TDR Targets

Basic information

Technical information

TDR Targets ID: 833877
Name: N-(3-nitrophenyl)-1,2,3-benzothiadiazole-5-ca rboxamide
MW: 300.293 | Formula: C13H8N4O3S
H donors: 1 H acceptors: 5 LogP: 2.53 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc2c(c1)nns2)Nc1cccc(c1)[N+](=O)[O-]
InChi: 1S/C13H8N4O3S/c18-13(8-4-5-12-11(6-8)15-16-21-12)14-9-2-1-3-10(7-9)17(19)20/h1-7H,(H,14,18)
InChiKey: MBJXONHVGQZRPW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ZINC00312930

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0231	0.0215
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0142	0.0741	0.2055
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0661	0.3604	1
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0015	0.0037	0.0033
Giardia lamblia	Cathepsin B precursor	0.0142	0.0741	0.1974
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0142	0.0741	0.1974
Toxoplasma gondii	cathepsin CPC1	0.0142	0.0741	0.1974
Leishmania major	cathepsin L-like protease	0.0379	0.2049	0.564
Onchocerca volvulus		0.0379	0.2049	1
Schistosoma mansoni	cpg binding protein	0.0037	0.0159	0.0155
Giardia lamblia	Cathepsin B precursor	0.0142	0.0741	0.1974
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0142	0.0741	0.0726
Echinococcus granulosus	cathepsin L cysteine protease	0.0142	0.0741	0.0737
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0379	0.2049	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0741	0.0726
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0142	0.0741	0.2055
Entamoeba histolytica	hypothetical protein	0.0142	0.0741	0.3499
Onchocerca volvulus		0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0741	0.2055
Onchocerca volvulus	Cathepsin L homolog	0.0142	0.0741	0.3499
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0037	0.0021
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0043	0.0039
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0037	0.0102
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0379	0.2049	0.2046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0142	0.0741	0.0737
Plasmodium falciparum	serine repeat antigen 3	0.0142	0.0741	0.3499
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0379	0.2049	0.202
Trypanosoma cruzi	major cysteine proteinase, putative	0.0142	0.0741	0.0707
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0379	0.2049	0.5684
Onchocerca volvulus		0.0379	0.2049	1
Giardia lamblia	Cathepsin B precursor	0.0661	0.3604	1
Echinococcus granulosus	cathepsin l1	0.0379	0.2049	0.2046
Loa Loa (eye worm)	hypothetical protein	0.0379	0.2049	0.2036
Brugia malayi	Cathepsin L-like precursor	0.0379	0.2049	0.2037
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0362	0.0358
Schistosoma mansoni	cpg binding protein	0.0035	0.0148	0.0144
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0379	0.2049	0.5684
Loa Loa (eye worm)	prolyl oligopeptidase	0.0015	0.0037	0.0021
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0016	0.0012
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0741	0.0737
Brugia malayi	prolyl oligopeptidase family protein	0.0015	0.0037	0.0022
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Giardia lamblia	Cathepsin B precursor	0.0142	0.0741	0.1974
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0015	0.0037	0.0033
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1821	1	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0043	0.0039
Brugia malayi	prolyl oligopeptidase family protein	0.0015	0.0037	0.0022
Echinococcus granulosus	GPCR family 2	0.0016	0.0043	0.0039
Entamoeba histolytica	cysteine proteinase 1, putative	0.0142	0.0741	0.3499
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0379	0.2049	0.2046
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0043	0.0028
Echinococcus granulosus	cpg binding protein	0.0037	0.0159	0.0155
Brugia malayi	cathepsin L-like precursor	0.0379	0.2049	0.2037
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0741	0.2055
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0055	0.026	0.0626
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0142	0.0741	0.0737
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0142	0.0741	0.3499
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0055	0.026	0.0626
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0741	0.2055
Brugia malayi	Cathepsin L-like precursor	0.0379	0.2049	0.2037
Entamoeba histolytica	cysteine proteinase, putative	0.0379	0.2049	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0379	0.2049	0.2036
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Onchocerca volvulus		0.0035	0.0148	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0138	0.072	0.0705
Trypanosoma brucei	oligopeptidase b	0.0055	0.026	0.0626
Schistosoma mansoni	cathepsin B (C01 family)	0.0142	0.0741	0.0737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Plasmodium falciparum	serine repeat antigen 7	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0741	0.2055
Schistosoma mansoni	cathepsin S (C01 family)	0.0142	0.0741	0.0737
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0142	0.0741	0.1974
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0741	0.0727
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Trypanosoma cruzi	oligopeptidase b	0.0055	0.026	0.0224
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0037	0.0021
Leishmania major	oligopeptidase b	0.0055	0.026	0.0626
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0741	0.0727
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0016	0.0012
Loa Loa (eye worm)	ctsf protein	0.0379	0.2049	0.2036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0142	0.0741	0.3499
Loa Loa (eye worm)	hypothetical protein	0.0379	0.2049	0.2036
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0043	0.0028
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0142	0.0741	0.3499
Plasmodium falciparum	serine repeat antigen 9	0.0142	0.0741	0.3499
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0015	0.0037	0.0033
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0142	0.0741	0.3499
Schistosoma mansoni	hypothetical protein	0.0034	0.0144	0.014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Brugia malayi	Cathepsin L-like precursor	0.0379	0.2049	0.2037
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0379	0.2049	0.5684
Brugia malayi	cathepsin L precursor	0.0142	0.0741	0.0727
Trypanosoma cruzi	prolyl endopeptidase	0.0138	0.072	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0741	0.0726
Brugia malayi	prolyl oligopeptidase family protein	0.0015	0.0037	0.0022
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0379	0.2049	0.2046
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0142	0.0741	0.2055
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0661	0.3604	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0231	0.0216
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0142	0.0741	0.3499
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0379	0.2049	0.2036
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0741	0.0726
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0015	0.0037	0.0033
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Echinococcus multilocularis	cathepsin L	0.0142	0.0741	0.0737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0741	0.2055
Giardia lamblia	Cathepsin B precursor	0.0142	0.0741	0.1974
Plasmodium falciparum	serine repeat antigen 5	0.0142	0.0741	0.3499
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.1821	1	1
Echinococcus granulosus	cathepsin b	0.1821	1	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0231	0.0215
Trypanosoma cruzi	cysteine peptidase, putative	0.0379	0.2049	0.202
Plasmodium falciparum	serine repeat antigen 8	0.0142	0.0741	0.3499
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0319	0.0792
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0379	0.2049	0.5684
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0142	0.0741	0.0737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Brugia malayi	Cathepsin L-like precursor	0.0379	0.2049	0.2037
Schistosoma mansoni	cpg binding protein	0.0037	0.0159	0.0155
Toxoplasma gondii	cathepsin B	0.0661	0.3604	1
Onchocerca volvulus	Cathepsin L homolog	0.0379	0.2049	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0661	0.3604	1
Loa Loa (eye worm)	fibroinase	0.0379	0.2049	0.2036
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0741	0.0737
Trichomonas vaginalis	Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase	0.0015	0.0037	0.0102
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.0741	0.2055
Entamoeba histolytica	cysteine proteinase, putative	0.0142	0.0741	0.3499
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0142	0.0741	0.1974
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0142	0.0741	0.0727
Brugia malayi	fibroinase precursor	0.0142	0.0741	0.0727
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Brugia malayi	Cathepsin L-like precursor	0.0379	0.2049	0.2037
Plasmodium falciparum	serine repeat antigen 6	0.0142	0.0741	0.3499
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0379	0.2049	1
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0138	0.072	0.0716
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0741	0.0726
Entamoeba histolytica	cysteine proteinase, putative	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0142	0.0741	0.2055
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0055	0.026	0.0626
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0015	0.0037	0.0033
Brugia malayi	Papain family cysteine protease containing protein	0.0379	0.2049	0.2037
Echinococcus granulosus	cathepsin L	0.0142	0.0741	0.0737
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0144	0.0129
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0741	0.0737
Onchocerca volvulus		0.0379	0.2049	1
Giardia lamblia	Cathepsin L-like protease	0.0142	0.0741	0.1974
Plasmodium vivax	vivapain-2	0.0379	0.2049	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0142	0.0741	0.3499
Giardia lamblia	Hypothetical protein	0.0142	0.0741	0.1974
Echinococcus multilocularis	cathepsin L cysteine protease	0.0379	0.2049	0.2046
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0231	0.0216
Echinococcus multilocularis	cpg binding protein	0.0037	0.0159	0.0155
Trypanosoma cruzi	cysteine peptidase, putative	0.0379	0.2049	0.202
Loa Loa (eye worm)	hypothetical protein	0.0379	0.2049	0.2036
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0148	0.0133
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.0741	0.1974
Brugia malayi	cathepsin F-like cysteine proteinase	0.0142	0.0741	0.0727
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Toxoplasma gondii	cathepsin CPC2	0.0142	0.0741	0.1974
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0142	0.0741	0.3499
Mycobacterium tuberculosis	Probable protease II PtrBa [first part] (oligopeptidase B)	0.0124	0.064	1
Giardia lamblia	Cysteine protease	0.0142	0.0741	0.1974
Plasmodium vivax	unspecified product	0.0142	0.0741	0.3499
Onchocerca volvulus	Cathepsin F homolog	0.0379	0.2049	1
Toxoplasma gondii	prolyl endopeptidase	0.0138	0.072	0.1915
Trypanosoma cruzi	cysteine protease, putative	0.0142	0.0741	0.0707
Leishmania major	cathepsin L-like protease	0.0379	0.2049	0.564
Schistosoma mansoni	cathepsin F (C01 family)	0.0379	0.2049	0.2046
Entamoeba histolytica	cysteine proteinase 2	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0142	0.0741	0.2055
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0661	0.3604	0.3602
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0142	0.0741	0.0726
Echinococcus granulosus	cysteine protease	0.0142	0.0741	0.0737
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0142	0.0741	0.0737
Leishmania major	cathepsin L-like protease	0.0379	0.2049	0.564
Toxoplasma gondii	cathepsin CPL	0.0379	0.2049	0.564
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0379	0.2049	0.2037
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0138	0.072	0.3395
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Plasmodium vivax	unspecified product	0.0142	0.0741	0.3499
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1821	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0379	0.2049	0.2046
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0142	0.0741	0.3499
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0015	0.0037	0.0033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Entamoeba histolytica	cysteine proteinase, putative	0.0142	0.0741	0.3499
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0741	0.0726
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Leishmania major	cathepsin L-like protease	0.0379	0.2049	0.564
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0142	0.0741	0.0737
Trypanosoma cruzi	cysteine peptidase, putative	0.0379	0.2049	0.202
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0142	0.0741	0.3499
Brugia malayi	prolyl oligopeptidase family protein	0.0138	0.072	0.0706
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0379	0.2049	0.5684
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Giardia lamblia	Cathepsin L precursor	0.0142	0.0741	0.1974
Loa Loa (eye worm)	cathepsin B	0.0661	0.3604	0.3594
Plasmodium vivax	vivapain-3	0.0142	0.0741	0.3499
Echinococcus multilocularis	cathepsin L cysteine protease	0.0379	0.2049	0.2046
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.1821	1	1
Mycobacterium ulcerans	protease II (oligopeptidase B), PtrB	0.0055	0.026	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0043	0.0039
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0055	0.026	0.0224
Giardia lamblia	Cathepsin B precursor	0.0142	0.0741	0.1974
Plasmodium falciparum	serine repeat antigen 2	0.0142	0.0741	0.3499
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0379	0.2049	0.5684
Schistosoma mansoni	hypothetical protein	0.0016	0.0043	0.0039
Giardia lamblia	Cathepsin L-like protease	0.0142	0.0741	0.1974
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0043	0.0039
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.0741	0.2055
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0142	0.0741	0.3499
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0741	0.0727
Loa Loa (eye worm)	hypothetical protein	0.1821	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0142	0.0741	0.2055
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0043	0.0028
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0138	0.072	0.0716
Brugia malayi	Cathepsin L-like precursor	0.0379	0.2049	0.2037
Brugia malayi	cathepsin L-like cysteine proteinase	0.0142	0.0741	0.0727
Plasmodium vivax	vivapain-2	0.0379	0.2049	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0379	0.2049	0.5684
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Giardia lamblia	Cathepsin L precursor	0.0142	0.0741	0.1974
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0142	0.0741	0.1974
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0741	0.0727
Echinococcus granulosus	cathepsin b	0.1821	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0379	0.2049	0.5684
Giardia lamblia	Hypothetical protein	0.0142	0.0741	0.1974
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0015	0.0037	0.0033
Onchocerca volvulus		0.0379	0.2049	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0043	0.0039
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0741	0.0737
Entamoeba histolytica	cysteine protease, putative	0.0379	0.2049	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0144	0.0129
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0148	0.0132
Leishmania major	cysteine peptidase A (CPA)	0.0379	0.2049	0.564
Onchocerca volvulus	Cathepsin L homolog	0.0379	0.2049	1
Trypanosoma brucei	prolyl endopeptidase	0.0138	0.072	0.1915
Echinococcus multilocularis	cathepsin b	0.1821	1	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0015	0.0037	0.0033
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0055	0.026	0.0224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Plasmodium falciparum	serine repeat antigen 4	0.0142	0.0741	0.3499
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0142	0.0741	0.3499
Giardia lamblia	Cathepsin L precursor	0.0142	0.0741	0.1974
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0142	0.0741	0.0727
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.0741	0.0737
Giardia lamblia	Cathepsin B precursor	0.0661	0.3604	1
Leishmania major	cathepsin L-like protease	0.0379	0.2049	0.564
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0142	0.0741	0.3499
Onchocerca volvulus		0.0379	0.2049	1
Echinococcus granulosus	cathepsin l1	0.0379	0.2049	0.2046
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0741	0.0726
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Echinococcus multilocularis	cysteine protease	0.0379	0.2049	0.2046
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0379	0.2049	0.5684
Onchocerca volvulus		0.0379	0.2049	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0379	0.2049	0.2046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Giardia lamblia	Cysteine protease	0.0142	0.0741	0.1974
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Giardia lamblia	Encystation-specific protease	0.0142	0.0741	0.1974
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0142	0.0741	0.0737
Trypanosoma cruzi	oligopeptidase b	0.0055	0.026	0.0224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0741	0.2055
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0379	0.2049	0.5684
Entamoeba histolytica	cysteine proteinase, putative	0.0142	0.0741	0.3499
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0015	0.0037	0.0033
Trypanosoma cruzi	cysteine proteinase, putative	0.0142	0.0741	0.0707
Schistosoma mansoni	cathepsin F (C01 family)	0.0379	0.2049	0.2046
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Echinococcus granulosus	prolyl endopeptidase	0.0138	0.072	0.0716
Brugia malayi	prolyl oligopeptidase family protein	0.0015	0.0037	0.0022
Brugia malayi	Papain family cysteine protease containing protein	0.0142	0.0741	0.0727
Leishmania major	cathepsin L-like protease	0.0379	0.2049	0.564
Plasmodium vivax	serine-repeat antigen (SERA)	0.0142	0.0741	0.3499
Onchocerca volvulus		0.0379	0.2049	1
Echinococcus granulosus	acylamino acid releasing enzyme	0.0015	0.0037	0.0033
Giardia lamblia	Cathepsin L precursor	0.0142	0.0741	0.1974
Loa Loa (eye worm)	prolyl oligopeptidase	0.0015	0.0037	0.0021
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0138	0.072	0.1915
Trypanosoma cruzi	cysteine peptidase, putative	0.0379	0.2049	0.202
Loa Loa (eye worm)	cysteine protease	0.0379	0.2049	0.2036
Brugia malayi	Cathepsin L-like precursor	0.0379	0.2049	0.2037
Giardia lamblia	Cathepsin B precursor	0.0661	0.3604	1
Entamoeba histolytica	cysteine proteinase, putative	0.0379	0.2049	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0379	0.2049	0.5684
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0379	0.2049	0.564
Trypanosoma cruzi	cruzipain precursor, putative	0.0379	0.2049	0.202
Brugia malayi	Cathepsin L-like precursor	0.0379	0.2049	0.2037
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0142	0.0741	0.2055
Trypanosoma cruzi	cysteine proteinase, putative	0.0142	0.0741	0.0707
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0142	0.0741	0.1974
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0379	0.2049	1
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0142	0.0741	0.0707
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0142	0.0741	0.2055
Plasmodium vivax	vivapain-1	0.0142	0.0741	0.3499
Schistosoma mansoni	cathepsin C	0.0142	0.0741	0.0737
Echinococcus granulosus	cathepsin L	0.0142	0.0741	0.0737
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.0015	0.0037	0.0102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0741	0.2055
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0142	0.0741	0.2055
Onchocerca volvulus		0.0379	0.2049	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0043	0.0039
Schistosoma mansoni	hypothetical protein	0.0016	0.0043	0.0039
Entamoeba histolytica	cysteine protease, putative	0.0142	0.0741	0.3499
Giardia lamblia	Cathepsin L precursor	0.0142	0.0741	0.1974
Plasmodium falciparum	serine repeat antigen 1	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0741	0.2055
Giardia lamblia	Cysteine protease	0.0142	0.0741	0.1974
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.0741	0.2055
Giardia lamblia	Cysteine protease	0.0142	0.0741	0.1974
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0142	0.0741	0.0727
Trypanosoma cruzi	major cysteine proteinase, putative	0.0142	0.0741	0.0707
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0142	0.0741	0.2055
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0142	0.0741	0.0726
Leishmania major	cathepsin L-like protease	0.0379	0.2049	0.564
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.1821	1	1
Echinococcus multilocularis	cysteine protease	0.0379	0.2049	0.2046
Trypanosoma cruzi	cysteine peptidase, putative	0.0142	0.0741	0.0707
Echinococcus multilocularis	prolyl endopeptidase	0.0138	0.072	0.0716
Schistosoma mansoni	hypothetical protein	0.0016	0.0043	0.0039
Echinococcus multilocularis	cathepsin b	0.1821	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0379	0.2049	1
Leishmania major	cathepsin L-like protease	0.0379	0.2049	0.564
Plasmodium vivax	serine-repeat antigen (SERA)	0.0142	0.0741	0.3499
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0379	0.2049	0.5684
Mycobacterium leprae	PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B)	0.0055	0.026	0.5
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0043	0.0028
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0142	0.0741	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0379	0.2049	0.2036
Echinococcus multilocularis	cathepsin L	0.0142	0.0741	0.0737
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0142	0.0741	0.1974
Giardia lamblia	Cathepsin L precursor	0.0142	0.0741	0.1974
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0661	0.3604	0.3581

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 833877