Detailed information for compound 821887

Basic information

Technical information
  • TDR Targets ID: 821887
  • Name: 2-(4-bromophenyl)-1-oxido-6,7-dihydro-5H-cycl openta[b]pyrazin-4-ium 4-oxide
  • MW: 307.143 | Formula: C13H11BrN2O2
  • H donors: 0 H acceptors: 2 LogP: 0.87 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)c1c[n+]([O-])c2c([n+]1[O-])CCC2
  • InChi: 1S/C13H11BrN2O2/c14-10-6-4-9(5-7-10)13-8-15(17)11-2-1-3-12(11)16(13)18/h4-8H,1-3H2
  • InChiKey: LBKFAECMCXHSCO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6140-52-9
  • 2-(4-bromophenyl)-6,7-dihydro-5H-cyclopenta[b]pyrazine 1,4-dioxide
  • MLS000680239
  • SMR000268391
  • ZINC02954521
  • BIM-0006124.P001
  • CBMicro_006201
  • T5503725

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis muscleblind protein 0.018 0.127 1
Onchocerca volvulus Tankyrase homolog 0.0131 0.092 1
Schistosoma mansoni phospholipase 0.0002 0.0009 0.000000096934
Echinococcus multilocularis muscleblind protein 1 0.018 0.127 1
Schistosoma mansoni hypothetical protein 0.0013 0.0086 0.0758
Echinococcus granulosus Ankyrin 0.0002 0.001 0.0011
Trichomonas vaginalis cortactin-binding protein, putative 0.0002 0.0009 0.0559
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0021 0.0142 0.9085
Trichomonas vaginalis tankyrase, putative 0.0002 0.0009 0.0569
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0155 0.5
Schistosoma mansoni ap endonuclease 0.0023 0.0155 0.144
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0001 0 0.001
Loa Loa (eye worm) hypothetical protein 0.0002 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0002 0.0009 0.000000078211
Brugia malayi Muscleblind-like protein 0.018 0.127 1
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis protein phosphatase 1 regulatory subunit 12B, putative 0.0002 0.0009 0.0559
Echinococcus multilocularis Ankyrin 0.0002 0.0009 0.0067
Loa Loa (eye worm) hypothetical protein 0.0005 0.0027 0.0146
Trichomonas vaginalis ion channel nompc, putative 0.0002 0.001 0.0652
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.001 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0005 0.0027 0.1745
Schistosoma mansoni 26S proteasome subunit 0.0002 0.0009 0.000000096934
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Giardia lamblia Kinase, NEK 0.0002 0.0009 0.00000067308
Leishmania major RNA-editing complex protein MP100, putative 0.0005 0.0027 0.1257
Entamoeba histolytica hypothetical protein 0.0021 0.0142 0.9085
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0001 0 0.001
Echinococcus granulosus poly adp ribose polymerase 2 0.0021 0.0142 0.1056
Echinococcus multilocularis stromal interaction molecule 1 0.0013 0.0086 0.0675
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0013 0.0086 0.0612
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0005 0.0027 0.1257
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0027 0.1257
Giardia lamblia Kinase, NEK 0.0002 0.0009 0.00000067308
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0021 0.0142 0.1056
Echinococcus multilocularis neutral sphingomyelinase 0.0005 0.0027 0.0212
Brugia malayi Patatin-like phospholipase family protein 0.0002 0.001 0.0079
Trichomonas vaginalis ankyrin repeat-rich membrane-spanning protein, putative 0.0002 0.0009 0.0569
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0155 0.1221
Leishmania major hypothetical protein, conserved 0.0005 0.0027 0.1257
Schistosoma mansoni hypothetical protein 0.0013 0.0086 0.0758
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.001 0.0662
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0001 0 0.001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0155 1
Trichomonas vaginalis E3 ubiquitin protein ligase, putative 0.0002 0.0009 0.0569
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0003 0.0014 0.0912
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0027 0.1257
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0027 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0142 0.9136
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0155 1
Echinococcus multilocularis Ankyrin 0.0002 0.0009 0.0067
Plasmodium vivax tyrosine kinase-like protein, putative 0.0013 0.0086 0.4585
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0002 0.0009 0.0559
Brugia malayi WGR domain containing protein 0.0021 0.0142 0.1116
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0569
Echinococcus multilocularis ankyrin repeat domain containing protein 6 0.0002 0.0009 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis protein phosphatase 1 regulatory subunit 12C, putative 0.0002 0.001 0.0652
Trichomonas vaginalis multiple ankyrin repeats single kh domain protein, putative 0.0002 0.0009 0.0559
Brugia malayi Uncoordinated protein 44 0.0002 0.0009 0.0068
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0021 0.0142 0.1308
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0155 0.1162
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.001 0.0652
Entamoeba histolytica hypothetical protein 0.0021 0.0142 0.9085
Leishmania major endonuclease/exonuclease protein-like protein 0.0005 0.0027 0.1257
Schistosoma mansoni synaptojanin 0.0005 0.0027 0.0181
Echinococcus granulosus traf and tnf receptor associated protein 0.0005 0.0027 0.0146
Trichomonas vaginalis hypothetical protein 0.0002 0.0009 0.0559
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0005 0.0027 0.1257
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0005 0.0027 0.1257
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0005 0.0027 0.1745
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0155 1
Trichomonas vaginalis ankyrin repeat-cotaining protein, putative 0.0002 0.0009 0.0559
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0027 0.0212
Loa Loa (eye worm) hypothetical protein 0.018 0.127 1
Brugia malayi Leucine Rich Repeat family protein 0.0002 0.0009 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0086 0.553
Trichomonas vaginalis multiple ankyrin repeats single kh domain protein, putative 0.0002 0.001 0.0652
Brugia malayi Neurabin protein 1 0.0013 0.0086 0.0675
Loa Loa (eye worm) hypothetical protein 0.0002 0.0009 0.000000078211
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Entamoeba histolytica hypothetical protein 0.0021 0.0142 0.9085
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0005 0.0027 0.1257
Brugia malayi glutaminase DH11.1 0.0002 0.0009 0.0067
Schistosoma mansoni nocturnin 0.0005 0.0027 0.0181
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.001 0.0652
Echinococcus granulosus liprin beta 1 0.0013 0.0086 0.0612
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0021 0.0142 0.9085
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0013 0.0086 0.0758
Trichomonas vaginalis unc-44 ankyrins, putative 0.0002 0.0009 0.0559
Giardia lamblia Protein 21.1 0.0002 0.0009 0.00000067308
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0005 0.0027 0.0212
Echinococcus granulosus poly ADP ribose polymerase 1 0.0021 0.0142 0.1056
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0002 0.001 0.0652
Schistosoma mansoni hypothetical protein 0.0013 0.0086 0.0758
Leishmania major huntingtin interacting protein (HIP), putative 0.0002 0.001 0.0099
Trichomonas vaginalis centaurin beta, putative 0.0002 0.0009 0.0559
Schistosoma mansoni hypothetical protein 0.0013 0.0086 0.0758
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0005 0.0027 0.1257
Loa Loa (eye worm) hypothetical protein 0.0005 0.0027 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis ion channel nompc, putative 0.0002 0.0009 0.0569
Trichomonas vaginalis ankyrin, putative 0.0002 0.0009 0.0569
Schistosoma mansoni neutral sphingomyelinase 0.0005 0.0027 0.0181
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0021 0.0142 0.1308
Trichomonas vaginalis ion channel nompc, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis protein phosphatase 1 regulatory subunit 12B, putative 0.0002 0.0009 0.0569
Brugia malayi coiled-coil like protein 1 0.0013 0.0086 0.0675
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis unc-44 ankyrins, putative 0.0002 0.001 0.0652
Echinococcus multilocularis liprin beta 1 0.0013 0.0086 0.0675
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0002 0.001 0.0079
Mycobacterium ulcerans histidinol dehydrogenase 0.1415 1 1
Trichomonas vaginalis ankyrin, putative 0.0002 0.001 0.0652
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0002 0.0009 0.0569
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0002 0.0009 0.0559
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0027 0.1257
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0013 0.0086 0.5266
Onchocerca volvulus 0.0013 0.0086 0.0847
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0027 0.0212
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.001 0.0652
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0002 0.001 0.0652
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Echinococcus multilocularis liprin alpha 2 0.0013 0.0086 0.0675
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis tankyrase, putative 0.0001 0 0.001
Giardia lamblia Kinase, NEK-frag 0.0002 0.0009 0.00000067308
Brugia malayi Liprin-alpha 2 0.0013 0.0086 0.0675
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0027 0.0146
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0569
Echinococcus granulosus stromal interaction molecule 1 0.0013 0.0086 0.0612
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0005 0.0027 0.1257
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0005 0.0027 0.1257
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0013 0.0086 0.0675
Leishmania major hypothetical protein, conserved 0.0005 0.0027 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0142 0.9136
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0021 0.0142 0.1116
Echinococcus multilocularis traf and tnf receptor associated protein 0.0005 0.0027 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0155 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0155 1
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0 0.001
Onchocerca volvulus 0.0005 0.0027 0.0202
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0002 0.001 0.0011
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0027 0.1257
Trichomonas vaginalis serine/threonine-protein kinase ripk4, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0005 0.0027 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0142 0.9136
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0142 0.9136
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Loa Loa (eye worm) hypothetical protein 0.0013 0.0086 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0086 0.553
Echinococcus granulosus 26S proteasome non ATPase regulatory subunit 10 0.0002 0.0009 0.0001
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Loa Loa (eye worm) hypothetical protein 0.0013 0.0086 0.0612
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0005 0.0027 0.0146
Schistosoma mansoni ankyrin 23/unc44 0.0002 0.001 0.0014
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Giardia lamblia hypothetical protein 0.0005 0.0027 0.1257
Brugia malayi CCR4 0.0005 0.0027 0.0212
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0005 0.0027 0.0212
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Toxoplasma gondii exonuclease III APE 0.0023 0.0155 1
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0005 0.0027 0.1745
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Echinococcus granulosus Sterile alpha motif SAM 0.0013 0.0086 0.0612
Trichomonas vaginalis ankyrin, putative 0.0002 0.0009 0.0569
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0027 0.0146
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0005 0.0027 0.1257
Brugia malayi hypothetical protein 0.0013 0.0086 0.0675
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis TKL family protein kinase 0.0002 0.0009 0.0559
Trichomonas vaginalis Phospholipase C precursor, putative 0.0005 0.0027 0.1745
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Trypanosoma cruzi palmitoyl acyltransferase 1, putative 0.0002 0.001 0.0099
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0569
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0155 1
Trichomonas vaginalis ankyrin repeat-rich membrane-spanning protein, putative 0.0002 0.0009 0.0559
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0027 0.0212
Brugia malayi Tnks protein 0.0144 0.1016 0.8001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0027 0.0146
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0013 0.0086 0.0675
Trichomonas vaginalis serine/threonine-protein kinase ripk4, putative 0.0002 0.0009 0.0559
Echinococcus granulosus synaptojanin 1 0.0005 0.0027 0.0146
Schistosoma mansoni ga binding protein beta chain (transcription factor e4tf1-47) 0.0002 0.0009 0.000000096934
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis hypothetical protein 0.0002 0.0009 0.0559
Echinococcus multilocularis deoxyribonuclease 1 2 0.0005 0.0027 0.0212
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0155 0.0129
Schistosoma mansoni hypothetical protein 0.0005 0.0027 0.0181
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0027 0.0212
Brugia malayi hypothetical protein 0.0013 0.0086 0.0675
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0005 0.0027 0.0146
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0155 0.1162
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0155 1
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0021 0.0142 0.1116
Trypanosoma brucei Ankyrin repeats (many copies), putative 0.0002 0.0009 0.00000067308
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.001 0.0652
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0005 0.0027 0.0181
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0001 0 0.001
Leishmania major pantothenate kinase subunit, putative 0.0005 0.0027 0.1257
Trichomonas vaginalis ankyrin, putative 0.0002 0.001 0.0662
Plasmodium falciparum tyrosine kinase-like protein 0.0013 0.0086 0.4585
Schistosoma mansoni lip-related protein (liprin) alpha 0.0013 0.0086 0.0758
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0569
Echinococcus granulosus SAM domain containing protein 0.0013 0.0086 0.0612
Trichomonas vaginalis fibronectin type 3 and ankyrin repeat domains, putative 0.0002 0.0009 0.0559
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0155 1
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0005 0.0027 0.1745
Brugia malayi Patatin-like phospholipase family protein 0.0002 0.0009 0.0067
Brugia malayi WGR domain containing protein 0.0021 0.0142 0.1116
Schistosoma mansoni ap endonuclease 0.0023 0.0155 0.144
Giardia lamblia Kinase, NEK 0.0002 0.001 0.0099
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Echinococcus multilocularis synaptojanin 1 0.0005 0.0027 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Entamoeba histolytica hypothetical protein 0.0021 0.0142 0.9085
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0005 0.0027 0.1745
Loa Loa (eye worm) hypothetical protein 0.011 0.0774 0.6067
Onchocerca volvulus 0.0005 0.0027 0.0202
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0027 0.0146
Schistosoma mansoni tankyrase 0.0146 0.1027 1
Giardia lamblia Protein 21.1 0.0002 0.0009 0.00000067308
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0142 0.9136
Giardia lamblia Inositol 5-phosphatase 4 0.0005 0.0027 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0086 0.553
Loa Loa (eye worm) hypothetical protein 0.0013 0.0086 0.0612
Trypanosoma brucei poly(adp-ribose) polymerase 0.0021 0.0142 0.9085
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0 0.001
Schistosoma mansoni cript-related 0.0005 0.0027 0.0181
Onchocerca volvulus Putative neutral sphingomyelinase 0.0005 0.0027 0.0202
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0027 0.0212
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0155 0.1221
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0005 0.0027 0.1257
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0005 0.0027 0.1257
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0002 0.001 0.0652
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0142 0.9136
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0086 0.553
Plasmodium falciparum protein kinase, putative 0.0013 0.0086 0.4585
Loa Loa (eye worm) Notch2 0.0002 0.0009 0.0001
Leishmania major hypothetical protein, conserved 0.0005 0.0027 0.1257
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0021 0.0142 0.1116
Loa Loa (eye worm) tnks protein 0.0133 0.0935 0.7344
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0155 1
Trichomonas vaginalis 26S proteasome non-ATPase regulatory subunit, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat and sam domain-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0005 0.0027 0.1745
Trypanosoma cruzi mitochondrial protein 99, putative 0.0005 0.0027 0.1257
Trypanosoma brucei palmitoyl acyltransferase 1, putative 0.0002 0.001 0.0099
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trypanosoma brucei RNA editing exonuclease 2 0.0005 0.0027 0.1257
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis mind bomb, putative 0.0002 0.0009 0.0559
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0027 0.0212
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0569
Giardia lamblia Kinase, NEK 0.0002 0.001 0.0099
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0001 0 0.001
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0569
Echinococcus granulosus liprin alpha 2 0.0013 0.0086 0.0612
Trypanosoma cruzi mitochondrial protein 99, putative 0.0005 0.0027 0.1257
Loa Loa (eye worm) hypothetical protein 0.0005 0.0027 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis fetal globin-inducing factor, putative 0.0002 0.0009 0.0559
Entamoeba histolytica zinc finger protein, putative 0.0021 0.0142 0.9085
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0005 0.0027 0.1257
Trypanosoma cruzi ankyrin repeat protein, putative 0.0002 0.0009 0.00000067308
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0155 1
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0005 0.0027 0.0146
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0005 0.0027 0.1257
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0002 0.0009 0.0559
Echinococcus granulosus Ankyrin 0.0002 0.0009 0.000000078211
Onchocerca volvulus 0.0013 0.0086 0.0847
Echinococcus multilocularis Ankyrin 0.0002 0.001 0.008
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0005 0.0027 0.1257
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0013 0.0086 0.0612
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0005 0.0027 0.1745
Schistosoma mansoni carbon catabolite repressor protein 0.0005 0.0027 0.0181
Trichomonas vaginalis unc-44 ankyrins, putative 0.0002 0.001 0.0652
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0027 0.1257
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0005 0.0027 0.1257
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0005 0.0027 0.1257
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0002 0.001 0.0652
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0013 0.0086 0.553
Echinococcus granulosus muscleblind protein 0.018 0.127 1
Trichomonas vaginalis serine/threonine-protein kinase ripk4, putative 0.0002 0.0009 0.0569
Trichomonas vaginalis 2-5A-dependent ribonuclease, putative 0.0002 0.0009 0.0559
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0021 0.0142 0.9085
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0005 0.0027 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.001 0.0652
Schistosoma mansoni sarm1 0.0013 0.0086 0.0758
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0569
Loa Loa (eye worm) hypothetical protein 0.0013 0.0086 0.0612
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0027 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0142 0.9136
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0005 0.0027 0.1257
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0005 0.0027 0.1745
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0027 0.1257
Loa Loa (eye worm) hypothetical protein 0.018 0.127 1
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0005 0.0027 0.1257
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0142 0.9136
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Schistosoma mansoni synaptojanin 0.0005 0.0027 0.0181
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.001 0.0652
Trichomonas vaginalis homeobox-containing protein wariai, putative 0.0002 0.0009 0.0559
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0027 0.0212
Loa Loa (eye worm) hypothetical protein 0.0002 0.0009 0.000000078211
Loa Loa (eye worm) hypothetical protein 0.0005 0.0027 0.0146
Trichomonas vaginalis ankyrin, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis fetal globin-inducing factor, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Giardia lamblia Ankyrin 1 0.0002 0.0009 0.00000067308
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0002 0.0009 0.0559
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0021 0.0142 0.9085
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0003 0.0013 0.0809
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Loa Loa (eye worm) hypothetical protein 0.0002 0.0009 0.000000078211
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0003 0.0013 0.0818
Echinococcus multilocularis 26S proteasome non ATPase regulatory subunit 10 0.0002 0.0009 0.0068
Trichomonas vaginalis cask-interacting protein (caskin) 1,2, putative 0.0002 0.0009 0.0559
Entamoeba histolytica ankyrin repeat protein, putative 0.0002 0.0009 0.00000067308
Trichomonas vaginalis conserved hypothetical protein 0.0002 0.0009 0.0559
Trichomonas vaginalis inversin, putative 0.0002 0.0009 0.0569
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0155 1
Trichomonas vaginalis ion channel nompc, putative 0.0002 0.0009 0.0569
Mycobacterium tuberculosis Probable histidinol dehydrogenase HisD (HDH) 0.1415 1 1
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0002 0.001 0.0652
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Echinococcus multilocularis SAM domain containing protein 0.0013 0.0086 0.0675
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0005 0.0027 0.1257
Trichomonas vaginalis nf kappa B inhibitor I-kappa-B, putative 0.0002 0.0009 0.0559
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0005 0.0027 0.1257
Trypanosoma cruzi palmitoyl acyltransferase 1, putative 0.0002 0.001 0.0099
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0005 0.0027 0.1257
Trichomonas vaginalis ion channel nompc, putative 0.0002 0.0009 0.0559
Loa Loa (eye worm) hypothetical protein 0.0013 0.0086 0.0612
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0005 0.0027 0.0212
Echinococcus granulosus neutral sphingomyelinase 0.0005 0.0027 0.0146
Echinococcus granulosus tankyrase 0.0146 0.1025 0.8057
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0002 0.0009 0.0559
Echinococcus multilocularis tankyrase 0.0146 0.1025 0.807
Trichomonas vaginalis rolling pebbles, putative 0.0002 0.0009 0.0559
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0005 0.0027 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0142 0.9136
Trichomonas vaginalis ankyrin repeat domain-containing protein, putative 0.0002 0.0009 0.0569
Loa Loa (eye worm) hypothetical protein 0.0021 0.0142 0.1056

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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