Detailed information for compound 810380

Basic information

Technical information
  • TDR Targets ID: 810380
  • Name: N-(2,3-dimethylphenyl)-2H-1,2,4-triazole-3-ca rboxamide
  • MW: 216.239 | Formula: C11H12N4O
  • H donors: 2 H acceptors: 3 LogP: 1.19 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1n[nH]cn1)Nc1cccc(c1C)C
  • InChi: 1S/C11H12N4O/c1-7-4-3-5-9(8(7)2)14-11(16)10-12-6-13-15-10/h3-6H,1-2H3,(H,14,16)(H,12,13,15)
  • InChiKey: UFXDGHFDWZZIMF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00208982
  • CBMicro_017115
  • BIM-0017178.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0071 0.0266
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.1014 0.2078
Loa Loa (eye worm) hypothetical protein 0.0066 0.0632 0.1401
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0071 0.0146
Echinococcus granulosus geminin 0.0205 0.2429 0.4977
Loa Loa (eye worm) hypothetical protein 0.004 0.0294 0.0651
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0156 0.1798 1
Plasmodium falciparum metacaspase-like protein 0.0026 0.0107 0.04
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0107 0.0431
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0041 0.0301 0.1238
Mycobacterium ulcerans peptide deformylase 0.0223 0.2668 1
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0041 0.03 0.2352
Trypanosoma brucei cytochrome P450, putative 0.0019 0.002 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.0431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0349 0.1437
Loa Loa (eye worm) hypothetical protein 0.0097 0.103 0.2283
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0025 0.0097 0.0393
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0107 0.0219
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0041 0.03 0.2352
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0024 0.0082 0.0329
Echinococcus granulosus multidrug resistance protein 1 0.0041 0.0302 0.0618
Schistosoma mansoni aminopeptidase A (M01 family) 0.0041 0.0301 0.1238
Plasmodium falciparum peptide deformylase 0.0223 0.2668 1
Trypanosoma cruzi metacaspase, putative 0.0026 0.0107 0.0837
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0041 0.0301 0.1127
Echinococcus granulosus caspase 8 0.0026 0.0107 0.0219
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0041 0.03 0.2352
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0041 0.0301 0.1214
Trypanosoma cruzi metacaspase, putative 0.0026 0.0107 0.0837
Echinococcus multilocularis caspase 3 0.0071 0.0689 0.0689
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0041 0.0302 0.1218
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.017 0.0348
Echinococcus multilocularis multidrug resistance protein 1 0.0024 0.0082 0.0082
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0041 0.0301 0.2357
Trypanosoma cruzi metacaspase, putative 0.0026 0.0107 0.0837
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.002 0.0159
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0025 0.0097 0.0401
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0041 0.0302 0.0302
Toxoplasma gondii aminopeptidase N protein 0.0041 0.0301 0.1127
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0665
Echinococcus granulosus caspase 3 0.0071 0.0689 0.1413
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0349 0.0774
Echinococcus granulosus GPCR family 2 0.0031 0.017 0.0348
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0041 0.0302 0.0618
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0071 0.0395
Entamoeba histolytica hypothetical protein 0.0041 0.03 0.1668
Trypanosoma brucei multidrug resistance protein E 0.0041 0.03 0.2352
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0041 0.0302 0.1218
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0097 0.0393
Loa Loa (eye worm) hypothetical protein 0.0041 0.0301 0.0667
Loa Loa (eye worm) Ulp1 protease 0.0025 0.0097 0.0216
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0071 0.0266
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0223 0.2668 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0041 0.0302 0.0302
Schistosoma mansoni multidrug resistance protein 0.0041 0.03 0.1235
Schistosoma mansoni multidrug resistance protein 0.0041 0.0302 0.1242
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0075 0.0747 0.5856
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.017 0.0348
Entamoeba histolytica P-glycoprotein 5, putative 0.0041 0.0302 0.1677
Echinococcus multilocularis caspase 0.0096 0.1024 0.1024
Loa Loa (eye worm) hypothetical protein 0.0278 0.3376 0.7486
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0116 0.1275 1
Chlamydia trachomatis peptide deformylase 0.0223 0.2668 1
Entamoeba histolytica hypothetical protein 0.0035 0.0226 0.1256
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0025 0.0097 0.0764
Onchocerca volvulus 0.0365 0.451 0.9232
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0041 0.03 0.1124
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.0431
Entamoeba histolytica multidrug resistance protein, putative 0.0041 0.03 0.1668
Entamoeba histolytica ATP-binding cassette protein, putative 0.0041 0.03 0.1668
Loa Loa (eye worm) hypothetical protein 0.0023 0.0071 0.0158
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0082 0.0167
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1033 0.4253
Mycobacterium ulcerans aminopeptidase N PepN 0.0116 0.1275 0.4781
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0214 0.2553 0.5232
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0226 0.0226
Trichomonas vaginalis abcb9, putative 0.0041 0.0302 0.1218
Entamoeba histolytica P-glycoprotein-5 0.0041 0.0302 0.1677
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.017 0.017
Trypanosoma brucei Polypeptide deformylase 1 0.0085 0.0877 0.6875
Schistosoma mansoni hypothetical protein 0.0205 0.2429 1
Echinococcus multilocularis sentrin specific protease 1 0.0025 0.0097 0.0097
Trypanosoma cruzi multidrug resistance protein E, putative 0.0041 0.03 0.2352
Leishmania major ABC-thiol transporter 0.0041 0.03 0.2352
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0216
Trypanosoma cruzi hypothetical protein 0.0023 0.0072 0.0564
Plasmodium falciparum metacaspase 1 0.0026 0.0107 0.04
Brugia malayi TATA binding protein associated factor 0.0041 0.0301 0.0616
Brugia malayi multidrug resistance related protein 1 0.0041 0.03 0.0615
Echinococcus multilocularis sentrin specific protease 8 0.0025 0.0097 0.0097
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0041 0.0302 0.113
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.0431
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0116 0.1275 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0041 0.0302 0.1218
Trichomonas vaginalis taga, putative 0.0041 0.0302 0.1218
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.1275 0.1275
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0041 0.0302 0.1218
Loa Loa (eye worm) multidrug resistance protein 3 0.0041 0.0302 0.0669
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0025 0.0097 0.0542
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0041 0.0302 0.1218
Toxoplasma gondii aminopeptidase n, putative 0.0041 0.0301 0.1127
Brugia malayi Cell death protein 3 precursor 0.0026 0.0107 0.0219
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.103 0.2283
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0041 0.0301 0.1127
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0025 0.0097 0.0764
Entamoeba histolytica ATP-binding cassette protein, putative 0.0041 0.03 0.1668
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0025 0.0097 0.0764
Brugia malayi Cytochrome P450 family protein 0.0019 0.002 0.0042
Echinococcus granulosus sentrin specific protease 7 0.0156 0.1798 0.3684
Schistosoma mansoni hypothetical protein 0.004 0.0286 0.1176
Schistosoma mansoni multidrug resistance protein 0.0041 0.03 0.1235
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0237
Leishmania major pentamidine resistance protein 1 0.0041 0.03 0.2352
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0025 0.0097 0.0393
Trypanosoma cruzi Peptide deformylase 2, putative 0.0085 0.0877 0.6875
Trypanosoma brucei SUMO1/Ulp2, putative 0.0025 0.0097 0.0764
Schistosoma mansoni hypothetical protein 0.0031 0.017 0.07
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0041 0.0302 0.1218
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0156 0.1798 0.7403
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0116 0.1275 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0302 0.0669
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0041 0.0301 0.0301
Schistosoma mansoni smdr2 0.0041 0.0302 0.1242
Brugia malayi Peptidase family M1 containing protein 0.0041 0.0301 0.0616
Echinococcus multilocularis ATP binding cassette sub family B 0.004 0.0294 0.0294
Brugia malayi hypothetical protein 0.0365 0.451 0.9243
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0041 0.0302 0.1218
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0041 0.03 0.2352
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0107 0.04
Trypanosoma brucei Aminopeptidase M1, putative 0.0116 0.1275 1
Onchocerca volvulus 0.0116 0.1275 0.2505
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0025 0.0097 0.0393
Echinococcus granulosus caspase 0.0096 0.1024 0.2099
Entamoeba histolytica ABC transporter, putative 0.0041 0.03 0.1668
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.1275 0.2614
Entamoeba histolytica P-glycoprotein-1 0.0041 0.0302 0.1677
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0041 0.0302 0.1218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0349 0.0715
Leishmania major p-glycoprotein 0.0041 0.0302 0.2364
Loa Loa (eye worm) hypothetical protein 0.0214 0.2553 0.566
Loa Loa (eye worm) multidrug resistance-associated protein 0.0024 0.008 0.0177
Loa Loa (eye worm) peptidase family M1 containing protein 0.0318 0.3905 0.8658
Echinococcus multilocularis sentrin specific protease 7 0.0156 0.1798 0.1798
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0041 0.0301 0.1238
Trypanosoma cruzi metacaspase, putative 0.0026 0.0107 0.0837
Entamoeba histolytica hypothetical protein 0.0035 0.0226 0.1256
Echinococcus multilocularis geminin 0.0205 0.2429 0.2429
Schistosoma mansoni hypothetical protein 0.0066 0.0632 0.2601
Echinococcus multilocularis GPCR, family 2 0.0031 0.017 0.017
Giardia lamblia ABC transporter, putative 0.0041 0.03 1
Brugia malayi hypothetical protein 0.0041 0.0301 0.0616
Echinococcus granulosus expressed conserved protein 0.009 0.0938 0.1923
Trichomonas vaginalis ABC transporter, putative 0.0041 0.0302 0.1218
Plasmodium falciparum sentrin-specific protease 1 0.0025 0.0097 0.0365
Echinococcus granulosus multidrug resistance associated protein 4 0.0023 0.0072 0.0147
Echinococcus granulosus sentrin specific protease 8 0.0025 0.0097 0.02
Trypanosoma brucei Aminopeptidase M1, putative 0.0116 0.1275 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0107 0.04
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0116 0.1275 0.1275
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0041 0.0301 0.2357
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.2477 1
Toxoplasma gondii hypothetical protein 0.0223 0.2668 1
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0107 0.0837
Loa Loa (eye worm) aminopeptidase N 0.0116 0.1275 0.2828
Schistosoma mansoni caspase-7 (C14 family) 0.0096 0.1024 0.4217
Echinococcus granulosus Niemann Pick C1 protein 0.0137 0.1547 0.317
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0085 0.0877 0.6875
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0041 0.03 0.2352
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0041 0.0301 0.2357
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0041 0.0302 0.0794
Echinococcus multilocularis Niemann Pick C1 protein 0.0137 0.1547 0.1547
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0025 0.0097 0.0401
Loa Loa (eye worm) hypothetical protein 0.0365 0.451 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0025 0.0097 0.0393
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0041 0.0302 0.0618
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0041 0.0301 0.1127
Schistosoma mansoni hypothetical protein 0.0031 0.017 0.07
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0107 0.0431
Trypanosoma brucei metacaspase MCA3 0.0026 0.0107 0.0837
Trypanosoma cruzi Aminopeptidase M1, putative 0.0116 0.1275 1
Leishmania major metacaspase, putative 0.0026 0.0107 0.0837
Schistosoma mansoni multidrug resistance protein 0.0041 0.03 0.1235
Echinococcus granulosus caspase 2 0.0026 0.0107 0.0219
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0071 0.0557
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0025 0.0097 0.0393
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0025 0.0097 0.0365
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0107 0.0431
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0107 0.04
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0041 0.0302 0.0302
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0025 0.0097 0.0365
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0071 0.0266
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.103 0.211
Trypanosoma brucei aminopeptidase, putative 0.0041 0.0301 0.2357
Loa Loa (eye worm) hypothetical protein 0.0353 0.4351 0.9647
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0041 0.0302 0.0618
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0041 0.0302 0.1218
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0349 0.0715
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0041 0.0302 0.1218
Entamoeba histolytica P-glycoprotein-2, putative 0.0041 0.0302 0.1677
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0107 0.0431
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0071 0.0395
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0223 0.2668 1
Echinococcus multilocularis multidrug resistance associated protein 7 0.0041 0.03 0.03
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0075 0.0747 0.0747
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0041 0.0302 0.1218
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0305 0.0676
Brugia malayi Latrophilin receptor protein 2 0.0031 0.017 0.0348
Entamoeba histolytica ATP-binding cassette protein, putative 0.0041 0.03 0.1668
Schistosoma mansoni hypothetical protein 0.004 0.0286 0.1176
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0025 0.0097 0.0393
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0107 0.044
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.1014 0.2078
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.1014 0.5639
Echinococcus multilocularis multidrug resistance associated protein 4 0.0023 0.0072 0.0072
Echinococcus granulosus sentrin specific protease 1 0.0025 0.0097 0.02
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0075 0.0747 0.3075
Trypanosoma cruzi Peptide deformylase 2, putative 0.0085 0.0877 0.6875
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0025 0.0097 0.0542
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.002 0.0045
Brugia malayi Peptidase family M1 containing protein 0.0393 0.488 1
Leishmania major cytochrome p450-like protein 0.0019 0.002 0.0159
Loa Loa (eye worm) hypothetical protein 0.0075 0.0747 0.1656
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0107 0.04
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0041 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0075 0.0747 0.1656
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0071 0.0146
Loa Loa (eye worm) hypothetical protein 0.005 0.0425 0.0942
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0041 0.0302 0.1218
Schistosoma mansoni patched 1 0.0041 0.0305 0.1255
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0041 0.0302 0.1218
Leishmania major polypeptide deformylase-like protein, putative 0.0085 0.0877 0.6875
Trypanosoma brucei metacaspase 0.0026 0.0107 0.0837
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0107 0.0431
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0041 0.0301 0.0616
Echinococcus granulosus expressed conserved protein 0.0131 0.1472 0.3017
Loa Loa (eye worm) hypothetical protein 0.004 0.0292 0.0647
Echinococcus multilocularis caspase 8 0.0026 0.0107 0.0107
Plasmodium vivax peptide deformylase, putative 0.0223 0.2668 1
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0116 0.1275 1
Schistosoma mansoni caspase-3 (C14 family) 0.0096 0.1024 0.4217
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0071 0.0266
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0041 0.0301 0.0616
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0041 0.0302 0.113
Loa Loa (eye worm) hypothetical protein 0.0023 0.0071 0.0158
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.1275 0.1275
Entamoeba histolytica aminopeptidase, putative 0.0116 0.1275 0.7095
Trypanosoma brucei metacaspase MCA2 0.0026 0.0107 0.0837
Trypanosoma cruzi hypothetical protein 0.0025 0.0097 0.0764
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0107 0.0431
Schistosoma mansoni hypothetical protein 0.004 0.0286 0.1176
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.017 0.0377
Echinococcus multilocularis multidrug resistance associated protein 1 0.0041 0.03 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.0431
Brugia malayi Peptidase family M1 containing protein 0.0116 0.1275 0.2614
Brugia malayi ABC transporter transmembrane region family protein 0.0041 0.03 0.0615
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0085 0.0877 0.6875
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0041 0.0302 0.1218
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0107 0.0431
Echinococcus multilocularis expressed conserved protein 0.0131 0.1472 0.1472
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0071 0.0557
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0041 0.0301 0.0667
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.1275 0.1275
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0349 0.0349
Entamoeba histolytica ATP-binding cassette protein, putative 0.0041 0.03 0.1668
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0305 0.1231
Echinococcus granulosus multidrug resistance associated protein 1 0.0041 0.03 0.0615
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0107 0.0837
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0226 0.093
Trypanosoma cruzi cytochrome P450, putative 0.0019 0.002 0.0159
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0041 0.0301 0.2357
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0305 0.0305
Echinococcus granulosus multidrug resistance protein 1 0.0041 0.0302 0.0618
Mycobacterium ulcerans hypothetical protein 0.0023 0.0071 0.0266
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0632 0.1295
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0041 0.0302 0.2364
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0107 0.0837
Schistosoma mansoni multidrug resistance protein 0.0041 0.0302 0.1242
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0041 0.0302 0.1218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0349 0.0715
Plasmodium vivax multidrug resistance protein 1, putative 0.0041 0.0302 0.113
Entamoeba histolytica P-glyco protein 6, putative 0.0041 0.0302 0.1677
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0025 0.0097 0.02
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0041 0.0302 0.0618
Onchocerca volvulus 0.0041 0.0302 0.0479
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0107 0.0431
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0025 0.0097 0.02
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0041 0.03 0.2352
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0226 0.0463
Schistosoma mansoni hypothetical protein 0.0035 0.0226 0.093
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0041 0.03 0.0665
Trichomonas vaginalis ABC transporter, putative 0.0041 0.0302 0.1218
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0071 0.0266
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.1014 0.1014
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0041 0.0302 0.1218
Schistosoma mansoni hypothetical protein 0.004 0.0286 0.1176
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0041 0.03 0.2352
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0116 0.1275 0.515
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0025 0.0097 0.0393
Schistosoma mansoni multidrug resistance protein 0.0041 0.0302 0.1242
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0025 0.0097 0.0393
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.002 0.0045
Echinococcus granulosus multidrug resistance protein 1 0.0024 0.0082 0.0167
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0216
Echinococcus multilocularis multidrug resistance protein 1 0.0041 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.0031 0.017 0.07
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0041 0.0302 0.0669
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0071 0.0266
Brugia malayi hypothetical protein 0.0116 0.1275 0.2614
Trichomonas vaginalis abcb9, putative 0.0041 0.0302 0.1218
Trypanosoma brucei Metacaspase-4 0.0026 0.0107 0.0837
Echinococcus granulosus multidrug resistance protein 1 0.0041 0.0302 0.0618
Entamoeba histolytica P-glycoprotein-2 0.0041 0.0302 0.1677
Treponema pallidum polypeptide deformylase (def) 0.0223 0.2668 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.103 0.211
Echinococcus multilocularis protein patched 0.0041 0.0305 0.0305
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0025 0.0097 0.0393
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0071 0.0266
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0041 0.0302 0.1218
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0025 0.0097 0.0542
Schistosoma mansoni hypothetical protein 0.0205 0.2429 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.017 0.0377
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0041 0.0302 0.113
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.1275 0.2614
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0041 0.03 0.2352
Loa Loa (eye worm) hypothetical protein 0.0041 0.0301 0.0667
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0071 0.0266
Loa Loa (eye worm) Ulp1 protease 0.0025 0.0097 0.0216
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0071 0.0266
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.1275 0.2614
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0025 0.0097 0.0542
Mycobacterium ulcerans aminopeptidase N PepN 0.0041 0.0301 0.1127
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0025 0.0097 0.02
Echinococcus multilocularis caspase 2 0.0026 0.0107 0.0107
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.004 0.0294 0.0602
Plasmodium vivax sentrin-specific protease 2, putative 0.0025 0.0097 0.0365
Loa Loa (eye worm) hypothetical protein 0.0023 0.0071 0.0158
Echinococcus multilocularis expressed conserved protein 0.009 0.0938 0.0938
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0107 0.0074
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0041 0.0302 0.1218
Echinococcus multilocularis protein dispatched 1 0.0047 0.038 0.038
Schistosoma mansoni multidrug resistance protein 0.0041 0.03 0.1235
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0041 0.0301 0.1127
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.1275 0.1275
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0071 0.0395
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.017 0.017
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0019 0.002 0.0076
Giardia lamblia MRP-like ABC transporter 0.0041 0.03 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.017 0.0348
Trypanosoma cruzi aminopeptidase, putative 0.0116 0.1275 1
Echinococcus granulosus leukotriene A 4 hydrolase 0.0041 0.0301 0.0616
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0096 0.1024 0.1024
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0107 0.044
Onchocerca volvulus 0.0393 0.488 1
Trypanosoma brucei Peptide deformylase 2 0.0085 0.0877 0.6875
Entamoeba histolytica hypothetical protein 0.0035 0.0226 0.1256
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0071 0.0266
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0071 0.0557
Brugia malayi Cytochrome P450 family protein 0.0019 0.002 0.0042
Leishmania major p-glycoprotein e 0.0041 0.03 0.2352
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0107 0.0431
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0041 0.0301 0.2357
Plasmodium vivax metacaspase 1, putative 0.0026 0.0107 0.04
Loa Loa (eye worm) hypothetical protein 0.0041 0.03 0.0665
Brugia malayi CHE-14 protein 0.0041 0.0305 0.0625
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0041 0.0302 0.1218
Loa Loa (eye worm) hypothetical protein 0.0041 0.0305 0.0676
Onchocerca volvulus 0.0041 0.0301 0.0477
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0041 0.0302 0.0302
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0041 0.0302 0.1218
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0025 0.0097 0.0542
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.0431
Entamoeba histolytica P-glycoprotein-2 0.0041 0.0302 0.1677
Entamoeba histolytica hypothetical protein 0.0035 0.0226 0.1256
Brugia malayi hypothetical protein 0.0035 0.0226 0.0463
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0223 0.2668 1
Trichomonas vaginalis ABC transporter, putative 0.0041 0.0302 0.1218
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0025 0.0097 0.0365
Plasmodium falciparum multidrug resistance protein 1 0.0041 0.0302 0.113
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0041 0.0302 0.1218
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0041 0.0301 0.2357
Loa Loa (eye worm) hypothetical protein 0.0041 0.0301 0.0667
Echinococcus multilocularis multidrug resistance protein 1 0.0041 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0026 0.0107 0.0237
Schistosoma mansoni hypothetical protein 0.0031 0.017 0.07
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0305 0.0625
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0116 0.1275 0.5252
Giardia lamblia Multidrug resistance-associated protein 1 0.004 0.0292 0.9607
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0349 0.1437
Trypanosoma cruzi aminopeptidase, putative 0.0041 0.0301 0.2357
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0116 0.1275 0.2614
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0025 0.0097 0.0401
Loa Loa (eye worm) TATA binding protein associated factor 0.0041 0.0301 0.0667
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0349 0.1437
Brugia malayi multidrug resistance protein 3 0.0041 0.0302 0.0618
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0116 0.1275 0.1275
Loa Loa (eye worm) hypothetical protein 0.0025 0.0097 0.0216
Trichomonas vaginalis abcb9, putative 0.0041 0.0302 0.1218
Echinococcus multilocularis aminopeptidase N 0.0393 0.488 0.488
Echinococcus granulosus aminopeptidase N 0.0393 0.488 1
Trichomonas vaginalis Sentrin-specific protease, putative 0.0025 0.0097 0.0393
Plasmodium vivax sentrin-specific protease 1, putative 0.0025 0.0097 0.0365
Trypanosoma brucei p-glycoprotein 0.0041 0.03 0.2352
Onchocerca volvulus 0.0025 0.0097 0.0055
Brugia malayi ABC transporter family protein 0.0041 0.0302 0.0618
Loa Loa (eye worm) CYP4Cod1 0.0019 0.002 0.0045
Loa Loa (eye worm) hypothetical protein 0.0096 0.1014 0.2248
Echinococcus granulosus multidrug resistance associated protein 7 0.0041 0.03 0.0615
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0349 0.0349
Giardia lamblia Multidrug resistance-associated protein 1 0.0041 0.03 1
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0025 0.0097 0.0393
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0025 0.0097 0.02
Trichomonas vaginalis ABC transporter, putative 0.0041 0.0302 0.1218
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0071 0.0146
Loa Loa (eye worm) hypothetical protein 0.0041 0.0302 0.0669
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0041 0.0302 0.1218
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0107 0.0431
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0116 0.1275 0.515
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0116 0.1275 0.5252
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0305 0.0625
Giardia lamblia Multidrug resistance-associated protein 1 0.0041 0.03 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0096 0.1024 0.2099
Toxoplasma gondii aminopeptidase N, putative 0.0041 0.0301 0.1127
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0071 0.0266

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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