TDR Targets

Basic information

Technical information

TDR Targets ID: 845225
Name: 4-dimethoxyphosphoryl-N-[(4-fluorophenyl)meth yl]-2-[(4-methoxyphenyl)methyl]-1,3-oxazol-5- amine
MW: 420.371 | Formula: C20H22FN2O5P
H donors: 1 H acceptors: 2 LogP: 4.17 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Cc1oc(c(n1)P(=O)(OC)OC)NCc1ccc(cc1)F
InChi: 1S/C20H22FN2O5P/c1-25-17-10-6-14(7-11-17)12-18-23-20(29(24,26-2)27-3)19(28-18)22-13-15-4-8-16(21)9-5-15/h4-11,22H,12-13H2,1-3H3
InChiKey: KXOVKJUCFJVGPY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-dimethoxyphosphoryl-N-[(4-fluorophenyl)methyl]-2-[(4-methoxyphenyl)methyl]oxazol-5-amine
4-dimethoxyphosphoryl-N-[(4-fluorophenyl)methyl]-2-[(4-methoxyphenyl)methyl]-5-oxazolamine
[4-dimethoxyphosphoryl-2-(4-methoxybenzyl)oxazol-5-yl]-(4-fluorobenzyl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	EGF-like domain containing protein	0.0495	0.3224	0.3224
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.009	0.0441	0.0307
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Echinococcus multilocularis	fibrillin 1	0.1268	0.8525	1
Toxoplasma gondii	calcium binding egf domain-containing protein	0.1268	0.8525	1
Onchocerca volvulus		0.0495	0.3224	0.3224
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Brugia malayi	Calcium binding EGF domain containing protein	0.0495	0.3224	0.3224
Onchocerca volvulus		0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.0267	0.166	0.166
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0185	0.0185
Schistosoma mansoni	notch	0.0495	0.3224	0.3224
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.1268	0.8525	0.8525
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1483	1	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0185	0.0185
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0079	0.0366	0.0429
Brugia malayi	Delta serrate ligand family protein	0.0495	0.3224	0.3224
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0079	0.0366	0.0366
Echinococcus granulosus	neurogenic locus notch protein 4	0.0495	0.3224	0.3782
Loa Loa (eye worm)	PAN domain-containing protein	0.0052	0.0185	0.0185
Loa Loa (eye worm)	notch protein	0.0495	0.3224	0.3224
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0045	0.0137	0.0137
Echinococcus granulosus	protein jagged 2	0.0495	0.3224	0.3782
Toxoplasma gondii	calcium binding egf domain-containing protein	0.1268	0.8525	1
Brugia malayi	PAN domain containing protein	0.0052	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Echinococcus granulosus	Mastin	0.036	0.2297	0.2695
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0047	0.0147	0.0147
Onchocerca volvulus	Arrow homolog	0.1268	0.8525	0.8525
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Onchocerca volvulus		0.0052	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0185	0.0185
Brugia malayi	Protein kinase domain containing protein	0.0267	0.166	0.166
Onchocerca volvulus	Neurogenic locus notch homolog	0.0495	0.3224	0.3224
Schistosoma mansoni	notch	0.0495	0.3224	0.3224
Echinococcus multilocularis	neurogenic locus protein delta	0.0495	0.3224	0.3782
Echinococcus granulosus	neurogenic locus protein delta	0.0495	0.3224	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Echinococcus granulosus	fibropellin Ia	0.0495	0.3224	0.3782
Onchocerca volvulus		0.0495	0.3224	0.3224
Loa Loa (eye worm)	hypothetical protein	0.1268	0.8525	0.8525
Trypanosoma cruzi	hypothetical protein, conserved	0.0267	0.166	0.5
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0046	0.0046
Brugia malayi	EGF-like domain containing protein	0.0495	0.3224	0.3224
Loa Loa (eye worm)	Notch2	0.0495	0.3224	0.3224
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.036	0.2297	0.2297
Brugia malayi	Muscle positioning protein 4	0.0495	0.3224	0.3224
Brugia malayi	PAN domain containing protein	0.0052	0.0185	0.0185
Schistosoma mansoni	notch	0.0495	0.3224	0.3224
Loa Loa (eye worm)	hypothetical protein	0.009	0.0441	0.0441
Schistosoma mansoni	hypothetical protein	0.0267	0.166	0.166
Echinococcus multilocularis	neurogenic locus protein delta	0.0495	0.3224	0.3782
Brugia malayi	Trypsin-like protease protein 5	0.036	0.2297	0.2297
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.0122	0.0143
Brugia malayi	Trypsin family protein	0.036	0.2297	0.2297
Echinococcus multilocularis	enteropeptidase	0.036	0.2297	0.2695
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0267	0.166	0.5
Brugia malayi	PAN domain containing protein	0.0052	0.0185	0.0185
Schistosoma mansoni	laminin gamma-3 chain	0.0495	0.3224	0.3224
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0047	0.0147	0.0147
Schistosoma mansoni	hypothetical protein	0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.1268	0.8525	0.8525
Brugia malayi	Cadherin domain containing protein	0.0495	0.3224	0.3224
Loa Loa (eye worm)	PAN domain-containing protein	0.0052	0.0185	0.0185
Brugia malayi	GCC2 and GCC3 family protein	0.0495	0.3224	0.3224
Loa Loa (eye worm)	hypothetical protein	0.014	0.0786	0.0786
Brugia malayi	EGF-like domain containing protein	0.0495	0.3224	0.3224
Onchocerca volvulus		0.1123	0.753	0.753
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.009	0.0441	0.0517
Schistosoma mansoni	hypothetical protein	0.0495	0.3224	0.3224
Echinococcus granulosus	notch	0.0495	0.3224	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0185	0.0185
Echinococcus multilocularis	neurogenic locus notch protein	0.0495	0.3224	0.3782
Echinococcus multilocularis	protein jagged 1	0.0495	0.3224	0.3782
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Toxoplasma gondii	PAN domain-containing protein	0.0603	0.3964	0.4531
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Echinococcus granulosus	enteropeptidase	0.036	0.2297	0.2695
Loa Loa (eye worm)	hypothetical protein	0.1483	1	1
Onchocerca volvulus		0.0052	0.0185	0.0185
Toxoplasma gondii	PAN domain-containing protein	0.0603	0.3964	0.4531
Loa Loa (eye worm)	PAN domain-containing protein	0.0052	0.0185	0.0185
Brugia malayi	PAN domain containing protein	0.0052	0.0185	0.0185
Brugia malayi	PAN domain containing protein	0.0052	0.0185	0.0185
Echinococcus multilocularis	protein jagged 1	0.0495	0.3224	0.3782
Schistosoma mansoni	hypothetical protein	0.0495	0.3224	0.3224
Echinococcus granulosus	protein jagged 1	0.0495	0.3224	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Brugia malayi	PAN domain containing protein	0.0052	0.0185	0.0185
Onchocerca volvulus		0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.1268	0.8525	0.8525
Echinococcus multilocularis	muscleblind protein	0.014	0.0786	0.0923
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.0122	0.0143
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.036	0.2297	0.2297
Echinococcus granulosus	survival motor neuron protein 1	0.0221	0.1346	0.1579
Echinococcus multilocularis	muscleblind protein 1	0.014	0.0786	0.0923
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.1268	0.8525	0.8525
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.009	0.0441	0.0517
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0122	0.0122
Onchocerca volvulus		0.0052	0.0185	0.0185
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.036	0.2297	0.2695
Giardia lamblia	High cysteine protein	0.0495	0.3224	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0495	0.3224	0.3782
Onchocerca volvulus		0.0052	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Brugia malayi	Calcium binding EGF domain containing protein	0.0495	0.3224	0.3224
Onchocerca volvulus		0.0052	0.0185	0.0185
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.036	0.2297	0.2297
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0122	0.0122
Echinococcus granulosus	laminin	0.1268	0.8525	1
Schistosoma mansoni	microtubule-associated protein tau	0.065	0.4286	0.4286
Brugia malayi	Trypsin family protein	0.036	0.2297	0.2297
Schistosoma mansoni	cell polarity protein	0.0495	0.3224	0.3224
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.009	0.0441	0.0441
Echinococcus multilocularis	fibropellin Ia	0.0495	0.3224	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Schistosoma mansoni	survival motor neuron protein	0.0045	0.0137	0.0137
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0495	0.3224	0.3782
Echinococcus granulosus	neurogenic locus notch protein	0.0495	0.3224	0.3782
Brugia malayi	Muscleblind-like protein	0.014	0.0786	0.0786
Onchocerca volvulus		0.0495	0.3224	0.3224
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.1268	0.8525	0.8525
Schistosoma mansoni	hypothetical protein	0.0045	0.0137	0.0137
Onchocerca volvulus	Putative cubilin	0.0495	0.3224	0.3224
Echinococcus multilocularis	glycoprotein Antigen 5	0.036	0.2297	0.2695
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Schistosoma mansoni	hypothetical protein	0.0159	0.0915	0.0915
Brugia malayi	PAN domain containing protein	0.0052	0.0185	0.0185
Toxoplasma gondii	EGF family domain-containing protein	0.0495	0.3224	0.3645
Echinococcus granulosus	muscleblind protein	0.014	0.0786	0.0923
Onchocerca volvulus		0.0052	0.0185	0.0185
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0079	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Echinococcus granulosus	glycoprotein Antigen 5	0.036	0.2297	0.2695
Echinococcus multilocularis	Tolloid protein 1	0.1268	0.8525	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0185	0.0185
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0043	0.0122	0.0122
Schistosoma mansoni	hypothetical protein	0.0495	0.3224	0.3224
Echinococcus granulosus	tissue type plasminogen activator	0.0267	0.166	0.1947
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Onchocerca volvulus		0.1483	1	1
Echinococcus multilocularis	microtubule associated protein 2	0.065	0.4286	0.5027
Brugia malayi	latrophilin 2 splice variant baaae	0.0032	0.0046	0.0046
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.036	0.2297	0.2695
Schistosoma mansoni	hypothetical protein	0.0032	0.0046	0.0046
Echinococcus multilocularis	laminin	0.1268	0.8525	1
Echinococcus granulosus	protein jagged 2	0.0495	0.3224	0.3782
Loa Loa (eye worm)	trypsin family protein	0.036	0.2297	0.2297
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Onchocerca volvulus		0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.036	0.2297	0.2297
Brugia malayi	PAN domain containing protein	0.0052	0.0185	0.0185
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.1268	0.8525	0.8525
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.036	0.2297	0.2297
Brugia malayi	hypothetical protein	0.0221	0.1346	0.1346
Schistosoma mansoni	slit	0.0495	0.3224	0.3224
Echinococcus multilocularis	slit 2 protein	0.0495	0.3224	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Brugia malayi	Calcium binding EGF domain containing protein	0.0495	0.3224	0.3224
Loa Loa (eye worm)	hypothetical protein	0.1268	0.8525	0.8525
Echinococcus multilocularis	survival motor neuron protein 1	0.0221	0.1346	0.1579
Onchocerca volvulus		0.036	0.2297	0.2297
Schistosoma mansoni	hypothetical protein	0.036	0.2297	0.2297
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.036	0.2297	0.2297
Schistosoma mansoni	notch	0.0495	0.3224	0.3224
Echinococcus granulosus	neurogenic locus notch protein	0.0495	0.3224	0.3782
Echinococcus granulosus	delta-like protein 1	0.0495	0.3224	0.3782
Loa Loa (eye worm)	TK/ROR protein kinase	0.0267	0.166	0.166
Loa Loa (eye worm)	hypothetical protein	0.036	0.2297	0.2297
Mycobacterium ulcerans	hypothetical protein	0.036	0.2297	0.5
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Loa Loa (eye worm)	PAN domain-containing protein	0.0052	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Onchocerca volvulus		0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Brugia malayi	Kringle domain containing protein	0.0267	0.166	0.166
Echinococcus granulosus	geminin	0.0159	0.0915	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0221	0.1346	0.1346
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.036	0.2297	0.2297
Loa Loa (eye worm)	hypothetical protein	0.014	0.0786	0.0786
Echinococcus multilocularis	tissue type plasminogen activator	0.0267	0.166	0.1947
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0043	0.0122	0.0143
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0043	0.0122	0.0122
Echinococcus multilocularis	geminin	0.0159	0.0915	0.1074
Onchocerca volvulus		0.0052	0.0185	0.0185
Brugia malayi	Fibulin-1 precursor	0.1268	0.8525	0.8525
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0495	0.3224	0.3224
Brugia malayi	PAN domain containing protein	0.0052	0.0185	0.0185
Brugia malayi	hypothetical protein	0.036	0.2297	0.2297
Loa Loa (eye worm)	PAN domain-containing protein	0.0052	0.0185	0.0185
Echinococcus multilocularis	neural cadherin	0.0495	0.3224	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Schistosoma mansoni	septate junction protein	0.0495	0.3224	0.3224
Leishmania major	hypothetical protein, conserved	0.0267	0.166	0.5
Schistosoma mansoni	hypothetical protein	0.0495	0.3224	0.3224
Brugia malayi	EGF-like domain containing protein	0.0495	0.3224	0.3224
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0043	0.0122	0.0143
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Schistosoma mansoni	notch	0.0495	0.3224	0.3224
Onchocerca volvulus		0.0052	0.0185	0.0185
Schistosoma mansoni	cercarial elastase (S01 family)	0.036	0.2297	0.2297
Echinococcus multilocularis	protein jagged 2	0.0495	0.3224	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.009	0.0441	0.0517
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.1268	0.8525	0.8525
Onchocerca volvulus	Slit protein homolog	0.0495	0.3224	0.3224
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.009	0.0441	0.0517
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.076	0.5037	0.5909
Echinococcus granulosus	transmembrane protease serine 3	0.036	0.2297	0.2695
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.1268	0.8525	0.8525
Onchocerca volvulus		0.0052	0.0185	0.0185
Schistosoma mansoni	hypothetical protein	0.0495	0.3224	0.3224
Echinococcus granulosus	microtubule associated protein 2	0.065	0.4286	0.5027
Echinococcus granulosus	Tolloid protein 1	0.1268	0.8525	1
Brugia malayi	Calcium binding EGF domain containing protein	0.1268	0.8525	0.8525
Echinococcus multilocularis	notch	0.0495	0.3224	0.3782
Echinococcus multilocularis	transmembrane protease serine 3	0.036	0.2297	0.2695
Toxoplasma gondii	kringle domain-containing protein	0.0267	0.166	0.1769
Echinococcus granulosus	slit 2 protein	0.0495	0.3224	0.3782
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0079	0.0366	0.0429
Echinococcus granulosus	protein jagged 1	0.0495	0.3224	0.3782
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.036	0.2297	0.2695
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0147	0.0147
Schistosoma mansoni	egf-like domain protein	0.1268	0.8525	0.8525
Onchocerca volvulus		0.0495	0.3224	0.3224
Onchocerca volvulus		0.0495	0.3224	0.3224
Brugia malayi	EGF-like domain containing protein	0.0495	0.3224	0.3224
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.1483	1	1
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0495	0.3224	0.3224
Brugia malayi	notch-like transmembrane receptor	0.0495	0.3224	0.3224
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0043	0.0122	0.0122
Brugia malayi	Cadherin domain containing protein	0.0495	0.3224	0.3224
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0495	0.3224	0.3224
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0495	0.3224	0.3782
Onchocerca volvulus		0.0052	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Onchocerca volvulus		0.0045	0.0137	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0047	0.0147	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0495	0.3224	0.3224
Schistosoma mansoni	notch	0.0495	0.3224	0.3224
Loa Loa (eye worm)	hypothetical protein	0.1483	1	1
Brugia malayi	EGF-like domain containing protein	0.0495	0.3224	0.3224
Schistosoma mansoni	hypothetical protein	0.0159	0.0915	0.0915
Loa Loa (eye worm)	hypothetical protein	0.036	0.2297	0.2297
Brugia malayi	Trypsin family protein	0.036	0.2297	0.2297
Onchocerca volvulus		0.0267	0.166	0.166
Echinococcus multilocularis	Mastin	0.036	0.2297	0.2695
Brugia malayi	PAN domain containing protein	0.0052	0.0185	0.0185
Onchocerca volvulus		0.0052	0.0185	0.0185
Schistosoma mansoni	hypothetical protein	0.0495	0.3224	0.3224
Brugia malayi	EGF-like domain containing protein	0.0495	0.3224	0.3224
Echinococcus granulosus	neural cadherin	0.0495	0.3224	0.3782
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.036	0.2297	0.2695
Schistosoma mansoni	hypothetical protein	0.0495	0.3224	0.3224
Plasmodium falciparum	cysteine repeat modular protein 1	0.0267	0.166	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 845225