Detailed information for compound 81606

Basic information

Technical information
  • TDR Targets ID: 81606
  • Name: [2-(6-aminopurin-9-yl)ethoxymethyl-ethoxyphos phoryl]oxymethyl 2,2-dimethylpropanoate
  • MW: 415.381 | Formula: C16H26N5O6P
  • H donors: 1 H acceptors: 5 LogP: 0.59 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOP(=O)(COCCn1cnc2c1ncnc2N)OCOC(=O)C(C)(C)C
  • InChi: 1S/C16H26N5O6P/c1-5-26-28(23,27-10-25-15(22)16(2,3)4)11-24-7-6-21-9-20-12-13(17)18-8-19-14(12)21/h8-9H,5-7,10-11H2,1-4H3,(H2,17,18,19)
  • InChiKey: NOZLVTCICOSPFI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-(6-aminopurin-9-yl)ethoxymethyl-ethoxy-phosphoryl]oxymethyl 2,2-dimethylpropanoate
  • 2,2-dimethylpropanoic acid [2-(6-aminopurin-9-yl)ethoxymethyl-ethoxyphosphoryl]oxymethyl ester
  • 2,2-dimethylpropionic acid [2-adenin-9-ylethoxymethyl(ethoxy)phosphoryl]oxymethyl ester
  • 2,2-dimethylpropanoic acid [2-(6-amino-9-purinyl)ethoxymethyl-ethoxyphosphoryl]oxymethyl ester
  • 2,2-dimethylpropionic acid [2-(6-aminopurin-9-yl)ethoxymethyl-ethoxy-phosphoryl]oxymethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0174 0.0195
Brugia malayi intermediate filament protein 0.0027 0.0174 0.0195
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0037 0.0351 0.0473
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0035 0.0304 0.0212
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0755 0.0878
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.203 0.2333
Schistosoma mansoni alpha-glucosidase 0.0302 0.5047 0.6004
Brugia malayi bZIP transcription factor family protein 0.0196 0.3162 0.3944
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0459 0.2337
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.0491 0.8393 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0459 0.026
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0293 0.3242
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0029 0.0204 0.0111
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0094 0.0083
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0132 0.203 0.2861
Loa Loa (eye worm) hypothetical protein 0.0027 0.0166 0.0175
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1071 0.4929
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1772 0.2226
Brugia malayi jmjC domain containing protein 0.0247 0.4075 0.509
Loa Loa (eye worm) hypothetical protein 0.0041 0.0415 0.0472
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0459 0.0625
Onchocerca volvulus 0.006 0.0755 0.0743
Brugia malayi jmjC domain containing protein 0.0034 0.0293 0.0343
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.1127 0.1577
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.1071 0.0885
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.1071 0.0885
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1563 0.177
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0459 0.2337
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0421 0.048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0126 0.1919 0.2268
Brugia malayi 6-phosphofructokinase 0.0128 0.1963 0.2439
Brugia malayi Thioredoxin reductase 0.0046 0.0511 0.0617
Treponema pallidum fructose-bisphosphate aldolase 0.0582 1 1
Mycobacterium tuberculosis Probable reductase 0.0106 0.1563 0.195
Toxoplasma gondii aldehyde dehydrogenase 0.0132 0.203 1
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0415 0.0436
Brugia malayi CXXC zinc finger family protein 0.0058 0.0722 0.0882
Loa Loa (eye worm) hypothetical protein 0.0115 0.1724 0.2036
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0293 0.1491
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0041 0.0415 0.0497
Echinococcus granulosus jun protein 0.0196 0.3162 0.4472
Schistosoma mansoni lozenge 0.0059 0.073 0.0849
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0293 0.0389
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0293 0.0389
Loa Loa (eye worm) 6-phosphofructokinase 0.0128 0.1963 0.2321
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0041 0.0415 0.2114
Trichomonas vaginalis set domain proteins, putative 0.0468 0.7985 0.7943
Echinococcus multilocularis jumonji domain containing protein 0.0081 0.1121 0.1568
Toxoplasma gondii 6-phosphofructokinase 0.0035 0.0304 0.1387
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0293 0.1332
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0378 0.4605
Leishmania major ATP-dependent phosphofructokinase 0.0128 0.1963 0.9654
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0174 0.0185
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0755 0.3637
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0415 0.12
Trypanosoma brucei glycosyl hydrolase-like protein 0.0029 0.0204 0.1039
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0041 0.0415 0.0563
Toxoplasma gondii hypothetical protein 0.0041 0.0415 0.1943
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0421 0.034
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0132 0.203 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0045 0.049 0.04
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0415 0.12
Brugia malayi RE18450p 0.0041 0.0415 0.0497
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0041 0.0415 0.0387
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.0718 0.0834
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0041 0.0415 0.0387
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1563 0.195
Schistosoma mansoni hypothetical protein 0.0172 0.2737 0.3245
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0293 0.0389
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.6981 0.8313
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0378 0.0287
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0094 0.0079
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0441 0.06
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0415 0.0387
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.2245 0.2658
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1563 0.195
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.1127 0.139
Loa Loa (eye worm) glutathione reductase 0.0046 0.0511 0.0587
Schistosoma mansoni fad oxidoreductase 0.0041 0.0415 0.0472
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0582 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 1 1
Echinococcus multilocularis muscleblind protein 1 0.0152 0.2376 0.3354
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0459 0.2337
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0041 0.0415 0.2114
Giardia lamblia PHD finger protein 15 0.0058 0.0718 0.0639
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 1 1
Echinococcus granulosus geminin 0.0172 0.2737 0.3868
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0304 0.6531
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0459 0.2337
Loa Loa (eye worm) hypothetical protein 0.0059 0.0732 0.0851
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0036 0.0321 0.036
Plasmodium falciparum thioredoxin reductase 0.0046 0.0511 0.6709
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0755 0.1046
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0284 0.4726 0.5581
Trichomonas vaginalis phosphofructokinase, putative 0.0128 0.1963 0.1795
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0247 0.4075 0.5772
Plasmodium vivax SET domain protein, putative 0.006 0.0755 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0459 0.1449
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0284 0.4726 0.5581
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0041 0.0415 0.0324
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0511 0.07
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0304 0.0102
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0351 0.5914 0.7039
Loa Loa (eye worm) runx1 0.0059 0.073 0.0849
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.1127 0.1323
Brugia malayi glutathione reductase 0.0046 0.0511 0.0617
Loa Loa (eye worm) hypothetical protein 0.0041 0.0415 0.0472
Loa Loa (eye worm) hypothetical protein 0.0034 0.0293 0.0326
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.0718 0.0994
Echinococcus multilocularis 6 phosphofructokinase 0.0128 0.1963 0.2766
Echinococcus multilocularis lysine specific demethylase 5A 0.0128 0.1951 0.275
Loa Loa (eye worm) histone methyltransferase 0.002 0.0047 0.0034
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0421 0.033
Schistosoma mansoni ap endonuclease 0.0041 0.0421 0.048
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0459 0.044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0196 0.3162 0.4472
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0029 0.0204 0.0038
Brugia malayi PHD-finger family protein 0.0058 0.0718 0.0877
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.1071 0.0885
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0041 0.0415 0.0563
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0459 0.1449
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0247 0.4075 0.5772
Loa Loa (eye worm) phosphofructokinase 0.0128 0.1963 0.2321
Leishmania major glycosyl hydrolase-like protein 0.0029 0.0204 0.0615
Loa Loa (eye worm) acetyltransferase 0.0144 0.2245 0.2658
Brugia malayi 6-phosphofructokinase 0.0128 0.1963 0.2439
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1772 0.2226
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0755 0.1046
Loa Loa (eye worm) hypothetical protein 0.0491 0.8393 1
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0415 0.12
Brugia malayi Glycosyl hydrolases family 31 protein 0.0029 0.0204 0.0232
Trypanosoma brucei glucosidase, putative 0.0078 0.1071 0.5455
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0293 0.0505
Brugia malayi Pre-SET motif family protein 0.006 0.0755 0.0923
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0415 0.2114
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0755 0.0878
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0293 0.0389
Brugia malayi hypothetical protein 0.0154 0.2416 0.3008
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0059 0.0732 0.0894
Schistosoma mansoni jumonji domain containing protein 0.0208 0.3383 0.4016
Echinococcus granulosus intermediate filament protein 0.0027 0.0174 0.0221
Echinococcus granulosus neutral alpha glucosidase AB 0.0078 0.1071 0.1496
Echinococcus multilocularis Protein lozenge 0.0059 0.073 0.1012
Loa Loa (eye worm) jmjC domain-containing protein 0.0131 0.201 0.2378
Schistosoma mansoni hypothetical protein 0.0019 0.0026 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 1 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0293 0.1332
Plasmodium falciparum phd finger protein, putative 0.0058 0.0718 1
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0041 0.0415 0.0563
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0755 0.0878
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0272 0.1385
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0293 0.0505
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.0718 0.0834
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0459 0.2337
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0421 0.0504
Loa Loa (eye worm) hypothetical protein 0.0029 0.0204 0.022
Brugia malayi jmjC domain containing protein 0.0131 0.201 0.2499
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0379 0.0452
Schistosoma mansoni d-amino acid oxidase 0.0491 0.8393 1
Schistosoma mansoni hypothetical protein 0.0415 0.7046 0.8391
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0421 0.2145
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0293 0.0326
Leishmania major alpha glucosidase II subunit, putative 0.0078 0.1071 0.507
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0718 0.3454
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0421 0.0222
Echinococcus multilocularis neutral alpha glucosidase AB 0.0078 0.1071 0.1496
Schistosoma mansoni cpg binding protein 0.0062 0.0781 0.091
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1772 0.2022
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0196 0.3162 0.4472
Echinococcus granulosus peregrin 0.0062 0.078 0.1083
Echinococcus multilocularis lamin 0.0027 0.0174 0.0221
Echinococcus granulosus lamin 0.0027 0.0174 0.0221
Loa Loa (eye worm) hypothetical protein 0.006 0.0755 0.0878
Schistosoma mansoni NAD dehydrogenase 0.0041 0.0415 0.0472
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0041 0.0415 0.0497
Schistosoma mansoni lamin 0.0027 0.0174 0.0185
Schistosoma mansoni cpg binding protein 0.0058 0.0722 0.084
Brugia malayi hypothetical protein 0.0468 0.7987 1
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0718 0.945
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.045 0.7668 1
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0041 0.0415 0.0387
Onchocerca volvulus Alhambra homolog 0.0058 0.0718 0.0696
Giardia lamblia Fructose-bisphosphate aldolase 0.0582 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0722 0.084
Schistosoma mansoni jumonji/arid domain-containing protein 0.0131 0.201 0.2378
Onchocerca volvulus 0.0154 0.2416 0.2869
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0421 0.0572
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0459 0.1449
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0755 0.0878
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0035 0.0304 0.0102
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0128 0.1963 0.2477
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0491 0.8393 1
Schistosoma mansoni lamin 0.0027 0.0174 0.0185
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.0732 0.0894
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0511 0.1745
Loa Loa (eye worm) hypothetical protein 0.0027 0.0174 0.0185
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0284 0.4726 0.6121
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0421 0.0222
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0511 0.0587
Trichomonas vaginalis phosphofructokinase, putative 0.0128 0.1963 0.1795
Echinococcus multilocularis lysosomal alpha glucosidase 0.0351 0.5914 0.8389
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0128 0.1963 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0272 0.0301
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0459 0.2337
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0459 0.2337
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.1071 0.0986
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0755 0.1046
Echinococcus multilocularis cpg binding protein 0.0062 0.0781 0.1085
Schistosoma mansoni alpha glucosidase 0.0078 0.1071 0.1255
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0041 0.0415 0.12
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.0718 0.3454
Brugia malayi polk-prov protein 0.0033 0.0272 0.0317
Plasmodium falciparum glutathione reductase 0.0046 0.0511 0.6709
Schistosoma mansoni jumonji/arid domain-containing protein 0.0131 0.201 0.2378
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.2245 0.3168
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0041 0.0415 0.0563
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0421 0.1731
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0128 0.1963 0.2252
Trichomonas vaginalis phosphofructokinase, putative 0.0128 0.1963 0.1795
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.1071 0.0986
Brugia malayi jmjC domain containing protein 0.0034 0.0293 0.0343
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0041 0.0415 0.0472
Loa Loa (eye worm) hypothetical protein 0.0468 0.7987 0.9515
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.1071 0.0885
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0041 0.0415 0.17
Brugia malayi cDNA sequence BC016226 0.0041 0.0415 0.0497
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0041 0.0415 0.0308
Plasmodium vivax glutathione reductase, putative 0.0046 0.0511 0.634
Schistosoma mansoni hypothetical protein 0.0058 0.0718 0.0834
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1563 0.195
Schistosoma mansoni alpha-glucosidase 0.0302 0.5047 0.6004
Echinococcus multilocularis peregrin 0.0062 0.078 0.1083
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0041 0.0415 0.0308
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0459 0.1449
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 1 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0304 0.3416
Trypanosoma brucei trypanothione reductase 0.0046 0.0511 0.2603
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0094 0.034
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0293 0.0389
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0128 0.1963 0.1886
Leishmania major trypanothione reductase 0.0046 0.0511 0.2193
Loa Loa (eye worm) hypothetical protein 0.0058 0.0718 0.0834
Loa Loa (eye worm) 6-phosphofructokinase 0.0128 0.1963 0.2321
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0511 0.634
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0293 0.0326
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0421 0.1234
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0293 0.0326
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0378 0.0297
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0441 0.0242
Loa Loa (eye worm) hypothetical protein 0.0152 0.2376 0.2814
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0415 0.12
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0045 0.049 0.041
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0078 0.1071 0.5214
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0459 0.026
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0047 0.004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 1 1
Onchocerca volvulus 0.0468 0.7985 0.9997
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0441 0.2072
Loa Loa (eye worm) hypothetical protein 0.019 0.3067 0.3639
Schistosoma mansoni hypothetical protein 0.0159 0.2511 0.2976
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.2173 0.3066
Echinococcus multilocularis lysosomal alpha glucosidase 0.0351 0.5914 0.8389
Loa Loa (eye worm) jmjC domain-containing protein 0.012 0.1813 0.2142
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0694 0.096
Echinococcus multilocularis musashi 0.0027 0.0174 0.0221
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.2245 0.2793
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0421 0.5282
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.1127 0.1577
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0304 0.0102
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0041 0.0415 0.1943
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0041 0.0415 0.2114
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0421 0.1234
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0293 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0272 0.1385
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 1 1
Loa Loa (eye worm) hypothetical protein 0.0468 0.7987 0.9515
Schistosoma mansoni hypothetical protein 0.004 0.0402 0.0457
Leishmania major hypothetical protein, conserved 0.0041 0.0415 0.17
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0094 0.0013
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0094 0.0049
Loa Loa (eye worm) hypothetical protein 0.004 0.0402 0.0457
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0293 0.0326
Echinococcus multilocularis geminin 0.0172 0.2737 0.3868
Echinococcus granulosus lamin dm0 0.0027 0.0174 0.0221
Echinococcus multilocularis lamin dm0 0.0027 0.0174 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0459 0.2337
Loa Loa (eye worm) hypothetical protein 0.0152 0.2376 0.2814
Echinococcus granulosus phd:f box containing protein 0.0034 0.0293 0.0389
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0459 0.2337
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0304 0.0102
Brugia malayi Muscleblind-like protein 0.0152 0.2376 0.2958
Entamoeba histolytica phosphofructokinase, putative 0.0128 0.1963 0.1886
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.0732 0.0851
Echinococcus granulosus dna polymerase kappa 0.0043 0.0459 0.0625
Brugia malayi Pre-SET motif family protein 0.0411 0.6981 0.8737
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0041 0.0415 0.12
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0084 0.0429
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0304 0.0102
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0293 0.0326
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0415 0.5186
Entamoeba histolytica phosphofructokinase, putative 0.0128 0.1963 0.1886
Schistosoma mansoni jun-related protein 0.0159 0.2511 0.2976
Toxoplasma gondii exonuclease III APE 0.0041 0.0421 0.1973
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.203 0.2333
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0293 0.0389
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.1071 0.0885
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0026 0.013
Mycobacterium ulcerans 6-phosphofructokinase 0.0128 0.1963 0.2252
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0441 0.2072
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0402 0.048
Echinococcus granulosus lysine specific demethylase 5A 0.0131 0.201 0.2834
Onchocerca volvulus 0.0058 0.0722 0.0701
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0035 0.0304 0.0212
Loa Loa (eye worm) hypothetical protein 0.0081 0.1127 0.1323
Schistosoma mansoni 6-phosphofructokinase 0.0128 0.1963 0.2321
Schistosoma mansoni hypothetical protein 0.0172 0.2737 0.3245
Schistosoma mansoni ap endonuclease 0.0041 0.0421 0.048
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0041 0.0421 0.0444
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.203 0.2401
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0459 0.2337
Brugia malayi Glycosyl hydrolases family 31 protein 0.0078 0.1071 0.1319
Echinococcus granulosus lysosomal alpha glucosidase 0.0351 0.5914 0.8389
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1563 0.195
Trypanosoma brucei unspecified product 0.0036 0.0335 0.1708
Schistosoma mansoni fad oxidoreductase 0.0041 0.0415 0.0472
Echinococcus multilocularis jun protein 0.0196 0.3162 0.4472
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0041 0.0415 0.49
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1071 0.4929
Toxoplasma gondii phosphofructokinase PFKII 0.0035 0.0304 0.1387
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0035 0.0304 0.1387
Brugia malayi PHD-finger family protein 0.0022 0.0084 0.0082
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0335 0.1708
Onchocerca volvulus 0.0468 0.7987 1
Leishmania major hypothetical protein, conserved 0.0034 0.0293 0.1071
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0459 0.2337
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0041 0.0415 0.0472
Onchocerca volvulus 0.0081 0.1127 0.1219
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0128 0.1963 1
Chlamydia trachomatis D-amino acid dehydrogenase 0.0041 0.0415 1
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0041 0.0415 0.0387
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0035 0.0304 0.6531
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0132 0.203 0.2566
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0293 0.0326
Loa Loa (eye worm) hypothetical protein 0.0034 0.0293 0.0326
Echinococcus granulosus dnaJ subfamily B 0.0415 0.7046 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0094 0.0478
Schistosoma mansoni intermediate filament proteins 0.0027 0.0174 0.0185
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0304 0.3228
Echinococcus granulosus cpg binding protein 0.0062 0.0781 0.1085
Echinococcus granulosus jumonji domain containing protein 0.0081 0.1121 0.1568
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.7046 1
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0035 0.0304 0.0221
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0041 0.0415 0.0387
Brugia malayi Bromodomain containing protein 0.0062 0.078 0.0955
Brugia malayi jmjC domain containing protein 0.0034 0.0293 0.0343
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0441 0.0242
Trichomonas vaginalis sucrase-isomaltase, putative 0.0078 0.1071 0.0885
Toxoplasma gondii thioredoxin reductase 0.0046 0.0511 0.2421
Onchocerca volvulus Putative fad oxidoreductase 0.0041 0.0415 0.0308
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0041 0.0415 0.0472
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0304 0.0102
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0421 0.4991
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0421 0.033
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0094 0.034
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0041 0.0421 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0441 0.5291
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0132 0.203 0.2861
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0041 0.0415 0.12
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0026 0.013
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0293 0.0326
Leishmania major hypothetical protein, conserved 0.0041 0.0415 0.17
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0078 0.1071 0.1255
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0037 0.0351 0.0473
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0293 0.0389
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 1 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.1071 0.0885
Trichomonas vaginalis maltase-glucoamylase, putative 0.0078 0.1071 0.0885
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0421 0.0572
Brugia malayi AF-10 protein 0.0019 0.0026 0.0008
Echinococcus multilocularis muscleblind protein 0.0152 0.2376 0.3354
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.203 0.2401
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0582 1 1
Schistosoma mansoni cpg binding protein 0.0062 0.0781 0.091
Loa Loa (eye worm) hypothetical protein 0.0022 0.0084 0.0078
Brugia malayi phosphofructokinase 0.0128 0.1963 0.2439
Plasmodium vivax JmjC domain containing protein 0.0034 0.0293 0.3064
Plasmodium vivax 6-phosphofructokinase, putative 0.0035 0.0304 0.3228
Echinococcus granulosus 6 phosphofructokinase 0.0128 0.1963 0.2766
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0041 0.0415 0.2114
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0174 0.0185
Schistosoma mansoni 6-phosphofructokinase 0.0128 0.1963 0.2321
Brugia malayi jmjC domain containing protein 0.0034 0.0293 0.0343
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0421 0.0394
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.1747 0.8591
Entamoeba histolytica phosphofructokinase, putative 0.0128 0.1963 0.1886
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0035 0.0304 0.3416
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.203 0.2333
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0511 0.0563
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1772 0.2226
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0459 0.044
Onchocerca volvulus 0.0203 0.329 0.3987
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0047 0.004
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1563 0.195
Brugia malayi Glycosyl hydrolases family 31 protein 0.0351 0.5914 0.7398
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.1071 0.0885
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0511 0.07
Trichomonas vaginalis phosphofructokinase, putative 0.0035 0.0304 0.0102
Loa Loa (eye worm) hypothetical protein 0.0041 0.0415 0.0472
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.0718 0.0994
Echinococcus granulosus muscleblind protein 0.0152 0.2376 0.3354
Trichomonas vaginalis phosphofructokinase, putative 0.0128 0.1963 0.1795

Activities

Activity type Activity value Assay description Source Reference
F (ADMET) = 34.9 % Bioavailability in rat of PMEA prodrug ChEMBL. 8021925

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.