Detailed information for compound 83589

Basic information

Technical information
  • TDR Targets ID: 83589
  • Name: (2S)-3-methyl-2-[[(2S)-pyrrolidine-2-carbonyl ]amino]butanoic acid
  • MW: 214.262 | Formula: C10H18N2O3
  • H donors: 3 H acceptors: 3 LogP: -1.66 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC([C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1)C
  • InChi: 1S/C10H18N2O3/c1-6(2)8(10(14)15)12-9(13)7-4-3-5-11-7/h6-8,11H,3-5H2,1-2H3,(H,12,13)(H,14,15)/t7-,8-/m0/s1
  • InChiKey: AWJGUZSYVIVZGP-YUMQZZPRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-3-methyl-2-[[oxo-[(2S)-2-pyrrolidinyl]methyl]amino]butanoic acid
  • (2S)-3-methyl-2-[[(2S)-pyrrolidin-2-yl]carbonylamino]butanoic acid
  • (2S)-3-methyl-2-[[(2S)-prolyl]amino]butyric acid
  • (2S)-3-methyl-2-[[(2S)-pyrrolidin-1-ium-2-carbonyl]amino]butanoate
  • (2S)-3-methyl-2-[[oxo-[(2S)-2-pyrrolidin-1-iumyl]methyl]amino]butanoate
  • (2S)-3-methyl-2-[[(2S)-pyrrolidin-1-ium-2-yl]carbonylamino]butanoate
  • (2S)-3-methyl-2-[[(2S)-pyrrolidin-1-ium-2-carbonyl]amino]butyrate
  • (2S)-3-methyl-2-(prolylamino)butyric acid
  • 20488-27-1
  • L-Proline, 1-L-valyl-
  • pro-val
  • prolylvaline
  • STOCK1N-32451
  • Val-pro
  • Valylproline
  • ZINC01572030

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis proline--tRNA ligase 0.0048 0.0169 0.2978
Mycobacterium ulcerans lipase LipD 0.0035 0.0103 0.142
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0078 0.0067
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0512 0.2196
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0533 0.2288
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0063 0.0251 0.3255
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0512 1
Plasmodium vivax proline--tRNA ligase, putative 0.0158 0.0748 0.0737
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0158 0.0748 1
Trichomonas vaginalis glucose transporter, putative 0.014 0.0654 0.2816
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0101 0.0447 0.8638
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0101 0.0447 0.8638
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0103 0.0634
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0025 0.0051 0.0221
Brugia malayi Sugar transporter family protein 0.0063 0.0251 0.1095
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.0748 1
Schistosoma mansoni sugar transporter 0.0063 0.0251 0.1051
Entamoeba histolytica hypothetical protein 0.0037 0.0114 0.1063
Plasmodium falciparum calcium-dependent protein kinase 3 0.0139 0.0647 0.0637
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0103 0.1243
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0103 0.0634
Schistosoma mansoni protein kinase 0.0139 0.0647 0.2786
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0086 0.0367 0.3107
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.0512 0.8024
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0251 0.1051
Trypanosoma brucei glucose transporter, putative 0.014 0.0654 0.8723
Trypanosoma brucei glucose transporter 1E 0.014 0.0654 0.8723
Brugia malayi Cam kinase protein 1 0.0139 0.0647 0.2822
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0048 0.0169 0.2801
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.073 0.3757 0.566
Echinococcus granulosus apoptotic protease activating factor 1 0.0042 0.0137 0.0549
Echinococcus multilocularis lysyl tRNA synthetase 0.0101 0.0447 0.1911
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0114 0.045
Toxoplasma gondii transporter, major facilitator family protein 0.0063 0.0251 0.0362
Schistosoma mansoni glucose transport protein 0.0451 0.2292 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Leishmania major hypothetical protein, conserved 0.0022 0.0035 0.0323
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0139 0.0647 0.0961
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0046 0.0034
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0251 0.1095
Toxoplasma gondii sugar transporter ST1 0.0063 0.0251 0.0362
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0025 0.0051 0.0326
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.017 0.0697
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0512 1
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0025 0.0051 0.0326
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Leishmania major hypothetical protein, conserved 0.0022 0.0035 0.0323
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0025 0.0051 0.0173
Echinococcus granulosus Threonyl tRNA synthetase C 0.0025 0.0051 0.0173
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0158 0.0748 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0035 0.0104
Toxoplasma gondii protein kinase, putative 0.1275 0.663 1
Onchocerca volvulus 0.0042 0.0137 0.2273
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0139 0.0647 0.2822
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.017 0.0697
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0134 0.0186
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.006 0.0234 0.3023
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0046 0.0034
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0647 0.2786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.017 0.0697
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0103 0.0401
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Brugia malayi major facilitator superfamily protein 0.0063 0.0251 0.1095
Onchocerca volvulus Cell death protein 3 homolog 0.006 0.0231 0.8634
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0512 0.7742
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0103 0.0401
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0292
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0512 0.2196
Leishmania major hypothetical protein, conserved 0.0024 0.0046 0.0464
Schistosoma mansoni lysyl-tRNA synthetase 0.0101 0.0447 0.1911
Echinococcus granulosus Sugar transporter ERD6 protein 0.0063 0.0251 0.1051
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0103 0.1243
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0103 0.0401
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0512 0.2196
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0103 0.0401
Loa Loa (eye worm) hypothetical protein 0.0035 0.0103 0.0401
Onchocerca volvulus 0.0063 0.0251 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0103 0.0401
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0451 0.2292 1
Brugia malayi hypothetical protein 0.0063 0.0251 0.1095
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0251 0.1051
Schistosoma mansoni hypothetical protein 0.0164 0.0781 0.3373
Plasmodium falciparum mitogen-activated protein kinase 2 0.073 0.3757 0.375
Leishmania major hypothetical protein, conserved 0.0063 0.0251 0.3255
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0139 0.0647 0.0637
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0139 0.0647 0.2786
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Schistosoma mansoni glucose transport protein 0.0451 0.2292 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0101 0.0447 0.5919
Plasmodium vivax lysine--tRNA ligase, putative 0.0101 0.0447 0.0436
Echinococcus granulosus mitogen activated protein kinase 3 0.006 0.0234 0.0976
Echinococcus multilocularis General substrate transporter 0.0388 0.1958 0.8536
Trypanosoma brucei glucose transporter, putative 0.014 0.0654 0.8723
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0086 0.0367 0.3107
Onchocerca volvulus 0.0063 0.0251 1
Trypanosoma brucei glucose transporter, putative 0.014 0.0654 0.8723
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0103 0.0634
Onchocerca volvulus 0.0063 0.0251 1
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0512 0.2196
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0654 0.2816
Onchocerca volvulus 0.0063 0.0251 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0063 0.0251 0.202
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0234 0.0976
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0135 0.063 0.2711
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trypanosoma brucei sugar transporter, putative 0.0063 0.0251 0.3255
Brugia malayi hypothetical protein 0.0042 0.0137 0.0596
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0103 0.0401
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0512 0.2196
Brugia malayi glycyl-tRNA synthetase 0.0025 0.0051 0.0221
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0025 0.0051 0.0059
Brugia malayi beta-lactamase 0.0035 0.0103 0.0449
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0134 0.0539
Brugia malayi beta-lactamase family protein 0.0035 0.0103 0.0449
Echinococcus granulosus solute carrier family 22 0.0063 0.0251 0.1051
Plasmodium falciparum calcium-dependent protein kinase 5 0.0139 0.0647 0.0637
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0135 0.063 0.2747
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0512 0.2196
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0292
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0025 0.0051 0.0535
Leishmania major glucose transporter, lmgt2 0.014 0.0654 0.8723
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0078 0.0685
Loa Loa (eye worm) major facilitator superfamily transporter 0.0063 0.0251 0.1051
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0046 0.0052
Trypanosoma cruzi hexose transporter, putative 0.0076 0.032 0.4188
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0139 0.0647 0.863
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0135 0.063 0.2711
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0139 0.0647 0.2786
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0139 0.0647 0.2786
Echinococcus multilocularis solute carrier family 22 0.0063 0.0251 0.1051
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0063 0.0251 0.1051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0103 0.0401
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0139 0.0647 0.0961
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0088 0.0382 0.1625
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0025 0.0051 0.0535
Onchocerca volvulus 0.0063 0.0251 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0063 0.0251 0.4526
Brugia malayi hypothetical protein 0.0063 0.0251 0.1095
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1104 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0063 0.0251 0.1051
Schistosoma mansoni sugar transporter 0.0063 0.0251 0.1051
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0114 0.045
Onchocerca volvulus 0.0063 0.0251 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0139 0.0647 0.2786
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0078 0.0067
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.0051 0.0535
Toxoplasma gondii 6-phosphofructokinase 0.0031 0.0078 0.0101
Schistosoma mansoni hypothetical protein 0.0164 0.0781 0.3373
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.0512 0.6802
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0103 0.1139
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Schistosoma mansoni hypothetical protein 0.0037 0.0114 0.045
Brugia malayi hypothetical protein 0.0037 0.0114 0.0498
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.017 0.0743
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.006 0.0234 0.0976
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0101 0.0447 0.6932
Chlamydia trachomatis lysine--tRNA ligase 0.0101 0.0447 1
Onchocerca volvulus 0.0063 0.0251 1
Toxoplasma gondii glycyl-tRNA synthetase 0.0025 0.0051 0.0059
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0025 0.0051 0.0173
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0114 0.045
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.073 0.3757 0.375
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0035 0.0323
Plasmodium falciparum threonine--tRNA ligase 0.0025 0.0051 0.0039
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0512 0.2196
Giardia lamblia Lysyl-tRNA synthetase 0.0101 0.0447 0.6849
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.006 0.0234 0.3023
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0139 0.0647 0.0637
Echinococcus multilocularis caspase 2 0.006 0.0231 0.0962
Toxoplasma gondii sugar transporter ST3 0.0063 0.0251 0.0362
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0139 0.0647 0.2786
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0134 0.0539
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0139 0.0647 0.0961
Mycobacterium tuberculosis Conserved protein 0.0035 0.0103 0.0634
Trypanosoma brucei glucose transporter, putative 0.014 0.0654 0.8723
Loa Loa (eye worm) hypothetical protein 0.0035 0.0103 0.0401
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0063 0.0251 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.006 0.0234 0.3023
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.2292 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.006 0.0234 0.0976
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0063 0.0251 0.024
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0031 0.0078 0.0101
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0451 0.2292 1
Trichomonas vaginalis glucose transporter, putative 0.0063 0.0251 0.1051
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0251 0.1051
Echinococcus multilocularis geminin 0.0164 0.0781 0.3373
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0103 0.0449
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Echinococcus multilocularis solute carrier family 22 0.0063 0.0251 0.1051
Plasmodium vivax CDK-related protein kinase 6, putative 0.1916 1 1
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0022 0.0035 0.0323
Mycobacterium ulcerans beta-lactamase 0.0035 0.0103 0.142
Onchocerca volvulus Putative transporter 0.0063 0.0251 1
Trichomonas vaginalis sugar transporter, putative 0.014 0.0654 0.2816
Echinococcus granulosus General substrate transporter 0.0388 0.1958 0.8536
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0103 0.142
Schistosoma mansoni hypothetical protein 0.0042 0.0137 0.0549
Brugia malayi Sugar transporter family protein 0.0451 0.2292 1
Mycobacterium ulcerans sugar transporter 0.0063 0.0251 0.4526
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0116 0.0105
Brugia malayi Sugar transporter family protein 0.0063 0.0251 0.1095
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0025 0.0051 0.0262
Brugia malayi major facilitator superfamily protein 0.0063 0.0251 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0022 0.0035 0.0323
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0103 0.1243
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0025 0.0051 0.0173
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0512 0.2196
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0635 0.2734
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0018 0.0011 0.0049
Plasmodium vivax threonine--tRNA ligase, putative 0.0025 0.0051 0.0039
Echinococcus multilocularis mitogen activated protein kinase 0.006 0.0234 0.0976
Schistosoma mansoni glycyl-tRNA synthetase 0.0025 0.0051 0.0173
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0135 0.063 0.9712
Loa Loa (eye worm) hypothetical protein 0.0139 0.0647 0.2786
Plasmodium falciparum calcium-dependent protein kinase 1 0.0139 0.0647 0.0637
Trypanosoma brucei glucose transporter, putative 0.014 0.0654 0.8723
Echinococcus granulosus geminin 0.0164 0.0781 0.3373
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0139 0.0647 0.2786
Loa Loa (eye worm) hypothetical protein 0.0135 0.063 0.2711
Plasmodium falciparum calcium-dependent protein kinase 4 0.0139 0.0647 0.0637
Mycobacterium ulcerans hypothetical protein 0.0035 0.0103 0.142
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0103 0.0634
Entamoeba histolytica protein kinase, putative 0.0139 0.0647 1
Leishmania major protein kinase, putative 0.0139 0.0647 0.863
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0031 0.0078 0.0685
Loa Loa (eye worm) hypothetical protein 0.0042 0.0137 0.0549
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0656 0.2861
Schistosoma mansoni serine/threonine protein kinase 0.006 0.0234 0.0976
Plasmodium falciparum hexose transporter 0.0451 0.2292 0.2283
Entamoeba histolytica hypothetical protein 0.0037 0.0114 0.1063
Brugia malayi beta-lactamase family protein 0.0035 0.0103 0.0449
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0116 0.1099
Plasmodium vivax glycine--tRNA ligase, putative 0.0025 0.0051 0.0039
Brugia malayi phosphofructokinase 0.0113 0.0512 0.2234
Mycobacterium ulcerans integral membrane transport protein 0.0063 0.0251 0.4526
Echinococcus multilocularis solute carrier family 22 0.0063 0.0251 0.1051
Trypanosoma cruzi hexose transporter, putative 0.0063 0.0251 0.3255
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.0748 1
Echinococcus multilocularis apoptotic protease activating factor 1 0.0042 0.0137 0.0549
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0103 0.0634
Echinococcus granulosus solute carrier family 22 0.0063 0.0251 0.1051
Mycobacterium tuberculosis Conserved protein 0.0035 0.0103 0.0634
Echinococcus multilocularis synaptic vesicle 2 protein 0.0063 0.0251 0.1051
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.017 0.0697
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0063 0.0251 0.4526
Plasmodium vivax 6-phosphofructokinase, putative 0.0031 0.0078 0.0067
Loa Loa (eye worm) hypothetical protein 0.0135 0.063 0.2711
Brugia malayi MH2 domain containing protein 0.0117 0.0533 0.2326
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0234 0.3023
Echinococcus granulosus lysyl tRNA synthetase 0.0101 0.0447 0.1911
Trypanosoma cruzi hexose transporter, putative 0.014 0.0654 0.8723
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0135 0.063 0.2711
Echinococcus granulosus caspase 2 0.006 0.0231 0.0962
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.2292 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.006 0.0234 0.3023
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0063 0.0251 1
Loa Loa (eye worm) sugar transporter 0.0451 0.2292 1
Echinococcus granulosus solute carrier family 22 0.0063 0.0251 0.1051
Loa Loa (eye worm) sugar transporter 0.0063 0.0251 0.1051
Schistosoma mansoni glucose transport protein 0.0451 0.2292 1
Leishmania major glucose transporter, lmgt3 0.014 0.0654 0.8723
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0134 0.0539
Schistosoma mansoni protein kinase 0.0139 0.0647 0.2786
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0116 0.1131
Schistosoma mansoni sugar transporter 0.0063 0.0251 0.1051
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0292
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0101 0.0447 0.1911
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Echinococcus multilocularis calcium dependent protein kinase 0.013 0.0599 0.2578
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0139 0.0647 0.2786
Leishmania major myo-inositol/proton symporter (MIT) 0.0063 0.0251 0.3255
Loa Loa (eye worm) hypothetical protein 0.0101 0.0447 0.1911
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0103 0.0401
Echinococcus granulosus glycyl tRNA synthetase 0.0025 0.0051 0.0173
Giardia lamblia Kinase, CMGC MAPK 0.006 0.0234 0.3165
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0031 0.0078 0.0588
Trypanosoma brucei THT1 - hexose transporter, putative 0.014 0.0654 0.8723
Plasmodium vivax calcium-dependent protein kinase, putative 0.0139 0.0647 0.0637
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.2292 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0103 0.0634
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Loa Loa (eye worm) beta-lactamase 0.0035 0.0103 0.0401
Leishmania major lysyl-tRNA synthetase, putative 0.0101 0.0447 0.5919
Trypanosoma brucei THT1 - hexose transporter, putative 0.014 0.0654 0.8723
Mycobacterium tuberculosis Conserved protein 0.0035 0.0103 0.0634
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0139 0.0647 0.2786
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0292
Loa Loa (eye worm) hypothetical protein 0.0035 0.0103 0.0401
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0512 0.7742
Onchocerca volvulus 0.0063 0.0251 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0656 0.2825
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Plasmodium vivax hexose transporter 0.0451 0.2292 0.2283
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0031 0.0078 0.0469
Brugia malayi 6-phosphofructokinase 0.0113 0.0512 0.2234
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0035 0.0104
Brugia malayi 6-phosphofructokinase 0.0113 0.0512 0.2234
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0046 0.0034
Entamoeba histolytica hypothetical protein 0.0037 0.0114 0.1063
Plasmodium falciparum proline--tRNA ligase 0.0158 0.0748 0.0737
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Schistosoma mansoni glucose transporter 0.0063 0.0251 0.1051
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0234 0.0976
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0251 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0025 0.0051 0.0145
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0134 0.0186
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0656 0.2825
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0135 0.063 0.2711
Schistosoma mansoni hypothetical protein 0.0451 0.2292 1
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0022 0.0035 0.0036
Trichomonas vaginalis esterase, putative 0.0035 0.0103 0.0401
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Plasmodium falciparum protein kinase 7 0.1275 0.663 0.6626
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0451 0.2292 1
Brugia malayi hypothetical protein 0.0024 0.0046 0.0199
Trypanosoma brucei glucose transporter, putative 0.014 0.0654 0.8723
Trypanosoma cruzi hexose transporter, putative 0.014 0.0654 0.8723
Toxoplasma gondii phosphofructokinase PFKII 0.0031 0.0078 0.0101
Treponema pallidum prolyl-tRNA synthetase 0.0048 0.0169 0.2558
Trypanosoma brucei glucose transporter, putative 0.014 0.0654 0.8723
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0046 0.0464
Onchocerca volvulus 0.0063 0.0251 1
Onchocerca volvulus 0.0063 0.0251 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.017 0.0697
Brugia malayi MAP kinase sur-1 0.006 0.0234 0.102
Trichomonas vaginalis sugar transporter, putative 0.014 0.0654 0.2816
Trypanosoma brucei glucose transporter, putative 0.014 0.0654 0.8723
Toxoplasma gondii facilitative glucose transporter GT1 0.0451 0.2292 0.3446
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.2292 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0046 0.0464
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.006 0.0234 0.3023
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0158 0.0748 0.1113
Onchocerca volvulus 0.0063 0.0251 1
Echinococcus multilocularis solute carrier family 22 0.0063 0.0251 0.1051
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.017 0.0697
Schistosoma mansoni sugar transporter 0.0063 0.0251 0.1051
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0134 0.0123
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0031 0.0078 0.0456
Plasmodium falciparum calcium-dependent protein kinase 2 0.0139 0.0647 0.0637
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0173
Brugia malayi hypothetical protein 0.0063 0.0251 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Onchocerca volvulus 0.0063 0.0251 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0103 0.0634
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0086 0.0367 0.5587
Trypanosoma cruzi hexose transporter, putative 0.014 0.0654 0.8723
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Loa Loa (eye worm) acetyltransferase 0.014 0.0656 0.2825
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0103 0.0401
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0234 0.0976
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0056 0.021 0.0869
Brugia malayi lysyl-tRNA synthetase 0.0101 0.0447 0.1951
Loa Loa (eye worm) hypothetical protein 0.0035 0.0103 0.0401
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.006 0.0234 0.3023
Trichomonas vaginalis sugar transport protein, putative 0.0063 0.0251 0.1051
Plasmodium falciparum lysine--tRNA ligase 0.0101 0.0447 0.0436
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0451 0.2292 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0035 0.0104
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0139 0.0647 0.0637
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0139 0.0647 0.2786
Onchocerca volvulus 0.0063 0.0251 1
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0292
Leishmania major threonyl-tRNA synthetase, putative 0.0025 0.0051 0.0535
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Loa Loa (eye worm) hypothetical protein 0.011 0.0496 0.2125
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0101 0.0447 0.5919
Onchocerca volvulus 0.0063 0.0251 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0063 0.0251 0.202
Schistosoma mansoni protein kinase 0.0139 0.0647 0.2786
Trypanosoma cruzi sugar transporter, putative 0.0063 0.0251 0.3255
Giardia lamblia Prolyl-tRNA synthetase 0.0135 0.063 1
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0025 0.0051 0.0221
Leishmania major hypothetical protein, conserved 0.0035 0.0103 0.1243
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0139 0.0647 0.2786
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0103 0.0401
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0103 0.0092
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0135 0.063 0.2747
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0512 0.6802
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Entamoeba histolytica protein kinase, putative 0.0139 0.0647 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0512 0.4463
Brugia malayi Cell death protein 3 precursor 0.006 0.0231 0.1007
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0031 0.0078 0.0067
Schistosoma mansoni caspase-7 (C14 family) 0.006 0.0231 0.0962
Mycobacterium leprae Probable lipase LipE 0.0035 0.0103 0.1139
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0533 0.2288
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0512 0.7742
Trichomonas vaginalis phosphofructokinase, putative 0.0031 0.0078 0.0292
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0103 0.0401
Echinococcus granulosus mitogen activated protein kinase 0.006 0.0234 0.0976
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0031 0.0078 0.0292
Trichomonas vaginalis myo-inositol transporter, putative 0.0063 0.0251 0.1051
Trypanosoma brucei glucose transporter 2A 0.014 0.0654 0.8723
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0512 0.2196
Brugia malayi Major Facilitator Superfamily protein 0.0063 0.0251 0.1095
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0022 0.0035 0.0323
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0046 0.0464
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0103 0.0401
Plasmodium vivax sugar transporter, putative 0.0063 0.0251 0.024
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.006 0.0234 0.0336
Giardia lamblia Hexose transporter 0.0063 0.0251 0.346
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trichomonas vaginalis glucose transporter, putative 0.014 0.0654 0.2816
Echinococcus multilocularis glycyl tRNA synthetase 0.0025 0.0051 0.0173
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Trichomonas vaginalis conserved hypothetical protein 0.014 0.0654 0.2816
Trypanosoma brucei protein kinase, putative 0.006 0.0234 0.3023
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0135 0.063 1
Trypanosoma cruzi hexose transporter 0.014 0.0654 0.8723
Leishmania major glucose transporter, lmgt1 0.014 0.0654 0.8723
Entamoeba histolytica hypothetical protein 0.0037 0.0114 0.1063
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0451 0.2292 1
Entamoeba histolytica hypothetical protein 0.0101 0.0447 0.6652
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0035 0.0323
Toxoplasma gondii lysine-tRNA ligase 0.0101 0.0447 0.0659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.017 0.0697
Giardia lamblia Sugar-proton symporter 0.0063 0.0251 0.346
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.0512 0.6802
Schistosoma mansoni lysyl-tRNA synthetase 0.0101 0.0447 0.1911
Trichomonas vaginalis CAMK family protein kinase 0.0139 0.0647 0.2786
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0046 0.015
Onchocerca volvulus 0.0063 0.0251 1
Trichomonas vaginalis sugar transporter, putative 0.014 0.0654 0.2816
Leishmania major glucose transporter/membrane transporter D2, putative 0.014 0.0654 0.8723
Trichomonas vaginalis sugar transporter, putative 0.0063 0.0251 0.1051
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0135 0.063 0.2711
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Toxoplasma gondii sugar transporter ST2 0.0063 0.0251 0.0362
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0025 0.0051 0.0173
Toxoplasma gondii ABC1 family protein 0.0035 0.0103 0.0138
Trichomonas vaginalis CMGC family protein kinase 0.006 0.0234 0.0976
Loa Loa (eye worm) hypothetical protein 0.0063 0.0251 0.1051
Trypanosoma brucei THT1 - hexose transporter, putative 0.014 0.0654 0.8723
Echinococcus granulosus calcium dependent protein kinase 0.013 0.0599 0.2578
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0251 0.1051
Onchocerca volvulus 0.0063 0.0251 1
Echinococcus granulosus solute carrier family 22 0.0063 0.0251 0.1051
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0251 0.1051
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0158 0.0748 1
Echinococcus granulosus synaptic vesicle 2 protein 0.0063 0.0251 0.1051
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0512 0.2196
Trypanosoma cruzi glucose transporter, putative 0.0063 0.0251 0.3255
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.017 0.0697
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0103 0.142
Loa Loa (eye worm) hypothetical protein 0.006 0.0231 0.0962
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0025 0.0051 0.0535
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0512 0.2196

Activities

Activity type Activity value Assay description Source Reference
Log 1/T (functional) NI 0 Bitter threshold value; NI denotes'Not identifiable (Citrous or fruity taste)' ChEMBL. 3656360

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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