Detailed information for compound 836998

Basic information

Technical information
  • TDR Targets ID: 836998
  • Name: N-(4-bromophenyl)-2-[3-[(4-fluorophenyl)methy l]-4-oxopyrido[2,3-d]pyrimidin-2-yl]sulfanyla cetamide
  • MW: 499.355 | Formula: C22H16BrFN4O2S
  • H donors: 1 H acceptors: 3 LogP: 4.27 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Br)CSc1nc2ncccc2c(=O)n1Cc1ccc(cc1)F
  • InChi: 1S/C22H16BrFN4O2S/c23-15-5-9-17(10-6-15)26-19(29)13-31-22-27-20-18(2-1-11-25-20)21(30)28(22)12-14-3-7-16(24)8-4-14/h1-11H,12-13H2,(H,26,29)
  • InChiKey: QIKDHWDENBPGBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromophenyl)-2-[3-[(4-fluorophenyl)methyl]-4-oxo-pyrido[2,3-d]pyrimidin-2-yl]sulfanyl-acetamide
  • N-(4-bromophenyl)-2-[[3-[(4-fluorophenyl)methyl]-4-oxo-2-pyrido[2,3-d]pyrimidinyl]thio]acetamide
  • N-(4-bromophenyl)-2-[[3-(4-fluorobenzyl)-4-keto-pyrido[2,3-d]pyrimidin-2-yl]thio]acetamide
  • N-(4-bromophenyl)-2-[3-[(4-fluorophenyl)methyl]-4-oxo-pyrido[2,3-d]pyrimidin-2-yl]sulfanyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0699 0.1399
Brugia malayi Muscleblind-like protein 0.0325 0.4053 1
Echinococcus multilocularis dnaJ subfamily B 0.0399 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0013 0.0079 0.0123
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0012 0.0012
Schistosoma mansoni hypothetical protein 0.0019 0.0157 0.0313
Echinococcus multilocularis RUN 0.0019 0.0157 0.0157
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0699 0.17
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.002 0.002
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0088 0.1027 0.3419
Loa Loa (eye worm) TOPoisomerase family member 0.0013 0.0079 0.0164
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.048 0.1158
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1397 0.3426
Giardia lamblia Heat shock protein HSP 90-alpha 0.0013 0.0079 0.5
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0079 0.0123
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0013 0.0079 1
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Loa Loa (eye worm) hypothetical protein 0.0087 0.1016 0.2484
Loa Loa (eye worm) TK/FAK protein kinase 0.025 0.3093 0.7624
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0013 0.0079 1
Trypanosoma brucei heat shock protein, putative 0.0013 0.0079 0.0123
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0013 0.0079 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0598 0.0598
Echinococcus multilocularis smad 0.0008 0.0012 0.0012
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0043 0.0076
Trypanosoma brucei heat shock protein, putative 0.0013 0.0079 0.0123
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0013 0.0079 0.5476
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0108 0.0224
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0036 0.0373 0.0891
Echinococcus granulosus c-Jun N-terminal kinases 0.0225 0.2785 0.5569
Entamoeba histolytica protein kinase, putative 0.0088 0.1027 1
Schistosoma mansoni polycystin 1-related 0.0019 0.0157 0.0313
Echinococcus granulosus Smad4 0.0008 0.0012 0.0025
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0013 0.0079 1
Brugia malayi Cytochrome P450 family protein 0.001 0.0043 0.0076
Mycobacterium leprae Probable two-component sensor kinase 0.0013 0.0079 0.5476
Brugia malayi Endoplasmin precursor 0.0013 0.0079 0.0164
Echinococcus granulosus smad 0.0008 0.0012 0.0025
Echinococcus granulosus RUN 0.0019 0.0157 0.0313
Loa Loa (eye worm) heat shock protein 90 0.0013 0.0079 0.0164
Echinococcus granulosus heat shock protein 90 0.0013 0.0079 0.0157
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0052 0.0569 0.1378
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Schistosoma mansoni rab6-interacting 0.0019 0.0157 0.0313
Schistosoma mansoni hypothetical protein 0.0399 0.5 1
Echinococcus multilocularis cpg binding protein 0.003 0.0289 0.0289
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.048 0.048
Schistosoma mansoni endoplasmin 0.0013 0.0079 0.0157
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0157 0.0313
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0119 0.0264
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0119 0.0264
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0157 0.0313
Brugia malayi hypothetical protein 0.0019 0.0157 0.0357
Trypanosoma brucei developmentally regulated phosphoprotein 0.0236 0.2921 1
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0013 0.0079 0.5476
Loa Loa (eye worm) hypothetical protein 0.0036 0.0369 0.0883
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0013 0.0079 1
Echinococcus granulosus dual specificity 0.0088 0.1027 0.2055
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Echinococcus multilocularis protein tyrosine kinase 0.0247 0.3056 0.3056
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0013 0.0079 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0088 0.1027 0.2512
Echinococcus multilocularis geminin 0.0171 0.2094 0.2094
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0598 0.1196
Mycobacterium leprae Possible regulatory protein 0.0015 0.0108 1
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0108 0.0224
Trypanosoma brucei DNA topoisomerase ii 0.0013 0.0079 0.0123
Trypanosoma brucei heat shock protein 90, putative 0.0013 0.0079 0.0123
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0096 0.1131 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0269 0.0634
Leishmania major protein kinase, putative 0.0016 0.0119 0.0264
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0588 0.501
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0236 0.2921 1
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0013 0.0079 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0236 0.2921 0.2921
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0013 0.0079 0.5
Leishmania major DNA topoisomerase ii 0.0013 0.0079 0.0123
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0044
Giardia lamblia Pms1-like protein 0.0013 0.0079 0.5
Trypanosoma cruzi Heat shock protein 83, putative 0.0013 0.0079 0.0123
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0013 0.0079 1
Echinococcus granulosus protein tyrosine kinase 0.0247 0.3056 0.6111
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0036 0.0373 0.0745
Trypanosoma cruzi heat shock protein 85, putative 0.0013 0.0079 0.0123
Brugia malayi PAS domain containing protein 0.0015 0.0108 0.0236
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0083 0.0963 0.3197
Mycobacterium ulcerans DNA gyrase subunit B 0.0013 0.0079 1
Onchocerca volvulus 0.0051 0.0566 1
Echinococcus granulosus dnaJ subfamily B 0.0399 0.5 1
Loa Loa (eye worm) CYP4Cod1 0.001 0.0043 0.0076
Echinococcus multilocularis heat shock protein 0.0013 0.0079 0.0079
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0013 0.0079 0.0123
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0013 0.0079 1
Schistosoma mansoni single-minded 0.0015 0.0108 0.0216
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0022 0.0023
Echinococcus multilocularis heat shock protein 90 0.0013 0.0079 0.0079
Echinococcus multilocularis muscleblind protein 1 0.0325 0.4053 0.4053
Loa Loa (eye worm) hypothetical protein 0.0051 0.0566 0.137
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0108 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0079 0.0164
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0108 0.0224
Echinococcus multilocularis dual specificity 0.0088 0.1027 0.1027
Onchocerca volvulus 0.0028 0.0269 0.3897
Echinococcus granulosus cytochrome P450 2K1 0.001 0.0043 0.0087
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0108 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0108 1
Loa Loa (eye worm) endoplasmin 0.0013 0.0079 0.0164
Schistosoma mansoni rab6-interacting 0.0019 0.0157 0.0313
Trypanosoma brucei heat shock protein, putative 0.0013 0.0079 0.0123
Brugia malayi Stress-activated protein kinase jnk-1 0.0225 0.2785 0.6861
Schistosoma mansoni tyrosine kinase 0.0247 0.3056 0.6111
Echinococcus granulosus aryl hydrocarbon receptor 0.0052 0.0569 0.1138
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0269 0.0634
Loa Loa (eye worm) hypothetical protein 0.0036 0.0369 0.0883
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0699 0.1399
Brugia malayi Protein kinase domain containing protein 0.0088 0.1027 0.2512
Brugia malayi hypothetical protein 0.0036 0.0369 0.0883
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0013 0.0079 0.5
Trypanosoma brucei heat shock protein, putative 0.0013 0.0079 0.0123
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0088 0.1027 0.3419
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0013 0.0079 1
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0083 0.0963 0.3197
Loa Loa (eye worm) hypothetical protein 0.0015 0.0108 0.0236
Trypanosoma brucei heat shock protein, putative 0.0013 0.0079 0.0123
Mycobacterium tuberculosis Conserved protein 0.0013 0.0079 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0108 1
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Schistosoma mansoni pyruvate dehydrogenase 0.0236 0.2921 0.5842
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0013 0.0079 0.0123
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0036 0.0373 0.0891
Schistosoma mansoni cpg binding protein 0.003 0.0289 0.0578
Mycobacterium ulcerans two component regulator - sensor kinase 0.0013 0.0079 1
Echinococcus granulosus heat shock protein 0.0013 0.0079 0.0157
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0079 0.0123
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0157 1
Mycobacterium tuberculosis Possible two component sensor kinase 0.0013 0.0079 1
Schistosoma mansoni hypothetical protein 0.0171 0.2094 0.4187
Trypanosoma cruzi heat shock protein 90, putative 0.0013 0.0079 0.0123
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0012 0.0012
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1397 0.3426
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0013 0.0079 0.5
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0111 0.0222
Mycobacterium ulcerans two component sensor kinase MprB 0.0013 0.0079 1
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0088 0.1027 0.3419
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0079 0.0123
Brugia malayi Cytochrome P450 family protein 0.001 0.0043 0.0076
Schistosoma mansoni smad1 5 8 and 0.0008 0.0012 0.0025
Mycobacterium leprae Probable two component sensor kinase MprB 0.0013 0.0079 0.5476
Echinococcus granulosus muscleblind protein 0.0325 0.4053 0.8105
Brugia malayi kinase, mitochondrial precursor 0.0236 0.2921 0.7199
Trypanosoma brucei heat shock protein, putative 0.0013 0.0079 0.0123
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0225 0.2785 0.2785
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0013 0.0079 1
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0013 0.0079 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0699 0.1399
Brugia malayi hypothetical protein 0.0036 0.0373 0.0891
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0013 0.0079 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0699 0.1399
Trypanosoma brucei Heat shock protein 83, putative 0.0013 0.0079 0.0123
Entamoeba histolytica hypothetical protein 0.0088 0.1027 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0699 0.1399
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0083 0.0963 0.8461
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0088 0.1027 0.3419
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Leishmania major developmentally regulated phosphoprotein-like protein 0.0236 0.2921 1
Loa Loa (eye worm) hypothetical protein 0.0325 0.4053 1
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0013 0.0079 1
Leishmania major protein kinase, putative 0.0016 0.0119 0.0264
Trypanosoma cruzi DNA topoisomerase II, putative 0.0013 0.0079 0.0123
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Brugia malayi TAR-binding protein 0.0062 0.0699 0.17
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Schistosoma mansoni endoplasmin 0.0013 0.0079 0.0157
Trypanosoma brucei heat shock protein, putative 0.0013 0.0079 0.0123
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0012 0.0025
Brugia malayi Doublecortin family protein 0.0019 0.0157 0.0357
Toxoplasma gondii DNA topoisomerase 2, putative 0.0013 0.0079 0.0325
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0013 0.0079 0.0164
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0699 0.17
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0029 0.0275 1
Schistosoma mansoni pyruvate dehydrogenase 0.0223 0.2754 0.5507
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0013 0.0079 0.0123
Echinococcus granulosus geminin 0.0171 0.2094 0.4187
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0079 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0108 1
Schistosoma mansoni lipoxygenase 0.0019 0.0157 0.0313
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0013 0.0079 0.0079
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Toxoplasma gondii heat shock protein HSP90 0.0013 0.0079 0.0325
Brugia malayi Cytochrome P450 family protein 0.001 0.0043 0.0076
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0236 0.2921 0.5842
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0012 0.0025
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0108 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0157 0.0357
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.048 0.0961
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.048 0.1158
Toxoplasma gondii heat shock protein 90, putative 0.0013 0.0079 0.0325
Schistosoma mansoni smad 0.0008 0.0012 0.0025
Schistosoma mansoni DNA topoisomerase II 0.0013 0.0079 0.0157
Trypanosoma cruzi heat shock protein 90, putative 0.0013 0.0079 0.0123
Schistosoma mansoni cpg binding protein 0.003 0.0289 0.0578
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0013 0.0079 1
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0518 0.1252
Brugia malayi heat shock protein 90 0.0013 0.0079 0.0164
Loa Loa (eye worm) hypothetical protein 0.0325 0.4053 1
Mycobacterium tuberculosis Probable two component sensor kinase 0.0013 0.0079 1
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0036 0.0369 0.0883
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0225 0.2785 0.6861
Onchocerca volvulus Protein cycle homolog 0.0036 0.0373 0.6032
Trypanosoma cruzi heat shock protein 85, putative 0.0013 0.0079 0.0123
Schistosoma mansoni Smad4 0.0008 0.0012 0.0025
Brugia malayi MH2 domain containing protein 0.0117 0.1397 0.3426
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0699 0.17
Brugia malayi hypothetical protein 0.0051 0.0566 0.137
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0013 0.0079 0.0164
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0013 0.0079 1
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Onchocerca volvulus 0.0019 0.0157 0.1598
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0108 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0079 0.0164
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0111 0.0111
Trypanosoma brucei heat shock protein 90, putative 0.0013 0.0079 0.0123
Brugia malayi cytochrome P450 0.001 0.0043 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.048 0.0961
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0013 0.0079 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.048 0.0961
Echinococcus granulosus cpg binding protein 0.003 0.0289 0.0578
Loa Loa (eye worm) hypothetical protein 0.0036 0.0369 0.0883
Loa Loa (eye worm) RNA binding protein 0.0062 0.0699 0.17
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0013 0.0079 1
Brugia malayi Probable DNA topoisomerase II 0.0013 0.0079 0.0164
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0119 0.0264
Trypanosoma cruzi heat shock protein 85, putative 0.0013 0.0079 0.0123
Schistosoma mansoni pyruvate dehydrogenase 0.0223 0.2754 0.5507
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0157 0.0357
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.1027 0.2055
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0013 0.0079 0.0123
Schistosoma mansoni cpg binding protein 0.0028 0.0269 0.0537
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Schistosoma mansoni lipoxygenase 0.0054 0.0598 0.1196
Schistosoma mansoni loxhd1 0.0019 0.0157 0.0313
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.048 0.0961
Leishmania major mitochondrial DNA topoisomerase II 0.0013 0.0079 0.0123
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0022
Schistosoma mansoni smad1 5 8 and 0.0008 0.0012 0.0025
Schistosoma mansoni smad1 5 8 and 0.0008 0.0012 0.0025
Echinococcus multilocularis 0.001 0.0043 0.0043
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Loa Loa (eye worm) hypothetical protein 0.0019 0.0157 0.0357
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0108 1
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Schistosoma mansoni cytochrome P450 0.001 0.0043 0.0087
Brugia malayi Protein kinase domain containing protein 0.025 0.3093 0.7624
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0108 1
Trypanosoma brucei heat shock protein, putative 0.0013 0.0079 0.0123
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0669 0.1338
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0083 0.0963 0.3197
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0157 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0119 0.0264
Echinococcus multilocularis muscleblind protein 0.0325 0.4053 0.4053
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0108 1
Loa Loa (eye worm) cytochrome P450 0.001 0.0043 0.0076
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0013 0.0079 0.5
Echinococcus multilocularis aryl hydrocarbon receptor 0.0052 0.0569 0.0569
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Brugia malayi hypothetical protein 0.0019 0.0157 0.0357
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0013 0.0079 1
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0013 0.0079 1
Loa Loa (eye worm) hypothetical protein 0.0236 0.2921 0.7199
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0157 0.0157
Echinococcus multilocularis Smad4 0.0008 0.0012 0.0012
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0236 0.2921 0.2921
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0157 0.0157
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0108 1
Schistosoma mansoni serine/threonine protein kinase 0.0225 0.2785 0.5569
Schistosoma mansoni hypothetical protein 0.001 0.0043 0.0087
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0699 0.0699
Schistosoma mansoni heat shock protein 0.0013 0.0079 0.0157
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0036 0.0373 0.0891
Mycobacterium ulcerans putative regultory protein 0.0013 0.0079 1
Brugia malayi Cytochrome P450 family protein 0.0048 0.0518 0.1252
Leishmania major heat shock protein 83-1 0.0013 0.0079 0.0123
Loa Loa (eye worm) hypothetical protein 0.0036 0.0369 0.0883
Onchocerca volvulus 0.0019 0.0157 0.1598
Brugia malayi RNA binding protein 0.0062 0.0699 0.17
Loa Loa (eye worm) cytochrome P450 family protein 0.001 0.0043 0.0076
Loa Loa (eye worm) hypothetical protein 0.0087 0.1016 0.2484
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.048 0.0961
Schistosoma mansoni heat shock protein 0.0013 0.0079 0.0157
Entamoeba histolytica protein kinase, putative 0.0088 0.1027 1
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0157 0.0313
Schistosoma mansoni hypothetical protein 0.0171 0.2094 0.4187
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0111 0.0222
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0013 0.0079 0.5
Echinococcus granulosus tar DNA binding protein 0.0062 0.0699 0.1399
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0013 0.0079 0.0157
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0012 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.048 0.048
Entamoeba histolytica protein kinase domain containing protein 0.0088 0.1027 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0157 0.0157

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.