Detailed information for compound 837502

Basic information

Technical information
  • TDR Targets ID: 837502
  • Name: 6-chloro-N-[3-(3-methoxypropylcarbamoyl)-4,5, 6,7-tetrahydro-1-benzothiophen-2-yl]-4-oxochr omene-2-carboxamide
  • MW: 474.957 | Formula: C23H23ClN2O5S
  • H donors: 2 H acceptors: 3 LogP: 4.5 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCNC(=O)c1c(NC(=O)c2cc(=O)c3c(o2)ccc(c3)Cl)sc2c1CCCC2
  • InChi: 1S/C23H23ClN2O5S/c1-30-10-4-9-25-22(29)20-14-5-2-3-6-19(14)32-23(20)26-21(28)18-12-16(27)15-11-13(24)7-8-17(15)31-18/h7-8,11-12H,2-6,9-10H2,1H3,(H,25,29)(H,26,28)
  • InChiKey: KCCDJSYHCLOYBJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-N-[3-(3-methoxypropylcarbamoyl)-4,5,6,7-tetrahydrobenzothiophen-2-yl]-4-oxo-chromene-2-carboxamide
  • 6-chloro-N-[3-[(3-methoxypropylamino)-oxomethyl]-4,5,6,7-tetrahydrobenzothiophen-2-yl]-4-oxo-2-chromenecarboxamide
  • 6-chloro-4-keto-N-[3-(3-methoxypropylcarbamoyl)-4,5,6,7-tetrahydrobenzothiophen-2-yl]chromene-2-carboxamide
  • 6-chloro-N-[3-(3-methoxypropylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-4-oxo-chromene-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus expressed conserved protein 0.0181 0.1062 0.2347
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0045 0.0084
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1387 0.1375
Onchocerca volvulus 0.0047 0.0213 0.0645
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1387 0.3074
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0513 0.1886
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0173 0.0474
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0587 0.878
Brugia malayi CHE-14 protein 0.0083 0.0438 0.1602
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0662 0.1938
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0045 0.0114
Brugia malayi SWIRM domain containing protein 0.0041 0.0173 0.06
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0587 0.1713
Loa Loa (eye worm) hypothetical protein 0.0193 0.1137 0.4194
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0438 0.1602
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0045 0.0084
Schistosoma mansoni tyrosine kinase 0.0096 0.0521 0.1135
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0045 0.0084
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0438 0.0947
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0173 0.6738
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0364 0.5169
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0045 0.1559
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0071 0.0364 0.1045
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0045 0.0114
Schistosoma mansoni DNA polymerase eta 0.002 0.004 0.0056
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0208 0.0579
Echinococcus multilocularis epidermal growth factor receptor 0.0298 0.1804 0.1793
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0045 0.0019
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0173 0.8194
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0045 0.009
Brugia malayi MH2 domain containing protein 0.0117 0.0657 0.2432
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.004 0.0095
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0196 0.1156 0.2555
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0373 0.0803
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0173 0.6738
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0045 0.1559
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0045 0.1559
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0071 0.0364 0.5169
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0071 0.0364 0.1045
Toxoplasma gondii thioredoxin reductase 0.0047 0.0208 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0173 0.0474
Schistosoma mansoni tyrosine kinase 0.0298 0.1804 0.4008
Giardia lamblia Glycogen phosphorylase 0.0432 0.2656 1
Echinococcus multilocularis expressed conserved protein 0.0181 0.1062 0.105
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0657 0.2359
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0905
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0231 0.0648
Loa Loa (eye worm) hypothetical protein 0.0053 0.025 0.0802
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0513 0.1115
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0694
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0173 0.0355
Schistosoma mansoni amine oxidase 0.0041 0.0173 0.0355
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0045 0.0019
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0021 0.0045 0.0084
Brugia malayi RNA binding protein 0.006 0.0296 0.1065
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0071 0.0364 0.097
Loa Loa (eye worm) hypothetical protein 0.0053 0.025 0.0802
Echinococcus granulosus tar DNA binding protein 0.006 0.0296 0.063
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0045 0.0084
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0019
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0694
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0045 0.009
Mycobacterium ulcerans hypothetical protein 0.0071 0.0364 0.097
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0587 0.1713
Echinococcus multilocularis microtubule associated protein 2 0.0719 0.448 0.4472
Loa Loa (eye worm) TK/INSR protein kinase 0.0096 0.0521 0.1841
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0173 0.6738
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0045 0.0019
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0014 0.5
Echinococcus granulosus microtubule associated protein 2 0.0719 0.448 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0021 0.0045 0.0084
Plasmodium vivax glutathione reductase, putative 0.0047 0.0208 0.8224
Onchocerca volvulus 0.0049 0.0221 0.0674
Echinococcus multilocularis tumor protein p63 0.0332 0.202 0.2009
Mycobacterium ulcerans DNA polymerase IV 0.002 0.004 0.007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0014 0.0694
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0173 0.8194
Schistosoma mansoni tyrosine kinase 0.0161 0.0932 0.2054
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0096 0.0521 0.1135
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.0173 0.0355
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0173 0.8194
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.006 0.0296 0.0979
Loa Loa (eye worm) RNA binding protein 0.006 0.0296 0.0979
Entamoeba histolytica glycogen phosphorylase, putative 0.0432 0.2656 1
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0364 0.1323
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0045 0.0114
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0071 0.0364 0.097
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0905
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.004 0.1908
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0509
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0587 0.1713
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0905
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.1908
Leishmania major trypanothione reductase 0.0047 0.0208 0.5535
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0041 0.0173 0.2077
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0657 0.2359
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0045 0.1282
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0045 0.0084
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.004 0.0095
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0513 0.0499
Chlamydia trachomatis glycogen phosphorylase 0.0432 0.2656 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0053 0.025 0.0653
Loa Loa (eye worm) hypothetical protein 0.0021 0.0045 0.0019
Echinococcus granulosus insulin receptor 0.0096 0.0521 0.1135
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0509
Echinococcus multilocularis glycogen phosphorylase 0.0432 0.2656 0.2645
Entamoeba histolytica glycogen phosphorylase, putative 0.0187 0.1098 0.4046
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0045 0.009
Loa Loa (eye worm) glutathione reductase 0.0047 0.0208 0.0643
Entamoeba histolytica glycogenphosphorylase, putative 0.0187 0.1098 0.4046
Schistosoma mansoni tyrosine kinase 0.0158 0.0914 0.2015
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0045 0.009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0513 0.1115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0231 0.0648
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0045 0.009
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0096 0.0521 0.0507
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0438 0.0424
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0509
Echinococcus granulosus Niemann Pick C1 protein 0.0275 0.1662 0.369
Loa Loa (eye worm) oxidoreductase 0.0021 0.0045 0.0019
Echinococcus multilocularis Niemann Pick C1 protein 0.0275 0.1662 0.165
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0045 0.1559
Trichomonas vaginalis glycogen phosphorylase, putative 0.0432 0.2656 1
Schistosoma mansoni tyrosine kinase 0.0158 0.0914 0.2015
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0364 0.1323
Schistosoma mansoni tar DNA-binding protein 0.006 0.0296 0.063
Onchocerca volvulus Glycogen phosphorylase homolog 0.0432 0.2656 1
Echinococcus multilocularis 0.0041 0.0173 0.0159
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0373 0.0359
Schistosoma mansoni tar DNA-binding protein 0.006 0.0296 0.063
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0045 0.003
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0045 0.0067
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0161 0.0932 0.2054
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0045 0.0084
Treponema pallidum NADH oxidase 0.0016 0.0014 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.004 0.0095
Brugia malayi glutathione reductase 0.0047 0.0208 0.0732
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0231 0.0648
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0045 0.0084
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0173 0.0355
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0213 0.0751
Trichomonas vaginalis glycogen phosphorylase, putative 0.0432 0.2656 1
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0438 0.0947
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0364 0.1239
Echinococcus granulosus Glycosyl transferase family 35 0.0432 0.2656 0.5914
Echinococcus multilocularis dna polymerase eta 0.002 0.004 0.0025
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.004 0.0075
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.1908
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0053 0.025 0.0703
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0045 0.0084
Schistosoma mansoni tar DNA-binding protein 0.006 0.0296 0.063
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0364 0.097
Schistosoma mansoni tyrosine kinase 0.0161 0.0932 0.2054
Brugia malayi carbohydrate phosphorylase 0.0432 0.2656 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0173 0.0355
Plasmodium falciparum thioredoxin reductase 0.0047 0.0208 0.8224
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.004 0.1908
Brugia malayi hypothetical protein 0.0073 0.0373 0.1358
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.1908
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0173 0.06
Schistosoma mansoni glycogen phosphorylase 0.0432 0.2656 0.5914
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0662 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0045 0.009
Entamoeba histolytica acyl-coA synthetase, putative 0.0071 0.0364 0.1239
Echinococcus granulosus epidermal growth factor receptor 0.0161 0.0932 0.2054
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.1908
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.004 0.1304
Loa Loa (eye worm) hypothetical protein 0.0083 0.0438 0.1521
Loa Loa (eye worm) hypothetical protein 0.0101 0.0556 0.1973
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0542 0.3357 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0045 0.0114
Echinococcus granulosus tumor protein p63 0.0332 0.202 0.4492
Loa Loa (eye worm) TAR-binding protein 0.006 0.0296 0.0979
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.1908
Echinococcus multilocularis 0.0092 0.0496 0.0482
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.0173 0.0159
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0587 0.1713
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0045 0.0863
Schistosoma mansoni tyrosine kinase 0.0096 0.0521 0.1135
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0187 0.1098 0.3242
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0053 0.025 0.089
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.004 0.0056
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0662 0.1938
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0045 0.0084
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0364 1
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0045 0.2145
Schistosoma mansoni hypothetical protein 0.0047 0.0213 0.0444
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0173 0.6738
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.0173 0.044
Loa Loa (eye worm) glycogen phosphorylase 0.0432 0.2656 1
Giardia lamblia DINP protein human, muc B family 0.002 0.004 0.0095
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0364 0.097
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0509
Echinococcus multilocularis protein patched 0.0083 0.0438 0.0424
Plasmodium vivax acyl-CoA synthetase, putative 0.0053 0.025 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0045 0.0863
Loa Loa (eye worm) TK/EGFR protein kinase 0.0298 0.1804 0.6746
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.004 0.0025
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0045 0.0084
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0045 0.0067
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0173 0.6738
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.004 0.1908
Loa Loa (eye worm) hypothetical protein 0.0071 0.0364 0.1239
Echinococcus granulosus geminin 0.0343 0.2094 0.4657
Echinococcus multilocularis epidermal growth factor receptor 0.0161 0.0932 0.0919
Brugia malayi hypothetical protein 0.0041 0.0173 0.06
Trypanosoma brucei unspecified product 0.002 0.004 0.1908
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0221 0.0461
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0021 0.0045 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0513 0.1115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.1908
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0587 0.1713
Brugia malayi Furin-like cysteine rich region family protein 0.0298 0.1804 0.6777
Loa Loa (eye worm) hypothetical protein 0.0053 0.025 0.0802
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0045 0.009
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0509
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0208 0.0433
Schistosoma mansoni glycogen phosphorylase 0.0187 0.1098 0.2427
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0208 1
Echinococcus multilocularis glycogen phosphorylase 0.0432 0.2656 0.2645
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0364 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.004 0.007
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0173 0.6738
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0208 0.0194
Entamoeba histolytica hypothetical protein 0.0073 0.0373 0.1275
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.004 0.0056
Brugia malayi Niemann-Pick C1 protein precursor 0.0193 0.1137 0.4249
Echinococcus multilocularis protein dispatched 1 0.0094 0.0512 0.0498
Schistosoma mansoni hypothetical protein 0.0343 0.2094 0.4657
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0045 0.0114
Brugia malayi hypothetical protein 0.0232 0.1387 0.5199
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.004 0.1304
Echinococcus multilocularis Glycosyl transferase, family 35 0.0432 0.2656 0.2645
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0438 0.1521
Schistosoma mansoni microtubule-associated protein tau 0.0719 0.448 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0045 0.009
Onchocerca volvulus 0.0071 0.0364 0.1223
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0583 0.3618 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.004 0.0722
Plasmodium falciparum glutathione reductase 0.0047 0.0208 0.8224
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0071 0.0364 0.097
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0021 0.0045 0.0084
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0173 0.6738
Mycobacterium ulcerans dehydrogenase 0.0041 0.0173 0.044
Echinococcus multilocularis geminin 0.0343 0.2094 0.2083
Echinococcus granulosus glycogen phosphorylase 0.0432 0.2656 0.5914
Brugia malayi AMP-binding enzyme family protein 0.0071 0.0364 0.1323
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0041 0.0173 0.8194
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0231 0.0648
Plasmodium falciparum acyl-CoA synthetase 0.0053 0.025 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.025 0.0802
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.1908
Loa Loa (eye worm) hypothetical protein 0.0232 0.1387 0.5152
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0045 0.0114
Entamoeba histolytica hypothetical protein 0.0073 0.0373 0.1275
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0045 0.009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0513 0.1115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.1908
Schistosoma mansoni tar DNA-binding protein 0.006 0.0296 0.063
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0513 0.1808
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.1908
Leishmania major DNA polymerase kappa, putative 0.002 0.004 0.0722
Leishmania major 4-coumarate:coa ligase-like protein 0.0071 0.0364 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0193 0.1137 0.4194
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.004 0.1908
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0513 0.1115
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0045 0.1559
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0208 0.0643
Schistosoma mansoni tyrosine kinase 0.0158 0.0914 0.2015
Brugia malayi Thioredoxin reductase 0.0047 0.0208 0.0732
Entamoeba histolytica glycogen phosphorylase, putative 0.0432 0.2656 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0071 0.0364 0.1239
Onchocerca volvulus 0.0041 0.0173 0.0491
Loa Loa (eye worm) hypothetical protein 0.0071 0.0364 0.1239
Entamoeba histolytica hypothetical protein 0.0073 0.0373 0.1275
Echinococcus multilocularis insulin receptor 0.0096 0.0521 0.0507
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.004 0.1304
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0208 0.8224
Trypanosoma brucei trypanothione reductase 0.0047 0.0208 1
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0045 0.1559
Leishmania major UDP-galactopyranose mutase 0.0041 0.0173 0.4535
Schistosoma mansoni survival motor neuron protein 0.0047 0.0213 0.0444
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.004 0.1304
Schistosoma mansoni tar DNA-binding protein 0.006 0.0296 0.063
Loa Loa (eye worm) hypothetical protein 0.0049 0.0221 0.0691
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0045 0.0084
Entamoeba histolytica hypothetical protein 0.0073 0.0373 0.1275
Loa Loa (eye worm) hypothetical protein 0.0053 0.025 0.0802
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0014 0.0694
Brugia malayi Protein kinase domain containing protein 0.0096 0.0521 0.1918
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0662 0.1938
Loa Loa (eye worm) hypothetical protein 0.0041 0.0173 0.0509
Brugia malayi RNA recognition motif domain containing protein 0.006 0.0296 0.1065
Mycobacterium ulcerans acyl-CoA synthetase 0.0071 0.0364 0.097
Echinococcus granulosus dna polymerase kappa 0.002 0.004 0.0056
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.004 0.1304
Echinococcus granulosus glycogen phosphorylase 0.0432 0.2656 0.5914
Schistosoma mansoni amine oxidase 0.0041 0.0173 0.0355
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0045 0.0084
Echinococcus multilocularis tar DNA binding protein 0.006 0.0296 0.0282
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0045 0.1559
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.0364 0.097
Schistosoma mansoni hypothetical protein 0.0343 0.2094 0.4657
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0045 0.0863
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0513 0.0499
Schistosoma mansoni glycogen phosphorylase 0.0432 0.2656 0.5914
Entamoeba histolytica glycogen phosphorylase, putative 0.0187 0.1098 0.4046
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0373 0.0803
Echinococcus multilocularis Niemann Pick C1 protein 0.0193 0.1137 0.1124
Echinococcus multilocularis dna polymerase kappa 0.002 0.004 0.0025
Brugia malayi TAR-binding protein 0.006 0.0296 0.1065
Schistosoma mansoni patched 1 0.0083 0.0438 0.0947
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0014 0.5
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0583 0.3618 1
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0018 0.0026 0.0035
Leishmania major DNA polymerase eta, putative 0.002 0.004 0.0722
Echinococcus granulosus epidermal growth factor receptor 0.0298 0.1804 0.4008
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0045 0.2145
Mycobacterium ulcerans monoamine oxidase 0.0041 0.0173 0.044
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0045 0.009
Mycobacterium ulcerans oxidoreductase 0.0041 0.0173 0.044
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0045 0.0084
Echinococcus granulosus dna polymerase eta 0.002 0.004 0.0056
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0045 0.1282
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.004 0.1908
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0045 0.0114
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.004 0.0056
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0187 0.1098 0.3008
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0045 0.009
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0173 0.0159
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0045 0.0114
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0905
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.004 0.0075
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.0173 0.06
Mycobacterium tuberculosis Probable reductase 0.0106 0.0587 0.1713
Schistosoma mansoni hypothetical protein 0.0073 0.0373 0.0803
Echinococcus granulosus Niemann Pick C1 protein 0.0193 0.1137 0.2513
Loa Loa (eye worm) hypothetical protein 0.0071 0.0364 0.1239
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.004 0.0095

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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