Detailed information for compound 846251

Basic information

Technical information
  • TDR Targets ID: 846251
  • Name: 6-chloro-3-(4-methoxyphenyl)sulfonyl-N-(pheny lmethyl)quinolin-4-amine
  • MW: 438.927 | Formula: C23H19ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 5.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)S(=O)(=O)c1cnc2c(c1NCc1ccccc1)cc(cc2)Cl
  • InChi: 1S/C23H19ClN2O3S/c1-29-18-8-10-19(11-9-18)30(27,28)22-15-25-21-12-7-17(24)13-20(21)23(22)26-14-16-5-3-2-4-6-16/h2-13,15H,14H2,1H3,(H,25,26)
  • InChiKey: ACQISXKBKDKDSB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-3-(4-methoxyphenyl)sulfonyl-N-(phenylmethyl)-4-quinolinamine
  • benzyl-[6-chloro-3-(4-methoxyphenyl)sulfonyl-4-quinolyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Carboxylesterase family protein 0.0037 0.0108 0.0817
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0182 0.1432
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0004 0.0003
Brugia malayi Pre-SET motif family protein 0.0241 0.1087 0.8533
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0716 0.3377 0.3885
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0094 0.0372
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0036 0.0252
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0009 0.0122
Echinococcus granulosus intermediate filament protein 0.0031 0.0078 0.0611
Echinococcus multilocularis carbonic anhydrase II 0.0279 0.1273 0.328
Onchocerca volvulus Putative sulfate transporter 0.0381 0.1763 1
Echinococcus multilocularis carbonic anhydrase 0.0104 0.0427 0.1101
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.1087 0.8537
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0533 0.1374
Schistosoma mansoni carbonic anhydrase-related 0.0104 0.0427 0.1751
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0171 0.1313
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0078 0.0611
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0031
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0004 0.001
Echinococcus granulosus cathepsin l1 0.0017 0.0009 0.0072
Echinococcus multilocularis cysteine protease 0.0017 0.0009 0.0024
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0004 0.0031
Echinococcus multilocularis acetylcholinesterase 0.0221 0.0994 0.2561
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0031
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0036 0.0282
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0043 0.0134 0.0712
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Echinococcus granulosus GPCR family 2 0.0016 0.0004 0.0035
Giardia lamblia DNA repair protein RAD52 0.0371 0.1713 1
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0061 0.022 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.008 0.0313 0.03
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0009 0.0041
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0199 0.0214
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0104 0.0427 0.3355
Entamoeba histolytica carbonic anhydrase, putative 0.0518 0.2419 1
Leishmania major cytochrome p450-like protein 0.0023 0.0036 0.0132
Schistosoma mansoni carbonic anhydrase-related 0.0104 0.0427 0.1751
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0104 0.0427 0.3334
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0004 0.0003
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.008 0.0313 0.1279
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.008 0.0313 0.2434
Trichomonas vaginalis conserved hypothetical protein 0.2092 1 1
Schistosoma mansoni hypothetical protein 0.0042 0.0128 0.0513
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0199 0.0186
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0019 0.0151
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0021
Echinococcus multilocularis lamin dm0 0.0031 0.0078 0.02
Schistosoma mansoni carbonic anhydrase 0.0104 0.0427 0.1751
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0009 0.0041
Onchocerca volvulus 0.0037 0.0108 0.0562
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0242 0.109 0.1244
Brugia malayi Carboxylesterase family protein 0.0221 0.0994 0.78
Leishmania major cathepsin L-like protease 0.0065 0.0238 0.0971
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0004 0.001
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0279 0.1273 1
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0036 0.0252
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0019 0.0049
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0031
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0182 0.1405
Schistosoma mansoni BC026374 protein (S09 family) 0.0037 0.0108 0.0429
Loa Loa (eye worm) hypothetical protein 0.0221 0.0994 0.7807
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0533 0.417
Schistosoma mansoni hypothetical protein 0.0104 0.0427 0.1751
Schistosoma mansoni acetylcholinesterase 0.0037 0.0108 0.0429
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0126 0.0533 0.4188
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0238 0.1848
Echinococcus granulosus para nitrobenzyl esterase 0.0037 0.0108 0.0846
Brugia malayi jmjC domain containing protein 0.006 0.0214 0.1657
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0108 0.0429
Brugia malayi Cytochrome P450 family protein 0.0033 0.0085 0.0637
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0019 0.012
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0518 0.2419 1
Onchocerca volvulus 0.0274 0.1247 0.7056
Leishmania major carbonic anhydrase family protein, putative 0.0518 0.2419 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Schistosoma mansoni lamin 0.0031 0.0078 0.0305
Brugia malayi hypothetical protein 0.0042 0.0128 0.0977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Schistosoma mansoni gliotactin 0.0037 0.0108 0.0429
Leishmania major carbonic anhydrase-like protein 0.0279 0.1273 0.5253
Echinococcus granulosus phd:f box containing protein 0.0016 0.0004 0.0031
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0533 0.417
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0533 0.1374
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0004 0.0031
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0019 1
Echinococcus granulosus carbonic anhydrase II 0.0279 0.1273 1
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.008 0.0313 0.0806
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0009 0.0122
Onchocerca volvulus 0.0037 0.0108 0.0562
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0094 0.0372
Echinococcus granulosus carbonic anhydrase 0.0104 0.0427 0.3355
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0182 0.0738
Echinococcus granulosus mitogen activated protein kinase 11 0.0126 0.0533 0.4188
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0371 0.1713 0.707
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0019 0.012
Schistosoma mansoni hypothetical protein 0.0035 0.0094 0.0371
Schistosoma mansoni carbonic anhydrase 0.0518 0.2419 1
Onchocerca volvulus 0.0031 0.0078 0.0391
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.008 0.0313 0.0304
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0009 0.0072
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0214 0.087
Echinococcus multilocularis carbonic anhydrase 0.0104 0.0427 0.1101
Mycobacterium ulcerans carbonic anhydrase 0.0518 0.2419 0.2409
Echinococcus multilocularis carbonic anhydrase 0.0104 0.0427 0.1101
Echinococcus multilocularis carboxylesterase 5A 0.0221 0.0994 0.2561
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0063
Trypanosoma brucei carbonic anhydrase-like protein 0.0279 0.1273 1
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0061 0.022 0.5105
Mycobacterium tuberculosis Carboxylesterase LipT 0.0037 0.0108 0.0109
Echinococcus multilocularis GPCR, family 2 0.0016 0.0004 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0238 0.1848
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0061 0.022 0.5105
Echinococcus granulosus lamin dm0 0.0031 0.0078 0.0611
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0004 0.001
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0094 0.2123
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0085 0.0666
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0009 0.0021
Toxoplasma gondii hypothetical protein 0.0104 0.0427 1
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0279 0.1273 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0037 0.0108 0.0846
Entamoeba histolytica hypothetical protein 0.0042 0.0128 0.0493
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Plasmodium vivax SET domain protein, putative 0.0035 0.0094 0.4158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0072
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0094 0.0737
Loa Loa (eye worm) hypothetical protein 0.0104 0.0427 0.3355
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0088 0.0689
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Echinococcus multilocularis c Jun NH2 terminal kinase 0.023 0.1034 0.2665
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0037 0.0108 0.0277
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0126 0.0533 0.417
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0037 0.0108 0.0099
Loa Loa (eye worm) hypothetical protein 0.005 0.0171 0.134
Brugia malayi hypothetical protein 0.0037 0.0108 0.0817
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0279 0.1273 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0108 0.0429
Loa Loa (eye worm) fibroinase 0.0017 0.0009 0.0072
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Loa Loa (eye worm) hypothetical protein 0.0104 0.0427 0.3355
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.008 0.0313 0.2458
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0279 0.1273 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.001
Trichomonas vaginalis set domain proteins, putative 0.0274 0.1247 0.1239
Loa Loa (eye worm) ctsf protein 0.0017 0.0009 0.0072
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0004 0.0035
Schistosoma mansoni jumonji domain containing protein 0.006 0.0214 0.087
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0036 0.0023
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0009 0.0021
Loa Loa (eye worm) carbonic anhydrase 3 0.0279 0.1273 1
Brugia malayi Carboxylesterase family protein 0.0037 0.0108 0.0817
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Echinococcus multilocularis lamin 0.0031 0.0078 0.02
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0211 0.1636
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0106 0.0436 0.1769
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0004 0.001
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0037 0.0108 0.0109
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0094 0.0372
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0009 0.0024
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.008 0.0313 0.2434
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0009 0.0024
Echinococcus granulosus BC026374 protein S09 family 0.0037 0.0108 0.0846
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0031
Brugia malayi Carboxylesterase family protein 0.0037 0.0108 0.0817
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0128 0.033
Echinococcus multilocularis para nitrobenzyl esterase 0.0037 0.0108 0.0277
Onchocerca volvulus 0.0381 0.1763 1
Leishmania major cathepsin L-like protease 0.0065 0.0238 0.0971
Schistosoma mansoni neuroligin 3 (S09 family) 0.0037 0.0108 0.0429
Leishmania major cathepsin L-like protease 0.0065 0.0238 0.0971
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.008 0.0313 0.2434
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0199 0.0807
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Entamoeba histolytica hypothetical protein 0.0042 0.0128 0.0493
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0199 0.1537
Loa Loa (eye worm) cysteine protease 0.0017 0.0009 0.0072
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0021
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0108 0.0429
Mycobacterium ulcerans carboxylesterase, LipT 0.0037 0.0108 0.0094
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0037 0.0108 0.0109
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0035
Entamoeba histolytica hypothetical protein 0.0042 0.0128 0.0493
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0019 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.023 0.1034 0.4264
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0019 0.0006
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.008 0.0313 0.0346
Brugia malayi Carboxylesterase family protein 0.0221 0.0994 0.78
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0036 0.0282
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0094 0.0707
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0104 0.0427 0.3334
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0199 0.1563
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0094 0.0242
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0533 0.1374
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0171 0.1313
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1816 0.8671 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0821 0.388 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0036 0.0282
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0011
Loa Loa (eye worm) carboxylesterase 0.0221 0.0994 0.7807
Echinococcus multilocularis acetylcholinesterase 0.0221 0.0994 0.2561
Onchocerca volvulus 0.0037 0.0108 0.0562
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0214 0.1683
Echinococcus granulosus carbonic anhydrase 0.0104 0.0427 0.3355
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0736
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Onchocerca volvulus 0.0037 0.0108 0.0562
Loa Loa (eye worm) carboxylesterase 0.0037 0.0108 0.0846
Entamoeba histolytica hypothetical protein 0.0042 0.0128 0.0493
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0182 0.0738
Plasmodium vivax vivapain-2 0.0017 0.0009 0.0239
Plasmodium falciparum carbonic anhydrase 0.0104 0.0427 1
Plasmodium vivax vivapain-2 0.0017 0.0009 0.0239
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0019 0.0042
Onchocerca volvulus 0.0037 0.0108 0.0562
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0009 0.0122
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.023 0.1034 0.8124
Brugia malayi Cytochrome P450 family protein 0.0023 0.0036 0.0252
Echinococcus granulosus carbonic anhydrase 0.0104 0.0427 0.3355
Trichomonas vaginalis conserved hypothetical protein 0.2092 1 1
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0021
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0104 0.0427 0.3334
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.036
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.008 0.0313 0.2434
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0182 0.1432
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0078 0.0581
Brugia malayi Pre-SET motif family protein 0.0035 0.0094 0.0708
Echinococcus granulosus acetylcholinesterase 0.0221 0.0994 0.7807
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.0031 0.0075 0.0589
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0171 0.134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0737
Onchocerca volvulus 0.0031 0.0078 0.0391
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0021
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0238 0.1848
Toxoplasma gondii exonuclease III APE 0.0019 0.0019 0.036
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0063
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.044 0.2048 0.235
Trichomonas vaginalis spcc417.12 protein, putative 0.0037 0.0108 0.0099
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0061 0.022 0.1702
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0181 0.1419
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0214 0.0552
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0061 0.022 0.1702
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0182 0.0738
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0008 0.0032
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0199 0.0186
Brugia malayi jmjC domain containing protein 0.006 0.0214 0.1657
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Brugia malayi Cytochrome P450 family protein 0.0023 0.0036 0.0252
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0094 0.0372
Loa Loa (eye worm) carboxylesterase 0.0037 0.0108 0.0846
Loa Loa (eye worm) hypothetical protein 0.0104 0.0427 0.3355
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.012
Schistosoma mansoni intermediate filament proteins 0.0031 0.0078 0.0305
Echinococcus granulosus carboxylesterase 5A 0.0221 0.0994 0.7807
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0705
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0182 0.047
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0004 0.0031
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0214 0.087
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0128 0.1005
Loa Loa (eye worm) hypothetical protein 0.0221 0.0994 0.7807
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0172 0.1324
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0009 0.0072
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0061 0.022 0.1702
Brugia malayi Carboxylesterase family protein 0.0037 0.0108 0.0817
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0126 0.0533 0.219
Onchocerca volvulus 0.0035 0.0094 0.0483
Schistosoma mansoni lamin 0.0031 0.0078 0.0305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0182 0.1432
Echinococcus granulosus mitogen activated protein kinase 14 0.0126 0.0533 0.4188
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0238 0.1848
Mycobacterium ulcerans integral membrane transporter 0.0061 0.022 0.0207
Entamoeba histolytica hypothetical protein 0.0106 0.0436 0.1769
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0061 0.022 0.0207
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0279 0.1273 0.5253
Echinococcus multilocularis neuroligin 0.0037 0.0108 0.0277
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0279 0.1273 0.5253
Echinococcus multilocularis cysteine protease 0.0017 0.0009 0.0024
Echinococcus multilocularis BC026374 protein (S09 family) 0.0037 0.0108 0.0277
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0128 0.0513
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0104 0.0427 0.3334
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0008 0.0063
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.008 0.0313 0.2434
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0004 0.0031
Plasmodium vivax sulfate transporter, putative 0.0061 0.022 1
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.008 0.0313 0.0304
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.008 0.0313 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0199 0.0513
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0221 0.0994 0.4097
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0533 0.1374
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0009 0.0072
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0031
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0004 0.001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0019 0.0063
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0009 0.0021
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0214 0.0552
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0035
Echinococcus granulosus c-Jun N-terminal kinases 0.023 0.1034 0.8124
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0036 0.0252
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0019 0.0151
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0279 0.1273 1
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0021
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0104 0.0427 0.3334
Loa Loa (eye worm) acetylcholinesterase 1 0.0221 0.0994 0.7807
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0078 0.0611
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0094 0.0242
Chlamydia trachomatis sulfate transporter 0.0061 0.022 0.5
Echinococcus granulosus acetylcholinesterase 0.0221 0.0994 0.7807
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.008 0.0313 0.2458
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0214 0.1683
Echinococcus granulosus neuroligin 0.0037 0.0108 0.0846
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0009 0.0072
Brugia malayi P38 map kinase family protein 2 0.0126 0.0533 0.417
Echinococcus granulosus lamin 0.0031 0.0078 0.0611
Schistosoma mansoni carbonic anhydrase-related 0.0104 0.0427 0.1751
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0182 0.047
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0031
Brugia malayi Stress-activated protein kinase jnk-1 0.023 0.1034 0.8118
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0199 0.0807
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0214 0.1683
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.008 0.0313 0.1279
Loa Loa (eye worm) hypothetical protein 0.0031 0.0078 0.0611
Toxoplasma gondii cathepsin CPL 0.0017 0.0009 0.0122
Brugia malayi intermediate filament protein 0.0031 0.0078 0.0581
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0009 0.0024
Echinococcus multilocularis musashi 0.0031 0.0078 0.02

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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