Detailed information for compound 846251

Basic information

Technical information
  • TDR Targets ID: 846251
  • Name: 6-chloro-3-(4-methoxyphenyl)sulfonyl-N-(pheny lmethyl)quinolin-4-amine
  • MW: 438.927 | Formula: C23H19ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 5.61 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)S(=O)(=O)c1cnc2c(c1NCc1ccccc1)cc(cc2)Cl
  • InChi: 1S/C23H19ClN2O3S/c1-29-18-8-10-19(11-9-18)30(27,28)22-15-25-21-12-7-17(24)13-20(21)23(22)26-14-16-5-3-2-4-6-16/h2-13,15H,14H2,1H3,(H,25,26)
  • InChiKey: ACQISXKBKDKDSB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-chloro-3-(4-methoxyphenyl)sulfonyl-N-(phenylmethyl)-4-quinolinamine
  • benzyl-[6-chloro-3-(4-methoxyphenyl)sulfonyl-4-quinolyl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lamin 0.0031 0.0078 0.0611
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0094 0.0372
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0031
Echinococcus multilocularis cysteine protease 0.0017 0.0009 0.0024
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0821 0.388 1
Onchocerca volvulus 0.0037 0.0108 0.0562
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0021
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0199 0.1563
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0037 0.0108 0.0846
Echinococcus multilocularis lamin dm0 0.0031 0.0078 0.02
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0036 0.0252
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0279 0.1273 1
Onchocerca volvulus 0.0037 0.0108 0.0562
Onchocerca volvulus Putative sulfate transporter 0.0381 0.1763 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0031
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0009 0.0122
Onchocerca volvulus 0.0381 0.1763 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0182 0.0738
Echinococcus granulosus neuroligin 0.0037 0.0108 0.0846
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0078 0.0611
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0009 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0182 0.0738
Loa Loa (eye worm) ctsf protein 0.0017 0.0009 0.0072
Loa Loa (eye worm) hypothetical protein 0.0104 0.0427 0.3355
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0004 0.001
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0533 0.1374
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0061 0.022 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Brugia malayi Cytochrome P450 family protein 0.0033 0.0085 0.0637
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0031
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0182 0.1432
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Echinococcus multilocularis neuroligin 0.0037 0.0108 0.0277
Onchocerca volvulus 0.0031 0.0078 0.0391
Toxoplasma gondii hypothetical protein 0.0104 0.0427 1
Brugia malayi Pre-SET motif family protein 0.0241 0.1087 0.8533
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0009 0.0024
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0199 0.0186
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0004 0.0035
Onchocerca volvulus 0.0037 0.0108 0.0562
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0104 0.0427 0.3334
Brugia malayi Stress-activated protein kinase jnk-1 0.023 0.1034 0.8118
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0104 0.0427 0.3334
Loa Loa (eye worm) fibroinase 0.0017 0.0009 0.0072
Schistosoma mansoni intermediate filament proteins 0.0031 0.0078 0.0305
Echinococcus granulosus carbonic anhydrase 0.0104 0.0427 0.3355
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0199 0.0513
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.044 0.2048 0.235
Leishmania major cathepsin L-like protease 0.0065 0.0238 0.0971
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0088 0.0689
Schistosoma mansoni hypothetical protein 0.0035 0.0094 0.0371
Brugia malayi Cytochrome P450 family protein 0.0023 0.0036 0.0252
Brugia malayi Carboxylesterase family protein 0.0037 0.0108 0.0817
Trichomonas vaginalis conserved hypothetical protein 0.2092 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0221 0.0994 0.4097
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0031
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0036 0.0282
Schistosoma mansoni carbonic anhydrase-related 0.0104 0.0427 0.1751
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.008 0.0313 0.0304
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0238 0.1848
Mycobacterium ulcerans NADH dehydrogenase I subunit F 0.008 0.0313 0.03
Onchocerca volvulus NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial homolog 0.0043 0.0134 0.0712
Echinococcus granulosus GPCR family 2 0.0016 0.0004 0.0035
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0106 0.0436 0.1769
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0004 0.0003
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.008 0.0313 0.2434
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0085 0.0666
Trypanosoma cruzi NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.008 0.0313 0.2434
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0019 0.0063
Plasmodium vivax vivapain-2 0.0017 0.0009 0.0239
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0199 0.1537
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0128 0.0513
Plasmodium vivax sulfate transporter, putative 0.0061 0.022 1
Schistosoma mansoni lamin 0.0031 0.0078 0.0305
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Schistosoma mansoni carbonic anhydrase 0.0104 0.0427 0.1751
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0104 0.0427 0.3334
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0019 0.012
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0214 0.1683
Loa Loa (eye worm) hypothetical protein 0.005 0.0171 0.134
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0019 0.0151
Echinococcus granulosus lamin dm0 0.0031 0.0078 0.0611
Echinococcus granulosus intermediate filament protein 0.0031 0.0078 0.0611
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0004 0.0031
Mycobacterium ulcerans carbonic anhydrase 0.0518 0.2419 0.2409
Mycobacterium ulcerans carboxylesterase, LipT 0.0037 0.0108 0.0094
Leishmania major carbonic anhydrase family protein, putative 0.0518 0.2419 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0182 0.0738
Echinococcus granulosus carbonic anhydrase II 0.0279 0.1273 1
Plasmodium vivax SET domain protein, putative 0.0035 0.0094 0.4158
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0238 0.1848
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0214 0.087
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0181 0.1419
Echinococcus granulosus carboxylesterase 5A 0.0221 0.0994 0.7807
Loa Loa (eye worm) acetylcholinesterase 1 0.0221 0.0994 0.7807
Trichomonas vaginalis spcc417.12 protein, putative 0.0037 0.0108 0.0099
Echinococcus multilocularis acetylcholinesterase 0.0221 0.0994 0.2561
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0063
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0104 0.0427 0.3355
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0171 0.1313
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.001
Chlamydia trachomatis sulfate transporter 0.0061 0.022 0.5
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0061 0.022 0.1702
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Mycobacterium tuberculosis Carboxylesterase LipT 0.0037 0.0108 0.0109
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0214 0.1683
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0199 0.0186
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0094 0.0372
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0008 0.0063
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0371 0.1713 0.707
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0279 0.1273 0.5253
Loa Loa (eye worm) NADH-ubiquinone oxidoreductase 51 kDa subunit 0.008 0.0313 0.2458
Schistosoma mansoni BC026374 protein (S09 family) 0.0037 0.0108 0.0429
Echinococcus multilocularis musashi 0.0031 0.0078 0.02
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0009 0.0021
Giardia lamblia DNA repair protein RAD52 0.0371 0.1713 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Brugia malayi Cytochrome P450 family protein 0.0023 0.0036 0.0252
Entamoeba histolytica carbonic anhydrase, putative 0.0518 0.2419 1
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0061 0.022 0.1702
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0036 0.0252
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0279 0.1273 1
Schistosoma mansoni acetylcholinesterase 0.0037 0.0108 0.0429
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0242 0.109 0.1244
Echinococcus granulosus BC026374 protein S09 family 0.0037 0.0108 0.0846
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.1087 0.8537
Toxoplasma gondii cathepsin CPL 0.0017 0.0009 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0182 0.047
Mycobacterium ulcerans integral membrane transporter 0.0061 0.022 0.0207
Onchocerca volvulus 0.0037 0.0108 0.0562
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0021
Brugia malayi hypothetical protein 0.0037 0.0108 0.0817
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0171 0.134
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0035
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0279 0.1273 1
Loa Loa (eye worm) cysteine protease 0.0017 0.0009 0.0072
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0094 0.0242
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0009 0.0021
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0.008 0.0313 0.2434
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0126 0.0533 0.219
Brugia malayi Carboxylesterase family protein 0.0221 0.0994 0.78
Leishmania major cytochrome p450-like protein 0.0023 0.0036 0.0132
Echinococcus multilocularis carbonic anhydrase 0.0104 0.0427 0.1101
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0518 0.2419 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0009 0.0072
Schistosoma mansoni neuroligin 3 (S09 family) 0.0037 0.0108 0.0429
Schistosoma mansoni jumonji domain containing protein 0.006 0.0214 0.087
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0004 0.001
Schistosoma mansoni carbonic anhydrase-related 0.0104 0.0427 0.1751
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0078 0.0581
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0004 0.001
Echinococcus granulosus c-Jun N-terminal kinases 0.023 0.1034 0.8124
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0279 0.1273 1
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0094 0.0707
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0004 0.001
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0009 0.0041
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0128 0.1005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0094 0.0372
Brugia malayi Carboxylesterase family protein 0.0221 0.0994 0.78
Echinococcus granulosus acetylcholinesterase 0.0221 0.0994 0.7807
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0009 0.0072
Leishmania major carbonic anhydrase-like protein 0.0279 0.1273 0.5253
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0004 0.0031
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0019 0.0006
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0171 0.1313
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0037 0.0108 0.0109
Trichomonas vaginalis set domain proteins, putative 0.0274 0.1247 0.1239
Brugia malayi Carboxylesterase family protein 0.0037 0.0108 0.0817
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0011
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0004 0.001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0019 0.012
Echinococcus multilocularis lamin 0.0031 0.0078 0.02
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0004 0.0003
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0061 0.022 0.0207
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0736
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain F) NuoF (NADH-ubiquinone oxidoreductase chain F) 0.008 0.0313 0.0346
Brugia malayi hypothetical protein 0.0042 0.0128 0.0977
Trichomonas vaginalis conserved hypothetical protein 0.2092 1 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0279 0.1273 0.5253
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0019 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0182 0.1432
Brugia malayi jmjC domain containing protein 0.006 0.0214 0.1657
Echinococcus multilocularis carbonic anhydrase II 0.0279 0.1273 0.328
Echinococcus granulosus mitogen activated protein kinase 14 0.0126 0.0533 0.4188
Brugia malayi jmjC domain containing protein 0.006 0.0214 0.1657
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0019 0.0042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0011
Schistosoma mansoni carbonic anhydrase 0.0518 0.2419 1
Brugia malayi Pre-SET motif family protein 0.0035 0.0094 0.0708
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0009 0.0072
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0008 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0238 0.1848
Schistosoma mansoni serine/threonine protein kinase 0.023 0.1034 0.4264
Loa Loa (eye worm) hypothetical protein 0.0031 0.0075 0.0589
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0211 0.1636
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0716 0.3377 0.3885
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0214 0.087
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0094 0.0737
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0094 0.0372
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0037 0.0108 0.0109
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0019 0.0007
Loa Loa (eye worm) hypothetical protein 0.0104 0.0427 0.3355
Echinococcus granulosus cathepsin l1 0.0017 0.0009 0.0072
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0533 0.417
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0037 0.0108 0.0099
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0214 0.1683
Echinococcus multilocularis GPCR, family 2 0.0016 0.0004 0.0011
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0104 0.0427 0.3334
Trypanosoma brucei carbonic anhydrase-like protein 0.0279 0.1273 1
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1816 0.8671 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0199 0.0807
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Brugia malayi intermediate filament protein 0.0031 0.0078 0.0581
Plasmodium vivax vivapain-2 0.0017 0.0009 0.0239
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.012
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0279 0.1273 1
Onchocerca volvulus 0.0037 0.0108 0.0562
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0061 0.022 0.5105
Onchocerca volvulus 0.0274 0.1247 0.7056
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0061 0.022 0.1702
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.008 0.0313 0.1279
Brugia malayi Carboxylesterase family protein 0.0037 0.0108 0.0817
Echinococcus granulosus acetylcholinesterase 0.0221 0.0994 0.7807
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0126 0.0533 0.417
Echinococcus multilocularis acetylcholinesterase 0.0221 0.0994 0.2561
Brugia malayi NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial precursor 0.008 0.0313 0.2434
Echinococcus multilocularis NADH dehydrogenase (ubiquinone) flavoprotein 1 0.008 0.0313 0.0806
Trichomonas vaginalis NADH-ubiquinone oxidoreductase flavoprotein, putative 0.008 0.0313 0.0304
Loa Loa (eye worm) hypothetical protein 0.0104 0.0427 0.3355
Echinococcus multilocularis carbonic anhydrase 0.0104 0.0427 0.1101
Plasmodium falciparum carbonic anhydrase 0.0104 0.0427 1
Loa Loa (eye worm) hypothetical protein 0.0221 0.0994 0.7807
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0021
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0172 0.1324
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0031
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0019 0.0151
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0104 0.0427 0.3334
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0182 0.1432
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0004 0.0031
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0238 0.1848
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0035
Schistosoma mansoni hypothetical protein 0.0104 0.0427 0.1751
Echinococcus granulosus mitogen activated protein kinase 11 0.0126 0.0533 0.4188
Leishmania major cathepsin L-like protease 0.0065 0.0238 0.0971
Entamoeba histolytica hypothetical protein 0.0042 0.0128 0.0493
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0182 0.1405
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0009 0.0024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0019 0.0705
Leishmania major cathepsin L-like protease 0.0017 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0035 0.0094 0.0737
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0199 0.0214
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0035
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0061 0.022 0.5105
Echinococcus multilocularis mitogen activated protein kinase 11 0.0126 0.0533 0.1374
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase I subunit F 0.008 0.0313 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Schistosoma mansoni hypothetical protein 0.0042 0.0128 0.0513
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0004 0.0031
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0036 0.0282
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0108 0.0429
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0108 0.0429
Entamoeba histolytica hypothetical protein 0.0042 0.0128 0.0493
Leishmania major NADH-ubiquinone oxidoreductase, mitochondrial, putative 0.008 0.0313 0.1279
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0094 0.2123
Echinococcus granulosus para nitrobenzyl esterase 0.0037 0.0108 0.0846
Leishmania major cathepsin L-like protease 0.0065 0.0238 0.0971
Brugia malayi P38 map kinase family protein 2 0.0126 0.0533 0.417
Onchocerca volvulus 0.0035 0.0094 0.0483
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Toxoplasma gondii exonuclease III APE 0.0019 0.0019 0.036
Schistosoma mansoni carbonic anhydrase-related 0.0104 0.0427 0.1751
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0009 0.0122
Schistosoma mansoni ap endonuclease 0.0019 0.0019 0.0063
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0037 0.0108 0.0429
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0009 0.0021
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0009 0.0024
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0019 0.0049
Schistosoma mansoni lamin 0.0031 0.0078 0.0305
Brugia malayi Cathepsin L-like precursor 0.0017 0.0009 0.0041
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0078 0.0611
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0533 0.1374
Echinococcus multilocularis BC026374 protein (S09 family) 0.0037 0.0108 0.0277
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0126 0.0533 0.4188
Echinococcus multilocularis c Jun NH2 terminal kinase 0.023 0.1034 0.2665
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0009 0.0024
Onchocerca volvulus 0.0031 0.0078 0.0391
Echinococcus multilocularis mitogen activated protein kinase 14 0.0126 0.0533 0.1374
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Loa Loa (eye worm) hypothetical protein 0.0221 0.0994 0.7807
Entamoeba histolytica hypothetical protein 0.0042 0.0128 0.0493
Echinococcus granulosus phd:f box containing protein 0.0016 0.0004 0.0031
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0199 0.0807
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Schistosoma mansoni gliotactin 0.0037 0.0108 0.0429
Entamoeba histolytica hypothetical protein 0.0042 0.0128 0.0493
Echinococcus granulosus NADH dehydrogenase ubiquinone flavoprotein 1 0.008 0.0313 0.2458
Loa Loa (eye worm) hypothetical protein 0.0037 0.0108 0.0846
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0037 0.0108 0.0277
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0214 0.0552
Loa Loa (eye worm) carboxylesterase 0.0221 0.0994 0.7807
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0019 0.001
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0019 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0036 0.0023
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0036 0.0282
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0214 0.0552
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0094 0.0242
Echinococcus granulosus carbonic anhydrase 0.0104 0.0427 0.3355
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0036 0.0252
Entamoeba histolytica hypothetical protein 0.0106 0.0436 0.1769
Echinococcus multilocularis cysteine protease 0.0017 0.0009 0.0024
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0126 0.0533 0.417
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0009 0.0122
Loa Loa (eye worm) carboxylesterase 0.0037 0.0108 0.0846
Loa Loa (eye worm) carbonic anhydrase 3 0.0279 0.1273 1
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0078 0.0611
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0004 0.0031
Echinococcus multilocularis carbonic anhydrase 0.0104 0.0427 0.1101
Echinococcus granulosus carbonic anhydrase 0.0104 0.0427 0.3355
Brugia malayi Carboxylesterase family protein 0.0037 0.0108 0.0817
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0128 0.033
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0009 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0182 0.047
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0009 0.0072
Echinococcus multilocularis para nitrobenzyl esterase 0.0037 0.0108 0.0277
Trypanosoma brucei NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial, putative 0.008 0.0313 0.2434
Echinococcus multilocularis carboxylesterase 5A 0.0221 0.0994 0.2561
Loa Loa (eye worm) carboxylesterase 0.0037 0.0108 0.0846
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0238 0.1848
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.023 0.1034 0.8124

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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