Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cytochrome p450-like protein | 0.0283 | 0.0467 | 0.1175 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0175 | 0.0158 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.0158 | 0.0015 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0175 | 0.0158 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0175 | 0.0158 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0283 | 0.0467 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.1093 | 0.2783 | 0.403 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0181 | 0.0176 | 0.0255 |
Trypanosoma brucei | cytochrome P450, putative | 0.0283 | 0.0467 | 0.1175 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0419 | 0.0855 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0175 | 0.0158 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0744 | 0.1786 | 0.62 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0744 | 0.1786 | 0.62 |
Trypanosoma brucei | aurora B kinase | 0.0419 | 0.0855 | 0.2657 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0175 | 0.0158 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.1093 | 0.2783 | 0.8732 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0196 | 0.022 | 0.0319 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0419 | 0.0855 | 0.2356 |
Schistosoma mansoni | nephrin | 0.0198 | 0.0226 | 0.0084 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0181 | 0.0176 | 0.0108 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.2535 | 0.6906 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0283 | 0.0467 | 0.1069 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Echinococcus granulosus | Immunoglobulin | 0.0181 | 0.0176 | 0.0255 |
Loa Loa (eye worm) | AUR protein kinase | 0.0419 | 0.0855 | 0.2356 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.1227 | 0.3166 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0746 | 0.1993 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0175 | 0.0158 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0175 | 0.0158 | 0.0049 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0175 | 0.0158 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0283 | 0.0467 | 0.1069 |
Echinococcus multilocularis | 0.0175 | 0.0158 | 0.0229 | |
Mycobacterium leprae | Conserved hypothetical protein | 0.0175 | 0.0158 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0175 | 0.0158 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0283 | 0.0467 | 0.1175 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.1093 | 0.2783 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.1041 | 0.2634 | 0.3946 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0175 | 0.0158 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0214 | 0.027 | 0.0391 |
Brugia malayi | serine/threonine kinase 12 | 0.0419 | 0.0855 | 0.2356 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0175 | 0.0158 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0175 | 0.0158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.024 | 0.0318 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0181 | 0.0176 | 0.0033 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.1093 | 0.2783 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0175 | 0.0158 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0175 | 0.0158 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0135 | 0.0045 | 0.0065 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0419 | 0.0855 | 0.2657 |
Brugia malayi | Cytochrome P450 family protein | 0.0283 | 0.0467 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0289 | 0.0482 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.1093 | 0.2783 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0175 | 0.0158 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0283 | 0.0467 | 0.1175 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0175 | 0.0158 | 0.0229 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Brugia malayi | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0419 | 0.0855 | 0.1239 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0175 | 0.0158 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0203 | 0.024 | 0.0097 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.1093 | 0.2783 | 0.403 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0275 | 0.0445 | 0.0306 |
Echinococcus granulosus | neuroglian | 0.0198 | 0.0226 | 0.0327 |
Brugia malayi | Cytochrome P450 family protein | 0.0283 | 0.0467 | 0.1069 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0419 | 0.0855 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0419 | 0.0855 | 0.0722 |
Echinococcus multilocularis | neuroglian | 0.0198 | 0.0226 | 0.0327 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0744 | 0.1786 | 0.62 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Brugia malayi | cytochrome P450 | 0.0175 | 0.0158 | 0.0049 |
Echinococcus granulosus | defective proboscis extension response | 0.0181 | 0.0176 | 0.0255 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0175 | 0.0158 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0419 | 0.0855 | 0.1239 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1093 | 0.2783 | 0.2678 |
Loa Loa (eye worm) | AUR protein kinase | 0.0419 | 0.0855 | 0.2356 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0214 | 0.027 | 0.0391 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.1093 | 0.2783 | 0.8732 |
Echinococcus granulosus | roundabout 2 | 0.0221 | 0.0289 | 0.0419 |
Mycobacterium leprae | putative cytochrome p450 | 0.0175 | 0.0158 | 0.5 |
Echinococcus multilocularis | Immunoglobulin | 0.0181 | 0.0176 | 0.0255 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0203 | 0.024 | 0.0347 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0175 | 0.0158 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0419 | 0.0855 | 0.1239 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0335 | 0.0616 | 0.0892 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0175 | 0.0158 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.017 | 0.0144 | 0.0208 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0196 | 0.022 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0645 | 0.1502 | 0.4494 |
Echinococcus granulosus | twitchin | 0.0209 | 0.0255 | 0.037 |
Echinococcus multilocularis | roundabout 2 | 0.0221 | 0.0289 | 0.0419 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0181 | 0.0176 | 0.0108 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0175 | 0.0158 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0335 | 0.0616 | 0.048 |
Leishmania major | protein kinase, putative | 0.0419 | 0.0855 | 0.2657 |
Trypanosoma brucei | polo-like protein kinase | 0.1093 | 0.2783 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0175 | 0.0158 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Giardia lamblia | Kinase, PLK | 0.1093 | 0.2783 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0744 | 0.1786 | 0.5433 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0283 | 0.0467 | 0.1069 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0289 | 0.0482 |
Echinococcus granulosus | glutamate receptor 2 | 0.0196 | 0.022 | 0.0319 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0196 | 0.022 | 0.0319 |
Brugia malayi | Cytochrome P450 family protein | 0.0645 | 0.1502 | 0.4494 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.1227 | 0.3166 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0335 | 0.0616 | 0.0892 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.1093 | 0.2783 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.1093 | 0.2783 | 1 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0181 | 0.0176 | 0.0033 |
Echinococcus multilocularis | aurora kinase A | 0.0419 | 0.0855 | 0.1239 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0175 | 0.0158 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0175 | 0.0158 | 0.0015 |
Loa Loa (eye worm) | AUR protein kinase | 0.0419 | 0.0855 | 0.2356 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.2535 | 0.6906 | 1 |
Schistosoma mansoni | protein kinase | 0.0419 | 0.0855 | 0.0722 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0744 | 0.1786 | 0.5433 |
Toxoplasma gondii | aurora kinase | 0.0419 | 0.0855 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0181 | 0.0176 | 0.0255 |
Schistosoma mansoni | vesicular amine transporter | 0.0181 | 0.0176 | 0.0033 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0419 | 0.0855 | 0.2356 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.