Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.015 | 0.0166 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.2135 | 0.3033 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0406 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.4683 | 0.4664 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0146 | 0.6045 | 0.6031 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0406 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.4683 | 0.4664 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.6045 | 0.6031 |
Echinococcus multilocularis | geminin | 0.0165 | 0.6956 | 0.6946 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.6956 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0198 | 0.0163 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.6045 | 0.6031 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0406 | 0.5 |
Brugia malayi | hypothetical protein | 0.0064 | 0.2256 | 0.2256 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.297 | 0.2945 |
Brugia malayi | bZIP transcription factor family protein | 0.0082 | 0.3075 | 0.3075 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0406 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0893 | 0.086 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0231 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1198 | 0.1166 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0285 | 0.025 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.2473 | 0.2446 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1972 | 0.1944 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1004 | 0.0972 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0231 | 1 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.015 | 0.0115 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.015 | 0.0115 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0406 | 0.0406 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0082 | 0.3075 | 0.305 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.1 | 0.1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0406 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.2667 | 0.2667 |
Brugia malayi | Muscleblind-like protein | 0.0146 | 0.6045 | 0.6045 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0406 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1111 | 0.1079 |
Echinococcus granulosus | geminin | 0.0165 | 0.6956 | 0.6946 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0198 | 0.0235 |
Echinococcus granulosus | jun protein | 0.0082 | 0.3075 | 0.305 |
Echinococcus multilocularis | muscleblind protein | 0.0146 | 0.6045 | 0.6031 |
Onchocerca volvulus | 0.0064 | 0.2256 | 1 | |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0406 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0406 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.1972 | 0.1944 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0893 | 0.086 |
Echinococcus multilocularis | jun protein | 0.0082 | 0.3075 | 0.305 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0285 | 0.025 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1451 | 0.2046 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0017 | 0.0063 | 0.0028 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0406 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0146 | 0.6045 | 0.6031 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1451 | 0.2046 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0285 | 0.036 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.4683 | 0.4683 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.236 | 0.3359 |
Schistosoma mansoni | jun-related protein | 0.0067 | 0.236 | 0.3359 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.6956 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0082 | 0.3075 | 0.305 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1451 | 0.1451 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.0392 | 0.0392 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | 0 % | In vivo inhibition of 10 nmole/kg PAF-induced plasma N-acetyl-beta-glucosaminidase (NAGA) after oral administration to rats; Not done | ChEMBL. | No reference |
Inhibition (functional) | 0 % | In vivo inhibition of 10 nmole/kg PAF-induced hemoconcentration was determined at 1 mg/kg peroral administration of the compound in rats; ; Not done | ChEMBL. | No reference |
Inhibition (binding) | = 57 % | In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor. | ChEMBL. | No reference |
Inhibition (binding) | = 57 % | In vitro inhibition of [3H]-C18 PAF binding to human platelet membrane Platelet activating factor receptor. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.