Detailed information for compound 81528

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 457.439 | Formula: C25H30Cl2N4
  • H donors: 0 H acceptors: 2 LogP: 5.44 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cn1)C1CC2N(C1CC2)CCCN1C2CCC1C(C2)c1ccc(nc1)Cl
  • InChi: 1S/C25H30Cl2N4/c26-24-8-2-16(14-28-24)20-12-18-4-6-22(20)30(18)10-1-11-31-19-5-7-23(31)21(13-19)17-3-9-25(27)29-15-17/h2-3,8-9,14-15,18-23H,1,4-7,10-13H2
  • InChiKey: OIVBEDQUKPTTRJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta2 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta4 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta4 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha3/beta4 Starlite/ChEMBL References
Rattus norvegicus Neuronal acetylcholine receptor; alpha2/beta2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus 39S ribosomal protein L13, mitochondrial homolog Neuronal acetylcholine receptor; alpha3/beta2   500 aa 463 aa 36.1 %
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative Neuronal acetylcholine receptor; alpha3/beta2   500 aa 492 aa 39.8 %
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative Neuronal acetylcholine receptor; alpha3/beta2   500 aa 502 aa 34.7 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha3/beta2   500 aa 463 aa 36.1 %
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) Neuronal acetylcholine receptor; alpha3/beta2   500 aa 486 aa 24.3 %
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 Neuronal acetylcholine receptor; alpha3/beta4   499 aa 569 aa 25.5 %
Brugia malayi acetylcholine receptor alpha subunit precursor, putative Neuronal acetylcholine receptor; alpha3/beta2   500 aa 510 aa 38.6 %
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 487 aa 34.3 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha3/beta2   500 aa 477 aa 39.2 %
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein Neuronal acetylcholine receptor; alpha3/beta2   500 aa 532 aa 24.2 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha2/beta4   495 aa 502 aa 40.0 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha3/beta4   499 aa 549 aa 24.0 %
Onchocerca volvulus Neuronal acetylcholine receptor; alpha3/beta2   500 aa 500 aa 33.8 %
Schistosoma mansoni nAChR subunit Neuronal acetylcholine receptor; alpha3/beta4   499 aa 538 aa 24.9 %
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 481 aa 38.0 %
Loa Loa (eye worm) acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 524 aa 38.7 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor; alpha3/beta2   500 aa 516 aa 42.1 %
Schistosoma japonicum Neuronal acetylcholine receptor subunit alpha-3 precursor, putative Neuronal acetylcholine receptor; alpha2/beta4   495 aa 501 aa 23.4 %
Onchocerca volvulus Putative zinc finger protein Neuronal acetylcholine receptor; alpha3/beta2   500 aa 509 aa 40.3 %
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 507 aa 37.9 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor; alpha3/beta2   500 aa 482 aa 42.5 %
Brugia malayi Cation transporter family protein Neuronal acetylcholine receptor; alpha3/beta2   500 aa 482 aa 32.8 %
Drosophila melanogaster nicotinic Acetylcholine Receptor alpha2 Neuronal acetylcholine receptor; alpha3/beta2   500 aa 511 aa 40.9 %
Loa Loa (eye worm) hypothetical protein Neuronal acetylcholine receptor; alpha3/beta2   500 aa 521 aa 40.1 %
Echinococcus multilocularis nAChR subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 476 aa 30.3 %
Schistosoma mansoni nAChR subunit Neuronal acetylcholine receptor; alpha3/beta4   499 aa 546 aa 26.0 %
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor Neuronal acetylcholine receptor; alpha3/beta2   500 aa 476 aa 41.4 %
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 Neuronal acetylcholine receptor; alpha3/beta4   499 aa 569 aa 25.8 %
Onchocerca volvulus Acetylcholine receptor subunit alpha-type homolog Neuronal acetylcholine receptor; alpha3/beta2   500 aa 482 aa 42.5 %
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 508 aa 34.3 %
Echinococcus granulosus acetylcholine receptor subunit beta 1 Neuronal acetylcholine receptor; alpha3/beta4   499 aa 523 aa 35.9 %
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit Neuronal acetylcholine receptor; alpha3/beta2   500 aa 491 aa 37.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0058 0.0123 0.0123
Brugia malayi hypothetical protein 0.0075 0.0244 0.0244
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0244 0.0473
Echinococcus multilocularis neuropeptide s receptor 0.0075 0.0244 0.0473
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0128 0.0618 0.0618
Schistosoma mansoni high-affinity choline transporter 0.0354 0.2215 0.9633
Schistosoma mansoni myosin xvIII 0.0075 0.0244 0.1061
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0128 0.0618 0.0618
Echinococcus granulosus follistatin 0.0062 0.0151 0.0221
Brugia malayi MAP kinase sur-1 0.0099 0.0412 0.0412
Brugia malayi RE15519p 0.0075 0.0244 0.0244
Entamoeba histolytica hypothetical protein 0.0069 0.0201 0.5
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0128 0.0618 0.12
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.0821 0.0821
Echinococcus multilocularis G protein coupled receptor 139 0.0075 0.0244 0.0473
Loa Loa (eye worm) hypothetical protein 0.0058 0.0123 0.0123
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.0244 0.0358
Schistosoma mansoni neurotransmitter gated ion channel 0.0069 0.0201 0.0876
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0075 0.0244 0.0473
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Brugia malayi photoreceptor-specific nuclear receptor 0.0058 0.0123 0.0123
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0128 0.0618 0.12
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0201
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0059 0.0131 0.0255
Loa Loa (eye worm) hypothetical protein 0.0354 0.2215 0.2215
Schistosoma mansoni alpha-1 adrenergic receptor 0.0075 0.0244 0.1061
Schistosoma mansoni amine GPCR 0.0075 0.0244 0.1061
Echinococcus granulosus tachykinin peptides receptor 99D 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0107 0.0471 0.0471
Giardia lamblia Kinase, CMGC MAPK 0.0099 0.0412 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0123 0.0123
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0244 0.1061
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0075 0.0244 0.1061
Brugia malayi Serotonin receptor 0.0075 0.0244 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0043 0.0189
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0128 0.0618 0.269
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0128 0.0618 0.0908
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Echinococcus granulosus neuropeptide receptor 0.0075 0.0244 0.0358
Onchocerca volvulus 0.0059 0.0131 0.0039
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0058 0.0123 0.0536
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0043 0.0189
Echinococcus multilocularis serotonin receptor 0.0075 0.0244 0.0473
Onchocerca volvulus 0.0075 0.0244 0.0153
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0043 0.0064
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0151 0.0151
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0128 0.0618 0.0618
Brugia malayi Steroid receptor seven-up type 2 0.0058 0.0123 0.0123
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0244 0.0358
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0128 0.0618 0.269
Onchocerca volvulus 0.0075 0.0244 0.0153
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0128 0.0618 0.0908
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0131 0.0131
Echinococcus multilocularis lamin 0.0054 0.0092 0.0179
Echinococcus granulosus peptide allatostatin:somatostatin 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0058 0.0123 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0123 0.0123
Schistosoma mansoni organic anion transporter 0.0176 0.0959 0.417
Loa Loa (eye worm) hypothetical protein 0.0058 0.0123 0.0123
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni acetylcholine receptor-related 0.0059 0.0131 0.0571
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Brugia malayi G protein-coupled receptor F59B2.13 0.0075 0.0244 0.0244
Echinococcus granulosus mitogen activated protein kinase 3 0.0099 0.0412 0.0604
Echinococcus multilocularis fmrfamide receptor 0.0075 0.0244 0.0473
Brugia malayi Cation transporter family protein 0.0128 0.0618 0.0618
Onchocerca volvulus 0.0059 0.0131 0.0039
Brugia malayi sodium-independent organic anion transporter family protein 0.0176 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0058 0.0123 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0043 0.0189
Brugia malayi Tachykinin-like peptides receptor 99D 0.0075 0.0244 0.0244
Echinococcus granulosus 7tm_1 domain containing protein 0.0075 0.0244 0.0358
Onchocerca volvulus 0.0075 0.0244 0.0153
Echinococcus multilocularis GPCR, family 2 0.005 0.0064 0.0125
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.0244 0.0473
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0064 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0128 0.0618 0.269
Schistosoma mansoni steroid hormone receptor ad4bp 0.0058 0.0123 0.0536
Brugia malayi hypothetical protein 0.0059 0.0131 0.0131
Brugia malayi hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi secreted modular calcium-binding protein 1 0.0062 0.0151 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0933 0.4495
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0092 0.0092
Loa Loa (eye worm) TYRA-2 protein 0.0075 0.0244 0.0244
Echinococcus granulosus Solute carrier family 22 5 0.1005 0.6814 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Onchocerca volvulus 0.0176 0.0959 0.0874
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0075 0.0244 0.0473
Echinococcus multilocularis dro:myosuppressin receptor 0.0075 0.0244 0.0473
Onchocerca volvulus 0.0075 0.0244 0.0153
Toxoplasma gondii transporter, major facilitator family protein 0.0176 0.0959 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Onchocerca volvulus 0.0176 0.0959 0.0874
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0058 0.0123 0.0536
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi Dopamine receptor protein 2 0.0075 0.0244 0.0244
Echinococcus multilocularis allatostatin A receptor 0.0075 0.0244 0.0473
Schistosoma mansoni follistatin 0.0062 0.0151 0.0656
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0131 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0058 0.0123 0.0123
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0069 0.0201 0.0201
Onchocerca volvulus Protein ultraspiracle homolog 0.0058 0.0123 0.0031
Echinococcus granulosus neuropeptide receptor 0.0075 0.0244 0.0358
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0128 0.0618 0.12
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0201
Echinococcus granulosus serotonin receptor 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0201
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0069 0.0201 0.0876
Schistosoma mansoni hypothetical protein 0.0075 0.0244 0.1061
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0128 0.0618 0.12
Echinococcus granulosus alpha 1A adrenergic receptor 0.0075 0.0244 0.0358
Onchocerca volvulus 0.0069 0.0201 0.011
Schistosoma mansoni neuropeptide receptor 0.0075 0.0244 0.1061
Loa Loa (eye worm) hypothetical protein 0.0479 0.31 0.31
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0075 0.0244 0.0358
Schistosoma mansoni neuropeptide receptor 0.0075 0.0244 0.1061
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0933 0.4495
Schistosoma mansoni retinoic acid receptor RXR 0.0058 0.0123 0.0536
Brugia malayi hypothetical protein 0.0059 0.0131 0.0131
Echinococcus granulosus glycine receptor subunit beta 0.0128 0.0618 0.0908
Echinococcus multilocularis Protein lozenge 0.006 0.0139 0.027
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0128 0.0618 0.0618
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0092 0.0092
Schistosoma mansoni nuclear hormone receptor 0.0058 0.0123 0.0536
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0075 0.0244 0.0473
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Schistosoma mansoni coup transcription factor 0.0058 0.0123 0.0536
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0058 0.0123 0.0123
Brugia malayi G-protein coupled receptor 0.0075 0.0244 0.0244
Schistosoma mansoni histamine h1 receptor 0.0075 0.0244 0.1061
Brugia malayi follicle stimulating hormone receptor 0.052 0.3392 0.3392
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.0244 0.1061
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0123 0.0123
Echinococcus granulosus lamin 0.0054 0.0092 0.0136
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0099 0.0412 0.5
Echinococcus granulosus G protein coupled receptor 139 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0157 0.0821 0.0821
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0059 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) agrin synaptic family protein 0.0062 0.0151 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0058 0.0123 0.0123
Brugia malayi Cation transporter family protein 0.0128 0.0618 0.0618
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0933 0.4495
Echinococcus granulosus allatostatin A receptor 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Onchocerca volvulus 0.0128 0.0618 0.0531
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0128 0.0618 0.269
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0075 0.0244 0.0473
Onchocerca volvulus 0.0062 0.0151 0.0059
Loa Loa (eye worm) hypothetical protein 0.0054 0.0092 0.0092
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0128 0.0618 0.0618
Schistosoma mansoni neuropeptide receptor 0.0075 0.0244 0.1061
Onchocerca volvulus 0.0176 0.0959 0.0874
Brugia malayi sodium-independent organic anion transporter family protein 0.0176 0.0959 0.0959
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0412 0.179
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Echinococcus granulosus intermediate filament protein 0.0054 0.0092 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0933 0.4495
Echinococcus granulosus sex peptide receptor 0.0075 0.0244 0.0358
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0128 0.0618 0.0618
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0058 0.0123 0.0123
Echinococcus granulosus 7TM GPCR rhodopsin 0.0075 0.0244 0.0358
Onchocerca volvulus 0.0075 0.0244 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0244 0.0473
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1572 1
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.0244 0.0473
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0059 0.0131 0.0193
Onchocerca volvulus 0.0128 0.0618 0.0531
Schistosoma mansoni hypothetical protein 0.005 0.0064 0.028
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0652 0.2838
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0123 0.0239
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0128 0.0618 0.0618
Echinococcus granulosus neuropeptide s receptor 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0158 0.0828 0.0828
Brugia malayi PAS domain containing protein 0.0047 0.0046 0.0046
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0244 0.1061
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0075 0.0244 0.0244
Onchocerca volvulus 0.0075 0.0244 0.0153
Echinococcus granulosus GPCR family 2 0.005 0.0064 0.0094
Onchocerca volvulus 0.0075 0.0244 0.0153
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0201
Echinococcus granulosus dro:myosuppressin receptor 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0176 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0201
Echinococcus multilocularis nAChR subunit 0.0128 0.0618 0.12
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Echinococcus multilocularis neuropeptide receptor 0.0075 0.0244 0.0473
Brugia malayi Cation transporter family protein 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0176 0.0959 0.0959
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0069 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni hypothetical protein 0.005 0.0064 0.028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0128 0.0618 0.0618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0058 0.0123 0.0123
Brugia malayi nuclear hormone receptor 0.0058 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.0244 0.0473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0244 0.1061
Brugia malayi neuropeptide F receptor 0.0075 0.0244 0.0244
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0059 0.0131 0.0131
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0075 0.0244 0.0244
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0244 0.0358
Onchocerca volvulus 0.0128 0.0618 0.0531
Brugia malayi AKH receptor 0.0075 0.0244 0.0244
Brugia malayi hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi hypothetical protein 0.0479 0.31 0.31
Schistosoma mansoni RAR-like nuclear receptor 0.0058 0.0123 0.0536
Schistosoma mansoni hypothetical protein 0.0075 0.0244 0.1061
Echinococcus granulosus Solute carrier organic anion transporter family 0.0176 0.0959 0.1407
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0123 0.0123
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.0244 0.0473
Loa Loa (eye worm) hypothetical protein 0.0058 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0107 0.0471 0.2047
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0128 0.0618 0.0618
Brugia malayi sulfakinin receptor protein 0.0075 0.0244 0.0244
Onchocerca volvulus 0.0075 0.0244 0.0153
Brugia malayi Latrophilin receptor protein 2 0.005 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi putative neuropeptide receptor NPR1 0.0075 0.0244 0.0244
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0058 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Brugia malayi Nuclear hormone receptor-like 1 0.0058 0.0123 0.0123
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0244 0.0473
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Onchocerca volvulus 0.0069 0.0201 0.011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0058 0.0123 0.0536
Echinococcus multilocularis glycine receptor subunit beta 0.0128 0.0618 0.12
Echinococcus multilocularis orexin receptor type 2 0.0075 0.0244 0.0473
Echinococcus multilocularis high affinity choline transporter 1 0.0354 0.2215 0.4297
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0058 0.0123 0.0536
Echinococcus multilocularis neuropeptide receptor 0.0075 0.0244 0.0473
Brugia malayi ecdysteroid receptor 0.0058 0.0123 0.0123
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0043 0.0043
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.0244 0.1061
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Echinococcus granulosus hypothetical protein 0.0075 0.0244 0.0358
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0244 0.0473
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0099 0.0412 0.0412
Echinococcus granulosus FTZ F1 alpha 0.0058 0.0123 0.0181
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0058 0.0123 0.0181
Schistosoma mansoni amine GPCR 0.0075 0.0244 0.1061
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0128 0.0618 0.12
Loa Loa (eye worm) hypothetical protein 0.0058 0.0123 0.0123
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0075 0.0244 0.1061
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0075 0.0244 0.0358
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0128 0.0618 0.0618
Echinococcus multilocularis neuropeptide FF receptor 2 0.0075 0.0244 0.0473
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0244 0.0358
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0999 0.5061
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0069 0.0201 0.0201
Onchocerca volvulus 0.0128 0.0618 0.0531
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0128 0.0618 0.0908
Schistosoma mansoni intermediate filament proteins 0.0054 0.0092 0.0402
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0128 0.0618 0.12
Echinococcus multilocularis ecdysone induced protein 78C 0.0058 0.0123 0.0239
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi neuropeptide F receptor 0.0075 0.0244 0.0244
Onchocerca volvulus 0.0128 0.0618 0.0531
Echinococcus multilocularis FTZ F1 alpha 0.0058 0.0123 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1572 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) ACC-1 protein 0.0128 0.0618 0.0618
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0075 0.0244 0.0244
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0128 0.0618 0.0618
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.0244 0.0358
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0244 0.1061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0064 0.0125
Echinococcus granulosus g protein coupled receptor 0.0075 0.0244 0.0358
Schistosoma mansoni nAChR subunit 0.0128 0.0618 0.269
Brugia malayi Serotonin receptor 0.0075 0.0244 0.0244
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0064 0.0094
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.0244 0.1061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0244 0.0473
Schistosoma mansoni hypothetical protein 0.0075 0.0244 0.1061
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0244 0.1061
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0064 0.0125
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0075 0.0244 0.0473
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0058 0.0123 0.0123
Brugia malayi Dopamine receptor 0.0075 0.0244 0.0244
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0069 0.0201 0.0201
Onchocerca volvulus Putative organic anion transporter 0.0176 0.0959 0.0874
Brugia malayi ORL1-like opioid receptor 0.0075 0.0244 0.0244
Schistosoma mansoni biogenic amine receptor 0.0075 0.0244 0.1061
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0075 0.0244 0.0473
Schistosoma mansoni aldehyde dehydrogenase 0.0133 0.0652 0.2838
Onchocerca volvulus 0.0075 0.0244 0.0153
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni nAChR subunit 0.0128 0.0618 0.269
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0123 0.0181
Onchocerca volvulus Putative organic anion transporter 0.0176 0.0959 0.0874
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0133 0.0652 0.1266
Onchocerca volvulus Neuropeptide F receptor homolog 0.0075 0.0244 0.0153
Echinococcus multilocularis follistatin 0.0062 0.0151 0.0293
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0043 0.0064
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.0244 0.0358
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0128 0.0618 0.0908
Onchocerca volvulus 0.0176 0.0959 0.0874
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0176 0.0959 0.1407
Schistosoma mansoni amine GPCR 0.0075 0.0244 0.1061
Onchocerca volvulus 0.0128 0.0618 0.0531
Echinococcus granulosus somatostatin receptor 0.0075 0.0244 0.0358
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0244 0.0473
Loa Loa (eye worm) melatonin receptor type 1A 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0201
Trypanosoma brucei protein kinase, putative 0.0099 0.0412 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0058 0.0123 0.0123
Echinococcus granulosus neuropeptide FF receptor 2 0.0075 0.0244 0.0358
Echinococcus granulosus rhodopsin orphan GPCR 0.0075 0.0244 0.0358
Echinococcus multilocularis G-protein coupled receptor, putative 0.0075 0.0244 0.0473
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0075 0.0244 0.0244
Echinococcus granulosus orexin receptor type 2 0.0075 0.0244 0.0358
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0151 0.0151
Onchocerca volvulus 0.0075 0.0244 0.0153
Echinococcus granulosus neuropeptide receptor A26 0.0075 0.0244 0.0358
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0244 0.1061
Brugia malayi nuclear receptor NHR-88 0.0058 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi hypothetical protein 0.0059 0.0131 0.0131
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0128 0.0618 0.0618
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.0244 0.0473
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0933 0.4495
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0075 0.0244 0.0473
Loa Loa (eye worm) hypothetical protein 0.0176 0.0959 0.0959
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Echinococcus granulosus nAChR subunit 0.0128 0.0618 0.0908
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0128 0.0618 0.0908
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0244 0.0473
Schistosoma mansoni biogenic amine receptor 0.0075 0.0244 0.1061
Echinococcus multilocularis nAChR subunit 0.0069 0.0201 0.0391
Schistosoma mansoni organic anion transporter 0.0176 0.0959 0.417
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Brugia malayi Melatonin receptor type 1A 0.0075 0.0244 0.0244
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0128 0.0618 0.12
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0244 0.1061
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0058 0.0123 0.0123
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0075 0.0244 0.0473
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0176 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni lozenge 0.006 0.0139 0.0604
Echinococcus multilocularis mitogen activated protein kinase 0.0099 0.0412 0.0798
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0133 0.0652 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0123 0.0123
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0128 0.0618 0.12
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0069 0.0201 0.0876
Loa Loa (eye worm) ACC-1 protein 0.0128 0.0618 0.0618
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0043 0.0084
Schistosoma mansoni nAChR subunit 0.0128 0.0618 0.269
Loa Loa (eye worm) hypothetical protein 0.0479 0.31 0.31
Brugia malayi GH02984p 0.0354 0.2215 0.2215
Onchocerca volvulus Putative nachr subunit 0.0128 0.0618 0.0531
Schistosoma mansoni biogenic amine (5HT) receptor 0.0075 0.0244 0.1061
Echinococcus multilocularis neuropeptides capa receptor 0.0075 0.0244 0.0473
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0244 0.1061
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0075 0.0244 0.0244
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0075 0.0244 0.0153
Schistosoma mansoni nAChR subunit 0.0128 0.0618 0.269
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0058 0.0123 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1572 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0176 0.0959 0.0959
Schistosoma mansoni opsin-like receptor 0.0075 0.0244 0.1061
Schistosoma mansoni thyroid hormone receptor 0.0058 0.0123 0.0536
Schistosoma mansoni lamin 0.0054 0.0092 0.0402
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0075 0.0244 0.1061
Onchocerca volvulus Putative organic anion transporter 0.1456 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0058 0.0123 0.0181
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0062 0.0151 0.0151
Toxoplasma gondii aldehyde dehydrogenase 0.0133 0.0652 0.6208
Brugia malayi hypothetical protein 0.0075 0.0244 0.0244
Echinococcus multilocularis mitogen activated protein kinase 3 0.0099 0.0412 0.0798
Schistosoma mansoni hypothetical protein 0.005 0.0064 0.028
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0263 0.1572 0.1572
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0064 0.0064
Loa Loa (eye worm) neuropeptide F receptor 0.0075 0.0244 0.0244
Brugia malayi hypothetical protein 0.0059 0.0131 0.0131
Onchocerca volvulus 0.0479 0.31 0.3035
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0075 0.0244 0.0244
Echinococcus multilocularis neuropeptide receptor A26 0.0075 0.0244 0.0473
Echinococcus multilocularis thyroid hormone receptor alpha 0.0058 0.0123 0.0239
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.0244 0.0244
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0075 0.0244 0.0473
Echinococcus multilocularis expressed protein 0.0062 0.0151 0.0293
Echinococcus granulosus mitogen activated protein kinase 0.0099 0.0412 0.0604
Loa Loa (eye worm) GABA receptor subunit 0.0069 0.0201 0.0201
Brugia malayi excitatory GABA receptor EXP-1A 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Onchocerca volvulus Bile acid receptor homolog 0.0058 0.0123 0.0031
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni biogenic amine receptor 0.0075 0.0244 0.1061
Brugia malayi hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0244 0.1061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0058 0.0123 0.0123
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0075 0.0244 0.1061
Schistosoma mansoni amine GPCR 0.0075 0.0244 0.1061
Schistosoma mansoni neurotransmitter gated ion channel 0.0059 0.0131 0.0571
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0058 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0058 0.0123 0.0239
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0058 0.0123 0.0536
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0058 0.0123 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0933 0.4495
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0075 0.0244 0.1061
Schistosoma mansoni thyroid hormone receptor 0.0058 0.0123 0.0536
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0059 0.0131 0.0131
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0058 0.0123 0.0536
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0075 0.0244 0.1061
Schistosoma mansoni neuropeptide receptor 0.0075 0.0244 0.1061
Loa Loa (eye worm) hypothetical protein 0.0053 0.0085 0.0085
Brugia malayi hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi hypothetical protein 0.0176 0.0959 0.0959
Echinococcus granulosus ecdysone induced protein 78C 0.0058 0.0123 0.0181
Brugia malayi hypothetical protein 0.0176 0.0959 0.0959
Brugia malayi GnHR receptor homolog 0.0075 0.0244 0.0244
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0062 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni lamin 0.0054 0.0092 0.0402
Loa Loa (eye worm) hypothetical protein 0.0062 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Echinococcus granulosus glycine receptor subunit alpha 1 0.0128 0.0618 0.0908
Brugia malayi Dopamine receptor protein 1 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Echinococcus multilocularis g-protein coupled receptor 0.0075 0.0244 0.0473
Echinococcus multilocularis geminin 0.036 0.2256 0.4376
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Echinococcus granulosus fmrfamide receptor 0.0075 0.0244 0.0358
Onchocerca volvulus 0.0176 0.0959 0.0874
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0043 0.0084
Schistosoma mansoni neuropeptide f receptor 76f 0.0075 0.0244 0.1061
Loa Loa (eye worm) hypothetical protein 0.1456 1 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0145 0.0742 0.0742
Echinococcus granulosus lamin dm0 0.0054 0.0092 0.0136
Brugia malayi SPARC precursor 0.0062 0.0151 0.0151
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Onchocerca volvulus 0.0075 0.0244 0.0153
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.0244 0.0358
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0244 0.1061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0058 0.0123 0.0239
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni adenoreceptor 0.0075 0.0244 0.1061
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0058 0.0123 0.0181
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0128 0.0618 0.269
Schistosoma mansoni nAChR subunit 0.0128 0.0618 0.269
Onchocerca volvulus 0.0075 0.0244 0.0153
Loa Loa (eye worm) hypothetical protein 0.0176 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0201
Schistosoma mansoni acetylcholine receptor subunit beta 0.0059 0.0131 0.0571
Schistosoma mansoni hypothetical protein 0.036 0.2256 0.9813
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0244 0.0473
Echinococcus multilocularis agrin 0.0062 0.0151 0.0293
Echinococcus granulosus high affinity choline transporter 1 0.0354 0.2215 0.325
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.005 0.0064 0.028
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0128 0.0618 0.0618
Echinococcus multilocularis lamin dm0 0.0054 0.0092 0.0179
Echinococcus granulosus tm gpcr rhodopsin 0.0075 0.0244 0.0358
Brugia malayi hypothetical protein 0.0059 0.0131 0.0131
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.0821 0.0821
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1572 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi intermediate filament protein 0.0054 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0059 0.0131 0.0255
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0059 0.0131 0.0131
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Schistosoma mansoni hypothetical protein 0.036 0.2256 0.9813
Echinococcus granulosus nAChR subunit 0.0069 0.0201 0.0296
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0075 0.0244 0.0244
Schistosoma mansoni nAChR subunit 0.0128 0.0618 0.269
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0128 0.0618 0.0908
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0075 0.0244 0.1061
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi G protein-coupled receptor 0.0075 0.0244 0.0244
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0075 0.0244 0.0244
Schistosoma mansoni agrin 0.0062 0.0151 0.0656
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0128 0.0618 0.0618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0058 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.005 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0201
Echinococcus granulosus neuropeptide Y receptor 0.0075 0.0244 0.0358
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0058 0.0123 0.0181
Onchocerca volvulus 0.0075 0.0244 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0058 0.0123 0.0123
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.0999 0.5061
Brugia malayi sodium-independent organic anion transporter family protein 0.0176 0.0959 0.0959
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0075 0.0244 0.1061
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0176 0.0959 0.0959
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0075 0.0244 0.1061
Schistosoma mansoni opsin-like receptor 0.0075 0.0244 0.1061
Echinococcus granulosus glycine receptor subunit beta 0.0128 0.0618 0.0908
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0058 0.0123 0.0123
Echinococcus granulosus neuropeptides capa receptor 0.0075 0.0244 0.0358
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0092 0.0092
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.0244 0.0358
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0176 0.0959 0.186
Loa Loa (eye worm) runx1 0.006 0.0139 0.0139
Brugia malayi G-protein coupled receptor 0.0075 0.0244 0.0244
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0058 0.0123 0.0031
Loa Loa (eye worm) follicle stimulating hormone receptor 0.052 0.3392 0.3392
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Echinococcus multilocularis expressed protein 0.077 0.5154 1
Echinococcus granulosus agrin 0.0062 0.0151 0.0221
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0128 0.0618 0.12
Brugia malayi putative neuropeptide receptor 0.0075 0.0244 0.0244
Loa Loa (eye worm) acetylcholine receptor protein 0.0059 0.0131 0.0131
Echinococcus multilocularis serotonin receptor 0.0075 0.0244 0.0473
Loa Loa (eye worm) steroid hormone receptor 0.0058 0.0123 0.0123
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0058 0.0123 0.0239
Schistosoma mansoni amine GPCR 0.0075 0.0244 0.1061
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0075 0.0244 0.1061
Brugia malayi hypothetical protein 0.0158 0.0828 0.0828
Brugia malayi hypothetical protein 0.0075 0.0244 0.0244
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0128 0.0618 0.0908
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1572 1
Loa Loa (eye worm) G-protein coupled receptor 0.0075 0.0244 0.0244
Onchocerca volvulus 0.0058 0.0123 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0263 0.1572 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0128 0.0618 0.12
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0075 0.0244 0.1061
Schistosoma mansoni opsin-like receptor 0.0075 0.0244 0.1061
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0933 0.4495
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0059 0.0131 0.0255
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0075 0.0244 0.0473
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Echinococcus granulosus glycine receptor subunit alpha 1 0.0128 0.0618 0.0908
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0043 0.0043
Echinococcus granulosus geminin 0.036 0.2256 0.3311
Onchocerca volvulus 0.0059 0.0131 0.0039
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0058 0.0123 0.0239
Schistosoma mansoni nAChR subunit 0.0059 0.0131 0.0571
Schistosoma mansoni nAChR subunit 0.0059 0.0131 0.0571
Loa Loa (eye worm) hypothetical protein 0.0069 0.0201 0.0201
Echinococcus granulosus expressed protein 0.077 0.5154 0.7565
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0652 0.5
Echinococcus granulosus g protein coupled receptor 0.0075 0.0244 0.0358
Onchocerca volvulus 0.0075 0.0244 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0058 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0075 0.0244 0.1061
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0075 0.0244 0.0358
Echinococcus granulosus biogenic amine 5HT receptor 0.0075 0.0244 0.0358
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0244 0.0473
Schistosoma mansoni single-minded 0.0047 0.0046 0.0202
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0059 0.0131 0.0131
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0128 0.0618 0.0618
Brugia malayi hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni neurotransmitter gated ion channel 0.0059 0.0131 0.0571
Schistosoma mansoni neuropeptide F-like receptor 0.0075 0.0244 0.1061
Brugia malayi hypothetical protein 0.0075 0.0244 0.0244
Echinococcus multilocularis fmrfamide receptor 0.0075 0.0244 0.0473
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0059 0.0131 0.0131
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0128 0.0618 0.0618
Echinococcus multilocularis glycine receptor subunit beta 0.0128 0.0618 0.12
Trypanosoma cruzi MFS transporter, putative 0.0176 0.0959 1
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.0933 0.0849
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0059 0.0131 0.0131
Echinococcus granulosus g protein coupled receptor 0.0075 0.0244 0.0358
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0058 0.0123 0.0181
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0128 0.0618 0.0908
Echinococcus granulosus glycine receptor subunit alpha 1 0.0128 0.0618 0.0908
Loa Loa (eye worm) LGC-31 protein 0.0128 0.0618 0.0618
Brugia malayi hypothetical protein 0.0075 0.0244 0.0244
Onchocerca volvulus 0.0075 0.0244 0.0153
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Echinococcus multilocularis somatostatin receptor 0.0075 0.0244 0.0473
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0128 0.0618 0.269
Echinococcus granulosus g-protein coupled receptor 0.0075 0.0244 0.0358
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Schistosoma mansoni growth hormone secretagogue receptor 0.0075 0.0244 0.1061
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0133 0.0652 0.0957
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0176 0.0959 0.186
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0263 0.1572 0.1572
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0652 0.5
Brugia malayi hypoxia-induced factor 1 0.0145 0.0742 0.0742
Echinococcus multilocularis neuropeptide Y receptor 0.0075 0.0244 0.0473
Brugia malayi larval opioid receptor 0.0075 0.0244 0.0244
Mycobacterium ulcerans aldehyde dehydrogenase 0.0133 0.0652 0.5
Onchocerca volvulus 0.0075 0.0244 0.0153
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0075 0.0244 0.0244
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0366 0.2299 1
Echinococcus multilocularis musashi 0.0054 0.0092 0.0179
Onchocerca volvulus 0.0075 0.0244 0.0153
Schistosoma mansoni nAChR subunit 0.0128 0.0618 0.269
Brugia malayi steroid hormone receptor 0.0058 0.0123 0.0123
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0128 0.0618 0.0618
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0133 0.0652 1
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0128 0.0618 0.0618
Echinococcus multilocularis g protein coupled receptor 0.0075 0.0244 0.0473
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0075 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0128 0.0618 0.0618
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0059 0.0131 0.0193
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0046 0.0202
Echinococcus multilocularis rhodopsin orphan GPCR 0.0075 0.0244 0.0473
Echinococcus multilocularis sex peptide receptor 0.0075 0.0244 0.0473
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0128 0.0618 0.0618
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0099 0.0412 0.3228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0058 0.0123 0.0123
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.0471 0.0471
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0075 0.0244 0.0473

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.53 nM Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 5.53 nM Binding affinity towards nicotinic acetylcholine receptor alpha2-beta2 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 8.99 nM Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta2 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 8.99 nM Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta2 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 15.7 nM Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 15.7 nM Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 54.2 nM Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta4 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 54.2 nM Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta4 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 57.3 nM Binding affinity towards Nicotinic acetylcholine receptor alpha2-beta4 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 57.3 nM Binding affinity towards Nicotinic acetylcholine receptor alpha2-beta4 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 112 nM Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta4 using [3H]-epibatidine ChEMBL. 15050615
Ki (binding) = 112 nM Binding affinity towards Nicotinic acetylcholine receptor alpha3-beta4 using [3H]-epibatidine ChEMBL. 15050615

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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