Detailed information for compound 848410

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 427.316 | Formula: C16H19BrN4O3S
  • H donors: 3 H acceptors: 4 LogP: 2.32 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)NC(=O)CCNS(=O)(=O)c1cc(Br)cnc1N
  • InChi: 1S/C16H19BrN4O3S/c1-2-11-3-5-13(6-4-11)21-15(22)7-8-20-25(23,24)14-9-12(17)10-19-16(14)18/h3-6,9-10,20H,2,7-8H2,1H3,(H2,18,19)(H,21,22)
  • InChiKey: ZEGXTSLUSDMKJV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0913 0.2691
Echinococcus granulosus carbonic anhydrase 0.0027 0.0244 0.0244
Brugia malayi steroid hormone receptor 0.0092 0.1596 0.3558
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0092 0.1596 0.3558
Schistosoma mansoni cpg binding protein 0.0035 0.0404 0.0404
Loa Loa (eye worm) hypothetical protein 0.0092 0.1596 0.3558
Loa Loa (eye worm) steroid hormone receptor 0.0092 0.1596 0.3558
Onchocerca volvulus 0.013 0.2397 1
Schistosoma mansoni rab6-interacting 0.0038 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0048 0.0692 0.1542
Brugia malayi hypothetical protein 0.0038 0.048 0.1071
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.1433 0.2613
Brugia malayi Heterochromatin protein 1 0.0068 0.1095 0.2441
Loa Loa (eye worm) hypothetical protein 0.0041 0.0539 0.1201
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0583 0.1467
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1095 1
Brugia malayi hypothetical protein 0.023 0.4486 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0119 0.2157 0.3707
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.048 0.048
Schistosoma mansoni hypothetical protein 0.0028 0.0271 0.0271
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.1167 0.1167
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.1629 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.1095 0.1095
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0043 0.0583 0.0583
Brugia malayi nuclear receptor NHR-67 0.0043 0.0583 0.13
Loa Loa (eye worm) hypothetical protein 0.0161 0.3045 0.6788
Echinococcus granulosus chromobox protein 1 0.0068 0.1095 0.1095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0092 0.1596 0.1596
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0913 0.0913
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.2584 0.4442
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0966 0.2155
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0583 0.0583
Plasmodium falciparum carbonic anhydrase 0.0027 0.0244 0.5073
Loa Loa (eye worm) glutathione reductase 0.0037 0.0448 0.0998
Echinococcus granulosus thyroid hormone receptor alpha 0.0043 0.0583 0.0583
Echinococcus granulosus tar DNA binding protein 0.0062 0.0966 0.0966
Echinococcus multilocularis thyroid hormone receptor alpha 0.0092 0.1596 0.1596
Onchocerca volvulus Bile acid receptor homolog 0.0092 0.1596 0.6233
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0244 0.0244
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0923 0.0923
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0692 0.1542
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0913 0.0913
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0119 0.2157 0.4808
Leishmania major trypanothione reductase 0.0037 0.0448 0.077
Loa Loa (eye worm) hypothetical protein 0.0043 0.0587 0.1309
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Brugia malayi jmjC domain containing protein 0.0036 0.0437 0.0975
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.1549 0.3454
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0429 0.0429
Mycobacterium tuberculosis Conserved protein 0.0024 0.0177 0.0323
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0473 0.0947
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.1021 0.1021
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0177 0.0304
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.1095 0.2441
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0448 0.7624
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.0692 0.0692
Loa Loa (eye worm) doublecortin family protein 0.0038 0.048 0.1071
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0379 0.2984
Onchocerca volvulus 0.0038 0.048 0.0983
Brugia malayi hypothetical protein 0.0038 0.048 0.1071
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.1021 0.1754
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.4003 0.6881
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0966 0.0966
Loa Loa (eye worm) hypothetical protein 0.023 0.4486 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0092 0.1596 0.1596
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1021 0.1754
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.162 0.162
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0043 0.0583 0.13
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.1167 0.1167
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0913 0.1569
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0966 0.0966
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0587 0.1309
Echinococcus multilocularis geminin 0.033 0.6568 0.6568
Loa Loa (eye worm) hypothetical protein 0.0038 0.048 0.1071
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.1021 0.1021
Loa Loa (eye worm) hypothetical protein 0.006 0.0937 0.2088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0092 0.1596 0.1596
Schistosoma mansoni nuclear receptor 0.0043 0.0583 0.0583
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.5483 1
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.0177 0.0177
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.5818 1
Schistosoma mansoni cpg binding protein 0.0037 0.0445 0.0445
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.1433 0.2613
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1021 0.1754
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0092 0.1596 0.3558
Loa Loa (eye worm) hypothetical protein 0.0031 0.033 0.0735
Brugia malayi hypothetical protein 0.0043 0.0583 0.13
Schistosoma mansoni hypothetical protein 0.0019 0.0077 0.0077
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0271 0.0271
Echinococcus granulosus nuclear receptor nhr 48 0.0043 0.0583 0.0583
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0966 0.0966
Loa Loa (eye worm) DR-78 0.0043 0.0583 0.13
Brugia malayi hypothetical protein 0.0071 0.1167 0.2601
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.048 0.048
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0539 0.1201
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0966 0.0966
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0833 0.0833
Schistosoma mansoni retinoic acid receptor RXR 0.0287 0.5673 0.5673
Brugia malayi conserved hypotetical protein 0.0043 0.0583 0.13
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0168 0.3198 0.3198
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.048 0.048
Echinococcus granulosus FTZ F1 alpha 0.0092 0.1596 0.1596
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0092 0.1596 0.3558
Echinococcus granulosus peregrin 0.0028 0.0271 0.0271
Schistosoma mansoni hypothetical protein 0.0027 0.0244 0.0244
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0119 0.2157 0.4808
Schistosoma mansoni jumonji domain containing protein 0.0074 0.1221 0.1221
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0583 0.1467
Loa Loa (eye worm) hypothetical protein 0.009 0.1549 0.3454
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0504 0.0504
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0966 0.2155
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.1433 0.2613
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.1167 0.1167
Schistosoma mansoni survival motor neuron protein 0.0047 0.0659 0.0659
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0092 0.1596 0.3558
Schistosoma mansoni thyroid hormone receptor 0.0092 0.1596 0.1596
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0923 0.2729
Brugia malayi ecdysteroid receptor 0.0092 0.1596 0.3558
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0092 0.1596 0.1596
Loa Loa (eye worm) tyrosinase 1 0.009 0.1549 0.3454
Onchocerca volvulus 0.009 0.1549 0.6012
Onchocerca volvulus 0.0035 0.0404 0.0621
Onchocerca volvulus 0.0092 0.1596 0.6233
Loa Loa (eye worm) hypothetical protein 0.0048 0.0692 0.1542
Echinococcus multilocularis FTZ F1 alpha 0.0092 0.1596 0.1596
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0587 0.1071
Loa Loa (eye worm) beta-lactamase 0.0043 0.0587 0.1309
Echinococcus multilocularis ecdysone induced protein 78C 0.0092 0.1596 0.1596
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0587 0.5024
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0966 0.0966
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0092 0.1596 0.3558
Echinococcus multilocularis carbonic anhydrase II 0.0119 0.2157 0.2157
Brugia malayi nuclear hormone receptor family member odr-7 0.0043 0.0583 0.13
Echinococcus granulosus chromobox protein 1 0.0068 0.1095 0.1095
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0587 0.101
Leishmania major hypothetical protein, conserved 0.0207 0.4003 0.6881
Schistosoma mansoni nuclear receptor 0.0043 0.0583 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0092 0.1596 0.3558
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0177 0.0304
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Entamoeba histolytica hypothetical protein 0.0071 0.1167 1
Schistosoma mansoni RAR-like nuclear receptor 0.0092 0.1596 0.1596
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0244 0.0244
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.2584 0.4442
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0119 0.2157 0.4808
Brugia malayi tailless protein 0.0043 0.0583 0.13
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0027 0.0244 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0473 0.39
Plasmodium falciparum LCCL domain-containing protein 0.0038 0.048 1
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0583 0.0583
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0271 0.0271
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0238 0.466 0.466
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0913 0.2691
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0533 0.4491
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0766 0.1709
Brugia malayi CXXC zinc finger family protein 0.0035 0.0404 0.09
Brugia malayi Doublecortin family protein 0.0038 0.048 0.1071
Loa Loa (eye worm) hypothetical protein 0.0092 0.1596 0.3558
Onchocerca volvulus 0.003 0.0301 0.014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0473 0.1054
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0731 0.1256
Schistosoma mansoni hypothetical protein 0.0071 0.1167 0.1167
Brugia malayi chromobox protein homolog 3 0.0038 0.0473 0.1054
Schistosoma mansoni polycystin 1-related 0.0038 0.048 0.048
Brugia malayi ShTK domain containing protein 0.009 0.1549 0.3454
Onchocerca volvulus Protein ultraspiracle homolog 0.0092 0.1596 0.6233
Schistosoma mansoni hypothetical protein 0.0135 0.2492 0.2492
Onchocerca volvulus 0.0043 0.0587 0.1486
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0092 0.1596 0.3558
Brugia malayi Thioredoxin reductase 0.0037 0.0448 0.0998
Brugia malayi hypothetical protein 0.0048 0.0692 0.1542
Loa Loa (eye worm) hypothetical protein 0.0043 0.0587 0.1309
Schistosoma mansoni hypothetical protein 0.0019 0.0077 0.0077
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0244 0.0543
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0937 0.2088
Mycobacterium ulcerans beta-lactamase 0.0043 0.0587 0.1501
Schistosoma mansoni hypothetical protein 0.0494 1 1
Leishmania major mitochondrial DNA polymerase beta 0.0294 0.5818 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0092 0.1596 0.1596
Giardia lamblia PHD finger protein 15 0.0028 0.0271 0.5
Onchocerca volvulus 0.009 0.1549 0.6012
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0092 0.1596 0.3558
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0244 0.0543
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0287 0.5673 0.5673
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.1021 0.1021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0833 0.1857
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0583 0.0583
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0437 0.0437
Schistosoma mansoni chromobox protein 0.0068 0.1095 0.1095
Schistosoma mansoni jun-related protein 0.0135 0.2492 0.2492
Schistosoma mansoni nuclear hormone receptor 0.0092 0.1596 0.1596
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0429 0.0956
Schistosoma mansoni chromobox protein 0.0068 0.1095 0.1095
Brugia malayi hypothetical protein 0.013 0.2397 0.5343
Trypanosoma brucei carbonic anhydrase-like protein 0.0119 0.2157 0.3707
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0396 0.0396
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0587 0.101
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0913 0.2691
Echinococcus multilocularis chromobox protein 1 0.0068 0.1095 0.1095
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0587 0.1309
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0923 0.1684
Entamoeba histolytica hypothetical protein 0.0071 0.1167 1
Onchocerca volvulus 0.0043 0.0587 0.1486
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0587 0.1071
Loa Loa (eye worm) hypothetical protein 0.0092 0.1596 0.3558
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0583 0.0583
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.048 0.048
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.0177 0.0177
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0429 0.0956
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.0043 0.0587 0.1309
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0244 0.0244
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0092 0.1596 0.1596
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0437 0.0437
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0077 0.0077
Plasmodium vivax multidomain scavenger receptor, putative 0.0038 0.048 0.8179
Onchocerca volvulus 0.0043 0.0587 0.1486
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0271 0.0605
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0913 0.1665
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0587 0.5024
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0583 0.13
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0024 0.0177 0.0323
Brugia malayi Bromodomain containing protein 0.0028 0.0271 0.0605
Echinococcus granulosus carbonic anhydrase II 0.0119 0.2157 0.2157
Loa Loa (eye worm) hypothetical protein 0.0092 0.1596 0.3558
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0587 0.5024
Brugia malayi nuclear receptor RXR 0.0043 0.0583 0.13
Echinococcus multilocularis jun protein 0.0166 0.314 0.314
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0966 0.2155
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0043 0.0583 0.0583
Echinococcus multilocularis cpg binding protein 0.0037 0.0445 0.0445
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0043 0.0583 0.0583
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.1549 0.3454
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0587 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0587 0.0587
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.4003 0.6881
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0533 0.4491
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0833 0.0833
Loa Loa (eye worm) hypothetical protein 0.0048 0.0692 0.1542
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0092 0.1596 0.3558
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0244 0.0543
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0043 0.0583 0.13
Mycobacterium tuberculosis Conserved protein 0.0043 0.0587 0.1071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0092 0.1596 0.3558
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0542 0.0932
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0498 0.0498
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0168 0.3198 0.3198
Loa Loa (eye worm) hypothetical protein 0.0092 0.1596 0.3558
Loa Loa (eye worm) hypothetical protein 0.0048 0.0692 0.1542
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1216 0.1216
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0404 0.09
Brugia malayi nuclear receptor NHR-88 0.0092 0.1596 0.3558
Schistosoma mansoni lipoxygenase 0.0168 0.3198 0.3198
Leishmania major hypothetical protein, conserved 0.0043 0.0587 0.101
Toxoplasma gondii hypothetical protein 0.0027 0.0244 0.2317
Trypanosoma brucei trypanothione reductase 0.0037 0.0448 0.077
Echinococcus granulosus RUN 0.0038 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0027 0.0244 0.0543
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0583 0.0583
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0379 0.2984
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Schistosoma mansoni hypothetical protein 0.0019 0.0077 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0092 0.1596 0.3558
Schistosoma mansoni lipoxygenase 0.0099 0.1756 0.1756
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0092 0.1596 0.1596
Echinococcus multilocularis peregrin 0.0028 0.0271 0.0271
Mycobacterium tuberculosis Conserved protein 0.0043 0.0587 0.1071
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0583 0.13
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0587 0.0587
Brugia malayi nuclear hormone receptor 0.0043 0.0583 0.13
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0092 0.1596 0.1596
Brugia malayi RNA binding protein 0.0062 0.0966 0.2155
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0027 0.0244 0.0543
Schistosoma mansoni zinc finger protein 0.0043 0.0583 0.0583
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0583 0.0583
Loa Loa (eye worm) hypothetical protein 0.009 0.1549 0.3454
Brugia malayi hypothetical protein 0.0048 0.0692 0.1542
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0092 0.1596 0.1596
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0456 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0241 0.1628
Trichomonas vaginalis esterase, putative 0.0043 0.0587 0.5024
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0437 0.0437
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0092 0.1596 0.3558
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0092 0.1596 0.3558
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0119 0.2157 0.2157
Loa Loa (eye worm) hypothetical protein 0.0092 0.1596 0.3558
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Brugia malayi orphan nuclear receptor NR2E1 0.0043 0.0583 0.13
Leishmania major carbonic anhydrase-like protein 0.0119 0.2157 0.3707
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0902 0.2012
Schistosoma mansoni tyrosinase precursor 0.009 0.1549 0.1549
Mycobacterium ulcerans hypothetical protein 0.0155 0.2913 1
Brugia malayi nuclear hormone receptor 0.0092 0.1596 0.3558
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0587 0.0587
Loa Loa (eye worm) hypothetical protein 0.0027 0.0244 0.0543
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0587 0.101
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0092 0.1596 0.3558
Loa Loa (eye worm) hypothetical protein 0.003 0.0301 0.0671
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0542 0.0932
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0077 0.0171
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0498 0.0498
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0092 0.1596 0.3558
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0587 0.1071
Loa Loa (eye worm) hypothetical protein 0.0038 0.048 0.1071
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0092 0.1596 0.1596
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0923 0.0923
Echinococcus granulosus ecdysone induced protein 78C 0.0092 0.1596 0.1596
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0092 0.1596 0.6233
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0913 0.0913
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0119 0.2157 0.2157
Brugia malayi glutathione reductase 0.0037 0.0448 0.0998
Schistosoma mansoni coup transcription factor 0.0092 0.1596 0.1596
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0092 0.1596 0.1596
Brugia malayi beta-lactamase family protein 0.0043 0.0587 0.1309
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0077 0.0171
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.1021 0.2275
Brugia malayi photoreceptor-specific nuclear receptor 0.0092 0.1596 0.3558
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0092 0.1596 0.1596
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0166 0.314 0.314
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0092 0.1596 0.1596
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0966 0.0966
Brugia malayi beta-lactamase family protein 0.0043 0.0587 0.1309
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.1549 0.3454
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0587 0.1071
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0937 0.2088
Loa Loa (eye worm) hypothetical protein 0.0027 0.0244 0.0543
Brugia malayi nuclear receptor NHR-88 0.0043 0.0583 0.13
Loa Loa (eye worm) hypothetical protein 0.0043 0.0587 0.1309
Loa Loa (eye worm) nuclear hormone receptor 0.0043 0.0583 0.13
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0542 0.0932
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0048 0.0692 0.0692
Entamoeba histolytica hypothetical protein 0.0071 0.1167 1
Schistosoma mansoni tyrosinase precursor 0.009 0.1549 0.1549
Echinococcus granulosus cpg binding protein 0.0037 0.0445 0.0445
Echinococcus multilocularis GPCR, family 2 0.0019 0.0077 0.0077
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0077 0.0171
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0048 0.0692 0.0692
Mycobacterium ulcerans lipase LipD 0.0043 0.0587 0.1501
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0587 0.1501
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0659 0.147
Plasmodium vivax glutathione reductase, putative 0.0037 0.0448 0.7624
Brugia malayi beta-lactamase 0.0043 0.0587 0.1309
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0171
Brugia malayi hypothetical protein 0.0043 0.0583 0.13
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.1433 0.2613
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0271 0.2581
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0048 0.0692 0.0692
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0092 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0043 0.0587 0.1309
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.1629 0.297
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0092 0.1596 0.1596
Schistosoma mansoni cpg binding protein 0.0037 0.0445 0.0445
Entamoeba histolytica hypothetical protein 0.0071 0.1167 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0458 0.0458
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0294 0.5818 1
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0587 0.1071
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0294 0.5818 1
Onchocerca volvulus 0.009 0.1549 0.6012
Onchocerca volvulus 0.009 0.1549 0.6012
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0587 0.1071
Schistosoma mansoni thyroid hormone receptor 0.0092 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0092 0.1596 0.3558
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0533 0.1231
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.009 0.1549 0.3454
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0587 0.1501
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.4003 0.6881
Mycobacterium tuberculosis Probable reductase 0.0084 0.1433 0.2613
Mycobacterium ulcerans hypothetical protein 0.0043 0.0587 0.1501
Loa Loa (eye worm) RNA binding protein 0.0062 0.0966 0.2155
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.1433 0.2613
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.2913 0.5312
Onchocerca volvulus 0.0043 0.0583 0.1467
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0092 0.1596 0.3558
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0833 0.0833
Loa Loa (eye worm) nuclear receptor NHR-67 0.0043 0.0583 0.13
Mycobacterium tuberculosis Conserved protein 0.0043 0.0587 0.1071
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0583 0.0583
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0937 0.2088
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0448 0.0817
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.0177 0.1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0043 0.0583 0.0583
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0429 0.0429
Schistosoma mansoni hypothetical protein 0.033 0.6568 0.6568
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0027 0.0244 0.0543
Schistosoma mansoni nuclear receptor nhr-48 0.0043 0.0583 0.0583
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0913 0.8681
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0923 0.0923
Toxoplasma gondii hypothetical protein 0.0047 0.0669 0.6361
Schistosoma mansoni hypothetical protein 0.0041 0.0539 0.0539
Brugia malayi Steroid receptor seven-up type 2 0.0092 0.1596 0.3558
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0271 0.2581
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0923 0.1587
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0092 0.1596 0.3558
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.1021 0.2275
Schistosoma mansoni carbonic anhydrase 0.0027 0.0244 0.0244
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.2584 0.4442
Echinococcus granulosus carbonic anhydrase 0.0027 0.0244 0.0244
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.0053 0.0053
Plasmodium falciparum thioredoxin reductase 0.0037 0.0448 0.9321
Echinococcus multilocularis nuclear receptor nhr 48 0.0043 0.0583 0.0583
Echinococcus granulosus GPCR family 2 0.0019 0.0077 0.0077
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0271 0.4622
Schistosoma mansoni loxhd1 0.0038 0.048 0.048
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0092 0.1596 0.3558
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0833 0.1857
Schistosoma mansoni hypothetical protein 0.0038 0.048 0.048
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0923 0.2729
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0092 0.1596 0.3558
Brugia malayi bZIP transcription factor family protein 0.0166 0.314 0.7
Plasmodium falciparum phd finger protein, putative 0.0028 0.0271 0.5651
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.009 0.1549 0.3454
Trichomonas vaginalis chromobox protein, putative 0.0068 0.1095 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.1433 0.812
Loa Loa (eye worm) ShTK domain-containing protein 0.009 0.1549 0.3454
Brugia malayi PHD-finger family protein 0.0028 0.0271 0.0605
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0833 0.0833
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0923 0.2059
Onchocerca volvulus 0.0038 0.048 0.0983
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0092 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0092 0.1596 0.3558
Toxoplasma gondii thioredoxin reductase 0.0037 0.0448 0.4257
Brugia malayi nuclear receptor RXR 0.0048 0.0692 0.1542
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.1021 0.1754
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.0177 0.0304
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0437 0.0975
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.4486 0.4486
Schistosoma mansoni hypothetical protein 0.033 0.6568 0.6568
Loa Loa (eye worm) hypothetical protein 0.0028 0.0271 0.0605
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0542 0.0932
Schistosoma mansoni rab6-interacting 0.0038 0.048 0.048
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0271 0.0271
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0448 0.077
Onchocerca volvulus 0.0043 0.0583 0.1467
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0587 0.0587
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0448 0.0998
Echinococcus multilocularis RUN 0.0038 0.048 0.048
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0049 0.0695 0.1549
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.1629 0.297
Loa Loa (eye worm) hypothetical protein 0.0043 0.0587 0.1309
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0094 0.0209
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0833 0.0833
Brugia malayi nuclear hormone receptor family member nhr-6 0.0043 0.0583 0.13
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0504 0.0504
Loa Loa (eye worm) carbonic anhydrase 3 0.0119 0.2157 0.4808
Schistosoma mansoni hypothetical protein 0.0019 0.0077 0.0077
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.048 0.048
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1052 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0166 0.314 0.314
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0833 0.0833
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0077 0.0077
Onchocerca volvulus 0.0047 0.0659 0.1825
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0458 0.0458
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0587 0.1071
Brugia malayi Nuclear hormone receptor-like 1 0.0092 0.1596 0.3558
Brugia malayi jmjC domain containing protein 0.0093 0.162 0.3611
Schistosoma mansoni carbonic anhydrase-related 0.0027 0.0244 0.0244
Loa Loa (eye worm) hypothetical protein 0.0048 0.0692 0.1542
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0913 0.0913
Brugia malayi Common central domain of tyrosinase family protein 0.009 0.1549 0.3454
Brugia malayi ecdysone receptor 0.0043 0.0583 0.13
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.048 0.048
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0048 0.0692 0.1542
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.1629 0.297
Echinococcus granulosus geminin 0.033 0.6568 0.6568
Echinococcus granulosus survival motor neuron protein 1 0.023 0.4486 0.4486
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0692 0.1542
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0119 0.2157 0.3707
Echinococcus multilocularis carbonic anhydrase 0.0027 0.0244 0.0244
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.162 0.162
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0092 0.1596 0.1596
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0833 0.0833
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0456 0.0456
Schistosoma mansoni steroid hormone receptor ad4bp 0.0092 0.1596 0.1596
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0473 0.39
Brugia malayi TAR-binding protein 0.0062 0.0966 0.2155
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0241 0.1628
Echinococcus granulosus jun protein 0.0166 0.314 0.314
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0092 0.1596 0.1596
Echinococcus granulosus carbonic anhydrase 0.0027 0.0244 0.0244
Toxoplasma gondii ABC1 family protein 0.0043 0.0587 0.5584
Loa Loa (eye worm) hypothetical protein 0.0043 0.0583 0.13
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0587 0.5024
Schistosoma mansoni hypothetical protein 0.0047 0.0659 0.0659
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0587 0.5024
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0092 0.1596 0.3558
Plasmodium falciparum glutathione reductase 0.0037 0.0448 0.9321

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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