinase 0.0232 0.3675 0.6394
Schistosoma mansoni hypothetical protein 0.0061 0.0436 0.0735
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0051 0.0236 0.023
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0391 0.1992
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0183 0.0227
Schistosoma mansoni titin 0.0047 0.0168 0.0266
Echinococcus multilocularis semaphorin 5B 0.0053 0.0277 0.0345
Onchocerca volvulus 0.0051 0.0242 0.0815
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.1099 0.3697
Schistosoma mansoni plexin 0.0114 0.1434 0.2478
Echinococcus granulosus tyrosine protein kinase Lyn 0.0125 0.1656 0.165
Schistosoma mansoni plexin 0.0061 0.0436 0.0735
Schistosoma mansoni cell adhesion molecule 0.0042 0.0074 0.0102
Echinococcus granulosus tyrosine protein kinase ABL1 0.0048 0.0183 0.0177
Brugia malayi Variant SH3 domain containing protein 0.0039 0.0016 0.0013
Schistosoma mansoni neuroglian 0.0042 0.0074 0.0102
Onchocerca volvulus 0.0135 0.1838 0.6184
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0122 0.1582 0.2005
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.016 0.23 0.7737
Brugia malayi serine/threonine kinase 12 0.0059 0.0391 0.0549
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0042 0.0074 0.0086
Leishmania major protein kinase, putative 0.0059 0.0391 0.1074
Schistosoma mansoni tyrosine kinase 0.0248 0.3974 0.6917
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0042 0.0074 0.0086
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0059 0.0391 0.2271
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.016 0.2301 0.2949
Loa Loa (eye worm) sema domain-containing protein 0.0053 0.0277 0.0348
Echinococcus granulosus tyrosine protein kinase Fyn 0.0122 0.1582 0.1576
Schistosoma mansoni semaphorin 5-related 0.0053 0.0277 0.0457
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.1099 0.1404
Entamoeba histolytica protein kinase, putative 0.0051 0.0236 0.0579
Trypanosoma brucei polo-like protein kinase 0.0096 0.1099 0.5979
Brugia malayi SRC-1 0.0122 0.1582 0.2247
Echinococcus multilocularis insulin receptor 0.0232 0.3675 0.467
Echinococcus granulosus growth factor receptor bound protein 2 0.0039 0.0016 0.0009
Echinococcus multilocularis tyrosine protein kinase Srms 0.0105 0.1264 0.1601
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0079 0.0779 0.0984

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (binding) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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