TDR Targets

Basic information

Technical information

TDR Targets ID: 840563
Name: 3-[(3-methylbenzoyl)amino]-N-(4-methylphenyl) -1-benzofuran-2-carboxamide
MW: 384.427 | Formula: C24H20N2O3
H donors: 2 H acceptors: 2 LogP: 5.61 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)NC(=O)c1oc2c(c1NC(=O)c1cccc(c1)C)cccc2
InChi: 1S/C24H20N2O3/c1-15-10-12-18(13-11-15)25-24(28)22-21(19-8-3-4-9-20(19)29-22)26-23(27)17-7-5-6-16(2)14-17/h3-14H,1-2H3,(H,25,28)(H,26,27)
InChiKey: STXVXWZZTUNKKW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[(3-methylbenzoyl)amino]-N-(4-methylphenyl)benzofuran-2-carboxamide
N-(4-methylphenyl)-3-[[(3-methylphenyl)-oxomethyl]amino]-2-benzofurancarboxamide
N-(4-methylphenyl)-3-[(3-methylphenyl)carbonylamino]-1-benzofuran-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0098	0.0064	0.0195
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.02	0.0154	1
Schistosoma mansoni	Nep2 peptidase (M13 family)	0.0098	0.0064	0.0195
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.02	0.0154	1
Schistosoma mansoni	fatty-acid amide hydrolase	0.0209	0.0162	0.0491
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.0179	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0104	0.0104
Echinococcus granulosus	leukotriene A 4 hydrolase	0.3759	0.3292	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Onchocerca volvulus		0.0146	0.0107	0.6517
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0144	0.0104	0.0104
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0154	0.0114	0.7624
Entamoeba histolytica	aminopeptidase, putative	0.02	0.0154	1
Mycobacterium leprae	probable zinc metalloprotease	0.0194	0.0149	1
Mycobacterium ulcerans	aminopeptidase N PepN	0.02	0.0154	1
Loa Loa (eye worm)	TATA binding protein associated factor	0.02	0.0154	0.0154
Brugia malayi	amidase	0.0209	0.0162	0.0162
Brugia malayi	Peptidase family M13 containing protein	0.0194	0.0149	0.0149
Brugia malayi	TATA binding protein associated factor	0.02	0.0154	0.0154
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0107	0.6944
Schistosoma mansoni	neprilysin	0.0051	0.0023	0.0069
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0209	0.0162	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0149	0.0149
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Schistosoma mansoni	endothelin-converting enzyme-related	0.0047	0.002	0.0059
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0194	0.0149	0.0453
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0209	0.0162	0.0491
Brugia malayi	hypothetical protein	0.02	0.0154	0.0154
Loa Loa (eye worm)	hypothetical protein	0.0228	0.0179	0.0179
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0025	0	0.5
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.02	0.0154	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0047	0.002	0.0059
Loa Loa (eye worm)	hypothetical protein	0.02	0.0154	0.0154
Mycobacterium ulcerans	carboxylesterase, LipT	0.0154	0.0114	0.7395
Brugia malayi	hypothetical protein	0.1728	0.1501	0.1501
Schistosoma mansoni	aminopeptidase A (M01 family)	0.02	0.0154	0.0467
Loa Loa (eye worm)	peptidase family M13 containing protein	0.0144	0.0104	0.0104
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0047	0.002	0.0059
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	1.1368	1	1
Toxoplasma gondii	aminopeptidase N protein	0.02	0.0154	1
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.02	0.0154	1
Schistosoma mansoni	family M13 non-peptidase homologue (M13 family)	0.0047	0.002	0.0059
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Schistosoma mansoni	hypothetical protein	0.0051	0.0023	0.0069
Trypanosoma cruzi	hypothetical protein, conserved	0.0146	0.0107	0.6944
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0224	0.0175	0.0175
Onchocerca volvulus		0.02	0.0154	1
Loa Loa (eye worm)	peptidase family M1 containing protein	0.02	0.0154	0.0154
Schistosoma mansoni	hypothetical protein	0.0051	0.0023	0.0069
Echinococcus granulosus	geminin	0.0164	0.0122	0.0371
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.02	0.0154	1
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.02	0.0154	0.0467
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.3759	0.3292	1
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.02	0.0154	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0033	0.0007	0.0022
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0019	0.0019
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0051	0.0023	0.0069
Trypanosoma brucei	lipase domain protein, putative	0.0146	0.0107	0.6944
Mycobacterium tuberculosis	Probable zinc metalloprotease Zmp1	0.0194	0.0149	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0107	0.0107
Echinococcus granulosus	aminopeptidase N	0.02	0.0154	0.0467
Echinococcus multilocularis	aminopeptidase N	0.02	0.0154	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0209	0.0162	0.0162
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.3759	0.3292	0.3292
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Trypanosoma cruzi	aminopeptidase, putative	0.02	0.0154	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Schistosoma mansoni	neprilysin-2 (M13 family)	0.0098	0.0064	0.0195
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.02	0.0154	0.0467
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0025	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0107	0.0107
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.02	0.0154	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.0179	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0107	0.0107
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.02	0.0154	1
Schistosoma mansoni	amidase	0.0209	0.0162	0.0491
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Brugia malayi	hypothetical protein	0.02	0.0154	0.0154
Toxoplasma gondii	aminopeptidase n, putative	0.02	0.0154	1
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.02	0.0154	1
Echinococcus multilocularis	geminin	0.0164	0.0122	0.0371
Schistosoma mansoni	hypothetical protein	0.0051	0.0023	0.0069
Brugia malayi	peptidase family M13 containing protein	0.0047	0.002	0.002
Onchocerca volvulus		0.0096	0.0063	0.325
Loa Loa (eye worm)	hypothetical protein	0.02	0.0154	0.0154
Brugia malayi	hypothetical protein	0.0033	0.0007	0.0007
Trypanosoma brucei	Aminopeptidase M1, putative	0.02	0.0154	1
Chlamydia trachomatis	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0025	0	0.5
Brugia malayi	hypothetical protein	0.0228	0.0179	0.0179
Schistosoma mansoni	endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase)	0.0047	0.002	0.0059
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.02	0.0154	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0047	0.0019	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0107	0.0107
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0209	0.0162	0.0491
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0047	0.002	0.0059
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.02	0.0154	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0104	0.0104
Brugia malayi	Peptidase family M1 containing protein	0.02	0.0154	0.0154
Mycobacterium ulcerans	zinc metalloprotease	0.0194	0.0149	0.9699
Echinococcus multilocularis	endothelin converting enzyme 1	0.0194	0.0149	0.0453
Mycobacterium ulcerans	aminopeptidase N PepN	0.02	0.0154	1
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.02	0.0154	1
Brugia malayi	Peptidase family M1 containing protein	0.02	0.0154	0.0154
Schistosoma mansoni	hypothetical protein	0.0164	0.0122	0.0371
Brugia malayi	Peptidase family M1 containing protein	0.02	0.0154	0.0154
Trypanosoma cruzi	Aminopeptidase M1, putative	0.02	0.0154	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0104	0.0104
Schistosoma mansoni	hypothetical protein	0.0051	0.0023	0.0069
Brugia malayi	Lipase family protein	0.0146	0.0107	0.0107
Trypanosoma cruzi	aminopeptidase, putative	0.02	0.0154	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.0107	0.0107
Trypanosoma brucei	Aminopeptidase M1, putative	0.02	0.0154	1
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.02	0.0154	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0209	0.0162	0.0491
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.02	0.0154	1
Onchocerca volvulus		0.02	0.0154	1
Schistosoma mansoni	hypothetical protein	0.0051	0.0023	0.0069
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.02	0.0154	1
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.02	0.0154	0.0467
Loa Loa (eye worm)	lipase	0.0146	0.0107	0.0107
Onchocerca volvulus		0.02	0.0154	1
Schistosoma mansoni	hypothetical protein	0.0033	0.0007	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0096	0.0063	0.0063
Loa Loa (eye worm)	hypothetical protein	0.02	0.0154	0.0154
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.3759	0.3292	1
Brugia malayi	follicle stimulating hormone receptor	0.0224	0.0175	0.0175
Toxoplasma gondii	aminopeptidase N, putative	0.02	0.0154	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Schistosoma mansoni	hypothetical protein	0.0051	0.0023	0.0069
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.02	0.0154	1
Echinococcus multilocularis	sn1 specific diacylglycerol lipase beta	0.0146	0.0107	0.0325
Schistosoma mansoni	hypothetical protein	0.0164	0.0122	0.0371
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0033	0.0007	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0144	0.0104	0.0104
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0194	0.0149	0.0149
Leishmania major	hypothetical protein, conserved	0.0146	0.0107	0.6944
Echinococcus granulosus	endothelin converting enzyme 1	0.0194	0.0149	0.0453
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.02	0.0154	1
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0098	0.0064	0.0195
Echinococcus granulosus	sn1 specific diacylglycerol lipase beta	0.0146	0.0107	0.0325
Trypanosoma brucei	lipase domain protein, putative	0.0146	0.0107	0.6944
Schistosoma mansoni	transcription factor LCR-F1	0.0033	0.0007	0.0022
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0019	0.0057
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0098	0.0064	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0149	0.0149
Loa Loa (eye worm)	aminopeptidase N	0.02	0.0154	0.0154
Loa Loa (eye worm)	zinc metallopeptidase 4	0.0047	0.002	0.002
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.02	0.0154	1
Loa Loa (eye worm)	hypothetical protein	0.0194	0.0149	0.0149
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0498	0.0417	0.1267
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.02	0.0154	0.0467
Trypanosoma brucei	aminopeptidase, putative	0.02	0.0154	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 840563