Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0175 | 0.0158 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0214 | 0.027 | 0.0391 |
Loa Loa (eye worm) | cytochrome P450 | 0.0175 | 0.0158 | 0.0049 |
Schistosoma mansoni | protein kinase | 0.0419 | 0.0855 | 0.0722 |
Leishmania major | protein kinase, putative | 0.0419 | 0.0855 | 0.2657 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0175 | 0.0158 | 0.5 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0335 | 0.0616 | 0.0892 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0181 | 0.0176 | 0.0108 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0419 | 0.0855 | 0.1239 |
Echinococcus multilocularis | serine:threonine protein kinase PLK1 | 0.1093 | 0.2783 | 0.403 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0283 | 0.0467 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0275 | 0.0445 | 0.0306 |
Brugia malayi | Cytochrome P450 family protein | 0.0645 | 0.1502 | 0.4494 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0175 | 0.0158 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0283 | 0.0467 | 0.1069 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0135 | 0.0045 | 0.0065 |
Echinococcus granulosus | serine:threonine protein kinase PLK1 | 0.1093 | 0.2783 | 0.403 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0175 | 0.0158 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0419 | 0.0855 | 0.2356 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0175 | 0.0158 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0221 | 0.0289 | 0.0419 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.1093 | 0.2783 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0181 | 0.0176 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0289 | 0.0482 |
Trypanosoma brucei | cytochrome P450, putative | 0.0283 | 0.0467 | 0.1175 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0419 | 0.0855 | 0.2356 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0283 | 0.0467 | 0.1175 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0419 | 0.0855 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0196 | 0.022 | 0.0319 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0744 | 0.1786 | 0.5433 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1093 | 0.2783 | 0.2678 |
Echinococcus multilocularis | 0.0175 | 0.0158 | 0.0229 | |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.1227 | 0.3166 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0175 | 0.0158 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0175 | 0.0158 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0419 | 0.0855 | 0.2657 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.1093 | 0.2783 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.1093 | 0.2783 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.1227 | 0.3166 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0196 | 0.022 | 0.0319 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0175 | 0.0158 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0175 | 0.0158 | 0.0015 |
Trypanosoma brucei | aurora B kinase | 0.0419 | 0.0855 | 0.2657 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0181 | 0.0176 | 0.0255 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0175 | 0.0158 | 0.5 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.1093 | 0.2783 | 0.8732 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.1093 | 0.2783 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0744 | 0.1786 | 0.62 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0203 | 0.024 | 0.0347 |
Echinococcus granulosus | aurora kinase A | 0.0419 | 0.0855 | 0.1239 |
Brugia malayi | serine/threonine kinase 12 | 0.0419 | 0.0855 | 0.2356 |
Echinococcus granulosus | glutamate receptor 2 | 0.0196 | 0.022 | 0.0319 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0175 | 0.0158 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0744 | 0.1786 | 0.62 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0175 | 0.0158 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Leishmania major | cytochrome p450-like protein | 0.0283 | 0.0467 | 0.1175 |
Giardia lamblia | Kinase, PLK | 0.1093 | 0.2783 | 1 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0181 | 0.0176 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0221 | 0.0289 | 0.0482 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0645 | 0.1502 | 0.4494 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0283 | 0.0467 | 0.1175 |
Brugia malayi | cytochrome P450 | 0.0175 | 0.0158 | 0.0049 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0419 | 0.0855 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0283 | 0.0467 | 0.1069 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0175 | 0.0158 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.1041 | 0.2634 | 0.3946 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0175 | 0.0158 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0744 | 0.1786 | 0.62 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.2535 | 0.6906 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0283 | 0.0467 | 0.1069 |
Echinococcus multilocularis | Immunoglobulin | 0.0181 | 0.0176 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.0158 | 0.0015 |
Echinococcus multilocularis | roundabout 2 | 0.0221 | 0.0289 | 0.0419 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0175 | 0.0158 | 0.5 |
Schistosoma mansoni | vesicular amine transporter | 0.0181 | 0.0176 | 0.0033 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0175 | 0.0158 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.1093 | 0.2783 | 1 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0419 | 0.0855 | 0.2356 |
Loa Loa (eye worm) | hypothetical protein | 0.0744 | 0.1786 | 0.5433 |
Mycobacterium leprae | putative cytochrome p450 | 0.0175 | 0.0158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.024 | 0.0318 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0419 | 0.0855 | 0.0722 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0335 | 0.0616 | 0.048 |
Echinococcus multilocularis | aurora kinase A | 0.0419 | 0.0855 | 0.1239 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0175 | 0.0158 | 0.0229 |
Echinococcus multilocularis | Immunoglobulin | 0.0181 | 0.0176 | 0.0255 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0181 | 0.0176 | 0.0033 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0196 | 0.022 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.1093 | 0.2783 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0335 | 0.0616 | 0.0892 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0175 | 0.0158 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0175 | 0.0158 | 0.0049 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0175 | 0.0158 | 0.5 |
Schistosoma mansoni | nephrin | 0.0198 | 0.0226 | 0.0084 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Echinococcus granulosus | twitchin | 0.0209 | 0.0255 | 0.037 |
Echinococcus granulosus | neuroglian | 0.0198 | 0.0226 | 0.0327 |
Trichomonas vaginalis | CAMK family protein kinase | 0.1093 | 0.2783 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0283 | 0.0467 | 0.1069 |
Toxoplasma gondii | aurora kinase | 0.0419 | 0.0855 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0175 | 0.0158 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0198 | 0.0226 | 0.0327 |
Brugia malayi | Cytochrome P450 family protein | 0.0283 | 0.0467 | 0.1069 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0214 | 0.027 | 0.0391 |
Brugia malayi | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.2535 | 0.6906 | 1 |
Loa Loa (eye worm) | AUR protein kinase | 0.0419 | 0.0855 | 0.2356 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.0176 | 0.0108 |
Echinococcus granulosus | Immunoglobulin | 0.0181 | 0.0176 | 0.0255 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0175 | 0.0158 | 0.5 |
Echinococcus multilocularis | glutamate receptor 2 | 0.017 | 0.0144 | 0.0208 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0175 | 0.0158 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0746 | 0.1993 |
Loa Loa (eye worm) | AUR protein kinase | 0.0419 | 0.0855 | 0.2356 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0181 | 0.0176 | 0.0033 |
Schistosoma mansoni | cell adhesion molecule | 0.0203 | 0.024 | 0.0097 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0419 | 0.0855 | 0.1239 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0175 | 0.0158 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.1093 | 0.2783 | 0.8732 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0196 | 0.022 | 0.0319 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.