Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.046 | 0.0527 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0218 | 0.1017 | 0.5 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0218 | 0.1017 | 0.1165 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0218 | 0.1017 | 0.1165 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1544 | 0.8731 | 0.8587 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0218 | 0.1017 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0101 | 0.0335 | 0.0731 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0102 | 0.0344 | 0.3383 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.1017 | 0.1165 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0218 | 0.1017 | 0.5 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.1544 | 0.8731 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0335 | 0.0384 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.046 | 0.0527 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0218 | 0.1017 | 0.222 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0101 | 0.0335 | 0.0384 |
Brugia malayi | acyl-CoA desaturase | 0.1544 | 0.8731 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1763 | 1 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1763 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.0045 | 0.0052 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0242 | 0.1158 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0218 | 0.1017 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.046 | 0.0527 |
Brugia malayi | hypothetical protein | 0.0242 | 0.1158 | 0.1326 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1544 | 0.8731 | 0.8587 |
Brugia malayi | Fatty acid desaturase family protein | 0.0218 | 0.1017 | 0.1165 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.0045 | 0.0052 |
Onchocerca volvulus | 0.1763 | 1 | 1 | |
Echinococcus granulosus | geminin | 0.0174 | 0.0758 | 0.6549 |
Schistosoma mansoni | fatty acid desaturase | 0.0218 | 0.1017 | 1 |
Leishmania major | fatty-acid desaturase, putative | 0.1763 | 1 | 1 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0218 | 0.1017 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0218 | 0.1017 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.0758 | 0.7455 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0057 | 0.0065 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0218 | 0.1017 | 0.222 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0218 | 0.1017 | 0.5 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0101 | 0.0335 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.0758 | 0.7455 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0242 | 0.1158 | 0.2527 |
Mycobacterium ulcerans | hypothetical protein | 0.0218 | 0.1017 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0218 | 0.1017 | 0.8785 |
Brugia malayi | Fatty acid desaturase family protein | 0.0218 | 0.1017 | 0.1165 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.0045 | 0.0052 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0831 | 0.4582 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.1544 | 0.8731 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0045 | 0.0052 |
Schistosoma mansoni | hypothetical protein | 0.0049 | 0.0036 | 0.0351 |
Echinococcus granulosus | expressed conserved protein | 0.0095 | 0.0299 | 0.2586 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0218 | 0.1017 | 0.8785 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.1158 | 0.1326 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0049 | 0.0036 | 0.0041 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0144 | 0.0587 | 0.5069 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.1544 | 0.8731 | 0.5 |
Loa Loa (eye worm) | FAT-3 protein | 0.0218 | 0.1017 | 0.1165 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0144 | 0.0587 | 0.1281 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0218 | 0.1017 | 0.1165 |
Schistosoma mansoni | survival motor neuron protein | 0.0049 | 0.0036 | 0.0351 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0218 | 0.1017 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0036 | 0.0078 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0101 | 0.0335 | 0.2894 |
Mycobacterium ulcerans | hypothetical protein | 0.0218 | 0.1017 | 0.5 |
Onchocerca volvulus | 0.0218 | 0.1017 | 0.0985 | |
Echinococcus multilocularis | geminin | 0.0174 | 0.0758 | 0.1655 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0218 | 0.1017 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0095 | 0.0299 | 0.0654 |
Onchocerca volvulus | 0.1763 | 1 | 1 | |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0218 | 0.1017 | 0.222 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.