Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0165 | 0.0488 | 0.1342 |
Brugia malayi | serine/threonine kinase 12 | 0.0237 | 0.0755 | 0.1852 |
Trypanosoma brucei | polo-like protein kinase | 0.0833 | 0.2938 | 1 |
Echinococcus multilocularis | neuroglian | 0.0112 | 0.0295 | 0.0053 |
Echinococcus granulosus | twitchin | 0.0119 | 0.0321 | 0.0093 |
Brugia malayi | cytochrome P450 | 0.0103 | 0.0264 | 0.0019 |
Echinococcus multilocularis | 0.0103 | 0.0264 | 0.0008 | |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0259 | 0.053 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0237 | 0.0755 | 0.1836 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0833 | 0.2938 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0259 | 0.053 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0237 | 0.0755 | 0.0739 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0833 | 0.2938 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0165 | 0.0488 | 0.0839 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0103 | 0.0264 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.0264 | 0.0264 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0833 | 0.2938 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0259 | 0.053 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0103 | 0.0264 | 0.5 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0237 | 0.0755 | 0.1852 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0833 | 0.2938 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0103 | 0.0264 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0165 | 0.0488 | 0.1342 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0692 | 0.2421 | 0.8172 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.034 | 0.0818 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.1932 | 0.6972 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0103 | 0.0264 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0103 | 0.0264 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0103 | 0.0264 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0833 | 0.2938 | 1 |
Giardia lamblia | Kinase, PLK | 0.0833 | 0.2938 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0103 | 0.0264 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0165 | 0.0488 | 0.0857 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0103 | 0.0264 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0413 | 0.1399 | 0.4558 |
Brugia malayi | Cytochrome P450 family protein | 0.0413 | 0.1399 | 0.4254 |
Loa Loa (eye worm) | AUR protein kinase | 0.0237 | 0.0755 | 0.2284 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0103 | 0.0264 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0103 | 0.0264 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0165 | 0.0488 | 0.1342 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.034 | 0.0818 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0237 | 0.0755 | 0.0739 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0833 | 0.2938 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0103 | 0.0264 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0833 | 0.2938 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0103 | 0.0264 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0103 | 0.0264 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0237 | 0.0755 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0259 | 0.053 |
Brugia malayi | Cytochrome P450 family protein | 0.0165 | 0.0488 | 0.0857 |
Loa Loa (eye worm) | AUR protein kinase | 0.0237 | 0.0755 | 0.2284 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0103 | 0.0264 | 0.5 |
Trypanosoma brucei | aurora B kinase | 0.0237 | 0.0755 | 0.1836 |
Echinococcus granulosus | neuroglian | 0.0112 | 0.0295 | 0.0053 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0103 | 0.0264 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0115 | 0.0305 | 0.0068 |
Leishmania major | cytochrome p450-like protein | 0.0165 | 0.0488 | 0.0839 |
Echinococcus multilocularis | roundabout 2 | 0.0124 | 0.034 | 0.0122 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0103 | 0.0264 | 0.5 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0102 | 0.0259 | 0.0259 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0833 | 0.2938 | 1 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0237 | 0.0755 | 0.1852 |
Toxoplasma gondii | aurora kinase | 0.0237 | 0.0755 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0102 | 0.0259 | 0.0259 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0833 | 0.2938 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0692 | 0.2421 | 0.807 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0833 | 0.2938 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0102 | 0.0259 | 0.0259 |
Schistosoma mansoni | cell adhesion molecule | 0.0115 | 0.0305 | 0.0305 |
Schistosoma mansoni | protein kinase | 0.0237 | 0.0755 | 0.0755 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0237 | 0.0755 | 0.0755 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0103 | 0.0264 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.0833 | 0.2938 | 0.3992 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0103 | 0.0264 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0124 | 0.034 | 0.0122 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0103 | 0.0264 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0237 | 0.0755 | 0.2284 |
Leishmania major | protein kinase, putative | 0.0237 | 0.0755 | 0.1836 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.1932 | 0.6972 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0259 | 0.053 |
Echinococcus multilocularis | aurora kinase A | 0.0237 | 0.0755 | 0.0739 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0259 | 0.053 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0165 | 0.0488 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0833 | 0.2938 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0833 | 0.2938 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0833 | 0.2938 | 0.2938 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0833 | 0.2938 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0103 | 0.0264 | 0.0264 |
Brugia malayi | Cytochrome P450 family protein | 0.0103 | 0.0264 | 0.0019 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0165 | 0.0488 | 0.0839 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0103 | 0.0264 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0237 | 0.0755 | 0.5 |
Trypanosoma brucei | cytochrome P450, putative | 0.0165 | 0.0488 | 0.0839 |
Echinococcus granulosus | aurora kinase A | 0.0237 | 0.0755 | 0.0739 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.0833 | 0.2938 | 0.3992 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.0305 | 0.0692 |
Schistosoma mansoni | nephrin | 0.0112 | 0.0295 | 0.0295 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0103 | 0.0264 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0103 | 0.0264 | 0.0008 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0103 | 0.0264 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0587 | 0.2037 | 0.0719 |
Loa Loa (eye worm) | cytochrome P450 | 0.0103 | 0.0264 | 0.0548 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0833 | 0.2938 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.