Detailed information for compound 834764

Basic information

Technical information
  • TDR Targets ID: 834764
  • Name: N-(2-bromophenyl)-2,4-dioxo-1,5-dihydro-1,5-b enzodiazepine-8-sulfonamide
  • MW: 410.242 | Formula: C15H12BrN3O4S
  • H donors: 3 H acceptors: 4 LogP: 1.4 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CC(=O)Nc2c(N1)cc(cc2)S(=O)(=O)Nc1ccccc1Br
  • InChi: 1S/C15H12BrN3O4S/c16-10-3-1-2-4-11(10)19-24(22,23)9-5-6-12-13(7-9)18-15(21)8-14(20)17-12/h1-7,19H,8H2,(H,17,20)(H,18,21)
  • InChiKey: KPKXLIRMPXZOGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-bromophenyl)-2,4-diketo-1,5-dihydro-1,5-benzodiazepine-8-sulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus granulosus cytosolic malate dehydrogenase 0.0075 0.1447 0.1447
Trypanosoma brucei cytosolic malate dehydrogenase 0.0075 0.1447 0.1628
Loa Loa (eye worm) hypothetical protein 0.0052 0.0854 0.1428
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0648 0.0648
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0192 0.4457 0.4457
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0642 0.0722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0932
Brugia malayi Bromodomain containing protein 0.0046 0.072 0.1203
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.095 0.2132
Brugia malayi jmjC domain containing protein 0.0045 0.0685 0.1146
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0458 0.0788
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0075 0.1447 0.242
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.8889 1
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0075 0.1447 0.1628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0932
Schistosoma mansoni zinc finger protein 0.0018 0.0007 0.0016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.095 0.1589
Trichomonas vaginalis malate dehydrogenase, putative 0.0036 0.0466 0.0678
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0231 0.0231
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0648 0.0648
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.1225
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.4461 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0925 0.1041
Brugia malayi lactate dehydrogenase. 0.0192 0.4457 0.7453
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0116 0.5
Plasmodium falciparum phd finger protein, putative 0.0035 0.0436 0.0738
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0191 0.0215
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0172 0.0288
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0685 0.0685
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Leishmania major glycosomal malate dehydrogenase 0.0075 0.1447 0.1628
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0626 0.0626
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0116 0.013
Trypanosoma cruzi ISWI complex protein 0.0018 0.0007 0.0008
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0642 0.0722
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0023 0.0111 0.0125
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0458 0.0458
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0072 0.1382 0.1382
Brugia malayi Bromodomain containing protein 0.0038 0.051 0.0852
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0986 0.0986
Trypanosoma brucei ISWI complex protein 0.0018 0.0007 0.0008
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0925 0.1041
Trypanosoma brucei glycosomal malate dehydrogenase 0.0075 0.1447 0.1628
Chlamydia trachomatis malate dehydrogenase 0.0075 0.1447 0.5
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.3961 0.4456
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0284 0.0413
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0986 0.0986
Echinococcus granulosus lactate dehydrogenase a 0.0192 0.4457 0.4457
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0925 0.1347
Trypanosoma cruzi malate dehydrogenase, putative 0.0075 0.1447 0.1628
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.095 0.095
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3961 0.4456
Mycobacterium ulcerans hypothetical protein 0.0192 0.4461 1
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0075 0.1447 0.1628
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0075 0.1447 0.1628
Trypanosoma brucei malate dehydrogenase-related 0.0075 0.1447 0.1628
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0061 0.0138
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.095 0.1589
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0075 0.1447 0.3067
Leishmania major malate dehydrogenase 0.0075 0.1447 0.1628
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0849 0.0955
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0116 0.0194
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0646 0.0646
Mycobacterium ulcerans malate dehydrogenase 0.0075 0.1447 0.3064
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1883 0.4225
Leishmania major mitochondrial malate dehydrogenase 0.0075 0.1447 0.1628
Echinococcus multilocularis zinc finger protein 0.0024 0.014 0.014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.095 0.095
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0458 0.1027
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.079 0.079
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Schistosoma mansoni hypothetical protein 0.0018 0.0007 0.0016
Loa Loa (eye worm) hypothetical protein 0.0085 0.1724 0.2883
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0925 0.1041
Plasmodium falciparum malate dehydrogenase 0.0192 0.4457 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0648 0.1453
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0436 0.073
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0849 0.0955
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0075 0.1447 0.1628
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0849 0.0955
Leishmania major hypothetical protein, conserved 0.0018 0.0007 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0415
Echinococcus granulosus malate dehydrogenase 0.0075 0.1447 0.1447
Onchocerca volvulus 0.0036 0.0458 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0436 0.0738
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0685 0.1538
Loa Loa (eye worm) hypothetical protein 0.0192 0.4457 0.7453
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0116 0.013
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0436 0.0979
Echinococcus multilocularis malate dehydrogenase 0.0075 0.1447 0.1447
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0925 0.1041
Loa Loa (eye worm) hypothetical protein 0.0049 0.0795 0.133
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0075 0.1447 0.1447
Entamoeba histolytica malate dehydrogenase, putative 0.0192 0.4457 1
Echinococcus granulosus cytosolic malate dehydrogenase 0.0075 0.1447 0.1447
Plasmodium vivax malate dehydrogenase, putative 0.0192 0.4457 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0116 0.013
Giardia lamblia PHD finger protein 15 0.0035 0.0436 0.2407
Echinococcus multilocularis lactate dehydrogenase protein 0.0192 0.4457 0.4457
Brugia malayi hypothetical protein 0.0043 0.0648 0.1083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0925 0.1347
Entamoeba histolytica malate dehydrogenase, putative 0.0075 0.1447 0.3067
Schistosoma mansoni hypothetical protein 0.0035 0.0436 0.0979
Schistosoma mansoni L-lactate dehydrogenase 0.0192 0.4457 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1081 0.1808
Onchocerca volvulus 0.006 0.1065 0.0977
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Schistosoma mansoni malate dehydrogenase 0.0192 0.4457 1
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0116 0.0168
Giardia lamblia Malate dehydrogenase 0.0075 0.1447 1
Echinococcus multilocularis L lactate dehydrogenase 0.0117 0.2543 0.2543
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0685 0.1146
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0061 0.0061
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.8889 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0284 0.0413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0415
Trichomonas vaginalis set domain proteins, putative 0.0286 0.6871 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0054 0.0925 0.1865
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0054 0.0925 0.1865
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0192 0.4457 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0722 0.105
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Loa Loa (eye worm) hypothetical protein 0.0057 0.0986 0.1649
Leishmania major malate dehydrogenase, putative 0.0192 0.4457 0.5015
Schistosoma mansoni malate dehydrogenase 0.0075 0.1447 0.3247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0365 0.0531
Toxoplasma gondii lactate dehydrogenase LDH1 0.0192 0.4457 1
Echinococcus multilocularis lactate dehydrogenase a 0.0192 0.4457 0.4457
Brugia malayi Bromodomain containing protein 0.0091 0.1856 0.3104
Trypanosoma cruzi malate dehydrogenase, putative 0.0075 0.1447 0.1628
Echinococcus granulosus jumonji domain containing protein 0.0049 0.079 0.079
Schistosoma mansoni cellular tumor antigen P53 0.006 0.1065 0.239
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.095 0.2132
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0075 0.1447 0.5
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0424 0.0424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0365 0.0531
Loa Loa (eye worm) hypothetical protein 0.0035 0.0436 0.073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0415
Loa Loa (eye worm) malate dehydrogenase 0.0075 0.1447 0.242
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0436 0.0436
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.8889 1
Echinococcus multilocularis lactate dehydrogenase a 0.0192 0.4457 0.4457
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0075 0.1447 0.3067
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.3961 0.4456
Schistosoma mansoni L-lactate dehydrogenase 0.0075 0.1447 0.3247
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0285 0.0415
Plasmodium falciparum L-lactate dehydrogenase 0.0192 0.4457 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0925 0.1347
Schistosoma mansoni bromodomain containing protein 0.0076 0.1493 0.335
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0061 0.0061
Leishmania major malate dehydrogenase, putative 0.0075 0.1447 0.1628
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0986 0.2212
Toxoplasma gondii lactate dehydrogenase LDH2 0.0192 0.4457 1
Loa Loa (eye worm) hypothetical protein 0.006 0.1065 0.1781
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Plasmodium falciparum lactate dehydrogenase, putative 0.0075 0.1447 0.3067
Echinococcus granulosus peregrin 0.0038 0.051 0.051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0932
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0925 0.2076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.095 0.2132
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus multilocularis peregrin 0.0038 0.051 0.051
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0458 0.1027
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0075 0.1447 0.2106
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.8889 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0061 0.0138
Schistosoma mansoni malate dehydrogenase 0.0075 0.1447 0.3247
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0642 0.0722
Brugia malayi PHD-finger family protein 0.003 0.0305 0.051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0646 0.0646
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0231 0.0231
Echinococcus multilocularis lactate dehydrogenase a 0.0192 0.4457 0.4457
Onchocerca volvulus 0.0286 0.6871 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0075 0.1447 0.2106
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0231 0.0519
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.1225
Loa Loa (eye worm) malate dehydrogenase 0.0075 0.1447 0.242
Trichomonas vaginalis malate dehydrogenase, putative 0.0075 0.1447 0.2106
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0075 0.1447 0.1628
Toxoplasma gondii malate dehydrogenase MDH 0.0192 0.4457 1
Brugia malayi Pre-SET motif family protein 0.0251 0.598 1
Echinococcus multilocularis malate dehydrogenase 0.0075 0.1447 0.1447
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0467 0.068
Echinococcus granulosus L lactate dehydrogenase 0.0117 0.2543 0.2543
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.1136 0.1278
Echinococcus granulosus lactate dehydrogenase protein 0.0192 0.4457 0.4457
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0925 0.1547
Schistosoma mansoni zinc finger protein 0.0024 0.014 0.0313
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.2491 0.2491
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0436 0.0738
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.095 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Schistosoma mansoni hypothetical protein 0.0025 0.0172 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0986 0.2212
Schistosoma mansoni hypothetical protein 0.0043 0.0648 0.1453
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.1225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.064 0.0932
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0116 0.0116
Echinococcus granulosus lactate dehydrogenase a 0.0192 0.4457 0.4457
Entamoeba histolytica hypothetical protein 0.0043 0.0648 0.1225
Schistosoma mansoni malate dehydrogenase 0.0075 0.1447 0.3247
Brugia malayi PHD-finger family protein 0.0035 0.0436 0.073
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0569 0.1043
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0116 0.0194
Schistosoma mansoni ap endonuclease 0.0023 0.0116 0.026
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0436 0.0738
Echinococcus granulosus zinc finger protein 0.0024 0.014 0.014
Loa Loa (eye worm) hypothetical protein 0.0046 0.0722 0.1207
Leishmania major cytosolic malate dehydrogenase 0.0075 0.1447 0.1628
Echinococcus granulosus malate dehydrogenase 0.0075 0.1447 0.1447
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0116 0.0168
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0075 0.1447 0.1447
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0925 0.0925
Brugia malayi jmjC domain containing protein 0.0115 0.2491 0.4165
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0072 0.1382 0.1382
Trichomonas vaginalis malate dehydrogenase, putative 0.0036 0.0466 0.0678
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0116 0.013
Brugia malayi Pre-SET motif family protein 0.0036 0.0458 0.0766
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0357 0.0519
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0925 0.1041
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0925 0.0925
Plasmodium vivax lactate dehydrogenase 0.0192 0.4457 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.598 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.2491 0.2491
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0075 0.1447 0.242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0357 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0437 0.0636
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0075 0.1447 0.3064
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0075 0.1447 0.1628
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0925 0.1041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.095 0.095
Plasmodium vivax SET domain protein, putative 0.0036 0.0458 0.0788
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0569 0.0827
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0075 0.1447 0.2106
Echinococcus multilocularis tumor protein p63 0.0408 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0365 0.0531
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0685 0.1538
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0436 0.0436
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0849 0.0955
Schistosoma mansoni ap endonuclease 0.0023 0.0116 0.026
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.008 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0284 0.0413
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0925 0.1547
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1398 0.2338
Echinococcus granulosus L lactate dehydrogenase B chain 0.0192 0.4457 0.4457
Giardia lamblia GTOR 0.0054 0.0925 0.608
Trypanosoma cruzi ISWI complex protein 0.0018 0.0007 0.0008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0116 0.0116
Toxoplasma gondii hypothetical protein 0.0059 0.1042 0.2134

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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