Detailed information for compound 85196

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.496 | Formula: C26H25N3O2
  • H donors: 1 H acceptors: 2 LogP: 4.33 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)C(N(Cc1noc(c1)c1ccccc1)Cc1ccccc1)Cc1ccccc1
  • InChi: 1S/C26H25N3O2/c27-26(30)24(16-20-10-4-1-5-11-20)29(18-21-12-6-2-7-13-21)19-23-17-25(31-28-23)22-14-8-3-9-15-22/h1-15,17,24H,16,18-19H2,(H2,27,30)
  • InChiKey: JGCVAOFCDPADLG-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0043 0.0536 0.2796
Plasmodium vivax CDK-related protein kinase 6, putative 0.0524 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0038 0.045 0.0666
Loa Loa (eye worm) hypothetical protein 0.003 0.0292 0.044
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0248 0.4578 0.6884
Plasmodium falciparum calcium-dependent protein kinase 1 0.0038 0.045 0.0437
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0037 0.0429 0.0642
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0167 0.0239
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Echinococcus multilocularis geminin 0.0338 0.6344 0.9544
Echinococcus multilocularis synaptic vesicle 2 protein 0.0035 0.0387 0.0571
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.045 0.0666
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0335 0.2069
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0248 0.4578 0.6884
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.2704 0.4061
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Brugia malayi hypothetical protein 0.0035 0.0387 0.0571
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0038 0.045 0.0666
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Schistosoma mansoni hypothetical protein 0.0034 0.0363 0.0536
Trichomonas vaginalis sugar transport protein, putative 0.0035 0.0387 0.0562
Schistosoma mansoni hypothetical protein 0.0338 0.6344 0.9544
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0335 0.049
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Echinococcus granulosus acetylcholinesterase 0.0067 0.1015 0.1517
Trypanosoma brucei THT1 - hexose transporter, putative 0.0077 0.1214 0.7744
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0335 0.0321
Brugia malayi Cam kinase protein 1 0.0038 0.045 0.0666
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.001
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0647 0.1146
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0549 0.3455
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.045 0.0666
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0335 0.2069
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0335 0.2069
Loa Loa (eye worm) hypothetical protein 0.0037 0.0429 0.0645
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0243 0.0354
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0014 0.001
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0919 0.1372
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.045 0.0666
Loa Loa (eye worm) hypothetical protein 0.0354 0.6647 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0335 0.2069
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.2704 0.4061
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0335 0.2069
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0028 0.0243 0.0195
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0035 0.0387 1
Trypanosoma brucei glucose transporter 1E 0.0077 0.1214 0.7744
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0093 0.1529 0.3505
Brugia malayi Sugar transporter family protein 0.0035 0.0387 0.0571
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1563 0.321
Schistosoma mansoni glucose transporter 0.0035 0.0387 0.0571
Brugia malayi hypothetical protein 0.0035 0.0387 0.0571
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0536 0.0796
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0037 0.0429 0.0634
Echinococcus granulosus survival motor neuron protein 1 0.0279 0.519 0.7805
Brugia malayi Major Facilitator Superfamily protein 0.0035 0.0387 0.0571
Schistosoma mansoni inositol transporter 0.0039 0.0467 0.0692
Echinococcus granulosus synaptic vesicle 2 protein 0.0035 0.0387 0.0571
Trichomonas vaginalis sugar transporter, putative 0.0077 0.1214 0.2423
Loa Loa (eye worm) hypothetical protein 0.0038 0.045 0.0677
Loa Loa (eye worm) hypothetical protein 0.0028 0.0243 0.0365
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0467 0.0692
Echinococcus multilocularis solute carrier family 22 0.0035 0.0387 0.0571
Loa Loa (eye worm) glutathione reductase 0.0093 0.1529 0.23
Loa Loa (eye worm) thioredoxin reductase 0.0093 0.1529 0.23
Trypanosoma cruzi hexose transporter, putative 0.0077 0.1214 0.7744
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0335 0.0321
Toxoplasma gondii thioredoxin reductase 0.0093 0.1529 0.2314
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0038 0.045 0.0437
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.045 0.0666
Toxoplasma gondii facilitative glucose transporter GT1 0.0248 0.4578 0.6974
Leishmania major hypothetical protein, conserved 0.0035 0.0387 0.2407
Trypanosoma cruzi glucose transporter, putative 0.0035 0.0387 0.2407
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Entamoeba histolytica hypothetical protein 0.0043 0.0536 0.2796
Brugia malayi Thioredoxin reductase 0.0093 0.1529 0.2291
Loa Loa (eye worm) hypothetical protein 0.0039 0.0467 0.0703
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0919 0.1372
Plasmodium vivax hexose transporter 0.0248 0.4578 0.4571
Schistosoma mansoni ap endonuclease 0.0022 0.0138 0.0196
Loa Loa (eye worm) hypothetical protein 0.0016 0.0008 0.0012
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0161 0.034
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0038 0.045 0.0437
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0035 0.0387 0.0863
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0335 0.7895
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.2704 0.4061
Schistosoma mansoni sodium/solute symporter 0.0039 0.0467 0.0692
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0919 0.1383
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0153 0.2704 0.4068
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.02 0.3626 0.3617
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0549 0.3455
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0335 0.2069
Brugia malayi TAR-binding protein 0.0062 0.0919 0.1372
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0014 0.0021
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0028 0.0243 0.1475
Leishmania major protein kinase, putative 0.0038 0.045 0.2812
Trypanosoma brucei THT1 - hexose transporter, putative 0.0077 0.1214 0.7744
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0037 0.0429 0.0634
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Toxoplasma gondii sugar transporter ST3 0.0035 0.0387 0.057
Trypanosoma cruzi trypanothione reductase, putative 0.0093 0.1529 0.9777
Leishmania major glucose transporter, lmgt2 0.0077 0.1214 0.7744
Loa Loa (eye worm) major facilitator superfamily transporter 0.0035 0.0387 0.0582
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0335 0.2069
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0038 0.045 0.0666
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0549 0.3455
Entamoeba histolytica protein kinase, putative 0.0038 0.045 0.2189
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0243 0.4207
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1563 0.321
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0138 0.0798
Echinococcus multilocularis carboxylesterase 5A 0.0067 0.1015 0.1517
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0138 0.0196
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.067 0.0997
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0067 0.1015 0.1517
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0038 0.045 0.0666
Loa Loa (eye worm) hypothetical protein 0.0067 0.1015 0.1527
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0335 0.2069
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0161 0.034
Echinococcus granulosus solute carrier family 22 0.0035 0.0387 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0248 0.4578 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.045 0.0666
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0335 0.2069
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0919 0.1383
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0335 0.2069
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0335 0.7895
Schistosoma mansoni protein kinase 0.0038 0.045 0.0666
Plasmodium vivax lysine--tRNA ligase, putative 0.0028 0.0243 0.0229
Echinococcus multilocularis solute carrier family 22 0.0035 0.0387 0.0571
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0335 0.7895
Trypanosoma brucei THT1 - hexose transporter, putative 0.0077 0.1214 0.7744
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1563 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Schistosoma mansoni hypothetical protein 0.0248 0.4578 0.6884
Schistosoma mansoni high-affinity choline transporter 0.0354 0.6647 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0467 0.0692
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0248 0.4578 0.6884
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0043 0.0549 0.3455
Toxoplasma gondii transporter, major facilitator family protein 0.0035 0.0387 0.057
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.067 0.1008
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0467 0.0692
Echinococcus granulosus geminin 0.0338 0.6344 0.9544
Echinococcus granulosus General substrate transporter 0.0213 0.3893 0.5852
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.001
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0467 0.0692
Loa Loa (eye worm) major facilitator superfamily transporter 0.0035 0.0387 0.0582
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0919 0.1372
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0138 0.0124
Plasmodium falciparum glutathione reductase 0.0093 0.1529 0.1517
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Brugia malayi GH02984p 0.0354 0.6647 1
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0035 0.0387 0.0571
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0536 0.0796
Plasmodium falciparum glutathione reductase 0.0032 0.0335 0.0321
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.1563 0.2343
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Trichomonas vaginalis myo-inositol transporter, putative 0.0035 0.0387 0.0562
Echinococcus granulosus tar DNA binding protein 0.0062 0.0919 0.1372
Plasmodium falciparum proline--tRNA ligase 0.0043 0.0549 0.0536
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.1563 0.2352
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0335 0.2069
Echinococcus granulosus high affinity choline transporter 1 0.0354 0.6647 1
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Plasmodium falciparum mitogen-activated protein kinase 2 0.02 0.3626 0.3617
Echinococcus multilocularis General substrate transporter 0.0213 0.3893 0.5852
Brugia malayi glutathione reductase 0.0093 0.1529 0.2291
Schistosoma mansoni protein kinase 0.0038 0.045 0.0666
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0335 0.049
Trypanosoma cruzi sugar transporter, putative 0.0035 0.0387 0.2407
Schistosoma mansoni glucose transport protein 0.0248 0.4578 0.6884
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Schistosoma mansoni survival motor neuron protein 0.0057 0.0821 0.1225
Echinococcus granulosus solute carrier family 22 0.0035 0.0387 0.0571
Mycobacterium ulcerans sugar transporter 0.0035 0.0387 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.001
Brugia malayi Major Facilitator Superfamily protein 0.0035 0.0387 0.0571
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.1563 1
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.045 0.0666
Brugia malayi Carboxylesterase family protein 0.0067 0.1015 0.1517
Trichomonas vaginalis glucose transporter, putative 0.0077 0.1214 0.2423
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0335 0.0492
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0138 0.0196
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0035 0.0387 0.0571
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0236 0.4335 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1563 0.321
Loa Loa (eye worm) hypothetical protein 0.0067 0.1015 0.1527
Mycobacterium tuberculosis Probable oxidoreductase 0.0236 0.4335 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Entamoeba histolytica hypothetical protein 0.0043 0.0536 0.2796
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0335 0.0321
Trichomonas vaginalis CAMK family protein kinase 0.0038 0.045 0.0703
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0138 0.0798
Schistosoma mansoni hypothetical protein 0.0043 0.0536 0.0796
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0032 0.0335 1
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0335 0.0443
Plasmodium vivax thioredoxin reductase, putative 0.0093 0.1529 0.1517
Plasmodium falciparum hexose transporter 0.0248 0.4578 0.4571
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0035 0.0387 1
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Trypanosoma brucei glucose transporter, putative 0.0077 0.1214 0.7744
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0038 0.045 0.0677
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.1563 0.2343
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1563 0.321
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0212 0.387 0.8886
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.1214 0.2423
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0467 0.0693
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0038 0.045 0.0666
Schistosoma mansoni sugar transporter 0.0035 0.0387 0.0571
Echinococcus multilocularis solute carrier family 22 0.0035 0.0387 0.0571
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0335 0.2069
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0014 0.001
Loa Loa (eye worm) sugar transporter 0.0035 0.0387 0.0582
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Plasmodium falciparum calcium-dependent protein kinase 5 0.0038 0.045 0.0437
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0236 0.4335 1
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Brugia malayi Carboxylesterase family protein 0.0067 0.1015 0.1517
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0335 0.0492
Echinococcus multilocularis acetylcholinesterase 0.0067 0.1015 0.1517
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0387 0.0562
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0035 0.0387 1
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Echinococcus multilocularis solute carrier family 5 0.0039 0.0467 0.0692
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Echinococcus multilocularis acetylcholinesterase 0.0067 0.1015 0.1517
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0387 0.0562
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0153 0.2704 0.4061
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0429 0.0634
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.2704 0.4061
Trypanosoma cruzi hexose transporter, putative 0.0042 0.0528 0.3318
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Plasmodium falciparum calcium-dependent protein kinase 2 0.0038 0.045 0.0437
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0028 0.0243 0.4207
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0335 0.2069
Loa Loa (eye worm) sugar transporter 0.0248 0.4578 0.6888
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0212 0.387 0.8923
Toxoplasma gondii sugar transporter ST2 0.0035 0.0387 0.057
Leishmania major glucose transporter/membrane transporter D2, putative 0.0077 0.1214 0.7744
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0153 0.2704 0.4061
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0467 0.0692
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0153 0.2704 0.4061
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0038 0.045 0.0437
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0919 0.1372
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0821 0.1225
Plasmodium falciparum thioredoxin reductase 0.0093 0.1529 0.1517
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0037 0.0429 0.0656
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0536 0.0796
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0043 0.0549 0.0818
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Entamoeba histolytica hypothetical protein 0.0028 0.0243 0.0736
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0467 0.0692
Trypanosoma brucei glucose transporter 2A 0.0077 0.1214 0.7744
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0335 0.0492
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Trichomonas vaginalis sugar transporter, putative 0.0077 0.1214 0.2423
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0008 0.0012
Brugia malayi RNA binding protein 0.0062 0.0919 0.1372
Trypanosoma cruzi hexose transporter, putative 0.0077 0.1214 0.7744
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0028 0.0243 0.0236
Schistosoma mansoni sugar transporter 0.0035 0.0387 0.0571
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0138 0.0798
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0919 0.1372
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Trichomonas vaginalis glucose transporter, putative 0.0077 0.1214 0.2423
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0038 0.045 0.2812
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0138 0.0207
Plasmodium vivax sugar transporter, putative 0.0035 0.0387 0.0373
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0335 0.0742
Loa Loa (eye worm) carboxylesterase 0.0067 0.1015 0.1527
Echinococcus granulosus carboxylesterase 5A 0.0067 0.1015 0.1517
Schistosoma mansoni ap endonuclease 0.0022 0.0138 0.0196
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0335 0.0443
Plasmodium vivax calcium-dependent protein kinase, putative 0.0038 0.045 0.0437
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0335 0.2069
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0038 0.045 0.0666
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0138 0.0286
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0176 0.0086
Trypanosoma brucei glucose transporter, putative 0.0077 0.1214 0.7744
Toxoplasma gondii sugar transporter ST1 0.0035 0.0387 0.057
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0398 0.0588
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.067 0.0997
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0035 0.0387 0.0373
Toxoplasma gondii lysine-tRNA ligase 0.0028 0.0243 0.0349
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.1563 0.2343
Plasmodium vivax proline--tRNA ligase, putative 0.0043 0.0549 0.0536
Mycobacterium tuberculosis Probable dehydrogenase 0.0212 0.387 0.8923
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0387 0.0562
Echinococcus granulosus thioredoxin glutathione reductase 0.0093 0.1529 0.2291
Trypanosoma brucei trypanothione reductase 0.0093 0.1529 0.9777
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0248 0.4578 0.6884
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0037 0.0429 0.0634
Brugia malayi hypothetical protein 0.0043 0.0536 0.0796
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Echinococcus granulosus lysyl tRNA synthetase 0.0028 0.0243 0.0354
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0398 0.0588
Leishmania major glucose transporter, lmgt1 0.0077 0.1214 0.7744
Onchocerca volvulus 0.0057 0.0821 0.3687
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0037 0.0429 0.0634
Schistosoma mansoni hypothetical protein 0.0057 0.0821 0.1225
Entamoeba histolytica protein kinase, putative 0.0038 0.045 0.2189
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0167 0.0239
Onchocerca volvulus 0.0039 0.0467 0.0683
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Echinococcus granulosus Sugar transporter ERD6 protein 0.0035 0.0387 0.0571
Brugia malayi isocitrate dehydrogenase 0.0016 0.0014 0.001
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0467 0.0692
Loa Loa (eye worm) hypothetical protein 0.0037 0.0429 0.0645
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0919 0.1372
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0335 0.0321
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0248 0.4578 0.6884
Echinococcus multilocularis solute carrier family 22 0.0035 0.0387 0.0571
Leishmania major lysyl-tRNA synthetase, putative 0.0028 0.0243 0.1475
Trypanosoma cruzi hexose transporter 0.0077 0.1214 0.7744
Brugia malayi hypothetical protein 0.0279 0.519 0.7805
Schistosoma mansoni sugar transporter 0.0035 0.0387 0.0571
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1563 0.321
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0038 0.045 0.0666
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0038 0.045 0.0677
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0153 0.2704 0.4061
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0138 0.0124
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0212 0.387 0.8923
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Echinococcus multilocularis high affinity choline transporter 1 0.0354 0.6647 1
Plasmodium falciparum protein kinase 7 0.0349 0.6559 0.6554
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0212 0.387 0.8923
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Brugia malayi hypothetical protein 0.0035 0.0387 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0387 0.0562
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0236 0.4335 1
Plasmodium falciparum calcium-dependent protein kinase 4 0.0038 0.045 0.0437
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0212 0.387 0.8923
Giardia lamblia Hexose transporter 0.0035 0.0387 0.1749
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.1563 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0248 0.4578 0.6884
Schistosoma mansoni hypothetical protein 0.0338 0.6344 0.9544
Schistosoma mansoni kinase 0.0049 0.067 0.0998
Schistosoma mansoni protein kinase 0.0038 0.045 0.0666
Giardia lamblia Lysyl-tRNA synthetase 0.0028 0.0243 0.0736
Trypanosoma brucei polo-like protein kinase 0.0095 0.1563 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0387 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.1214 0.2423
Loa Loa (eye worm) hypothetical protein 0.0049 0.067 0.1008
Giardia lamblia Prolyl-tRNA synthetase 0.0037 0.0429 0.2042
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.1563 1
Echinococcus multilocularis survival motor neuron protein 1 0.0279 0.519 0.7805
Giardia lamblia Kinase, PLK 0.0095 0.1563 1
Schistosoma mansoni sugar transporter 0.0035 0.0387 0.0571
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0028 0.0243 0.1475
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0014 0.001
Trypanosoma brucei glucose transporter, putative 0.0077 0.1214 0.7744
Toxoplasma gondii exonuclease III APE 0.0022 0.0138 0.0189
Treponema pallidum NADH oxidase 0.0032 0.0335 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.1563 0.2343
Schistosoma mansoni lysyl-tRNA synthetase 0.0028 0.0243 0.0354
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0647 0.1146
Brugia malayi major facilitator superfamily protein 0.0035 0.0387 0.0571
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0335 0.2069
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0138 0.0798
Loa Loa (eye worm) RNA binding protein 0.0062 0.0919 0.1383
Loa Loa (eye worm) hypothetical protein 0.0279 0.519 0.7808
Echinococcus granulosus acetylcholinesterase 0.0067 0.1015 0.1517
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0037 0.0429 0.2042
Schistosoma mansoni inositol transporter 0.0039 0.0467 0.0692
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1563 0.321
Plasmodium falciparum thioredoxin reductase 0.0032 0.0335 0.0321
Loa Loa (eye worm) acetylcholinesterase 1 0.0067 0.1015 0.1527
Trypanosoma cruzi hexose transporter, putative 0.0077 0.1214 0.7744
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0138 0.0196
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0335 0.2069
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0035 0.0387 0.0863
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0335 0.7895
Trichomonas vaginalis sugar transporter, putative 0.0035 0.0387 0.0562
Echinococcus granulosus solute carrier family 5 0.0039 0.0467 0.0692
Giardia lamblia Sugar-proton symporter 0.0035 0.0387 0.1749
Mycobacterium ulcerans integral membrane transport protein 0.0035 0.0387 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0248 0.4578 0.6884
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0035 0.0387 0.2407
Echinococcus granulosus solute carrier family 22 0.0035 0.0387 0.0571
Schistosoma mansoni glucose transport protein 0.0248 0.4578 0.6884
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.02 0.3626 0.5519
Entamoeba histolytica hypothetical protein 0.0043 0.0536 0.2796
Trichomonas vaginalis sugar transporter, putative 0.0077 0.1214 0.2423
Echinococcus granulosus solute carrier family 22 0.0035 0.0387 0.0571
Loa Loa (eye worm) hypothetical protein 0.0034 0.0363 0.0547
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0363 0.0536
Trypanosoma brucei glucose transporter, putative 0.0077 0.1214 0.7744
Toxoplasma gondii protein kinase, putative 0.0349 0.6559 1
Mycobacterium tuberculosis Probable reductase 0.0212 0.387 0.8923
Brugia malayi major facilitator superfamily protein 0.0035 0.0387 0.0571
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0043 0.0549 0.3455
Trypanosoma brucei sugar transporter, putative 0.0035 0.0387 0.2407
Brugia malayi lysyl-tRNA synthetase 0.0028 0.0243 0.0354
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0387 0.2407
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.1563 0.321
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0248 0.4578 0.6884
Trypanosoma brucei glucose transporter, putative 0.0077 0.1214 0.7744
Trypanosoma brucei glucose transporter, putative 0.0077 0.1214 0.7744
Echinococcus multilocularis thioredoxin glutathione reductase 0.0093 0.1529 0.2291
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0014 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0387 0.0562
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0335 0.0492
Trypanosoma brucei glucose transporter, putative 0.0077 0.1214 0.7744
Leishmania major glucose transporter, lmgt3 0.0077 0.1214 0.7744
Trypanosoma brucei glucose transporter, putative 0.0077 0.1214 0.7744
Plasmodium falciparum lysine--tRNA ligase 0.0028 0.0243 0.0229
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.1563 1
Brugia malayi Major Facilitator Superfamily protein 0.0035 0.0387 0.0571
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0335 0.1381
Schistosoma mansoni glucose transport protein 0.0248 0.4578 0.6884
Echinococcus multilocularis lysyl tRNA synthetase 0.0028 0.0243 0.0354
Plasmodium vivax glutathione reductase, putative 0.0093 0.1529 0.1517
Trichomonas vaginalis glucose transporter, putative 0.0035 0.0387 0.0562
Leishmania major trypanothione reductase 0.0093 0.1529 0.9777
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0335 0.2069
Leishmania major myo-inositol/proton symporter (MIT) 0.0035 0.0387 0.2407
Brugia malayi Sugar transporter family protein 0.0248 0.4578 0.6884
Brugia malayi Sugar transporter family protein 0.0035 0.0387 0.0571
Plasmodium falciparum calcium-dependent protein kinase 3 0.0038 0.045 0.0437
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0037 0.0429 0.0634
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0467 0.0692
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0014 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0335 0.7895
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0919 0.1372

Activities

Activity type Activity value Assay description Source Reference
Protection (functional) = 30 % In vivo antithrombotic activity in Swiss mice was determined when the compound was administered at 30 micromol/kg orally 1 hour prior to challenge ChEMBL. 12113805
Protection (functional) = 30 % In vivo antithrombotic activity in Swiss mice was determined when the compound was administered at 30 micromol/kg orally 1 hour prior to challenge ChEMBL. 12113805

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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