Detailed information for compound 843988

Basic information

Technical information
  • TDR Targets ID: 843988
  • Name: 2-(4-methyl-2-oxopyrimido[1,2-b]indazol-6-yl) -N-[3-(trifluoromethyl)phenyl]propanamide
  • MW: 414.38 | Formula: C21H17F3N4O2
  • H donors: 1 H acceptors: 2 LogP: 3.77 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1cc(C)n2c(n1)c1ccccc1n2C(C(=O)Nc1cccc(c1)C(F)(F)F)C
  • InChi: 1S/C21H17F3N4O2/c1-12-10-18(29)26-19-16-8-3-4-9-17(16)28(27(12)19)13(2)20(30)25-15-7-5-6-14(11-15)21(22,23)24/h3-11,13H,1-2H3,(H,25,30)
  • InChiKey: STBQLOGGSUMMJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methyl-2-oxo-pyrimido[1,2-b]indazol-6-yl)-N-[3-(trifluoromethyl)phenyl]propanamide
  • 2-(4-methyl-2-oxo-6-pyrimido[1,2-b]indazolyl)-N-[3-(trifluoromethyl)phenyl]propanamide
  • 2-(2-keto-4-methyl-pyrimido[1,2-b]indazol-6-yl)-N-[3-(trifluoromethyl)phenyl]propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0929 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0108 0.0669
Giardia lamblia hypothetical protein 0.0018 0.0114 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Mycobacterium tuberculosis Possible amidase (aminohydrolase) 0.008 0.0789 0.487
Schistosoma mansoni hypothetical protein 0.0049 0.0457 0.0643
Trypanosoma cruzi lipase, putative 0.0018 0.0114 0.0114
Brugia malayi DKFZp564C0469 protein 0.001 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Trypanosoma brucei Triglyceride lipase, putative 0.0018 0.0114 0.0114
Toxoplasma gondii lipase 0.0018 0.0114 0.4516
Trypanosoma cruzi lipase, putative 0.0018 0.0114 0.0114
Onchocerca volvulus 0.001 0.0032 0.0032
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0185 0.1145
Brugia malayi Amidase family protein 0.008 0.0789 0.0789
Entamoeba histolytica hypothetical protein 0.0018 0.0114 0.113
Trypanosoma cruzi lipase, putative 0.0018 0.0114 0.0114
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0018 0.0116 0.0164
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0032 0.0032
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0119 0.1509
Loa Loa (eye worm) hypothetical protein 0.0241 0.2541 0.2541
Trypanosoma cruzi lipase domain protein, putative 0.0018 0.0114 0.0114
Trypanosoma brucei lipase domain protein, putative 0.0929 1 1
Echinococcus granulosus carboxylesterase 5A 0.0018 0.0116 0.0116
Toxoplasma gondii lipase 0.0018 0.0114 0.4516
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0032 0.0197
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Schistosoma mansoni amidase 0.0662 0.7103 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0035
Trypanosoma cruzi Triglyceride lipase, putative 0.0018 0.0114 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0253 0.0357
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0018 0.0116 0.0718
Entamoeba histolytica hypothetical protein 0.001 0.0032 0.0315
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0032 0.0405
Trypanosoma cruzi Lipase (class 3), putative 0.0018 0.0114 0.0114
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0185 0.1145
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0185 0.183
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Toxoplasma gondii lipase 0.0018 0.0114 0.4516
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0035
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0032 0.0032
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0185 0.0185
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0101 0.1013 0.1013
Schistosoma mansoni fatty-acid amide hydrolase 0.0662 0.7103 1
Entamoeba histolytica hypothetical protein 0.0037 0.0321 0.3171
Brugia malayi topoisomerase 0.001 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0037 0.0321 0.0452
Onchocerca volvulus 0.0929 1 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0185
Echinococcus multilocularis nibrin 0.001 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Entamoeba histolytica hypothetical protein 0.0037 0.0321 0.3171
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0035 0.0035
Brugia malayi putative amidase 0.008 0.0789 0.0789
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0119 0.1509
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0185 0.183
Schistosoma mansoni thyroid hormone receptor 0.001 0.0035 0.0049
Onchocerca volvulus 0.0018 0.0116 0.0116
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0253 0.0253
Schistosoma mansoni coup transcription factor 0.001 0.0035 0.0049
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0457 0.0457
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.1013 0.1013
Onchocerca volvulus 0.0049 0.0457 0.0457
Leishmania major lipase, putative 0.0018 0.0114 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0253 0.0357
Schistosoma mansoni hypothetical protein 0.0042 0.0374 0.0526
Echinococcus multilocularis carboxylesterase 5A 0.0018 0.0116 0.0116
Brugia malayi hypothetical protein 0.0018 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0391 0.0391
Leishmania major hypothetical protein, unknown function 0.0018 0.0114 0.0114
Echinococcus granulosus para nitrobenzyl esterase 0.0018 0.0116 0.0116
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0035 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0253 0.0357
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0108 0.0669
Giardia lamblia hypothetical protein 0.0018 0.0114 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.008 0.0789 0.0789
Onchocerca volvulus 0.001 0.0035 0.0035
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.0018 0.0114 0.113
Mycobacterium ulcerans aspartyl/glutamyl-tRNA amidotransferase subunit A 0.008 0.0789 0.487
Echinococcus multilocularis BC026374 protein (S09 family) 0.0018 0.0116 0.0116
Leishmania major hypothetical protein, unknown function 0.0018 0.0114 0.0114
Brugia malayi nuclear hormone receptor 0.001 0.0035 0.0035
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0253 0.0253
Echinococcus multilocularis expressed conserved protein 0.0094 0.0947 0.0947
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0185 0.1145
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0042 0.0374 0.0526
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0018 0.0114 0.0114
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0035
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.0035
Wolbachia endosymbiont of Brugia malayi aspartyl/glutamyl-tRNA amidotransferase subunit A 0.008 0.0789 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.1013 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0035
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0035 0.0035
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0035 0.0035
Onchocerca volvulus 0.0018 0.0116 0.0116
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0185 0.1145
Echinococcus granulosus nibrin 0.001 0.0032 0.0032
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0032 0.0032
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0032 0.0405
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0114 0.0114
Trichomonas vaginalis lipase containing protein, putative 0.0018 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0035
Brugia malayi Lipase family protein 0.0018 0.0114 0.0114
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0035 0.0049
Mycobacterium ulcerans amidase 0.008 0.0789 0.487
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0032 0.0032
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0032 0.0032
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0032 0.0405
Loa Loa (eye worm) hypothetical protein 0.0053 0.0496 0.0496
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.103 0.145
Trypanosoma brucei triacylglycerol lipase, putative 0.0018 0.0114 0.0114
Loa Loa (eye worm) amidase 0.008 0.0789 0.0789
Leishmania major lipase precursor-like protein 0.0018 0.0114 0.0114
Entamoeba histolytica hypothetical protein 0.0037 0.0321 0.3171
Leishmania major lipase domain protein, putative 0.0018 0.0114 0.0114
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0035 0.0049
Echinococcus granulosus BC026374 protein S09 family 0.0018 0.0116 0.0116
Onchocerca volvulus 0.003 0.0253 0.0253
Loa Loa (eye worm) lipase 0.0018 0.0114 0.0114
Entamoeba histolytica hypothetical protein 0.0018 0.0114 0.113
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0035 0.0035
Brugia malayi Carboxylesterase family protein 0.0018 0.0116 0.0116
Leishmania major hypothetical protein, conserved 0.0018 0.0114 0.0114
Mycobacterium ulcerans amidase 0.008 0.0789 0.487
Onchocerca volvulus 0.0242 0.2546 0.2546
Loa Loa (eye worm) lipase 0.0929 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0321 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Loa Loa (eye worm) carboxylesterase 0.0018 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0032
Brugia malayi amidase 0.0662 0.7103 0.7103
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0185 0.183
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.1013 0.1013
Schistosoma mansoni fatty-acid amide hydrolase 0.008 0.0789 0.1111
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0114 0.0114
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0018 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0185 0.1145
Trypanosoma cruzi amidase, putative 0.008 0.0789 0.0789
Trypanosoma brucei Lipase (class 3), putative 0.0018 0.0114 0.0114
Echinococcus multilocularis Niemann Pick C1 protein 0.0144 0.1481 0.1481
Brugia malayi Carboxylesterase family protein 0.0018 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0185
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0035 0.0049
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0035
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0391 0.0391
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0108 0.0669
Leishmania major hypothetical protein, conserved 0.0018 0.0114 0.0114
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0391 0.0391
Brugia malayi Carboxylesterase family protein 0.0018 0.0116 0.0116
Echinococcus granulosus acetylcholinesterase 0.0018 0.0116 0.0116
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0032 0.0315
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.008 0.0789 0.1111
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0032 0.0032
Onchocerca volvulus 0.0018 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0119 0.0735
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Schistosoma mansoni neuroligin 3 (S09 family) 0.0018 0.0116 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.0929 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0035
Brugia malayi Amidase family protein 0.008 0.0789 0.0789
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0185 0.0185
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0035 0.0035
Onchocerca volvulus 0.0024 0.0185 0.0185
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0035 0.0049
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0035 0.0035
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0032 0.0032
Leishmania major hypothetical protein, conserved 0.0929 1 1
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0032 0.0032
Trypanosoma cruzi lipase, putative 0.0018 0.0114 0.0114
Echinococcus granulosus FTZ F1 alpha 0.001 0.0035 0.0035
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0391 0.0391
Schistosoma mansoni BC026374 protein (S09 family) 0.0018 0.0116 0.0164
Echinococcus granulosus fatty acid amide hydrolase 1 0.0662 0.7103 0.7103
Trypanosoma cruzi lipase, putative 0.0018 0.0114 0.0114
Leishmania major class 3 lipase, putative 0.0018 0.0114 0.0114
Leishmania major lipase, putative;with=GeneDB:LinJ31_V3.0860 0.0018 0.0114 0.0114
Trichomonas vaginalis set domain proteins, putative 0.0242 0.2546 0.2546
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0321 0.0321
Trichomonas vaginalis spcc417.12 protein, putative 0.0018 0.0116 0.0116
Chlamydia trachomatis glutamyl-tRNA(Gln) amidotransferase subunit A 0.008 0.0789 1
Mycobacterium tuberculosis Probable amidase AmiD (acylamidase) (acylase) 0.008 0.0789 0.487
Schistosoma mansoni acetylcholinesterase 0.0018 0.0116 0.0164
Mycobacterium ulcerans amidase 0.008 0.0789 0.487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Echinococcus multilocularis acetylcholinesterase 0.0018 0.0116 0.0116
Trypanosoma cruzi lipase domain protein, putative 0.0018 0.0114 0.0114
Trichomonas vaginalis lipase containing protein, putative 0.0929 1 1
Mycobacterium leprae PROBABLE AMIDASE AMIC (AMINOHYDROLASE) 0.008 0.0789 1
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0032 0.0032
Entamoeba histolytica lipase, putative 0.0018 0.0114 0.113
Trypanosoma brucei lipase, putative 0.0018 0.0114 0.0114
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0108 0.0669
Loa Loa (eye worm) lipase 0.0018 0.0114 0.0114
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0018 0.0116 0.0164
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0035
Schistosoma mansoni survival motor neuron protein 0.0049 0.0457 0.0643
Plasmodium falciparum lipase, putative 0.0018 0.0114 0.1451
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0391 0.0391
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.0035
Echinococcus granulosus expressed conserved protein 0.0094 0.0947 0.0947
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0032 0.0045
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0018 0.0116 0.0116
Schistosoma mansoni topbp1 0.001 0.0032 0.0045
Entamoeba histolytica lipase, putative 0.0018 0.0114 0.113
Giardia lamblia Hypothetical protein 0.0018 0.0114 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0035
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0929 1 1
Mycobacterium ulcerans amidase 0.008 0.0789 0.487
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0032 0.126
Schistosoma mansoni DNA ligase IV 0.001 0.0032 0.0045
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0018 0.0116 0.0116
Schistosoma mansoni lipase 0.0018 0.0114 0.0161
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Leishmania major hypothetical protein, conserved 0.008 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.003 0.0253 0.0253
Echinococcus granulosus replication factor c subunit 1 0.001 0.0032 0.0032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0253 1
Echinococcus multilocularis neuroligin 0.0018 0.0116 0.0116
Brugia malayi Pre-SET motif family protein 0.0213 0.2228 0.2228
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Trypanosoma cruzi lipase, putative 0.0018 0.0114 0.0114
Schistosoma mansoni thyroid hormone receptor 0.001 0.0035 0.0049
Schistosoma mansoni hypothetical protein 0.0042 0.0374 0.0526
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0185 0.1145
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0035 0.0049
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0035 0.0035
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0662 0.7103 0.7103
Loa Loa (eye worm) hypothetical protein 0.0024 0.0185 0.0185
Entamoeba histolytica hypothetical protein 0.0018 0.0114 0.113
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0018 0.0114 0.113
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0828 0.8902 0.8902
Trypanosoma cruzi amidase, putative 0.008 0.0789 0.0789
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.008 0.0789 1
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0662 0.7103 0.7103
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0035
Onchocerca volvulus 0.0018 0.0114 0.0114
Trypanosoma cruzi lipase, putative 0.0018 0.0114 0.0114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0035
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0185 0.0185
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0662 0.7103 0.7103
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0035
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0032 0.126
Brugia malayi Pre-SET motif family protein 0.003 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Plasmodium vivax hypothetical protein, conserved 0.0018 0.0114 0.1451
Echinococcus multilocularis para nitrobenzyl esterase 0.0018 0.0116 0.0116
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0185 0.0185
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0018 0.0116 0.0164
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2228 0.2228
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0035
Brugia malayi Lipase family protein 0.0018 0.0114 0.0114
Trypanosoma brucei fatty-acid amide hydrolase, putative 0.008 0.0789 0.0789
Echinococcus granulosus fatty acid amide hydrolase 1 0.0662 0.7103 0.7103
Mycobacterium ulcerans hypothetical protein 0.0024 0.0185 0.1145
Trypanosoma brucei Triglyceride lipase, putative 0.0018 0.0114 0.0114
Onchocerca volvulus 0.0018 0.0116 0.0116
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0185 0.235
Schistosoma mansoni hypothetical protein 0.0042 0.0374 0.0526
Loa Loa (eye worm) carboxylesterase 0.0018 0.0116 0.0116
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0035 0.0049
Echinococcus multilocularis fatty acid amide hydrolase 1 0.008 0.0789 0.0789
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Echinococcus multilocularis protein patched 0.0043 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0035
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.2541 0.2541
Brugia malayi Lipase family protein 0.0018 0.0114 0.0114
Brugia malayi Lipase family protein 0.0018 0.0114 0.0114
Plasmodium vivax SET domain protein, putative 0.003 0.0253 0.3212
Brugia malayi hypothetical protein 0.001 0.0032 0.0032
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0929 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Loa Loa (eye worm) carboxylesterase 0.0018 0.0116 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0035
Brugia malayi hypothetical protein 0.0037 0.0321 0.0321
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0253 0.0253
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.0035
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0035 0.0035
Brugia malayi CHE-14 protein 0.0043 0.0391 0.0391
Echinococcus granulosus acetylcholinesterase 0.0018 0.0116 0.0116
Echinococcus multilocularis protein dispatched 1 0.0049 0.0457 0.0457
Schistosoma mansoni nuclear hormone receptor 0.001 0.0035 0.0049
Schistosoma mansoni topbp1 0.001 0.0032 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0032
Mycobacterium tuberculosis Carboxylesterase LipT 0.0157 0.162 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0018 0.0116 0.0116
Entamoeba histolytica lipase, putative 0.0018 0.0114 0.113
Entamoeba histolytica lipase, putative 0.0018 0.0114 0.113
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0035
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.008 0.0789 0.0789
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.0037 0.0321 0.3171
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0032 0.0032
Brugia malayi ecdysteroid receptor 0.001 0.0035 0.0035
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.008 0.0789 1
Giardia lamblia Hypothetical protein 0.0018 0.0114 1
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Mycobacterium tuberculosis Probable amidase AmiB2 (aminohydrolase) 0.008 0.0789 0.487
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0035
Brugia malayi hypothetical protein 0.0241 0.2541 0.2541
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Echinococcus multilocularis acetylcholinesterase 0.0018 0.0116 0.0116
Trichomonas vaginalis lipase containing protein, putative 0.0929 1 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0119 0.1151
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0185 0.235
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0018 0.0116 0.0164
Brugia malayi steroid hormone receptor 0.001 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.0018 0.0114 0.113
Mycobacterium ulcerans amidase 0.008 0.0789 0.487
Loa Loa (eye worm) acetylcholinesterase 1 0.0018 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0032
Onchocerca volvulus 0.0018 0.0116 0.0116
Toxoplasma gondii lipase 0.0018 0.0114 0.4516
Loa Loa (eye worm) hypothetical protein 0.0043 0.0391 0.0391
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0032 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0185 0.1145
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.2541 0.2541
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Trypanosoma cruzi lipase-like protein, putative 0.0018 0.0114 0.0114
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0035 0.0035
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0321 0.0321
Trypanosoma brucei lipase-like protein, putative 0.0018 0.0114 0.0114
Mycobacterium ulcerans carboxylesterase, LipT 0.0157 0.162 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0253 0.0357
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0119 0.0735
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0241 0.0241
Giardia lamblia Hypothetical protein 0.0018 0.0114 1
Brugia malayi Carboxylesterase family protein 0.0018 0.0116 0.0116
Echinococcus granulosus neuroligin 0.0018 0.0116 0.0116
Mycobacterium ulcerans peptide amidase, GatA 0.008 0.0789 0.487
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0035 0.0035
Schistosoma mansoni patched 1 0.0043 0.0391 0.055
Brugia malayi hypothetical protein 0.001 0.0032 0.0032
Entamoeba histolytica hypothetical protein 0.0018 0.0114 0.113
Onchocerca volvulus 0.0018 0.0114 0.0114
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0035 0.0049
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.1013 0.1013
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0185 0.0185
Mycobacterium tuberculosis Probable amidase AmiC (aminohydrolase) 0.008 0.0789 0.487
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0035 0.0035
Trypanosoma cruzi lipase, putative 0.0018 0.0114 0.0114
Trichomonas vaginalis conserved hypothetical protein 0.0018 0.0114 0.0114
Trypanosoma brucei lipase domain protein, putative 0.0018 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0035 0.0049
Brugia malayi Carboxylesterase family protein 0.0018 0.0116 0.0116
Entamoeba histolytica hypothetical protein 0.0018 0.0114 0.113
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0185 0.1145
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0035
Brugia malayi Carboxylesterase family protein 0.0018 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0114 0.0114
Onchocerca volvulus 0.0018 0.0116 0.0116
Leishmania major hypothetical protein, conserved 0.0018 0.0114 0.0114
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0018 0.0116 0.0718
Schistosoma mansoni gliotactin 0.0018 0.0116 0.0164
Trypanosoma brucei lipase domain protein, putative 0.0929 1 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0032
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0032 0.0032
Brugia malayi nuclear receptor NHR-88 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0185 0.1145
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0185 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0114 0.0114
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0032 0.0032
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0018 0.0119 0.0119
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0035 0.0035
Mycobacterium tuberculosis Probable amidase AmiA2 (aminohydrolase) 0.008 0.0789 0.487
Loa Loa (eye worm) hypothetical protein 0.0018 0.0116 0.0116
Treponema pallidum aspartyl/glutamyl-tRNA amidotransferase subunit A 0.008 0.0789 1
Echinococcus granulosus Niemann Pick C1 protein 0.0144 0.1481 0.1481
Mycobacterium leprae PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) 0.008 0.0789 1
Loa Loa (eye worm) amidase 0.008 0.0789 0.0789
Echinococcus granulosus fatty acid amide hydrolase 1 0.008 0.0789 0.0789

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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