TDR Targets

Basic information

Technical information

TDR Targets ID: 830963
Name: N-[(2-fluorophenyl)methyl]-1-pyrazin-2-ylpipe ridine-4-carboxamide
MW: 314.357 | Formula: C17H19FN4O
H donors: 1 H acceptors: 3 LogP: 1.6 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CCN(CC1)c1cnccn1)NCc1ccccc1F
InChi: 1S/C17H19FN4O/c18-15-4-2-1-3-14(15)11-21-17(23)13-5-9-22(10-6-13)16-12-19-7-8-20-16/h1-4,7-8,12-13H,5-6,9-11H2,(H,21,23)
InChiKey: NROSPFOQLGMXBL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(2-fluorophenyl)methyl]-1-pyrazin-2-yl-piperidine-4-carboxamide
N-[(2-fluorophenyl)methyl]-1-(2-pyrazinyl)-4-piperidinecarboxamide
N-(2-fluorobenzyl)-1-pyrazin-2-yl-isonipecotamide
1-Pyrazin-2-yl-piperidine-4-carboxylic acid 2-fluoro-benzylamide
BAS 06570874
ZINC04965322

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium leprae	Probable lipase LipE	0.0072	0.0314	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0161	0.0826	0.0826
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0161	0.0826	0.0826
Onchocerca volvulus		0.0415	0.2282	1
Leishmania major	GTP-binding protein, putative	0.0021	0.002	0.0056
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0314	0.0314
Giardia lamblia	Cysteine protease	0.0147	0.0742	0.2014
Giardia lamblia	Hypothetical protein	0.0147	0.0742	0.2014
Brugia malayi	cathepsin L-like cysteine proteinase	0.0147	0.0742	0.0742
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0039	0.0137
Echinococcus granulosus	cathepsin l1	0.0415	0.2282	0.2282
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0415	0.2282	0.633
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0072	0.0314	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0742	0.0742
Plasmodium vivax	serine-repeat antigen (SERA)	0.0147	0.0742	0.3252
Plasmodium vivax	unspecified product	0.0147	0.0742	0.3252
Brugia malayi	Cathepsin L-like cysteine proteinase	0.04	0.2198	0.2198
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.04	0.2198	0.2198
Onchocerca volvulus	Matrilysin homolog	0.0043	0.0146	0.0478
Giardia lamblia	Cathepsin L precursor	0.0147	0.0742	0.2014
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0004	0.5
Brugia malayi	Papain family cysteine protease containing protein	0.0161	0.0826	0.0826
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Echinococcus granulosus	integrin beta 2	0.1081	0.61	0.61
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0039	0.1122
Loa Loa (eye worm)	fibroinase	0.0415	0.2282	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0004
Brugia malayi	Cathepsin L-like precursor	0.0415	0.2282	0.2282
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0039	0.1122
Onchocerca volvulus		0.0415	0.2282	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0063	0.0174
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0147	0.0742	0.2059
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0039	0.0083
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0415	0.2282	0.2282
Brugia malayi	beta-lactamase family protein	0.0072	0.0314	0.0314
Giardia lamblia	Cathepsin L-like protease	0.0147	0.0742	0.2014
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0147	0.0742	0.2014
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0314	0.0871
Schistosoma mansoni	cellular tumor antigen P53	0.005	0.0188	0.0188
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.04	0.2198	0.6097
Brugia malayi	Cathepsin L-like precursor	0.04	0.2198	0.2198
Plasmodium falciparum	serine repeat antigen 6	0.0147	0.0742	0.3252
Brugia malayi	hypothetical protein	0.004	0.0131	0.0131
Toxoplasma gondii	cathepsin CPC2	0.0147	0.0742	0.2059
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.0742	0.0742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Trypanosoma cruzi	cysteine protease, putative	0.0161	0.0826	0.0826
Brugia malayi	beta-lactamase	0.0072	0.0314	0.0314
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0147	0.0742	0.0742
Giardia lamblia	Cysteine protease	0.0147	0.0742	0.2014
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0039	0.0108
Brugia malayi	Papain family cysteine protease containing protein	0.0415	0.2282	0.2282
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0004	0.0019
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0742	0.3192
Schistosoma mansoni	cathepsin B (C01 family)	0.0147	0.0742	0.0742
Mycobacterium ulcerans	esterase/lipase LipP	0.0072	0.0314	1
Entamoeba histolytica	cysteine proteinase, putative	0.0415	0.2282	1
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0155	0.0791	0.0791
Trypanosoma cruzi	major cysteine proteinase, putative	0.0147	0.0742	0.0742
Trypanosoma cruzi	cysteine peptidase, putative	0.0415	0.2282	0.2282
Brugia malayi	Cathepsin L-like precursor	0.0415	0.2282	0.2282
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0415	0.2282	1
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0147	0.0742	0.3192
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Onchocerca volvulus	Cathepsin L homolog	0.0415	0.2282	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Brugia malayi	fibroinase precursor	0.0147	0.0742	0.0742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0742	0.2059
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0415	0.2282	0.2282
Brugia malayi	Cathepsin L-like precursor	0.0415	0.2282	0.2282
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Onchocerca volvulus	Cathepsin L homolog	0.0147	0.0742	0.3134
Schistosoma mansoni	hypothetical protein	0.0173	0.0896	0.0896
Echinococcus multilocularis	geminin	0.0173	0.0896	0.0896
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0646	0.3605	0.3605
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0004
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0039	0.0083
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0146
Onchocerca volvulus		0.04	0.2198	0.9625
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.0602	0.0602
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0415	0.2282	0.633
Onchocerca volvulus		0.0072	0.0314	0.1225
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.002	0.0089
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0147	0.0742	0.2059
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0099	0.0099
Loa Loa (eye worm)	ctsf protein	0.0415	0.2282	0.2282
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Giardia lamblia	Cathepsin L precursor	0.0147	0.0742	0.2014
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0052	0.0199	0.0771
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1761	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0147	0.0742	0.2014
Plasmodium falciparum	serine repeat antigen 7	0.0147	0.0742	0.3252
Leishmania major	hypothetical protein, conserved	0.0072	0.0314	0.0871
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0052	0.0199	0.0199
Echinococcus granulosus	cathepsin b	0.1761	1	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0147	0.0742	0.3252
Echinococcus multilocularis	cathepsin L	0.0161	0.0826	0.0826
Onchocerca volvulus		0.004	0.0131	0.0407
Brugia malayi	Papain family cysteine protease containing protein	0.0161	0.0826	0.0826
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0146
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0046	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0742	0.0742
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.002	0.0056
Schistosoma mansoni	hypothetical protein	0.0173	0.0896	0.0896
Brugia malayi	cathepsin L-like precursor	0.04	0.2198	0.2198
Echinococcus granulosus	geminin	0.0173	0.0896	0.0896
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0229	0.0229
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0032	0.009
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0147	0.0742	0.3252
Giardia lamblia	Encystation-specific protease	0.0147	0.0742	0.2014
Trichomonas vaginalis	esterase, putative	0.0072	0.0314	0.0871
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.0742	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0004
Brugia malayi	hypothetical protein	0.0025	0.0048	0.0048
Echinococcus multilocularis	snurportin 1	0.03	0.162	0.162
Brugia malayi	Cathepsin L-like precursor	0.0415	0.2282	0.2282
Loa Loa (eye worm)	hypothetical protein	0.04	0.2198	0.2198
Onchocerca volvulus		0.006	0.0248	0.0933
Entamoeba histolytica	cysteine proteinase 1, putative	0.0161	0.0826	0.3564
Giardia lamblia	Cathepsin B precursor	0.0646	0.3605	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0742	0.2059
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.002	0.002
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0415	0.2282	0.633
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0032	0.009
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0147	0.0742	0.3252
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Plasmodium falciparum	serine repeat antigen 4	0.0147	0.0742	0.3252
Loa Loa (eye worm)	calpain family protein 1	0.0032	0.0086	0.0086
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Schistosoma mansoni	cathepsin F (C01 family)	0.0415	0.2282	0.2282
Loa Loa (eye worm)	beta-lactamase	0.0072	0.0314	0.0314
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Entamoeba histolytica	cysteine protease, putative	0.0415	0.2282	1
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0742	0.3192
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0742	0.3192
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0039	0.1122
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0415	0.2282	0.2282
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0147	0.0742	0.2059
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.002	0.002
Trypanosoma cruzi	cruzipain precursor, putative	0.0415	0.2282	0.2282
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0147	0.0742	0.2059
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Brugia malayi	cathepsin L precursor	0.0147	0.0742	0.0742
Loa Loa (eye worm)	calpain family protein 1	0.0044	0.0152	0.0152
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0063	0.0174
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1761	1	1
Loa Loa (eye worm)	integrin beta-2	0.1476	0.8367	0.8367
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Entamoeba histolytica	cysteine proteinase, putative	0.0161	0.0826	0.3564
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.0742	0.0742
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0039	0.0108
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0742	0.2059
Giardia lamblia	Cathepsin B precursor	0.0646	0.3605	1
Echinococcus multilocularis	cysteine protease	0.0415	0.2282	0.2282
Brugia malayi	Papain family cysteine protease containing protein	0.0147	0.0742	0.0742
Trypanosoma cruzi	cysteine proteinase, putative	0.0161	0.0826	0.0826
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0004
Echinococcus granulosus	tumor protein p63	0.0341	0.1859	0.1859
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0147	0.0742	0.3252
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0048	0.0048
Leishmania major	cathepsin L-like protease	0.0415	0.2282	0.633
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0742	0.0742
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0742	0.3192
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0063	0.0063
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0415	0.2282	1
Mycobacterium ulcerans	beta-lactamase	0.0072	0.0314	1
Onchocerca volvulus		0.0415	0.2282	1
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0314	0.1223
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0428	0.0428
Trypanosoma cruzi	cysteine proteinase, putative	0.0161	0.0826	0.0826
Giardia lamblia	Cathepsin B precursor	0.0147	0.0742	0.2014
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0415	0.2282	0.2282
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0147	0.0742	0.2059
Plasmodium falciparum	serine repeat antigen 8	0.0147	0.0742	0.3252
Schistosoma mansoni	cathepsin S (C01 family)	0.0147	0.0742	0.0742
Plasmodium vivax	vivapain-2	0.0415	0.2282	1
Giardia lamblia	Cysteine protease	0.0147	0.0742	0.2014
Loa Loa (eye worm)	hypothetical protein	0.005	0.0191	0.0191
Onchocerca volvulus	Cathepsin F homolog	0.0415	0.2282	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0415	0.2282	0.2282
Entamoeba histolytica	cysteine proteinase, putative	0.0161	0.0826	0.3564
Leishmania major	hypothetical protein, conserved	0.0025	0.0048	0.0132
Mycobacterium ulcerans	hypothetical protein	0.0072	0.0314	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0415	0.2282	0.633
Plasmodium falciparum	serine repeat antigen 1	0.0147	0.0742	0.3252
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.002	0.0089
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0314	0.0871
Brugia malayi	Kelch motif family protein	0.0232	0.1231	0.1231
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0742	0.3192
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0147	0.0742	0.3252
Schistosoma mansoni	hypothetical protein	0.004	0.0131	0.0131
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0161	0.0826	0.3621
Giardia lamblia	Cathepsin B precursor	0.0147	0.0742	0.2014
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0742	0.0742
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0646	0.3605	0.3605
Onchocerca volvulus	Cathepsin L homolog	0.0415	0.2282	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.0428	0.0428
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0428	0.0428
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0048	0.0209
Onchocerca volvulus		0.0027	0.0058	0.0082
Onchocerca volvulus		0.0415	0.2282	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0199	0.0199
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0039	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.0314
Plasmodium falciparum	serine repeat antigen 5	0.0147	0.0742	0.3252
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1761	1	1
Onchocerca volvulus		0.0043	0.0146	0.0478
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Entamoeba histolytica	cysteine proteinase, putative	0.0161	0.0826	0.3564
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.0314
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0072	0.0314	0.1223
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0415	0.2282	1
Entamoeba histolytica	cysteine protease, putative	0.0147	0.0742	0.3192
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Entamoeba histolytica	cysteine proteinase, putative	0.04	0.2198	0.9628
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Giardia lamblia	Cathepsin B precursor	0.0147	0.0742	0.2014
Echinococcus multilocularis	cathepsin b	0.1761	1	1
Plasmodium vivax	vivapain-1	0.0161	0.0826	0.3621
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0072	0.0314	0.1223
Leishmania major	cathepsin L-like protease	0.0415	0.2282	0.633
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0742	0.0742
Giardia lamblia	Cysteine protease	0.0147	0.0742	0.2014
Loa Loa (eye worm)	cathepsin B	0.0646	0.3605	0.3605
Echinococcus granulosus	caspase 2	0.0057	0.0229	0.0229
Echinococcus multilocularis	cathepsin L cysteine protease	0.0415	0.2282	0.2282
Giardia lamblia	Cathepsin L precursor	0.0147	0.0742	0.2014
Loa Loa (eye worm)	hypothetical protein	0.0232	0.1231	0.1231
Plasmodium vivax	vivapain-2	0.0415	0.2282	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0742	0.2059
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.0314
Giardia lamblia	Cathepsin L precursor	0.0147	0.0742	0.2014
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0072	0.0314	0.1223
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0161	0.0826	0.2292
Mycobacterium tuberculosis	Probable hydrolase	0.0072	0.0314	0.1223
Giardia lamblia	Cathepsin B precursor	0.0147	0.0742	0.2014
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.002	0.0056
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1761	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0161	0.0826	0.0826
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0152	0.0152
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1761	1	1
Echinococcus multilocularis	tumor protein p63	0.0341	0.1859	0.1859
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0147	0.0742	0.0742
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.0742	0.0742
Mycobacterium tuberculosis	Probable lipase LipE	0.0072	0.0314	0.1223
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0742	0.0742
Echinococcus granulosus	cysteine protease	0.0161	0.0826	0.0826
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0013	0.0013
Schistosoma mansoni	hypothetical protein	0.006	0.0248	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.0314
Brugia malayi	Papain family cysteine protease containing protein	0.0147	0.0742	0.0742
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0147	0.0742	0.2059
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0039	0.0039
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0155	0.0791	0.0791
Entamoeba histolytica	hypothetical protein	0.0023	0.0032	0.0053
Plasmodium vivax	hypothetical protein, conserved	0.0072	0.0314	0.1375
Toxoplasma gondii	cathepsin CPL	0.0415	0.2282	0.633
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0147	0.0742	0.0742
Toxoplasma gondii	cathepsin B	0.0646	0.3605	1
Loa Loa (eye worm)	matrixin family protein	0.0103	0.0493	0.0493
Leishmania major	cysteine peptidase A (CPA)	0.0415	0.2282	0.633
Giardia lamblia	Cathepsin B precursor	0.0147	0.0742	0.2014
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0415	0.2282	0.633
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0742	0.2059
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0147	0.0742	0.3192
Plasmodium vivax	vivapain-3	0.0161	0.0826	0.3621
Trypanosoma brucei	hypothetical protein, conserved	0.0072	0.0314	0.0871
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0044	0.0152	0.0152
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0048	0.0048
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0099	0.0099
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0147	0.0742	0.0742
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.0428	0.0428
Echinococcus multilocularis	cysteine protease	0.0415	0.2282	0.2282
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0039	0.1122
Mycobacterium leprae	PROBABLE HYDROLASE	0.0052	0.0199	0.5837
Giardia lamblia	Cathepsin L-like protease	0.0147	0.0742	0.2014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0314	0.1223
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0147	0.0742	0.2059
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0046	0.0163	0.0163
Brugia malayi	calpain family protein 1	0.0044	0.0152	0.0152
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0147	0.0742	0.0742
Mycobacterium ulcerans	lipase LipD	0.0072	0.0314	1
Brugia malayi	MH2 domain containing protein	0.0122	0.0602	0.0602
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0147	0.0742	0.2059
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0039	0.1122
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0072	0.0314	0.0314
Echinococcus granulosus	cathepsin l1	0.04	0.2198	0.2198
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0415	0.2282	0.633
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0039	0.1122
Schistosoma mansoni	ran	0.0021	0.002	0.002
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0147	0.0742	0.0742
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0063	0.0063
Echinococcus granulosus	apoptotic protease activating factor 1	0.004	0.0131	0.0131
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0039	0.1122
Schistosoma mansoni	ran	0.0021	0.002	0.002
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.0314
Onchocerca volvulus		0.005	0.0188	0.0665
Brugia malayi	Cathepsin L-like precursor	0.04	0.2198	0.2198
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0048	0.0132
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0147	0.0742	0.2059
Loa Loa (eye worm)	hypothetical protein	0.0415	0.2282	0.2282
Mycobacterium tuberculosis	Probable lipase LipD	0.0072	0.0314	0.1223
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Leishmania major	cathepsin L-like protease	0.0415	0.2282	0.633
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.002	0.002
Brugia malayi	Matrixin family protein	0.0103	0.0493	0.0493
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.04	0.2198	0.2198
Trypanosoma cruzi	cysteine peptidase, putative	0.0415	0.2282	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0004	0.0004
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.002	0.002
Brugia malayi	RNA, U transporter 1	0.008	0.0359	0.0359
Toxoplasma gondii	cathepsin CPC1	0.0147	0.0742	0.2059
Entamoeba histolytica	cysteine proteinase, putative	0.0415	0.2282	1
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0032	0.0032
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0161	0.0826	0.2292
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0039	0.0039
Brugia malayi	Cathepsin L-like precursor	0.0415	0.2282	0.2282
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0161	0.0826	0.0826
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0086	0.0086
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Plasmodium vivax	unspecified product	0.0161	0.0826	0.3621
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0039	0.0039
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.0602	0.0602
Trypanosoma cruzi	cysteine peptidase, putative	0.0415	0.2282	0.2282
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0072	0.0314	0.0314
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0147	0.0742	0.0742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0032	0.009
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0147	0.0742	0.3252
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.002	0.002
Leishmania major	cathepsin L-like protease	0.0415	0.2282	0.633
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0048	0.0209
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0147	0.0742	0.3252
Plasmodium falciparum	importin beta, putative	0.0028	0.0063	0.0275
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0232	0.1231	0.1231
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0147	0.0742	0.2059
Trypanosoma cruzi	major cysteine proteinase, putative	0.0147	0.0742	0.0742
Giardia lamblia	Cathepsin L precursor	0.0147	0.0742	0.2014
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0058	0.0058
Entamoeba histolytica	hypothetical protein	0.0147	0.0742	0.3192
Giardia lamblia	Cathepsin B precursor	0.0646	0.3605	1
Schistosoma mansoni	integrin beta subunit	0.0849	0.4771	0.4771
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0048	0.0132
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0072	0.0314	0.0314
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0147	0.0742	0.2014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.04	0.2198	0.6097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.0826	0.2292
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0415	0.2282	0.633
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0147	0.0742	0.0742
Onchocerca volvulus		0.0415	0.2282	1
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0459	0.2535	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0147	0.0742	0.0742
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0415	0.2282	0.633
Trypanosoma cruzi	cysteine peptidase, putative	0.0415	0.2282	0.2282
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0048	0.0048
Onchocerca volvulus	Matrilysin homolog	0.0095	0.0444	0.1805
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0646	0.3605	1
Leishmania major	cathepsin L-like protease	0.0415	0.2282	0.633
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0191	0.0191
Echinococcus multilocularis	cathepsin b	0.1761	1	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.162	0.162
Plasmodium vivax	serine-repeat antigen (SERA)	0.0147	0.0742	0.3252
Brugia malayi	Matrixin family protein	0.0043	0.0146	0.0146
Schistosoma mansoni	importin beta-1	0.0028	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.1761	1	1
Loa Loa (eye worm)	matrixin family protein	0.0095	0.0444	0.0444
Echinococcus multilocularis	apoptotic protease activating factor 1	0.004	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.005	0.0188	0.0188
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0147	0.0742	0.3252
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0046	0.0163	0.0163
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0646	0.3605	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0428	0.0428
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0314	0.0314
Brugia malayi	beta-lactamase family protein	0.0072	0.0314	0.0314
Giardia lamblia	Cathepsin L precursor	0.0147	0.0742	0.2014
Brugia malayi	Importin beta-1 subunit	0.0028	0.0063	0.0063
Onchocerca volvulus		0.0147	0.0742	0.3134
Toxoplasma gondii	ABC1 family protein	0.0072	0.0314	0.0871
Entamoeba histolytica	cysteine proteinase 2	0.0161	0.0826	0.3564
Brugia malayi	Papain family cysteine protease containing protein	0.0147	0.0742	0.0742
Loa Loa (eye worm)	hypothetical protein	0.04	0.2198	0.2198
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0646	0.3605	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0147	0.0742	0.2014
Brugia malayi	Integrin beta pat-3 precursor	0.1476	0.8367	0.8367
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0314	0.0314
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0046	0.0163	0.0163
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0063	0.0174
Echinococcus multilocularis	cathepsin L cysteine protease	0.0415	0.2282	0.2282
Leishmania major	cathepsin L-like protease	0.0415	0.2282	0.633
Brugia malayi	Cathepsin L-like precursor	0.0415	0.2282	0.2282
Onchocerca volvulus		0.0072	0.0314	0.1225
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0314	0.0871
Mycobacterium leprae	conserved hypothetical protein	0.0072	0.0314	1
Brugia malayi	Matrixin family protein	0.0043	0.0146	0.0146
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0415	0.2282	0.633
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0742	0.2059
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0415	0.2282	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0146	0.0146
Mycobacterium ulcerans	hydrolase	0.0052	0.0199	0.6304
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Brugia malayi	Hemopexin family protein	0.006	0.0248	0.0248
Echinococcus multilocularis	caspase 2	0.0057	0.0229	0.0229
Brugia malayi	hypothetical protein	0.0232	0.1231	0.1231
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Mycobacterium tuberculosis	Probable esterase LipL	0.0072	0.0314	0.1223
Brugia malayi	calpain family protein 1	0.0044	0.0152	0.0152
Trichomonas vaginalis	ran, putative	0.0021	0.002	0.0056
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0147	0.0742	0.3252
Trichomonas vaginalis	conserved hypothetical protein	0.0147	0.0742	0.2059
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0032	0.009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0161	0.0826	0.2292
Schistosoma mansoni	hypothetical protein	0.0034	0.0099	0.0099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.0428	0.0428
Entamoeba histolytica	cysteine proteinase, putative	0.0161	0.0826	0.3564
Echinococcus granulosus	cathepsin L cysteine protease	0.0161	0.0826	0.0826
Plasmodium falciparum	serine repeat antigen 3	0.0147	0.0742	0.3252
Leishmania major	cathepsin L-like protease	0.0415	0.2282	0.633
Echinococcus granulosus	cathepsin L	0.0161	0.0826	0.0826
Echinococcus multilocularis	integrin beta 2	0.1081	0.61	0.61
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0072	0.0314	0.0314
Schistosoma mansoni	hypothetical protein	0.03	0.162	0.162
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0039	0.0108
Giardia lamblia	Hypothetical protein	0.0147	0.0742	0.2014
Schistosoma mansoni	cathepsin F (C01 family)	0.04	0.2198	0.2198
Onchocerca volvulus		0.0415	0.2282	1
Onchocerca volvulus		0.0415	0.2282	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0039	0.0137
Schistosoma mansoni	caspase-7 (C14 family)	0.0057	0.0229	0.0229
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.002	0.002
Echinococcus multilocularis	calpain family protein 1, d	0.0032	0.0086	0.0086
Loa Loa (eye worm)	hypothetical protein	0.004	0.0131	0.0131
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0095	0.0444	0.1805
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0039	0.0083
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0161	0.0826	0.0826
Echinococcus granulosus	calpain A	0.0046	0.0163	0.0163
Echinococcus granulosus	cathepsin L	0.0147	0.0742	0.0742
Echinococcus multilocularis	cathepsin L	0.0147	0.0742	0.0742
Loa Loa (eye worm)	cysteine protease	0.0415	0.2282	0.2282
Plasmodium falciparum	serine repeat antigen 9	0.0147	0.0742	0.3252
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0147	0.0742	0.3252
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0147	0.0742	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0039	0.0039
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0039	0.1122
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0147	0.0742	0.3252
Leishmania major	cathepsin L-like protease	0.0415	0.2282	0.633
Brugia malayi	Cell death protein 3 precursor	0.0057	0.0229	0.0229
Schistosoma mansoni	cathepsin C	0.0147	0.0742	0.0742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0147	0.0742	0.2059
Loa Loa (eye worm)	matrix metalloproteinase	0.0043	0.0146	0.0146
Schistosoma mansoni	cathepsin F (C01 family)	0.0415	0.2282	0.2282
Brugia malayi	Matrixin family protein	0.0043	0.0146	0.0146
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0415	0.2282	0.633
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0415	0.2282	0.633
Echinococcus granulosus	snurportin 1	0.03	0.162	0.162
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.0428	0.0428
Schistosoma mansoni	calpain-7 (C02 family)	0.0019	0.0013	0.0013
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0147	0.0742	0.2059
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0043	0.0146	0.0146
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.0314	0.0314
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0048	0.0209
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0147	0.0742	0.3252
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0147	0.0742	0.0742
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0147	0.0742	0.2059
Plasmodium falciparum	serine repeat antigen 2	0.0147	0.0742	0.3252
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0147	0.0742	0.0742
Onchocerca volvulus	Cell death protein 3 homolog	0.0057	0.0229	0.0845
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0004	0.0019
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.0428	0.0428
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0415	0.2282	0.633
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0063	0.0275
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0147	0.0742	0.3252
Mycobacterium tuberculosis	Conserved protein	0.0072	0.0314	0.1223
Entamoeba histolytica	cysteine protease, putative	0.0161	0.0826	0.3564
Echinococcus multilocularis	calpain A	0.0046	0.0163	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0124	0.0124
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0415	0.2282	0.633
Trichomonas vaginalis	penicillin-binding protein, putative	0.0072	0.0314	0.0871
Trichomonas vaginalis	D-aminoacylase, putative	0.0072	0.0314	0.0871
Echinococcus granulosus	cathepsin b	0.1761	1	1
Onchocerca volvulus		0.0072	0.0314	0.1225
Echinococcus granulosus	beta LACTamase domain containing family member	0.0072	0.0314	0.0314
Brugia malayi	Matrixin family protein	0.0043	0.0146	0.0146

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 830963