TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 406.926 | Formula: C20H23ClN2O3S
H donors: 1 H acceptors: 1 LogP: 3.39 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCC(N1CCc1cccs1)CCNCc1cc2OCOc2cc1Cl
InChi: 1S/C20H23ClN2O3S/c21-17-11-19-18(25-13-26-19)10-14(17)12-22-7-5-15-3-4-20(24)23(15)8-6-16-2-1-9-27-16/h1-2,9-11,15,22H,3-8,12-13H2
InChiKey: RSCRRLIJQSSMEV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	peter pan-related	0.0069	0.1105	0.0997
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.017	0.0168
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0092	0.1514	0.1513
Echinococcus granulosus	zinc finger protein 598	0.0069	0.1097	0.1095
Echinococcus granulosus	allatostatin A receptor	0.0092	0.1514	0.1513
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0092	0.1514	0.1412
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.031	0.0855
Echinococcus multilocularis	ectonucleoside triphosphate diphosphohydrolase	0.0016	0.012	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Echinococcus granulosus	orexin receptor type 2	0.0092	0.1514	0.1513
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0019	0.017	0.0168
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0019	0.017	0.0464
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.0415	0.2279
Brugia malayi	GnHR receptor homolog	0.0092	0.1514	0.418
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.017	0.0168
Echinococcus multilocularis	neuropeptide Y receptor	0.0092	0.1514	0.1513
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.017	0.0051
Schistosoma mansoni	histamine h1 receptor	0.0092	0.1514	0.1412
Brugia malayi	Dopamine receptor protein 2	0.0092	0.1514	0.418
Loa Loa (eye worm)	TYRA-2 protein	0.0092	0.1514	0.4177
Leishmania major	peter pan protein, putative	0.0069	0.1105	0.6123
Echinococcus multilocularis	fmrfamide receptor	0.0092	0.1514	0.1513
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0092	0.1514	0.418
Onchocerca volvulus		0.0092	0.1514	0.3354
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0092	0.1514	0.1513
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.1514	0.1412
Schistosoma mansoni	myosin xvIII	0.0092	0.1514	0.1412
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0356	0.0821
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0092	0.1514	0.1412
Schistosoma mansoni	amine GPCR	0.0092	0.1514	0.1412
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.1514	0.1412
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.1514	0.1412
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0092	0.1514	0.1513
Brugia malayi	6-phosphofructokinase	0.0107	0.1801	0.497
Trypanosoma brucei	nucleoside diphosphatase, putative	0.0016	0.012	0.0633
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0092	0.1514	0.1412
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.002	0.0186	0.0509
Echinococcus multilocularis	peter pan	0.0069	0.1105	0.1103
Echinococcus multilocularis	musashi	0.0026	0.031	0.0308
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0092	0.1514	0.4177
Toxoplasma gondii	phosphofructokinase domain-containing protein	0.0029	0.0356	0.2905
Echinococcus multilocularis	g-protein coupled receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.0075	0.121	0.6342
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0092	0.1514	0.418
Echinococcus multilocularis	zinc finger protein 598	0.0069	0.1097	0.1095
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0092	0.1514	0.1513
Brugia malayi	PXA domain containing protein	0.0019	0.017	0.047
Loa Loa (eye worm)	hypothetical protein	0.0019	0.017	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0092	0.1514	0.3354
Brugia malayi	Dopamine receptor protein 1	0.0092	0.1514	0.418
Schistosoma mansoni	amine GPCR	0.0092	0.1514	0.1412
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0301	0.0825
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.0032	0.0415	0.2279
Echinococcus granulosus	expressed protein	0.0368	0.6619	0.6618
Mycobacterium tuberculosis	Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase)	0.0107	0.1801	1
Brugia malayi	Nucleoside-diphosphatase mig-23	0.0016	0.012	0.033
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.1514	0.1412
Loa Loa (eye worm)	melatonin receptor type 1A	0.0092	0.1514	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0376	0.3073
Brugia malayi	hypothetical protein	0.0092	0.1514	0.418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.0075	0.121	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Leishmania major	ATP-dependent phosphofructokinase	0.0107	0.1801	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0092	0.1514	0.1513
Echinococcus multilocularis	ectonucleoside triphosphate diphosphohydrolase	0.0172	0.2997	0.2996
Echinococcus granulosus	tm gpcr rhodopsin	0.0092	0.1514	0.1513
Onchocerca volvulus		0.0092	0.1514	0.3354
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.017	0.0051
Echinococcus multilocularis	expressed protein	0.0033	0.0429	0.0427
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0019	0.017	0.047
Echinococcus multilocularis	serotonin receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Onchocerca volvulus		0.0092	0.1514	0.3354
Toxoplasma gondii	brix domain-containing protein	0.0069	0.1105	0.9125
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1801	0.4175
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.017	0.0051
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0356	0.0587
Loa Loa (eye worm)	G-protein coupled receptor	0.0092	0.1514	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0092	0.1514	0.418
Onchocerca volvulus		0.0028	0.0342	0.0392
Loa Loa (eye worm)	RGS-3 protein	0.0019	0.017	0.0464
Onchocerca volvulus		0.0092	0.1514	0.3354
Schistosoma mansoni	cpg binding protein	0.003	0.0371	0.0255
Entamoeba histolytica	brix domain containing protein	0.0069	0.1105	0.5733
Schistosoma mansoni	lamin	0.0026	0.031	0.0193
Onchocerca volvulus		0.0026	0.031	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0026	0.031	0.085
Schistosoma mansoni	axis inhibition protein axin	0.0019	0.017	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Echinococcus granulosus	G protein coupled receptor 139	0.0092	0.1514	0.1513
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.017	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Onchocerca volvulus		0.0092	0.1514	0.3354
Schistosoma mansoni	biogenic amine receptor	0.0092	0.1514	0.1412
Brugia malayi	G protein-coupled receptor	0.0092	0.1514	0.418
Brugia malayi	PXA domain containing protein	0.0019	0.017	0.047
Trichomonas vaginalis	ssf, putative	0.0069	0.1105	0.2447
Echinococcus multilocularis	expressed protein	0.0368	0.6619	0.6618
Toxoplasma gondii	endonuclease IV APN	0.0075	0.121	1
Onchocerca volvulus		0.0092	0.1514	0.3354
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Trypanosoma cruzi	nucleoside phosphatase, putative	0.0016	0.012	0.0633
Schistosoma mansoni	neuropeptide f receptor 76f	0.0092	0.1514	0.1412
Schistosoma mansoni	lamin	0.0026	0.031	0.0193
Loa Loa (eye worm)	PXA domain-containing protein	0.0019	0.017	0.0464
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.017	0.0051
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1801	1
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0356	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Schistosoma mansoni	rotamase	0.0033	0.0429	0.0314
Schistosoma mansoni	growth hormone secretagogue receptor	0.0092	0.1514	0.1412
Schistosoma mansoni	neuropeptide receptor	0.0092	0.1514	0.1412
Echinococcus multilocularis	neuropeptides capa receptor	0.0092	0.1514	0.1513
Echinococcus granulosus	Regulator of G protein signaling 20	0.0019	0.017	0.0168
Schistosoma mansoni	P2X receptor subunit	0.055	1	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0092	0.1514	0.1513
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.017	0.0051
Trichomonas vaginalis	rotamase, putative	0.0033	0.0429	0.0769
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0092	0.1514	0.1513
Trypanosoma cruzi	nucleoside phosphatase, putative	0.0016	0.012	0.0633
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.031	0.085
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.0075	0.121	0.6342
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0415	0.2279
Trichomonas vaginalis	rotamase, putative	0.0032	0.0415	0.0734
Echinococcus granulosus	cpg binding protein	0.003	0.0371	0.0369
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0092	0.1514	0.1412
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Onchocerca volvulus		0.0092	0.1514	0.3354
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.0075	0.121	0.3341
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.0075	0.121	0.379
Loa Loa (eye worm)	hypothetical protein	0.0019	0.017	0.0464
Treponema pallidum	diphosphate--fructose-6-phosphate 1-phosphotransferase	0.0107	0.1801	1
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.0032	0.0415	0.2279
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0092	0.1514	0.1513
Schistosoma mansoni	neuropeptide receptor	0.0092	0.1514	0.1412
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0206	0.3622	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0376	0.026
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Schistosoma mansoni	cpg binding protein	0.0028	0.0342	0.0225
Brugia malayi	G protein-coupled receptor F59B2.13	0.0092	0.1514	0.418
Plasmodium falciparum	apyrase, putative	0.0172	0.2997	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Onchocerca volvulus		0.0092	0.1514	0.3354
Brugia malayi	hypothetical protein	0.0092	0.1514	0.418
Echinococcus multilocularis	axis inhibition protein axin	0.0019	0.017	0.0168
Brugia malayi	hypothetical protein	0.0092	0.1514	0.418
Echinococcus granulosus	tm gpcr rhodopsin	0.0092	0.1514	0.1513
Echinococcus granulosus	ectonucleoside triphosphate diphosphohydrolase	0.0172	0.2997	0.2996
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0092	0.1514	0.1412
Echinococcus granulosus	neuropeptide receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0019	0.017	0.0464
Echinococcus granulosus	axis inhibition protein axin	0.0019	0.017	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0019	0.017	0.0464
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.1801	0.1701
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0019	0.017	0.0168
Onchocerca volvulus		0.0092	0.1514	0.3354
Echinococcus granulosus	g-protein coupled receptor	0.0092	0.1514	0.1513
Schistosoma mansoni	cpg binding protein	0.003	0.0371	0.0255
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0092	0.1514	0.1513
Onchocerca volvulus	Peter pan protein homolog	0.0069	0.1105	0.232
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.017	0.0126
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0092	0.1514	0.4177
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0376	0.0374
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0033	0.0429	0.1185
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0092	0.1514	0.1513
Echinococcus granulosus	neuropeptide s receptor	0.0542	0.9852	0.9852
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0019	0.017	0.0464
Brugia malayi	hypothetical protein	0.0019	0.017	0.047
Echinococcus granulosus	ectonucleoside triphosphate diphosphohydrolase	0.0016	0.012	0.0118
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.017	0.0051
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.017	0.0126
Brugia malayi	hypothetical protein	0.0092	0.1514	0.418
Schistosoma mansoni	P2X receptor subunit	0.055	1	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0376	0.0374
Echinococcus granulosus	p2X purinoceptor 4	0.055	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.1514	0.1412
Schistosoma mansoni	adenoreceptor	0.0092	0.1514	0.1412
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0356	0.0587
Schistosoma mansoni	hypothetical protein	0.0092	0.1514	0.1412
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0092	0.1514	0.1412
Onchocerca volvulus		0.0092	0.1514	0.3354
Echinococcus granulosus	neuropeptides capa receptor	0.0092	0.1514	0.1513
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0376	0.026
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0945	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Schistosoma mansoni	neuropeptide receptor	0.0092	0.1514	0.1412
Loa Loa (eye worm)	neuropeptide F receptor	0.0092	0.1514	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0048	0.0127
Echinococcus multilocularis	regulator of G protein signaling 3	0.0019	0.017	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Plasmodium falciparum	ATP-dependent 6-phosphofructokinase	0.0029	0.0356	0.0821
Brugia malayi	RE15519p	0.0092	0.1514	0.418
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0092	0.1514	0.1513
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0019	0.017	0.0051
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.017	0.0168
Onchocerca volvulus		0.0092	0.1514	0.3354
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Trichomonas vaginalis	6-phosphofructokinase, putative	0.0029	0.0356	0.0587
Loa Loa (eye worm)	G-protein coupled receptor	0.0092	0.1514	0.4177
Schistosoma mansoni	neuropeptide F-like receptor	0.0092	0.1514	0.1412
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0092	0.1514	0.1513
Onchocerca volvulus		0.0092	0.1514	0.3354
Brugia malayi	6-phosphofructokinase	0.0107	0.1801	0.497
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.1514	0.1412
Giardia lamblia	Peter pan protein	0.0069	0.1105	1
Brugia malayi	hypothetical protein	0.0019	0.017	0.047
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1801	0.4175
Brugia malayi	regulator of G-protein signaling rgs-7	0.0019	0.017	0.047
Toxoplasma gondii	GDA1/CD39 (nucleoside phosphatase) family protein	0.0016	0.012	0.0943
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.031	0.085
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0019	0.017	0.0464
Brugia malayi	G-protein coupled receptor	0.0092	0.1514	0.418
Schistosoma mansoni	opsin-like receptor	0.0092	0.1514	0.1412
Trypanosoma brucei	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.1801	1
Brugia malayi	phosphofructokinase	0.0107	0.1801	0.497
Brugia malayi	larval opioid receptor	0.0092	0.1514	0.418
Echinococcus granulosus	7tm_1 domain containing protein	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Brugia malayi	Hypothetical 29.7 kDa protein C05D11.5 in chromosome III	0.002	0.0186	0.0514
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.017	0.0051
Onchocerca volvulus		0.0092	0.1514	0.3354
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Brugia malayi	regulator of G-protein signaling egl-10	0.0019	0.017	0.047
Echinococcus granulosus	dro:myosuppressin receptor	0.0092	0.1514	0.1513
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.4146	1
Onchocerca volvulus		0.0092	0.1514	0.3354
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0092	0.1514	0.1412
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0092	0.1514	0.418
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0019	0.017	0.0464
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.1514	0.1412
Brugia malayi	Brix domain containing protein	0.0069	0.1105	0.305
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Toxoplasma gondii	phosphofructokinase PFKII	0.0029	0.0356	0.2905
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, putative	0.0032	0.0415	0.1502
Brugia malayi	Pre-SET motif family protein	0.0206	0.3622	1
Echinococcus granulosus	neuropeptides capa receptor	0.0092	0.1514	0.1513
Echinococcus granulosus	biogenic amine 5HT receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0083	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Echinococcus multilocularis	neuropeptide receptor	0.0092	0.1514	0.1513
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0356	0.0587
Brugia malayi	hypothetical protein	0.0092	0.1514	0.418
Echinococcus multilocularis	neuropeptide Y receptor	0.0092	0.1514	0.1513
Chlamydia trachomatis	endonuclease IV	0.0075	0.121	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.017	0.0168
Schistosoma mansoni	P2X receptor subunit	0.0273	0.4868	0.4806
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0092	0.1514	0.418
Mycobacterium leprae	PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE)	0.0107	0.1801	1
Echinococcus granulosus	neuropeptide Y receptor	0.0092	0.1514	0.1513
Trypanosoma brucei	brix domain containing protein, putative	0.0069	0.1105	0.6123
Echinococcus multilocularis	p2X purinoceptor 4	0.055	1	1
Echinococcus multilocularis	cpg binding protein	0.003	0.0371	0.0369
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.017	0.047
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0092	0.1514	0.1412
Schistosoma mansoni	serine/threonine protein kinase	0.0019	0.017	0.0051
Brugia malayi	G-protein coupled receptor	0.0092	0.1514	0.418
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0019	0.017	0.0168
Brugia malayi	follicle stimulating hormone receptor	0.0092	0.1514	0.418
Schistosoma mansoni	P2X receptor subunit	0.0273	0.4868	0.4806
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0092	0.1514	0.418
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0376	0.0374
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0092	0.1514	0.1412
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Brugia malayi	hypothetical protein	0.0092	0.1514	0.418
Brugia malayi	putative neuropeptide receptor NPR1	0.0092	0.1514	0.418
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0092	0.1514	0.1513
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0092	0.1514	0.4177
Echinococcus multilocularis	dro:myosuppressin receptor	0.0092	0.1514	0.1513
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0092	0.1514	0.1513
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0083	0.0223
Brugia malayi	A-kinase anchor protein 10, precursor	0.0019	0.017	0.047
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Echinococcus multilocularis	p2X purinoceptor 4	0.055	1	1
Entamoeba histolytica	pyrophosphate-dependent phosphofructokinase	0.0029	0.0356	0.1139
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0092	0.1514	0.4177
Onchocerca volvulus		0.0026	0.031	0.0312
Echinococcus granulosus	intermediate filament protein	0.0026	0.031	0.0308
Leishmania major	nucleoside phosphatase, putative,guanosine diphosphatase, putative	0.0016	0.012	0.0633
Echinococcus granulosus	neuropeptide Y receptor	0.0092	0.1514	0.1513
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0356	0.0587
Echinococcus multilocularis	g protein coupled receptor	0.0092	0.1514	0.1513
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.017	0.0168
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0019	0.017	0.0168
Schistosoma mansoni	z-protein (S1r protein)	0.0019	0.017	0.0051
Schistosoma mansoni	intermediate filament proteins	0.0026	0.031	0.0193
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0827	0.6819
Trypanosoma brucei	nucleoside phosphatase, putative	0.0016	0.012	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Echinococcus granulosus	g protein coupled receptor	0.0092	0.1514	0.1513
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0092	0.1514	0.1513
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0092	0.1514	0.1513
Onchocerca volvulus		0.0092	0.1514	0.3354
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0048	0.0127
Wolbachia endosymbiont of Brugia malayi	parvulin-like peptidyl-prolyl isomerase, PPID	0.001	0.0006	0.5
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Brugia malayi	putative neuropeptide receptor	0.0092	0.1514	0.418
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1801	0.4175
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.017	0.0051
Trypanosoma cruzi	peter pan protein, putative	0.0069	0.1105	0.6123
Plasmodium vivax	hypothetical protein, conserved	0.0069	0.1105	0.9034
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0019	0.017	0.0168
Echinococcus granulosus	neuropeptide receptor A26	0.0542	0.9852	0.9852
Echinococcus multilocularis	6 phosphofructokinase	0.0107	0.1801	0.1799
Echinococcus granulosus	6 phosphofructokinase	0.0107	0.1801	0.1799
Toxoplasma gondii	6-phosphofructokinase	0.0029	0.0356	0.2905
Schistosoma mansoni	opsin-like receptor	0.0092	0.1514	0.1412
Loa Loa (eye worm)	phosphofructokinase	0.0107	0.1801	0.4967
Echinococcus granulosus	g protein coupled receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0075	0.121	0.3337
Echinococcus multilocularis	lamin	0.0026	0.031	0.0308
Brugia malayi	Melatonin receptor type 1A	0.0092	0.1514	0.418
Echinococcus granulosus	7TM GPCR rhodopsin	0.0092	0.1514	0.1513
Echinococcus granulosus	p2X purinoceptor 4	0.055	1	1
Mycobacterium ulcerans	6-phosphofructokinase	0.0107	0.1801	1
Toxoplasma gondii	peptidylprolyl isomerase	0.0032	0.0415	0.3397
Loa Loa (eye worm)	hypothetical protein	0.003	0.0376	0.1033
Schistosoma mansoni	opsin-like receptor	0.0092	0.1514	0.1412
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0342	0.0938
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Echinococcus granulosus	sex peptide receptor	0.0092	0.1514	0.1513
Brugia malayi	ORL1-like opioid receptor	0.0092	0.1514	0.418
Echinococcus granulosus	regulator of G protein signaling 3	0.0019	0.017	0.0168
Echinococcus granulosus	neuropeptide receptor	0.0092	0.1514	0.1513
Toxoplasma gondii	Nucleoside-diphosphatase	0.0016	0.012	0.0943
Leishmania major	ATP diphosphohydrolase	0.0016	0.012	0.0633
Trypanosoma cruzi	peter pan protein, putative	0.0069	0.1105	0.6123
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0092	0.1514	0.1513
Brugia malayi	hypothetical protein	0.0092	0.1514	0.418
Onchocerca volvulus		0.003	0.0376	0.0479
Echinococcus granulosus	fmrfamide receptor	0.0092	0.1514	0.1513
Schistosoma mansoni	neuropeptide receptor	0.0092	0.1514	0.1412
Schistosoma mansoni	amine GPCR	0.0092	0.1514	0.1412
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.017	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Brugia malayi	Serotonin receptor	0.0092	0.1514	0.418
Schistosoma mansoni	regulator of G protein signaling	0.0019	0.017	0.0051
Echinococcus granulosus	tm gpcr rhodopsin	0.0092	0.1514	0.1513
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0429	0.0769
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0092	0.1514	0.1412
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.1801	0.4967
Echinococcus multilocularis	neuropeptide s receptor	0.0542	0.9852	0.9852
Echinococcus granulosus	peter pan	0.0069	0.1105	0.1103
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0092	0.1514	0.1412
Loa Loa (eye worm)	6-phosphofructokinase	0.0107	0.1801	0.4967
Echinococcus multilocularis	g protein coupled receptor	0.0092	0.1514	0.1513
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0057	0.0055
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0092	0.1514	0.1412
Brugia malayi	Pre-SET motif family protein	0.003	0.0376	0.1038
Echinococcus multilocularis	g protein coupled receptor	0.0092	0.1514	0.1513
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0019	0.017	0.0126
Echinococcus granulosus	g protein coupled receptor	0.0092	0.1514	0.1513
Brugia malayi	Serotonin receptor	0.0092	0.1514	0.418
Echinococcus multilocularis	serotonin receptor	0.0092	0.1514	0.1513
Schistosoma mansoni	peter pan-related	0.0069	0.1105	0.0997
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0092	0.1514	0.1412
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.1514	0.1412
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0092	0.1514	0.1412
Schistosoma mansoni	ATP-diphosphohydrolase 1	0.0172	0.2997	0.2913
Echinococcus multilocularis	G protein coupled receptor 139	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0057	0.0151
Echinococcus granulosus	hypothetical protein	0.0092	0.1514	0.1513
Brugia malayi	sulfakinin receptor protein	0.0092	0.1514	0.418
Schistosoma mansoni	amine GPCR	0.0092	0.1514	0.1412
Echinococcus granulosus	neuropeptide FF receptor 2	0.0092	0.1514	0.1513
Plasmodium falciparum	BRIX domain, putative	0.0069	0.1105	0.3424
Echinococcus multilocularis	allatostatin A receptor	0.0092	0.1514	0.1513
Brugia malayi	neuropeptide F receptor	0.0092	0.1514	0.418
Brugia malayi	hypothetical protein	0.0092	0.1514	0.418
Echinococcus multilocularis	orexin receptor type 2	0.0092	0.1514	0.1513
Trichomonas vaginalis	phosphofructokinase, putative	0.0029	0.0356	0.0587
Onchocerca volvulus		0.0092	0.1514	0.3354
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0092	0.1514	0.1412
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0342	0.0943
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.017	0.0126
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0092	0.1514	0.1513
Echinococcus multilocularis	neuropeptides capa receptor	0.0092	0.1514	0.1513
Echinococcus granulosus	lamin	0.0026	0.031	0.0308
Echinococcus multilocularis	sex peptide receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Toxoplasma gondii	GDA1/CD39 (nucleoside phosphatase) family protein	0.0016	0.012	0.0943
Echinococcus multilocularis	p2X purinoceptor 4	0.055	1	1
Brugia malayi	AKH receptor	0.0092	0.1514	0.418
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0092	0.1514	0.3354
Brugia malayi	intermediate filament protein	0.0026	0.031	0.0855
Schistosoma mansoni	6-phosphofructokinase	0.0107	0.1801	0.1701
Schistosoma mansoni	hypothetical protein	0.0092	0.1514	0.1412
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.017	0.0126
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1801	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0376	0.026
Loa Loa (eye worm)	brix domain-containing protein	0.0069	0.1105	0.3046
Schistosoma mansoni	hypothetical protein	0.0092	0.1514	0.1412
Echinococcus multilocularis	fmrfamide receptor	0.0092	0.1514	0.1513
Schistosoma mansoni	biogenic amine receptor	0.0092	0.1514	0.1412
Schistosoma mansoni	biogenic amine receptor	0.0092	0.1514	0.1412
Entamoeba histolytica	phosphofructokinase, putative	0.0107	0.1801	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0092	0.1514	0.1412
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0092	0.1514	0.1513
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0033	0.0429	0.118
Echinococcus granulosus	regulator of G protein signaling 7	0.0019	0.017	0.0168
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0356	0.2166
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0345	0.0343
Plasmodium vivax	6-phosphofructokinase, putative	0.0029	0.0356	0.2166
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0092	0.1514	0.1513
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0019	0.017	0.047
Trypanosoma cruzi	ATP-dependent 6-phosphofructokinase, glycosomal	0.0107	0.1801	1
Echinococcus multilocularis	ectonucleoside triphosphate diphosphohydrolase	0.0172	0.2997	0.2996
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0092	0.1514	0.1513
Echinococcus granulosus	serotonin receptor	0.0092	0.1514	0.1513
Onchocerca volvulus		0.0234	0.4146	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0542	0.9852	0.9852
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0092	0.1514	0.1513
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Echinococcus multilocularis	regulator of G protein signaling	0.0019	0.017	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0019	0.017	0.0051
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0092	0.1514	0.4177
Echinococcus granulosus	lamin dm0	0.0026	0.031	0.0308
Echinococcus multilocularis	lamin dm0	0.0026	0.031	0.0308
Echinococcus granulosus	somatostatin receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Brugia malayi	neuropeptide F receptor	0.0092	0.1514	0.418
Trichomonas vaginalis	phosphofructokinase, putative	0.0107	0.1801	0.4175
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Onchocerca volvulus		0.0092	0.1514	0.3354
Toxoplasma gondii	GDA1/CD39 (nucleoside phosphatase) family protein	0.0016	0.012	0.0943
Brugia malayi	hypothetical protein	0.0092	0.1514	0.418
Brugia malayi	Dopamine receptor	0.0092	0.1514	0.418
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0019	0.017	0.0464
Echinococcus multilocularis	somatostatin receptor	0.0092	0.1514	0.1513
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Plasmodium vivax	SET domain protein, putative	0.003	0.0376	0.2352
Toxoplasma gondii	NTPase II	0.0016	0.012	0.0943
Echinococcus multilocularis	ectonucleoside triphosphate diphosphohydrolase	0.0172	0.2997	0.2996
Echinococcus multilocularis	neuropeptide receptor	0.0092	0.1514	0.1513
Mycobacterium ulcerans	endonuclease IV	0.0075	0.121	0.6342
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.1514	0.1513
Schistosoma mansoni	amine GPCR	0.0092	0.1514	0.1412
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0092	0.1514	0.1412
Echinococcus granulosus	expressed protein	0.0033	0.0429	0.0427
Schistosoma mansoni	neuropeptide F-like receptor	0.0092	0.1514	0.1412
Echinococcus multilocularis	regulator of G protein signaling 7	0.0019	0.017	0.0168
Loa Loa (eye worm)	neuropeptide F receptor	0.0092	0.1514	0.4177
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0376	0.026
Brugia malayi	hypothetical protein	0.0092	0.1514	0.418
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Loa Loa (eye worm)	hypothetical protein	0.0016	0.012	0.0324
Echinococcus granulosus	3'partial\|ectonucleoside triphosphate diphosphohydrolase	0.0016	0.012	0.0118
Schistosoma mansoni	hypothetical protein	0.0092	0.1514	0.1412
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0057	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.017	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1514	0.4177
Echinococcus granulosus	rhodopsin orphan GPCR	0.0092	0.1514	0.1513

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 809260