Detailed information for compound 841763

Basic information

Technical information
  • TDR Targets ID: 841763
  • Name: N-(2-ethoxyphenyl)-1-(4-ethoxyphenyl)-4-oxopy ridazine-3-carboxamide
  • MW: 379.409 | Formula: C21H21N3O4
  • H donors: 1 H acceptors: 2 LogP: 3.5 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)n1ccc(=O)c(n1)C(=O)Nc1ccccc1OCC
  • InChi: 1S/C21H21N3O4/c1-3-27-16-11-9-15(10-12-16)24-14-13-18(25)20(23-24)21(26)22-17-7-5-6-8-19(17)28-4-2/h5-14H,3-4H2,1-2H3,(H,22,26)
  • InChiKey: HDQFKLKXDLRWMC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-ethoxyphenyl)-1-(4-ethoxyphenyl)-4-oxo-pyridazine-3-carboxamide
  • N-(2-ethoxyphenyl)-1-(4-ethoxyphenyl)-4-oxo-3-pyridazinecarboxamide
  • N-(2-ethoxyphenyl)-1-(4-ethoxyphenyl)-4-keto-pyridazine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Onchocerca volvulus 0.0467 0.2591 0.251
Brugia malayi PAN domain containing protein 0.0043 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Loa Loa (eye worm) hypothetical protein 0.1224 0.6901 0.6901
Onchocerca volvulus 0.0043 0.0176 0.007
Toxoplasma gondii EGF family domain-containing protein 0.0467 0.2591 0.3651
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.1312 0.1312
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Onchocerca volvulus Arrow homolog 0.1224 0.6901 0.6868
Echinococcus granulosus peregrin 0.0036 0.0133 0.0032
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1769 1 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0195 0.0123
Loa Loa (eye worm) hypothetical protein 0.0361 0.1983 0.1983
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0149 0.0056
Loa Loa (eye worm) hypothetical protein 0.1769 1 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0093 0.0458 0.0511
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0361 0.1983 0.2757
Brugia malayi PAN domain containing protein 0.0043 0.0176 0.0176
Plasmodium falciparum cysteine repeat modular protein 1 0.0199 0.1064 1
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.1224 0.6901 0.6901
Brugia malayi jmjC domain containing protein 0.0104 0.0522 0.0522
Loa Loa (eye worm) bone morphogenetic protein 1b 0.1224 0.6901 0.6901
Schistosoma mansoni serine/threonine protein kinase 0.0103 0.0515 0.0476
Echinococcus multilocularis protein jagged 1 0.0467 0.2591 0.3651
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0361 0.1983 0.195
Brugia malayi PAN domain containing protein 0.0043 0.0176 0.0176
Loa Loa (eye worm) Notch2 0.0467 0.2591 0.2591
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0159 0.0071
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Echinococcus multilocularis slit 2 protein 0.0467 0.2591 0.3651
Toxoplasma gondii subtilisin SUB12 0.0043 0.0176 0.0095
Brugia malayi Calcium binding EGF domain containing protein 0.0467 0.2591 0.2591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0211 0.0171
Echinococcus multilocularis fibropellin Ia 0.0467 0.2591 0.3651
Schistosoma mansoni hypothetical protein 0.0361 0.1983 0.195
Brugia malayi Bromodomain containing protein 0.0036 0.0133 0.0133
Brugia malayi Calcium binding EGF domain containing protein 0.0467 0.2591 0.2591
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0159 0.0119
Brugia malayi PAN domain containing protein 0.0043 0.0176 0.0176
Onchocerca volvulus 0.0467 0.2591 0.251
Brugia malayi Pre-SET motif family protein 0.0035 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Onchocerca volvulus 0.0199 0.1064 0.0968
Schistosoma mansoni slit 0.0467 0.2591 0.256
Brugia malayi Protein kinase domain containing protein 0.0199 0.1064 0.1064
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0176
Onchocerca volvulus Alhambra homolog 0.0032 0.0111 0.0004
Brugia malayi acetyltransferase, GNAT family protein 0.0158 0.0828 0.0828
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0361 0.1983 0.2757
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Onchocerca volvulus 0.0467 0.2591 0.251
Schistosoma mansoni cpg binding protein 0.0033 0.0117 0.0076
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Schistosoma mansoni kinase 0.0052 0.0228 0.0188
Loa Loa (eye worm) PAN domain-containing protein 0.0043 0.0176 0.0176
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0081 0.0394 0.0394
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0158 0.0828 0.1055
Plasmodium falciparum histone acetyltransferase GCN5 0.0042 0.0173 0.1618
Brugia malayi Calcium binding EGF domain containing protein 0.1224 0.6901 0.6901
Echinococcus multilocularis neurogenic locus protein delta 0.0467 0.2591 0.3651
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0361 0.1983 0.1983
Toxoplasma gondii PAN domain-containing protein 0.0043 0.0176 0.0095
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0093 0.0458 0.14
Echinococcus granulosus slit 2 protein 0.0467 0.2591 0.3651
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0132 0.0092
Brugia malayi PAN domain containing protein 0.0043 0.0176 0.0176
Echinococcus multilocularis neurogenic locus notch protein 0.0467 0.2591 0.3651
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Schistosoma mansoni hypothetical protein 0.0467 0.2591 0.256
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0211 0.0211
Schistosoma mansoni cpg binding protein 0.0031 0.0107 0.0066
Brugia malayi hypothetical protein 0.0361 0.1983 0.1983
Loa Loa (eye worm) hypothetical protein 0.0199 0.1064 0.1064
Brugia malayi Kringle domain containing protein 0.0199 0.1064 0.1064
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0159 0.0119
Brugia malayi EGF-like domain containing protein 0.0467 0.2591 0.2591
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0103 0.0515 0.0595
Loa Loa (eye worm) hypothetical protein 0.1224 0.6901 0.6901
Leishmania major hypothetical protein, conserved 0.0199 0.1064 1
Echinococcus granulosus notch 0.0467 0.2591 0.3651
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Loa Loa (eye worm) hypothetical protein 0.0035 0.0132 0.0132
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0111 0.0071
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0467 0.2591 0.251
Loa Loa (eye worm) hypothetical protein 0.1769 1 1
Brugia malayi CXXC zinc finger family protein 0.0031 0.0107 0.0107
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0121 0.0015
Echinococcus multilocularis peregrin 0.0036 0.0133 0.0032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0211 0.0147
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Loa Loa (eye worm) acetyltransferase 0.0158 0.0828 0.0828
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0211 0.0147
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0182 0.0104
Echinococcus multilocularis tissue type plasminogen activator 0.0199 0.1064 0.1403
Brugia malayi PAN domain containing protein 0.0043 0.0176 0.0176
Giardia lamblia Histone acetyltransferase GCN5 0.0042 0.0173 0.0248
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0211 0.0171
Schistosoma mansoni septate junction protein 0.0467 0.2591 0.256
Onchocerca volvulus 0.0043 0.0176 0.007
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0176
Toxoplasma gondii microneme protein MIC17B 0.0043 0.0176 0.0095
Toxoplasma gondii microneme protein MIC17A 0.0043 0.0176 0.0095
Schistosoma mansoni hypothetical protein 0.0184 0.098 0.0942
Echinococcus granulosus protein jagged 2 0.0467 0.2591 0.3651
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Schistosoma mansoni hypothetical protein 0.0184 0.098 0.0942
Toxoplasma gondii PAN domain-containing protein 0.0043 0.0176 0.0095
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0132 0.0092
Loa Loa (eye worm) hypothetical protein 0.0361 0.1983 0.1983
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0361 0.1983 0.2757
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0051 0.0051
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.1224 0.6901 0.6901
Brugia malayi Delta serrate ligand family protein 0.0467 0.2591 0.2591
Echinococcus multilocularis protein jagged 2 0.0467 0.2591 0.3651
Echinococcus granulosus Mastin 0.0361 0.1983 0.2757
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0093 0.0458 0.0511
Brugia malayi glutaminase DH11.1 0.0294 0.1607 0.1607
Brugia malayi jmjC domain containing protein 0.004 0.0159 0.0159
Brugia malayi Pre-SET motif family protein 0.0243 0.1312 0.1312
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0199 0.1064 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0199 0.1064 0.1064
Brugia malayi PAN domain containing protein 0.0043 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0176
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0361 0.1983 0.195
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0132 0.0031
Brugia malayi Trypsin-like protease protein 5 0.0361 0.1983 0.1983
Brugia malayi EGF-like domain containing protein 0.0467 0.2591 0.2591
Brugia malayi EGF-like domain containing protein 0.0467 0.2591 0.2591
Plasmodium falciparum phd finger protein, putative 0.0032 0.0111 0.1041
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Echinococcus granulosus histone acetyltransferase KAT2B 0.0153 0.0803 0.1018
Onchocerca volvulus 0.0361 0.1983 0.1897
Echinococcus granulosus transmembrane protease serine 3 0.0361 0.1983 0.2757
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0107 0.0107
Loa Loa (eye worm) hypothetical protein 0.1224 0.6901 0.6901
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0132 0.0031
Toxoplasma gondii microneme protein, putative 0.0043 0.0176 0.0095
Brugia malayi Trypsin family protein 0.0361 0.1983 0.1983
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0182 0.0104
Entamoeba histolytica serine/threonine protein kinase, putative 0.0103 0.0515 1
Echinococcus granulosus protein jagged 1 0.0467 0.2591 0.3651
Loa Loa (eye worm) hypothetical protein 0.1224 0.6901 0.6901
Echinococcus granulosus laminin 0.1224 0.6901 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0211 0.0211
Brugia malayi PAN domain containing protein 0.0043 0.0176 0.0176
Echinococcus granulosus glycoprotein Antigen 5 0.0361 0.1983 0.2757
Loa Loa (eye worm) notch protein 0.0467 0.2591 0.2591
Echinococcus granulosus neurogenic locus notch protein 0.0467 0.2591 0.3651
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Onchocerca volvulus 0.0361 0.1983 0.1897
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.022 0.0181
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0361 0.1983 0.195
Echinococcus multilocularis glycoprotein Antigen 5 0.0361 0.1983 0.2757
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0111 0.0111
Echinococcus multilocularis Mastin 0.0361 0.1983 0.2757
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0195 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0515 0.2271
Echinococcus multilocularis fat cadherin tumor suppressor 0.0467 0.2591 0.3651
Onchocerca volvulus 0.1769 1 1
Schistosoma mansoni notch 0.0467 0.2591 0.256
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.1769 1 1
Echinococcus multilocularis cpg binding protein 0.0033 0.0117 0.0008
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0043 0.0176 0.0095
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0303 0.0303
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Trichomonas vaginalis glutaminase, putative 0.0294 0.1607 1
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0159 0.0159
Toxoplasma gondii PAN domain-containing protein 0.0669 0.374 0.5344
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0158 0.0828 0.079
Loa Loa (eye worm) hypothetical protein 0.0032 0.0111 0.0111
Echinococcus multilocularis neurogenic locus notch protein 0.0467 0.2591 0.3651
Echinococcus granulosus protein jagged 1 0.0467 0.2591 0.3651
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0515 0.2271
Loa Loa (eye worm) hypothetical protein 0.0361 0.1983 0.1983
Echinococcus granulosus enteropeptidase 0.0361 0.1983 0.2757
Toxoplasma gondii kringle domain-containing protein 0.0199 0.1064 0.1403
Schistosoma mansoni egf-like domain protein 0.1224 0.6901 0.6889
Onchocerca volvulus 0.0361 0.1983 0.1897
Schistosoma mansoni hypothetical protein 0.0467 0.2591 0.256
Onchocerca volvulus 0.0043 0.0176 0.007
Schistosoma mansoni hypothetical protein 0.0199 0.1064 0.1028
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Echinococcus granulosus neurogenic locus notch protein 0.0467 0.2591 0.3651
Echinococcus multilocularis geminin 0.0184 0.098 0.1279
Brugia malayi GCC2 and GCC3 family protein 0.0467 0.2591 0.2591
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0515 0.2271
Loa Loa (eye worm) PAN domain-containing protein 0.0043 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Brugia malayi EGF-like domain containing protein 0.0467 0.2591 0.2591
Schistosoma mansoni notch 0.0467 0.2591 0.256
Echinococcus granulosus fibropellin Ia 0.0467 0.2591 0.3651
Brugia malayi Muscle positioning protein 4 0.0467 0.2591 0.2591
Schistosoma mansoni notch 0.0467 0.2591 0.256
Brugia malayi EGF-like domain containing protein 0.0467 0.2591 0.2591
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0294 0.0269
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0093 0.0458 0.0511
Echinococcus multilocularis neurogenic locus notch protein 4 0.0467 0.2591 0.3651
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0467 0.2591 0.2591
Echinococcus multilocularis notch 0.0467 0.2591 0.3651
Onchocerca volvulus 0.0043 0.0176 0.007
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0103 0.0515 0.0515
Onchocerca volvulus 0.0043 0.0176 0.007
Brugia malayi serine/threonine-protein kinase plk-2 0.0103 0.0515 0.0515
Trichomonas vaginalis set domain proteins, putative 0.0276 0.1503 0.9261
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0176
Toxoplasma gondii hypothetical protein 0.0043 0.0176 0.0095
Toxoplasma gondii PAN domain-containing protein 0.0043 0.0176 0.0095
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0211 0.0147
Giardia lamblia High cysteine protein 0.0467 0.2591 1
Onchocerca volvulus 0.0043 0.0176 0.007
Echinococcus granulosus geminin 0.0184 0.098 0.1279
Echinococcus multilocularis neurogenic locus protein delta 0.0467 0.2591 0.3651
Schistosoma mansoni notch 0.0467 0.2591 0.256
Onchocerca volvulus 0.0276 0.1503 0.1411
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0515 0.2271
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Onchocerca volvulus 0.0361 0.1983 0.1897
Brugia malayi PAN domain containing protein 0.0043 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.0467 0.2591 0.256
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.1224 0.6901 0.6889
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Echinococcus multilocularis protein jagged 1 0.0467 0.2591 0.3651
Schistosoma mansoni notch 0.0467 0.2591 0.256
Echinococcus granulosus cpg binding protein 0.0033 0.0117 0.0008
Onchocerca volvulus 0.0467 0.2591 0.251
Brugia malayi Trypsin family protein 0.0361 0.1983 0.1983
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Trypanosoma brucei polo-like protein kinase 0.0103 0.0515 0.5
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0515 0.2271
Onchocerca volvulus 0.0043 0.0176 0.007
Brugia malayi PHD-finger family protein 0.0032 0.0111 0.0111
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0081 0.0394 0.0417
Schistosoma mansoni hypothetical protein 0.0467 0.2591 0.256
Loa Loa (eye worm) glutaminase 2 0.0294 0.1607 0.1607
Echinococcus multilocularis Tolloid protein 1 0.1224 0.6901 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0458 0.0458
Onchocerca volvulus 0.0035 0.0132 0.0026
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0361 0.1983 0.195
Echinococcus granulosus tissue type plasminogen activator 0.0199 0.1064 0.1403
Loa Loa (eye worm) hypothetical protein 0.0054 0.024 0.024
Toxoplasma gondii microneme protein MIC17C 0.0043 0.0176 0.0095
Loa Loa (eye worm) hypothetical protein 0.0361 0.1983 0.1983
Echinococcus multilocularis laminin 0.1224 0.6901 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0467 0.2591 0.251
Onchocerca volvulus 0.0043 0.0176 0.007
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0361 0.1983 0.195
Toxoplasma gondii microneme protein MIC4 0.0043 0.0176 0.0095
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0132 0.0031
Echinococcus granulosus protein jagged 2 0.0467 0.2591 0.3651
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0361 0.1983 0.2757
Loa Loa (eye worm) hypothetical protein 0.0361 0.1983 0.1983
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0093 0.0458 0.0511
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.1224 0.6901 0.6901
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0093 0.0458 0.0419
Loa Loa (eye worm) hypothetical protein 0.0043 0.0176 0.0176
Echinococcus multilocularis neural cadherin 0.0467 0.2591 0.3651
Schistosoma mansoni cpg binding protein 0.0033 0.0117 0.0076
Echinococcus multilocularis enteropeptidase 0.0361 0.1983 0.2757
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0211 0.0171
Echinococcus granulosus neurogenic locus protein delta 0.0467 0.2591 0.3651
Echinococcus granulosus Tolloid protein 1 0.1224 0.6901 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0132 0.0092
Schistosoma mansoni hypothetical protein 0.0467 0.2591 0.256
Onchocerca volvulus 0.1408 0.7948 0.7925
Onchocerca volvulus 0.0043 0.0176 0.007
Brugia malayi Cadherin domain containing protein 0.0467 0.2591 0.2591
Onchocerca volvulus Putative cubilin 0.0467 0.2591 0.251
Plasmodium vivax SET domain protein, putative 0.0035 0.0132 0.1239
Mycobacterium ulcerans hypothetical protein 0.0361 0.1983 1
Toxoplasma gondii PAN domain-containing protein 0.0669 0.374 0.5344
Giardia lamblia Kinase, PLK 0.0103 0.0515 0.163
Onchocerca volvulus 0.0467 0.2591 0.251
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0132 0.0092
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0111 0.1041
Brugia malayi EGF-like domain containing protein 0.0467 0.2591 0.2591
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.022 0.0181
Echinococcus granulosus neurogenic locus notch protein 4 0.0467 0.2591 0.3651
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Schistosoma mansoni notch 0.0467 0.2591 0.256
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0195 0.0123
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0081 0.0394 0.0394
Echinococcus multilocularis transmembrane protease serine 3 0.0361 0.1983 0.2757
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Toxoplasma gondii PAN domain-containing protein 0.0043 0.0176 0.0095
Loa Loa (eye worm) hypothetical protein 0.1224 0.6901 0.6901
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.0522 0.0604
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0093 0.0458 0.0511
Trypanosoma cruzi hypothetical protein, conserved 0.0199 0.1064 1
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Onchocerca volvulus 0.0361 0.1983 0.1897
Loa Loa (eye worm) PAN domain-containing protein 0.0043 0.0176 0.0176
Schistosoma mansoni laminin gamma-3 chain 0.0467 0.2591 0.256
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0515 0.2271
Loa Loa (eye worm) PAN domain-containing protein 0.0043 0.0176 0.0176
Schistosoma mansoni jumonji domain containing protein 0.0082 0.04 0.0361
Echinococcus granulosus neural cadherin 0.0467 0.2591 0.3651
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0515 0.2271
Schistosoma mansoni glutaminase 0.0294 0.1607 0.1573
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0132 0.0031
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Brugia malayi PAN domain containing protein 0.0043 0.0176 0.0176
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0312 0.0272
Schistosoma mansoni cercarial elastase (S01 family) 0.0361 0.1983 0.195
Brugia malayi Calcium binding EGF domain containing protein 0.0467 0.2591 0.2591
Echinococcus multilocularis fibrillin 1 0.1224 0.6901 1
Toxoplasma gondii calcium binding egf domain-containing protein 0.1224 0.6901 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0103 0.0515 0.0413
Brugia malayi notch-like transmembrane receptor 0.0467 0.2591 0.2591
Onchocerca volvulus 0.0043 0.0176 0.007
Loa Loa (eye worm) glutaminase 0.0294 0.1607 0.1607
Schistosoma mansoni hypothetical protein 0.0467 0.2591 0.256
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0195 0.1824
Brugia malayi Cadherin domain containing protein 0.0467 0.2591 0.2591
Schistosoma mansoni hypothetical protein 0.0467 0.2591 0.256
Schistosoma mansoni hypothetical protein 0.0032 0.0111 0.0071
Brugia malayi Trypsin family protein 0.0361 0.1983 0.1983
Onchocerca volvulus Slit protein homolog 0.0467 0.2591 0.251
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0081 0.0394 0.0417
Toxoplasma gondii PAN/Apple domain-containing protein 0.0043 0.0176 0.0095
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0467 0.2591 0.256
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.0522 0.0604
Brugia malayi EGF-like domain containing protein 0.0467 0.2591 0.2591
Schistosoma mansoni cell polarity protein 0.0467 0.2591 0.256
Loa Loa (eye worm) PAN domain-containing protein 0.0043 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Toxoplasma gondii calcium binding egf domain-containing protein 0.1224 0.6901 1
Onchocerca volvulus 0.0043 0.0176 0.007
Brugia malayi Fibulin-1 precursor 0.1224 0.6901 0.6901
Schistosoma mansoni hypothetical protein 0.0361 0.1983 0.195
Echinococcus granulosus delta-like protein 1 0.0467 0.2591 0.3651
Loa Loa (eye worm) trypsin family protein 0.0361 0.1983 0.1983
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0103 0.0515 0.0595
Loa Loa (eye worm) hypothetical protein 0.0467 0.2591 0.2591
Toxoplasma gondii hypothetical protein 0.0043 0.0176 0.0095
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0361 0.1983 0.195
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0211 0.0147

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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