TDR Targets

Basic information

Technical information

TDR Targets ID: 842433
Name: 7-methyl-2-(3-methylphenyl)-3,5-dihydrochrome no[3,2-e]pyrimidin-4-one
MW: 304.343 | Formula: C19H16N2O2
H donors: 1 H acceptors: 3 LogP: 4.43 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc2c(c1)Cc1c(O2)nc(nc1O)c1cccc(c1)C
InChi: 1S/C19H16N2O2/c1-11-4-3-5-13(8-11)17-20-18(22)15-10-14-9-12(2)6-7-16(14)23-19(15)21-17/h3-9H,10H2,1-2H3,(H,20,21,22)
InChiKey: PYKIDALSCZKCNF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Leishmania major	gamma-tubulin	0.0414	0.5365	0.4081
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0584	0.7679	0.7679
Giardia lamblia	Gamma tubulin	0.0414	0.5365	0.4936
Echinococcus granulosus	tubulin alpha 1C chain	0.0584	0.7679	0.7036
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Giardia lamblia	Epsilon tubulin	0.018	0.217	0.1444
Echinococcus multilocularis	beta tubulin	0.0754	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0584	0.7679	0.7036
Trypanosoma brucei	beta tubulin	0.0414	0.5365	0.4081
Loa Loa (eye worm)	tubulin beta-2A chain	0.0754	1	1
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin alpha chain, putative	0.0234	0.2913	0.2913
Trypanosoma cruzi	epsilon tubulin, putative	0.0414	0.5365	0.4081
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0234	0.2913	0.2913
Plasmodium vivax	tubulin alpha chain, putative	0.0584	0.7679	0.7036
Echinococcus multilocularis	tubulin alpha chain	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin alpha chain, putative	0.0414	0.5365	0.5365
Toxoplasma gondii	beta-tubulin, putative	0.0754	1	1
Echinococcus multilocularis	tubulin alpha 3 chain	0.0584	0.7679	0.7036
Leishmania major	beta tubulin	0.0754	1	1
Schistosoma mansoni	tubulin subunit beta	0.0754	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0584	0.7679	0.7036
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0083	0.0848	0.0848
Loa Loa (eye worm)	tubulin alpha chain	0.0584	0.7679	0.7088
Loa Loa (eye worm)	tubulin alpha chain	0.0584	0.7679	0.7088
Plasmodium falciparum	tubulin beta chain	0.0754	1	1
Echinococcus granulosus	tubulin alpha chain	0.0584	0.7679	0.7036
Echinococcus granulosus	tubulin alpha 3 chain	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin, putative	0.018	0.217	0.217
Echinococcus granulosus	Tubulin beta 2C chain	0.0754	1	1
Schistosoma mansoni	tubulin subunit beta	0.0754	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0754	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0414	0.5365	0.5365
Echinococcus multilocularis	tubulin epsilon chain	0.0414	0.5365	0.4081
Echinococcus multilocularis	hypothetical protein	0.0584	0.7679	0.7036
Schistosoma mansoni	tubulin subunit epsilon	0.0414	0.5365	0.4081
Schistosoma mansoni	tubulin subunit beta	0.0754	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0584	0.7679	0.7088
Loa Loa (eye worm)	BEN-1 protein	0.0754	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0584	0.7679	0.7036
Plasmodium falciparum	tubulin epsilon chain, putative	0.0414	0.5365	0.4081
Mycobacterium tuberculosis	Cell division protein FtsZ	0.018	0.217	0.5
Trypanosoma brucei	epsilon tubulin	0.0414	0.5365	0.4081
Trichomonas vaginalis	tubulin beta chain, putative	0.0754	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.018	0.217	0.217
Trypanosoma brucei	epsilon tubulin	0.0414	0.5365	0.4081
Echinococcus granulosus	tubulin alpha chain	0.0584	0.7679	0.7036
Plasmodium falciparum	alpha tubulin 2	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0584	0.7679	0.7679
Echinococcus granulosus	tubulin beta 1 chain	0.0754	1	1
Entamoeba histolytica	tubulin alpha chain, putative	0.0584	0.7679	0.7679
Giardia lamblia	Beta tubulin	0.0754	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0754	1	1
Mycobacterium leprae	cell division protein FtsZ	0.018	0.217	0.5
Entamoeba histolytica	tubulin family protein	0.0754	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Echinococcus granulosus	Tubulin beta 2C chain	0.0754	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0584	0.7679	0.7036
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Echinococcus granulosus	tubulin alpha chain	0.0584	0.7679	0.7036
Loa Loa (eye worm)	tubulin beta-4 chain	0.0754	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0584	0.7679	0.7036
Echinococcus granulosus	Tubulin alpha 1 chain	0.0584	0.7679	0.7036
Giardia lamblia	Beta tubulin	0.0754	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0754	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0584	0.7679	0.7036
Loa Loa (eye worm)	tubulin alpha 2	0.0404	0.5227	0.401
Plasmodium vivax	tubulin alpha chain, putative	0.0584	0.7679	0.7036
Loa Loa (eye worm)	tubulin beta chain	0.0754	1	1
Echinococcus multilocularis	tubulin alpha	0.0414	0.5365	0.4081
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.217	0.217
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Echinococcus granulosus	Tubulin beta 2C chain	0.0754	1	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0754	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0754	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0414	0.5365	0.4081
Trichomonas vaginalis	tubulin beta chain, putative	0.0584	0.7679	0.7679
Echinococcus granulosus	tubulin subunit beta	0.0754	1	1
Giardia lamblia	Delta tubulin	0.018	0.217	0.1444
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0349	0.4484	0.3077
Trichomonas vaginalis	tubulin beta chain, putative	0.0584	0.7679	0.7679
Echinococcus granulosus	tubulin alpha	0.0414	0.5365	0.4081
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0414	0.5365	0.4081
Trichomonas vaginalis	tubulin gamma chain, putative	0.0414	0.5365	0.5365
Loa Loa (eye worm)	hypothetical protein	0.0404	0.5227	0.401
Leishmania major	beta tubulin	0.0754	1	1
Leishmania major	beta tubulin	0.0754	1	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0584	0.7679	0.7088
Echinococcus multilocularis	tubulin alpha 3 chain	0.0584	0.7679	0.7036
Schistosoma mansoni	tubulin subunit alpha	0.0584	0.7679	0.7036
Trypanosoma brucei	beta tubulin	0.0754	1	1
Trypanosoma brucei	alpha tubulin	0.0584	0.7679	0.7036
Trypanosoma cruzi	alpha tubulin, putative	0.0584	0.7679	0.7036
Echinococcus multilocularis	tubulin alpha chain	0.0584	0.7679	0.7036
Loa Loa (eye worm)	tubulin beta chain	0.018	0.217	0.0173
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0584	0.7679	0.7036
Echinococcus multilocularis	peroxisome assembly protein 26	0.0584	0.7679	0.7036
Trypanosoma brucei	alpha tubulin	0.0584	0.7679	0.7036
Schistosoma mansoni	tubulin subunit alpha	0.0584	0.7679	0.7036
Trypanosoma brucei	beta tubulin	0.0754	1	1
Leishmania major	beta tubulin	0.0754	1	1
Brugia malayi	alpha-tubulin	0.0584	0.7679	0.7036
Echinococcus granulosus	alpha tubulin	0.0584	0.7679	0.7036
Echinococcus multilocularis	Tubulin beta 2C chain	0.0754	1	1
Brugia malayi	beta-tubulin, identical	0.0754	1	1
Trypanosoma cruzi	tubulin gamma chain	0.0414	0.5365	0.4081
Echinococcus multilocularis	Tubulin beta 2C chain	0.0754	1	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.0414	0.5365	0.4081
Echinococcus granulosus	tubulin gamma 1 chain	0.0414	0.5365	0.4081
Schistosoma mansoni	tubulin subunit beta	0.0754	1	1
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Giardia lamblia	Alpha-tubulin	0.0584	0.7679	0.7464
Schistosoma mansoni	alpha tubulin	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin beta chain, putative	0.0584	0.7679	0.7679
Leishmania major	beta tubulin	0.0754	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0754	1	1
Echinococcus multilocularis	beta tubulin	0.0754	1	1
Leishmania major	beta tubulin	0.0754	1	1
Plasmodium vivax	tubulin gamma chain, putative	0.0414	0.5365	0.4081
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Echinococcus multilocularis	tubulin alpha chain	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin beta chain, putative	0.0584	0.7679	0.7679
Echinococcus multilocularis	tubulin subunit TubB	0.0584	0.7679	0.7036
Entamoeba histolytica	tubulin family protein	0.0754	1	1
Trypanosoma brucei	beta tubulin	0.0754	1	1
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0083	0.0848	0.0848
Echinococcus granulosus	tubulin alpha 1C chain	0.0584	0.7679	0.7036
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Echinococcus granulosus	tubulin alpha 3 chain	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin, putative	0.0234	0.2913	0.2913
Echinococcus multilocularis	tubulin alpha 1C chain	0.0584	0.7679	0.7036
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Brugia malayi	tubulin alpha chain - mouse	0.0584	0.7679	0.7036
Leishmania major	beta tubulin	0.0754	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.0404	0.5227	0.401
Brugia malayi	Tubulin gamma chain	0.0414	0.5365	0.4081
Echinococcus granulosus	beta tubulin	0.0754	1	1
Schistosoma mansoni	alpha tubulin	0.0584	0.7679	0.7036
Trypanosoma brucei	beta tubulin	0.0754	1	1
Onchocerca volvulus		0.0234	0.2913	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0062	0.0565	0.0565
Echinococcus granulosus	beta tubulin	0.0754	1	1
Giardia lamblia	Beta tubulin	0.0754	1	1
Leishmania major	beta tubulin	0.0754	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin alpha chain, putative	0.0234	0.2913	0.2913
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Leishmania major	beta tubulin	0.0754	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0349	0.4484	0.4484
Leishmania major	beta tubulin	0.0754	1	1
Echinococcus multilocularis	tubulin subunit beta	0.0754	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0584	0.7679	0.7679
Plasmodium falciparum	alpha tubulin 1	0.0584	0.7679	0.7036
Trypanosoma brucei	alpha tubulin	0.0584	0.7679	0.7036
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0215	0.2652	0.0615
Trichomonas vaginalis	tubulin, putative	0.0754	1	1
Entamoeba histolytica	tubulin gamma chain	0.0414	0.5365	0.5365
Schistosoma mansoni	alpha tubulin	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0584	0.7679	0.7679
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0404	0.5227	0.401
Mycobacterium ulcerans	cell division protein FtsZ	0.018	0.217	0.5
Echinococcus granulosus	tubulin beta 4A class IVa	0.0754	1	1
Trypanosoma cruzi	beta tubulin, putative	0.0754	1	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.0754	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0754	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0404	0.5227	0.5227
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0754	1	1
Brugia malayi	Tubulin beta chain	0.0234	0.2913	0.0949
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.018	0.217	0.5
Loa Loa (eye worm)	BEN-1 protein	0.0754	1	1
Leishmania major	beta tubulin	0.0754	1	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0754	1	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0754	1	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0584	0.7679	0.7036
Echinococcus granulosus	tubulin subunit TubB	0.0584	0.7679	0.7036
Entamoeba histolytica	tubulin alpha-1 chain	0.0584	0.7679	0.7679
Plasmodium vivax	tubulin epsilon chain, putative	0.0414	0.5365	0.4081
Trichomonas vaginalis	tubulin alpha chain, putative	0.0234	0.2913	0.2913
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin beta chain, putative	0.0584	0.7679	0.7679
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Leishmania major	beta tubulin	0.0754	1	1
Plasmodium falciparum	tubulin gamma chain	0.0414	0.5365	0.4081
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Brugia malayi	Tubulin alpha-2 chain	0.0584	0.7679	0.7036
Trypanosoma brucei	alpha tubulin, putative	0.0234	0.2913	0.0949
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Schistosoma mansoni	tubulin subunit gamma	0.0414	0.5365	0.4081
Loa Loa (eye worm)	beta-tubulin	0.0754	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Brugia malayi	tubulin alpha-2 chain	0.0584	0.7679	0.7036
Leishmania major	beta tubulin	0.0754	1	1
Trichomonas vaginalis	tubulin, putative	0.0234	0.2913	0.2913
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Echinococcus granulosus	tubulin alpha chain	0.0584	0.7679	0.7036
Trichomonas vaginalis	tubulin gamma chain, putative	0.018	0.217	0.217
Trichomonas vaginalis	tubulin beta-1 chain, putative	0.018	0.217	0.217
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Treponema pallidum	cell division protein FtsZ	0.018	0.217	0.5
Toxoplasma gondii	beta-1 tubulin, putative	0.0754	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0584	0.7679	0.7088
Giardia lamblia	Alpha-tubulin	0.0584	0.7679	0.7464
Brugia malayi	Tubulin alpha chain	0.0584	0.7679	0.7036
Toxoplasma gondii	alpha-tubulin I, putative	0.0584	0.7679	0.7036
Toxoplasma gondii	beta tubulin	0.0754	1	1
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Schistosoma mansoni	tubulin subunit beta	0.0754	1	1
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0215	0.2652	0.0615
Trypanosoma brucei	epsilon tubulin	0.0414	0.5365	0.4081
Leishmania major	beta tubulin	0.0754	1	1
Leishmania major	epsilon tubulin, putative	0.0414	0.5365	0.4081
Echinococcus multilocularis	tubulin alpha 1C chain	0.0584	0.7679	0.7036
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Leishmania major	beta tubulin	0.0754	1	1
Loa Loa (eye worm)	hypothetical protein	0.0584	0.7679	0.7088
Leishmania major	beta tubulin	0.0754	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0083	0.0848	0.0848
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0083	0.0848	0.0848
Echinococcus granulosus	tubulin epsilon chain	0.0414	0.5365	0.4081
Trypanosoma brucei	alpha tubulin	0.0584	0.7679	0.7036
Echinococcus multilocularis	Tubulin beta 2C chain	0.0754	1	1
Schistosoma mansoni	tubulin subunit beta	0.0754	1	1
Trypanosoma brucei	tubulin gamma chain	0.0414	0.5365	0.4081
Trichomonas vaginalis	tubulin beta chain, putative	0.0234	0.2913	0.2913
Trichomonas vaginalis	conserved hypothetical protein	0.018	0.217	0.217
Leishmania major	beta tubulin	0.0754	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0754	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0584	0.7679	0.7036
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0584	0.7679	0.7036
Leishmania major	alpha tubulin	0.0584	0.7679	0.7036
Loa Loa (eye worm)	hypothetical protein	0.0349	0.4484	0.3077
Leishmania major	beta tubulin	0.0754	1	1
Loa Loa (eye worm)	tubulin gamma chain	0.0414	0.5365	0.4184
Echinococcus granulosus	tubulin alpha chain	0.0584	0.7679	0.7036

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 842433