Detailed information for compound 836009

Basic information

Technical information
  • TDR Targets ID: 836009
  • Name: 4-[4-methyl-5-[[3-(4-methylphenyl)-1,2,4-oxad iazol-5-yl]methylsulfanyl]-1,2,4-triazol-3-yl ]pyridine
  • MW: 364.424 | Formula: C18H16N6OS
  • H donors: 0 H acceptors: 5 LogP: 2.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)c1noc(n1)CSc1nnc(n1C)c1ccncc1
  • InChi: 1S/C18H16N6OS/c1-12-3-5-13(6-4-12)16-20-15(25-23-16)11-26-18-22-21-17(24(18)2)14-7-9-19-10-8-14/h3-10H,11H2,1-2H3
  • InChiKey: ZGPYILCTJDRGJL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[4-methyl-5-[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methylthio]-1,2,4-triazol-3-yl]pyridine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0035 0.0033
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1174 0.4176
Brugia malayi Hemopexin family protein 0.0112 0.1205 0.5052
Entamoeba histolytica hypothetical protein 0.0071 0.0709 0.5832
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0205 0.061
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.009 0.0088
Echinococcus granulosus dnaJ subfamily C 6 0.0062 0.0596 0.1787
Brugia malayi hypothetical protein 0.002 0.009 0.0379
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0431 0.0429
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.028 0.0795
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0208 0.0571
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0385 0.1617
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0214 0.0605
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0079 0.0805 0.23
Mycobacterium ulcerans hydrolase 0.0096 0.1014 0.8636
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0145 0.1237
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0035 0.0033
Brugia malayi isocitrate dehydrogenase 0.0015 0.0035 0.0147
Echinococcus multilocularis geminin 0.0164 0.1833 0.1831
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.028 0.0835
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0431 0.1228
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0774 0.221
Entamoeba histolytica hypothetical protein 0.0071 0.0709 0.5832
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0205 0.9525
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0017 0.0059 0.0249
Echinococcus multilocularis unc 13 (munc13) 0.0015 0.0029 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0059 0.0163
Schistosoma mansoni rab6-interacting 0.002 0.009 0.0251
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1174 1
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0059 0.0163
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0511 0.0509
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.028 0.0277
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0208 0.9669
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0145 0.6163
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0288 0.3323 0.3321
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0208 0.9669
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0549 0.0546
Echinococcus multilocularis peregrin 0.0029 0.0205 0.0203
Loa Loa (eye worm) hypothetical protein 0.0079 0.0805 0.3378
Trypanosoma brucei rac serine-threonine kinase, putative 0.0017 0.0059 0.0505
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0205 0.0203
Echinococcus multilocularis serine threonine protein kinase 0.01 0.1054 0.1052
Schistosoma mansoni rab6-interacting 0.002 0.009 0.0251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0385 0.1097
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0145 0.6374
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.009 0.0088
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0379
Brugia malayi Protein kinase c protein 2 0.0095 0.0998 0.4185
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1174 0.4923
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1174 0.3356
Onchocerca volvulus 0.002 0.009 0.0227
Onchocerca volvulus Matrilysin homolog 0.0176 0.1969 0.7171
Schistosoma mansoni hypothetical protein 0.0293 0.3381 0.968
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0549 0.4511
Onchocerca volvulus 0.0112 0.1205 0.4346
Onchocerca volvulus Alhambra homolog 0.0029 0.0205 0.0652
Loa Loa (eye worm) hypothetical protein 0.0096 0.1014 0.4251
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0431 0.0429
Schistosoma mansoni unc-13 (munc13) 0.0017 0.0051 0.0139
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0017 0.0059 0.0171
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0035 0.0299
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0288 0.3323 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0176 0.1969 0.7171
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0013 0.0003 0.0011
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Brugia malayi phosphofructokinase 0.011 0.1174 0.4923
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0013 0.0003 0.0011
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.009 0.3091
Echinococcus granulosus protein kinase C gamma type 0.01 0.1054 0.3168
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.009 0.0264
Brugia malayi jmjC domain containing protein 0.0096 0.1013 0.4248
Brugia malayi hypothetical protein 0.0071 0.0709 0.2975
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0017 0.0059 0.0057
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.009 0.0264
Echinococcus granulosus Protein kinase C brain isozyme 0.0112 0.1202 0.3613
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0208 0.0571
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0059 0.0163
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0084 0.0858 0.2452
Brugia malayi hypothetical protein 0.0016 0.0041 0.017
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1174 1
Brugia malayi Matrixin family protein 0.0079 0.0805 0.3378
Echinococcus multilocularis RUN 0.002 0.009 0.0088
Trichomonas vaginalis protein kinase inhibitor, putative 0.0062 0.0596 0.202
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0385 0.0383
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0208 1
Brugia malayi C1-like domain containing protein 0.0013 0.0003 0.0011
Onchocerca volvulus Matrilysin homolog 0.0079 0.0805 0.2871
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0035 0.0033
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1174 0.1171
Loa Loa (eye worm) hypothetical protein 0.0079 0.0805 0.3378
Brugia malayi mbt repeat family protein 0.0048 0.0431 0.1808
Loa Loa (eye worm) hypothetical protein 0.0092 0.0962 0.4037
Loa Loa (eye worm) AGC/PKN protein kinase 0.0017 0.0059 0.0249
Loa Loa (eye worm) hypothetical protein 0.0055 0.0511 0.2145
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0385 0.1617
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1174 0.4176
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0145 0.6374
Brugia malayi 6-phosphofructokinase 0.011 0.1174 0.4923
Schistosoma mansoni unc-13 (munc13) 0.0015 0.0029 0.0075
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0431 0.1228
Echinococcus granulosus unc 13 munc13 0.0015 0.0029 0.0079
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0431 0.1487
Echinococcus granulosus serine:threonine protein kinase N2 0.0017 0.0059 0.0171
Brugia malayi hypothetical protein 0.002 0.009 0.0379
Schistosoma mansoni hypothetical protein 0.0164 0.1833 0.5244
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Loa Loa (eye worm) DnaJ domain-containing protein 0.0062 0.0596 0.25
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1247 0.5231
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0083 0.085 0.3565
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Brugia malayi MH2 domain containing protein 0.0116 0.1247 0.5231
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0431 0.1228
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0032 0.0238 0.0998
Onchocerca volvulus 0.0048 0.0431 0.1487
Echinococcus multilocularis protein kinase c epsilon type 0.0032 0.0238 0.0235
Schistosoma mansoni lipoxygenase 0.002 0.009 0.0251
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0017 0.0059 0.0171
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0035 0.0147
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.02 0.0596
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0035 0.0299
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0035 0.0299
Loa Loa (eye worm) hypothetical protein 0.002 0.009 0.0379
Brugia malayi Matrixin family protein 0.0079 0.0805 0.3378
Schistosoma mansoni polycystin 1-related 0.002 0.009 0.0251
Brugia malayi jmjC domain containing protein 0.0036 0.028 0.1174
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0017 0.0059 0.0249
Brugia malayi Protein kinase domain containing protein 0.0017 0.0059 0.0249
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0431 0.129
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0385 0.1153
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2734 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2384 1
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0238 0.0674
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0059 0.0163
Loa Loa (eye worm) hypothetical protein 0.008 0.0815 0.3417
Trypanosoma brucei RNA helicase, putative 0.0105 0.1111 0.9462
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0549 0.4675
Schistosoma mansoni hypothetical protein 0.0071 0.0709 0.2025
Entamoeba histolytica hypothetical protein 0.0071 0.0709 0.5832
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0709 0.2025
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0511 0.2145
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1174 1
Brugia malayi hypothetical protein 0.0024 0.0145 0.0609
Schistosoma mansoni lipoxygenase 0.0056 0.0522 0.1489
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0205 0.9525
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.008 0.0815 0.0812
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0017 0.0059 0.0249
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0205 0.9525
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0385 0.1153
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.1202 0.3437
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0511 0.1458
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0549 0.4675
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0096 0.1014 0.4251
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0214 0.0636
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1174 1
Loa Loa (eye worm) phosphofructokinase 0.011 0.1174 0.4923
Echinococcus granulosus RNA directed DNA polymerase 0.008 0.0815 0.2446
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0208 0.0571
Loa Loa (eye worm) doublecortin family protein 0.002 0.009 0.0379
Schistosoma mansoni loxhd1 0.002 0.009 0.0251
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.2139 0.6433
Loa Loa (eye worm) hypothetical protein 0.0079 0.0805 0.3378
Brugia malayi p70 ribosomal S6 kinase beta 0.0017 0.0059 0.0249
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1174 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0549 0.2301
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0344 0.1029
Echinococcus multilocularis protein kinase c iota type 0.003 0.0207 0.0205
Onchocerca volvulus 0.002 0.009 0.0227
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.009 0.0264
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0502 0.2104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0385 0.1097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0385 0.1097
Loa Loa (eye worm) hypothetical protein 0.005 0.0459 0.1924
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0511 0.0509
Schistosoma mansoni glucose-6-phosphatase 0.0302 0.3493 1
Brugia malayi PHD-finger family protein 0.0029 0.0205 0.0861
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0549 0.1645
Entamoeba histolytica hypothetical protein 0.0071 0.0709 0.5832
Brugia malayi Hr1 repeat family protein 0.0017 0.0059 0.0249
Echinococcus granulosus protein kinase c iota type 0.003 0.0207 0.0616
Schistosoma mansoni serine/threonine kinase 0.0017 0.0059 0.0163
Onchocerca volvulus 0.0079 0.0805 0.2871
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0035 0.0299
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0511 0.1532
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0214 0.0211
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1174 0.3356
Schistosoma mansoni hypothetical protein 0.0062 0.0596 0.17
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Loa Loa (eye worm) hypothetical protein 0.0048 0.0431 0.1808
Schistosoma mansoni hypothetical protein 0.0164 0.1833 0.5244
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0583 0.2446
Loa Loa (eye worm) AGC/AKT protein kinase 0.0017 0.0059 0.0249
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0208 1
Trichomonas vaginalis AGC family protein kinase 0.0017 0.0059 0.0017
Echinococcus multilocularis RNA directed DNA polymerase 0.008 0.0815 0.0812
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0035 0.0033
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0017 0.0059 0.0171
Brugia malayi protein kinase C3,putative 0.0013 0.0003 0.0011
Loa Loa (eye worm) AGC/NDR protein kinase 0.0017 0.0059 0.0249
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0145 0.1237
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0017 0.0059 0.0057
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0015 0.0029 0.0026
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0208 0.9669
Brugia malayi Protein kinase domain containing protein 0.0013 0.0003 0.0011
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0112 0.1202 0.12
Loa Loa (eye worm) MBCTL1 0.0055 0.0511 0.2145
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1174 0.4923
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0015 0.0029 0.0079
Schistosoma mansoni hypothetical protein 0.002 0.009 0.0251
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0096 0.1014 0.8594
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0511 0.1532
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0431 0.1808
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.1013 0.3042
Brugia malayi Pre-SET motif family protein 0.021 0.2384 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0205 0.0861
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0035 0.0147
Echinococcus multilocularis conserved hypothetical protein 0.03 0.3469 0.3467
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0017 0.0059 0.0057
Echinococcus granulosus RUN 0.002 0.009 0.0264
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0214 0.0605
Brugia malayi Matrixin family protein 0.0192 0.216 0.9059
Echinococcus granulosus peregrin 0.0029 0.0205 0.061
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0208 0.1332
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.009 0.0088
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1174 1
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1174 1
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0208 0.5
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1174 0.4176
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0709 0.2128
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0208 0.0571
Loa Loa (eye worm) hypothetical protein 0.0029 0.0205 0.0861
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0035 0.0098
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1174 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0145 0.1237
Brugia malayi mbt repeat family protein 0.0048 0.0431 0.1808
Schistosoma mansoni hypothetical protein 0.0112 0.1205 0.3444
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0208 0.0571
Brugia malayi Protein kinase domain containing protein 0.0017 0.0059 0.0249
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0145 0.6163
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0549 0.1565
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0549 0.4675
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0214 1
Toxoplasma gondii AGC kinase 0.0017 0.0059 0.1357
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0035 0.0093
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1174 1
Brugia malayi Doublecortin family protein 0.002 0.009 0.0379
Schistosoma mansoni atypical protein kinase C 0.003 0.0207 0.0586
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0385 0.0383
Leishmania major hypothetical protein, conserved 0.0024 0.0145 0.1237
Echinococcus multilocularis serine:threonine protein kinase 38 0.0017 0.0059 0.0057
Brugia malayi DnaJ domain containing protein 0.0062 0.0596 0.25
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1174 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0522 0.1565
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.1013 0.101
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0709 0.0707
Loa Loa (eye worm) matrixin family protein 0.0176 0.1969 0.8258
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0208 0.5
Echinococcus granulosus NDR protein kinase 0.0017 0.0059 0.0171
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0208 0.0571
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0344 0.0342
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.0059 0.0057
Schistosoma mansoni hypothetical protein 0.0105 0.1111 0.3175
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0214 0.0211
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0208 1
Brugia malayi 6-phosphofructokinase 0.011 0.1174 0.4923
Brugia malayi Matrixin family protein 0.0079 0.0805 0.3378
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0208 0.9669
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.028 0.1174
Onchocerca volvulus 0.0239 0.2734 1
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0208 0.9669
Plasmodium falciparum LCCL domain-containing protein 0.002 0.009 0.3197
Schistosoma mansoni protein kinase C 0.0015 0.0029 0.0075
Onchocerca volvulus 0.003 0.0214 0.0683
Brugia malayi Pre-SET motif family protein 0.003 0.0214 0.0896
Loa Loa (eye worm) hypothetical protein 0.0015 0.0029 0.0121
Loa Loa (eye worm) matrix metalloproteinase 0.0079 0.0805 0.3378
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.1202 0.3437
Loa Loa (eye worm) matrixin family protein 0.0192 0.216 0.9059
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0013 0.0003 0.0011
Echinococcus granulosus protein kinase c epsilon type 0.0032 0.0238 0.0709
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.028 0.0795
Loa Loa (eye worm) hypothetical protein 0.0017 0.0059 0.0249
Brugia malayi Bromodomain containing protein 0.0029 0.0205 0.0861
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0431 0.129
Echinococcus multilocularis serine:threonine protein kinase N2 0.0017 0.0059 0.0057
Brugia malayi protein kinase C II. 0.0032 0.0238 0.0998
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1174 0.4176
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0522 0.052
Brugia malayi Protein kinase domain containing protein 0.0017 0.0059 0.0249
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0035 0.0299
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0208 0.0571
Echinococcus granulosus geminin 0.0164 0.1833 0.5512
Schistosoma mansoni hypothetical protein 0.0029 0.0205 0.0581
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1247 0.5231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0214 0.0605
Echinococcus multilocularis conserved hypothetical protein 0.03 0.3469 0.3467
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0017 0.0059 0.0249
Plasmodium falciparum phd finger protein, putative 0.0029 0.0205 0.9851
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.0896
Loa Loa (eye worm) hypothetical protein 0.0024 0.0145 0.0609
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1174 0.3527
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0035 0.0033
Brugia malayi Matrixin family protein 0.0079 0.0805 0.3378
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0214 0.0605
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.2139 0.2137
Echinococcus multilocularis dnaJ subfamily C 6 0.0062 0.0596 0.0594
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0205 0.0581
Plasmodium vivax SET domain protein, putative 0.003 0.0214 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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