Detailed information for compound 814071

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 495.566 | Formula: C26H26FN3O4S
  • H donors: 1 H acceptors: 5 LogP: 2.39 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C(=O)CCC(=O)N1CCc2c(C1)cnc(c2CNS(=O)(=O)c1ccccc1)C
  • InChi: 1S/C26H26FN3O4S/c1-18-24(16-29-35(33,34)22-5-3-2-4-6-22)23-13-14-30(17-20(23)15-28-18)26(32)12-11-25(31)19-7-9-21(27)10-8-19/h2-10,15,29H,11-14,16-17H2,1H3
  • InChiKey: YCLFTYNMUDCCGX-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.1675 0.1672
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0042 0.0014
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0249 0.1724 0.1721
Echinococcus granulosus aryl hydrocarbon receptor 0.0025 0.0042 0.0038
Echinococcus granulosus MORC family CW type zinc finger protein 2B 0.0023 0.0027 0.0024
Leishmania major heat shock protein 83-1 0.135 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0113 0.011
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0249 0.1724 0.3358
Plasmodium falciparum heat shock protein 90 0.135 1 1
Brugia malayi Protein kinase domain containing protein 0.0049 0.0223 0.0219
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0238 0.0234
Giardia lamblia Heat shock protein HSP 90-alpha 0.1102 0.8133 0.8128
Echinococcus multilocularis epidermal growth factor receptor 0.0082 0.0473 0.0469
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0042 0.0038
Schistosoma mansoni hypothetical protein 0.0049 0.0227 0.0224
Echinococcus multilocularis aryl hydrocarbon receptor 0.0025 0.0042 0.0038
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0249 0.1724 0.1721
Echinococcus multilocularis geminin 0.0346 0.2455 0.2452
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0202 0.0175
Trichomonas vaginalis receptor histidine kinase, putative 0.0249 0.1724 0.1721
Echinococcus granulosus microtubule associated protein 2 0.0706 0.5163 0.5161
Mycobacterium leprae Probable two-component sensor kinase 0.0249 0.1724 0.2036
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0249 0.1724 0.1047
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2104 0.2101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0039
Loa Loa (eye worm) TK/EGFR protein kinase 0.0153 0.1003 0.1
Trypanosoma brucei heat shock protein, putative 0.135 1 1
Loa Loa (eye worm) hypothetical protein 0.0249 0.1724 0.1721
Mycobacterium tuberculosis Probable two component sensor kinase 0.0249 0.1724 0.1047
Leishmania major heat shock protein 83-1 0.135 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2104 0.2101
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.0056
Trichomonas vaginalis heat shock protein, putative 0.0828 0.6079 0.6078
Brugia malayi intermediate filament protein 0.0028 0.0064 0.006
Mycobacterium leprae Probable two component sensor kinase MprB 0.0249 0.1724 0.2036
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0131 0.0128
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0202 0.0175
Onchocerca volvulus 0.0242 0.1678 0.3267
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0249 0.1724 0.1721
Echinococcus granulosus intermediate filament protein 0.0028 0.0064 0.006
Trypanosoma cruzi heat shock protein 90, putative 0.135 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.1102 0.8133 0.8128
Leishmania major protein kinase, putative 0.0025 0.0042 0.0014
Echinococcus multilocularis heat shock protein 90 0.1102 0.8133 0.8132
Brugia malayi hypothetical protein 0.0242 0.1675 0.1672
Schistosoma mansoni hypothetical protein 0.0023 0.0027 0.0024
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0049 0.0223 0.0219
Chlamydia trachomatis DNA gyrase subunit B 0.0249 0.1724 0.9016
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0249 0.1724 0.1047
Plasmodium falciparum DNA topoisomerase 2 0.0249 0.1724 0.1701
Trypanosoma brucei heat shock protein 90, putative 0.135 1 1
Trypanosoma brucei mismatch repair protein MLH1 0.0023 0.0027 0.0027
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0117 0.0113
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0249 0.1724 0.1721
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0249 0.1724 0.1047
Schistosoma mansoni intermediate filament proteins 0.0028 0.0064 0.006
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0049 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0202 0.0198
Schistosoma mansoni hypothetical protein 0.0346 0.2455 0.2452
Giardia lamblia GTOR 0.0046 0.0202 0.0175
Trypanosoma cruzi heat shock protein 90, putative 0.0771 0.5645 0.5633
Trypanosoma cruzi heat shock protein 85, putative 0.135 1 1
Trypanosoma brucei heat shock protein, putative 0.135 1 1
Trichomonas vaginalis mismatch repair protein Pms1 (mutL homolog) 0.0023 0.0027 0.0024
Echinococcus multilocularis endoplasmin 0.1125 0.8304 0.8303
Schistosoma mansoni microtubule-associated protein tau 0.0706 0.5163 0.5161
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0249 0.1724 0.2036
Brugia malayi DNA mismatch repair protein MutL containing protein 0.0023 0.0027 0.0024
Leishmania major heat shock protein 83-1 0.135 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0039
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0064 0.006
Echinococcus granulosus geminin 0.0346 0.2455 0.2452
Plasmodium falciparum endoplasmin, putative 0.0828 0.6079 0.6068
Loa Loa (eye worm) hypothetical protein 0.0051 0.0238 0.0234
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0202 0.0198
Schistosoma mansoni tyrosine kinase 0.0049 0.0223 0.0219
Trichomonas vaginalis set domain proteins, putative 0.0242 0.1678 0.1675
Schistosoma mansoni endoplasmin 0.135 1 1
Brugia malayi Pre-SET motif family protein 0.0213 0.1457 0.1454
Schistosoma mansoni Microrchidia 2a 0.0023 0.0027 0.0024
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0025 0.0042 0.0038
Entamoeba histolytica DNA topoisomerase II, putative 0.0249 0.1724 0.1721
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0042 0.0038
Echinococcus multilocularis epidermal growth factor receptor 0.0153 0.1003 0.1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0202 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0061 0.0057
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0042 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0152 0.0148
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0249 0.1724 0.1724
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0025 0.0042 0.0014
Trypanosoma brucei heat shock protein, putative 0.135 1 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0249 0.1724 0.1701
Leishmania major heat shock protein 83-1 0.135 1 1
Trichomonas vaginalis DNA topoisomerase II, putative 0.0249 0.1724 0.1721
Echinococcus granulosus lamin 0.0028 0.0064 0.006
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0249 0.1724 0.205
Schistosoma mansoni tyrosine kinase 0.0081 0.0466 0.0462
Trypanosoma brucei heat shock protein, putative 0.135 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0049 0.0022
Echinococcus granulosus expressed protein 0.0382 0.2727 0.2724
Leishmania major heat shock protein 83-1 0.135 1 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0249 0.1724 0.1721
Leishmania major heat shock protein 83-1 0.135 1 1
Leishmania major heat shock protein 83-1 0.135 1 1
Leishmania major hypothetical protein, conserved 0.0249 0.1724 0.1701
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0249 0.1724 0.1701
Trichomonas vaginalis receptor histidine kinase, putative 0.0249 0.1724 0.1721
Plasmodium vivax endoplasmin, putative 0.135 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.1675 0.1672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0039
Trichomonas vaginalis adenylate cyclase, putative 0.0025 0.0042 0.0038
Onchocerca volvulus 0.007 0.0383 0.0683
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0692 0.5051 0.5049
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.002 0.002
Brugia malayi Hsp90 protein 0.0692 0.5051 0.5049
Trypanosoma cruzi heat shock protein 85, putative 0.1102 0.8133 0.8128
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.1125 0.8304 1
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0038
Toxoplasma gondii heat shock protein 90, putative 0.135 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.135 1 1
Plasmodium vivax DNA topoisomerase II, putative 0.0249 0.1724 0.1701
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0249 0.1724 0.1692
Loa Loa (eye worm) heat shock protein 75 0.0692 0.5051 0.5049
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0249 0.1724 0.1692
Brugia malayi hypoxia-induced factor 1 0.0293 0.206 0.2057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0086 0.0082
Mycobacterium tuberculosis Conserved protein 0.0249 0.1724 0.1047
Loa Loa (eye worm) hypothetical protein 0.0249 0.1724 0.1721
Mycobacterium tuberculosis Possible two component sensor kinase 0.0249 0.1724 0.1047
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0049 0.0223 0.0219
Trichomonas vaginalis heat shock protein, putative 0.1125 0.8304 0.8303
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0249 0.1724 0.1692
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0249 0.1724 0.1692
Schistosoma mansoni tyrosine kinase 0.0153 0.1003 0.1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0063 0.0059
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0086 0.0082
Trypanosoma brucei heat shock protein, putative 0.135 1 1
Schistosoma mansoni pyruvate dehydrogenase 0.0249 0.1724 0.1721
Echinococcus multilocularis expressed protein 0.0382 0.2727 0.2724
Leishmania major heat shock protein 83-1 0.135 1 1
Trypanosoma brucei heat shock protein, putative 0.135 1 1
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0249 0.1724 0.1701
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0086 0.0082
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0132 0.0132
Schistosoma mansoni DNA mismatch repair protein MLH1 0.0023 0.0027 0.0024
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0249 0.1724 0.1721
Brugia malayi heat shock protein 90 0.135 1 1
Trichomonas vaginalis heat shock protein, putative 0.1125 0.8304 0.8303
Trypanosoma cruzi heat shock protein 85, putative 0.135 1 1
Mycobacterium ulcerans putative regultory protein 0.0249 0.1724 0.1692
Trypanosoma cruzi heat shock protein, putative 0.0692 0.5051 0.5037
Brugia malayi Furin-like cysteine rich region family protein 0.0153 0.1003 0.1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0202 0.0202
Echinococcus multilocularis 0.0047 0.0211 0.0208
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0692 0.5051 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0025 0.0042 0.0038
Brugia malayi PAS domain containing protein 0.0095 0.0568 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2104 0.2101
Schistosoma mansoni lamin 0.0028 0.0064 0.006
Schistosoma mansoni endoplasmin 0.135 1 1
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0064 0.006
Trypanosoma cruzi DNA topoisomerase II, putative 0.0249 0.1724 0.1701
Trypanosoma brucei heat shock protein 90, putative 0.135 1 1
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0249 0.1724 0.1047
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0025 0.0042 0.0038
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0202 0.0202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0061 0.0057
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.1125 0.8304 1
Loa Loa (eye worm) hypothetical protein 0.0242 0.1675 0.1672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0039
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.0954 0.1105
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2104 0.2101
Echinococcus granulosus endoplasmin 0.1125 0.8304 0.8303
Schistosoma mansoni survival motor neuron protein 0.0049 0.0227 0.0224
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0249 0.1724 0.1721
Schistosoma mansoni DNA topoisomerase II 0.0249 0.1724 0.1721
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0202 0.0198
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0249 0.1724 0.205
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0042 0.0014
Treponema pallidum heat shock protein 90 0.1125 0.8304 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.0954 0.0721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0131 0.0128
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0249 0.1724 0.2036
Onchocerca volvulus 0.0049 0.0227 0.0371
Echinococcus multilocularis heat shock protein 90 0.135 1 1
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0249 0.1724 0.205
Leishmania major heat shock protein 83-1 0.135 1 1
Onchocerca volvulus 0.0028 0.0064 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0063 0.0059
Schistosoma mansoni tyrosine kinase 0.0082 0.0473 0.0469
Trichomonas vaginalis heat shock protein, putative 0.058 0.4212 0.421
Entamoeba histolytica heat shock protein 90, putative 0.135 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0202 0.0198
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0042 0.0014
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0025 0.0042 0.0038
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0249 0.1724 0.1701
Plasmodium vivax hypothetical protein, conserved 0.0249 0.1724 0.1701
Onchocerca volvulus 0.0028 0.0064 0.0045
Leishmania major developmentally regulated phosphoprotein-like protein 0.0249 0.1724 0.1701
Chlamydia trachomatis DNA gyrase subunit B 0.0249 0.1724 0.9016
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0086 0.0082
Schistosoma mansoni heat shock protein 0.135 1 1
Leishmania major DNA topoisomerase ii 0.0249 0.1724 0.1701
Echinococcus granulosus epidermal growth factor receptor 0.0082 0.0473 0.0469
Entamoeba histolytica DNA mismatch repair protein MLH1, putative 0.0023 0.0027 0.0024
Leishmania major hypothetical protein, conserved 0.0026 0.0049 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0131 0.0128
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0202 0.0198
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0113 0.011
Echinococcus granulosus insulin receptor 0.0049 0.0223 0.0219
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0249 0.1724 0.1701
Schistosoma mansoni hypothetical protein 0.0023 0.0027 0.0024
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.2104 0.2509
Echinococcus multilocularis lamin dm0 0.0028 0.0064 0.006
Toxoplasma gondii heat shock protein 75, putative 0.0692 0.5051 0.5037
Loa Loa (eye worm) TOPoisomerase family member 0.0249 0.1724 0.1721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0039
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0249 0.1724 0.3358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0113 0.011
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0202 0.0198
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0249 0.1724 0.1721
Trypanosoma cruzi DNA topoisomerase II, putative 0.0249 0.1724 0.1701
Echinococcus multilocularis transfer RNA-Lys 0.007 0.0383 0.038
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0038
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0238 0.0234
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0064 0.006
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0025 0.0042 0.0038
Plasmodium vivax heat shock protein 86, putative 0.135 1 1
Trypanosoma brucei DNA topoisomerase ii 0.0249 0.1724 0.1724
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0132 0.0104
Trypanosoma brucei Heat shock protein 83, putative 0.135 1 1
Trichomonas vaginalis mismatch repair protein Mlh2 (mutL homolog) 0.0023 0.0027 0.0024
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0249 0.1724 0.205
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0049 0.0022
Plasmodium falciparum heat shock protein 90, putative 0.0669 0.488 0.4866
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0249 0.1724 0.1047
Leishmania major protein kinase, putative 0.0025 0.0042 0.0014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0086 0.0082
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0042 0.0014
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0249 0.1724 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0131 0.0128
Schistosoma mansoni aryl hydrocarbon receptor 0.0095 0.0568 0.0565
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.1102 0.8133 0.8132
Echinococcus granulosus heat shock protein 0.135 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0113 0.011
Trichomonas vaginalis heat shock protein, putative 0.135 1 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0086 0.0082
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0025 0.0042 0.0014
Brugia malayi kinase, mitochondrial precursor 0.0249 0.1724 0.1721
Leishmania major heat shock protein 83-1 0.135 1 1
Plasmodium falciparum heat shock protein 90, putative 0.0603 0.4383 0.4367
Loa Loa (eye worm) hypothetical protein 0.0035 0.0117 0.0113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0049 0.0045
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0249 0.1724 0.1692
Toxoplasma gondii DNA topoisomerase 2, putative 0.0249 0.1724 0.1701
Schistosoma mansoni lamin 0.0028 0.0064 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0063 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0081 0.0077
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0078 0.0074
Leishmania major heat shock protein 83-1 0.135 1 1
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0025 0.0042 0.0038
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0025 0.0042 0.0014
Leishmania major heat shock protein 83-1 0.135 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.2104 0.2101
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0249 0.1724 0.1692
Plasmodium vivax heat shock protein 90, putative 0.0692 0.5051 0.5037
Schistosoma mansoni heat shock protein 0.0692 0.5051 0.5049
Trypanosoma brucei heat shock protein, putative 0.135 1 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0249 0.1724 0.1721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0088 0.0084
Mycobacterium ulcerans heat shock protein 90 0.1125 0.8304 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0202 0.0198
Schistosoma mansoni hypothetical protein 0.0346 0.2455 0.2452
Brugia malayi Probable DNA topoisomerase II 0.0249 0.1724 0.1721
Schistosoma mansoni hypothetical protein 0.0053 0.0254 0.025
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0249 0.1724 0.1721
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0086 0.0059
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0603 0.4383 0.4381
Trypanosoma cruzi Heat shock protein 83, putative 0.135 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0049 0.0049
Trypanosoma cruzi heat shock protein 85, putative 0.135 1 1
Schistosoma mansoni microrchidia 2a 0.0023 0.0027 0.0024
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0202 0.0175
Leishmania major heat shock protein, putative 0.0692 0.5051 0.5037
Plasmodium falciparum DNA gyrase subunit B 0.0249 0.1724 0.1701
Echinococcus granulosus lamin dm0 0.0028 0.0064 0.006
Brugia malayi bHLH-PAS transcription factor 0.007 0.0383 0.038
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0049 0.0022
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0082 0.0473 0.0469
Trypanosoma brucei heat shock protein, putative 0.135 1 1
Giardia lamblia Pms1-like protein 0.0249 0.1724 0.1701
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0249 0.1724 0.1692
Leishmania major mitochondrial DNA topoisomerase II 0.0249 0.1724 0.1701
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0299 0.2104 0.2101
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0249 0.1724 0.1047
Leishmania major heat shock protein 83-1 0.135 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0049 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0113 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0202 0.0198
Trypanosoma brucei developmentally regulated phosphoprotein 0.0249 0.1724 0.1724
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0132 0.0104
Trichomonas vaginalis sensor histidine kinase, putative 0.0249 0.1724 0.1721
Plasmodium vivax DNA gyrase subunit B, putative 0.0249 0.1724 0.1701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0113 0.011
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0249 0.1724 0.1047
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0249 0.1724 0.1724
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0249 0.1724 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0043 0.0039
Loa Loa (eye worm) hypothetical protein 0.0025 0.0042 0.0038
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.1125 0.8304 1
Mycobacterium ulcerans two component sensor kinase MprB 0.0249 0.1724 0.1692
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0249 0.1724 0.1047
Schistosoma mansoni single-minded 0.0095 0.0568 0.0565
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2104 0.2101
Schistosoma mansoni tyrosine kinase 0.0081 0.0466 0.0462
Loa Loa (eye worm) hypoxia-induced factor 1 0.0293 0.206 0.2057
Leishmania major heat shock protein 83-1 0.135 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0227 0.0224
Brugia malayi hypothetical protein 0.0318 0.2245 0.2242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0113 0.011
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0692 0.5051 0.5049
Trichomonas vaginalis mismatch repair protein Mlh1B (mutL homolog) 0.0023 0.0027 0.0024
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0249 0.1724 0.1701
Echinococcus multilocularis MORC family CW type zinc finger protein 2B 0.0023 0.0027 0.0024
Echinococcus multilocularis insulin receptor 0.0049 0.0223 0.0219
Loa Loa (eye worm) TK/INSR protein kinase 0.0049 0.0223 0.0219
Loa Loa (eye worm) hypothetical protein 0.0249 0.1724 0.1721
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0202 0.0198
Echinococcus multilocularis microtubule associated protein 2 0.0706 0.5163 0.5161
Echinococcus multilocularis heat shock protein 0.135 1 1
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0249 0.1724 0.1724
Mycobacterium ulcerans two component regulator - sensor kinase 0.0249 0.1724 0.1692
Echinococcus granulosus heat shock protein 90 0.135 1 1
Loa Loa (eye worm) heat shock protein 90 0.135 1 1
Loa Loa (eye worm) endoplasmin 0.135 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0113 0.0086
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.2104 0.2082
Schistosoma mansoni hypothetical protein 0.0035 0.0117 0.0113
Echinococcus multilocularis lamin 0.0028 0.0064 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0042 0.0038
Toxoplasma gondii Hsp90 domain-containing protein 0.0603 0.4383 0.4367
Schistosoma mansoni tyrosine kinase 0.0049 0.0223 0.0219
Entamoeba histolytica heat shock protein 90, putative 0.135 1 1
Trypanosoma brucei heat shock protein 84, putative 0.0692 0.5051 0.5051
Schistosoma mansoni tyrosine kinase 0.0082 0.0473 0.0469
Schistosoma mansoni tyrosine kinase 0.0081 0.0466 0.0462
Plasmodium vivax SET domain protein, putative 0.0031 0.0086 0.0059
Onchocerca volvulus 0.0031 0.0086 0.0089
Trypanosoma brucei mismatch repair protein PMS1, putative 0.0023 0.0027 0.0027
Echinococcus granulosus DNA mismatch repair protein Mlh1 0.0023 0.0027 0.0024
Entamoeba histolytica DNA mismatch repair protein PMS1, putative 0.0023 0.0027 0.0024
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0249 0.1724 0.1721
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1457 0.1454
Loa Loa (eye worm) hypothetical protein 0.0028 0.0064 0.006
Brugia malayi hypothetical protein 0.0026 0.0049 0.0045
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0249 0.1724 0.1721
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2104 0.2101
Trichomonas vaginalis mismatch repair protein Mlh3 (mutL homolog) 0.0023 0.0027 0.0024
Schistosoma mansoni DNA mismatch repair protein PMS2 0.0023 0.0027 0.0024
Leishmania major heat shock protein 83-1 0.135 1 1
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0273 0.1909 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0249 0.1724 0.1692
Trichomonas vaginalis guanylate cyclase, putative 0.0025 0.0042 0.0038
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0049 0.0022
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.1125 0.8304 0.8299
Echinococcus granulosus single minded 2 0.007 0.0383 0.038
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0249 0.1724 0.1701
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2104 0.2101
Echinococcus multilocularis DNA mismatch repair protein Mlh1 0.0023 0.0027 0.0024
Leishmania major heat shock protein 83-1 0.135 1 1
Trichomonas vaginalis heat shock protein, putative 0.1102 0.8133 0.8132
Giardia lamblia Grp94/Hsp90 0.1125 0.8304 0.8299
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0249 0.1724 0.1047
Loa Loa (eye worm) hypothetical protein 0.0318 0.2245 0.2242
Loa Loa (eye worm) hypothetical protein 0.0023 0.0027 0.0024
Brugia malayi DNA mismatch repair protein MutL containing protein 0.0023 0.0027 0.0024
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0238 0.0234
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0249 0.1724 0.1701
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0249 0.1724 0.3358
Echinococcus multilocularis musashi 0.0028 0.0064 0.006
Leishmania major heat shock protein 83-1 0.135 1 1
Trichomonas vaginalis endoplasmin, putative 0.0828 0.6079 0.6078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.2104 0.2101
Plasmodium vivax heat shock protein, putative 0.0603 0.4383 0.4367
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0249 0.1724 0.205
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0202 0.0175
Schistosoma mansoni heat shock protein 0.135 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0131 0.0128
Echinococcus granulosus heat shock protein 90 0.1102 0.8133 0.8132
Mycobacterium ulcerans DNA gyrase subunit B 0.0249 0.1724 0.1692
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0086 0.0082
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0086 0.0082
Echinococcus granulosus epidermal growth factor receptor 0.0153 0.1003 0.1
Toxoplasma gondii heat shock protein HSP90 0.135 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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