Detailed information for compound 866188

Basic information

Technical information
  • TDR Targets ID: 866188
  • Name: 1-(9-ethylcarbazol-3-yl)-N-[(4-methoxyphenyl) methyl]methanamine
  • MW: 344.449 | Formula: C23H24N2O
  • H donors: 1 H acceptors: 0 LogP: 4.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CNCc1ccc2c(c1)c1ccccc1n2CC
  • InChi: 1S/C23H24N2O/c1-3-25-22-7-5-4-6-20(22)21-14-18(10-13-23(21)25)16-24-15-17-8-11-19(26-2)12-9-17/h4-14,24H,3,15-16H2,1-2H3
  • InChiKey: PZCUFYOFOLBPAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(9-ethyl-3-carbazolyl)-N-[(4-methoxyphenyl)methyl]methanamine
  • (9-ethylcarbazol-3-yl)methyl-(4-methoxybenzyl)amine
  • CBMicro_023133
  • STK126673
  • Oprea1_423632
  • BIM-0023095.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0018 0.0254 0.0288
Schistosoma mansoni cpg binding protein 0.0035 0.0572 0.0648
Brugia malayi Peptidase family M1 containing protein 0.0372 0.6862 1
Echinococcus multilocularis neuropeptide receptor A26 0.0541 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0716 0.271
Loa Loa (eye worm) hypothetical protein 0.0015 0.0183 0.0285
Echinococcus granulosus dnaJ subfamily B 0.0478 0.8835 0.8827
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0194 0.0129
Loa Loa (eye worm) hypothetical protein 0.0143 0.2583 0.4198
Schistosoma mansoni lamin 0.0032 0.0499 0.0564
Onchocerca volvulus 0.0034 0.0537 0.006
Echinococcus multilocularis aminopeptidase N 0.0372 0.6862 0.6841
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.063 0.0568
Loa Loa (eye worm) histone methyltransferase 0.001 0.0104 0.0156
Brugia malayi hypothetical protein 0.0039 0.063 0.0907
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0716 0.271
Onchocerca volvulus 0.011 0.1956 0.2291
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.011 0.1956 1
Schistosoma mansoni hypothetical protein 0.0478 0.8835 1
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0039 0.063 1
Echinococcus multilocularis neuropeptide s receptor 0.0541 1 1
Loa Loa (eye worm) aminopeptidase N 0.011 0.1956 0.3176
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0039 0.063 0.0568
Mycobacterium ulcerans aminopeptidase N PepN 0.011 0.1956 1
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.011 0.1956 1
Schistosoma mansoni hypothetical protein 0.0018 0.0254 0.0288
Loa Loa (eye worm) hypothetical protein 0.0058 0.0998 0.1613
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.011 0.1956 0.1903
Echinococcus granulosus Smad4 0.001 0.0088 0.0022
Onchocerca volvulus 0.0039 0.063 0.0206
Trypanosoma cruzi aminopeptidase, putative 0.011 0.1956 1
Schistosoma mansoni hypothetical protein 0.004 0.0654 0.074
Schistosoma mansoni intermediate filament proteins 0.0032 0.0499 0.0564
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0255 0.019
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.063 0.2202
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.2515 0.4086
Brugia malayi hypothetical protein 0.0143 0.2583 0.3757
Loa Loa (eye worm) hypothetical protein 0.0015 0.0183 0.0285
Loa Loa (eye worm) hypothetical protein 0.0031 0.0488 0.0782
Echinococcus granulosus puromycin sensitive aminopeptidase 0.011 0.1956 0.1903
Onchocerca volvulus 0.0372 0.6862 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0039 0.063 0.2202
Echinococcus multilocularis mothers against decapentaplegic 5 0.001 0.0088 0.0022
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0071 0.1237 0.1179
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0225 0.0354
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0225 0.0317
Echinococcus granulosus puromycin sensitive aminopeptidase 0.011 0.1956 0.1903
Loa Loa (eye worm) MH1 domain-containing protein 0.001 0.0088 0.0129
Brugia malayi CXXC zinc finger family protein 0.0034 0.0537 0.0771
Brugia malayi MH2 domain containing protein 0.001 0.0088 0.0116
Schistosoma mansoni lamin 0.0032 0.0499 0.0564
Schistosoma mansoni Smad4 0.001 0.0088 0.0099
Brugia malayi isocitrate dehydrogenase 0.0018 0.0255 0.036
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0254 0.0359
Echinococcus multilocularis Smad4 0.001 0.0088 0.0022
Echinococcus granulosus lamin dm0 0.0032 0.0499 0.0436
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0499 0.0715
Echinococcus multilocularis dnaJ subfamily B 0.0478 0.8835 0.8827
Schistosoma mansoni inositol monophosphatase 0.0043 0.0716 0.081
Loa Loa (eye worm) inositol-1 0.0043 0.0716 0.1154
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0998 0.1444
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0499 0.0799
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0716 0.0655
Echinococcus granulosus puromycin sensitive aminopeptidase 0.011 0.1956 0.1903
Brugia malayi hypothetical protein 0.011 0.1956 0.2843
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0716 0.3486
Trypanosoma brucei Aminopeptidase M1, putative 0.011 0.1956 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0104 0.0038
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0255 0.019
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.2515 0.4086
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0716 0.0651
Entamoeba histolytica aminopeptidase, putative 0.011 0.1956 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0716 0.5
Trypanosoma brucei Aminopeptidase M1, putative 0.011 0.1956 1
Brugia malayi MH2 domain containing protein 0.014 0.2515 0.3658
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.011 0.1956 0.2215
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0255 0.019
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0998 0.1444
Echinococcus granulosus GPCR family 2 0.0018 0.0254 0.019
Echinococcus granulosus neuropeptide receptor A26 0.0541 1 1
Brugia malayi MH1 domain containing protein 0.001 0.0088 0.0116
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.011 0.1956 0.1903
Echinococcus granulosus cpg binding protein 0.0035 0.0572 0.051
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0632 1
Schistosoma mansoni cpg binding protein 0.0035 0.0572 0.0648
Loa Loa (eye worm) hypothetical protein 0.0039 0.063 0.1013
Brugia malayi Inositol-1 0.0043 0.0716 0.1033
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0066 0.0074
Echinococcus multilocularis smad 0.001 0.0088 0.0022
Trypanosoma cruzi Aminopeptidase M1, putative 0.011 0.1956 1
Echinococcus granulosus lamin 0.0032 0.0499 0.0436
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0654 0.0942
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0716 0.5474
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0499 0.0799
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0255 0.0402
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.011 0.1956 0.1903
Echinococcus granulosus leukotriene A 4 hydrolase 0.0039 0.063 0.0568
Schistosoma mansoni cpg binding protein 0.0034 0.0537 0.0608
Brugia malayi Smad1 0.001 0.0088 0.0116
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0716 0.3486
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0071 0.1237 0.5772
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0254 0.019
Echinococcus granulosus mothers against decapentaplegic 5 0.001 0.0088 0.0022
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0039 0.063 0.0713
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.011 0.1956 0.1903
Echinococcus multilocularis TGF beta signal transducer SmadC 0.001 0.0088 0.0022
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.1239 0.1403
Toxoplasma gondii aminopeptidase n, putative 0.0039 0.063 0.4448
Loa Loa (eye worm) hypothetical protein 0.0143 0.2583 0.4198
Echinococcus multilocularis musashi 0.0032 0.0499 0.0436
Schistosoma mansoni hypothetical protein 0.0018 0.0254 0.0288
Schistosoma mansoni smad1 5 8 and 0.001 0.0088 0.0099
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.011 0.1956 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0039 0.063 0.1013
Schistosoma mansoni inositol monophosphatase 0.0043 0.0716 0.081
Schistosoma mansoni smad 0.001 0.0088 0.0099
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0255 0.036
Toxoplasma gondii aminopeptidase N, putative 0.0039 0.063 0.4448
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0716 0.3486
Loa Loa (eye worm) hypothetical protein 0.0018 0.0254 0.0401
Loa Loa (eye worm) hypothetical protein 0.0032 0.0499 0.0799
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0255 0.019
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0716 0.0655
Schistosoma mansoni TGF-beta signal transducer Smad2 0.001 0.0088 0.0099
Brugia malayi Peptidase family M1 containing protein 0.011 0.1956 0.2843
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0039 0.063 0.0568
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0039 0.063 0.2202
Loa Loa (eye worm) hypothetical protein 0.0015 0.0194 0.0303
Loa Loa (eye worm) hypothetical protein 0.0039 0.063 0.1013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0254 0.019
Loa Loa (eye worm) hypothetical protein 0.0071 0.1237 0.2003
Loa Loa (eye worm) Smad1 0.001 0.0088 0.0129
Schistosoma mansoni hypothetical protein 0.0018 0.0254 0.0288
Onchocerca volvulus Huntingtin homolog 0.0143 0.2583 0.3276
Brugia malayi Peptidase family M1 containing protein 0.0039 0.063 0.0907
Brugia malayi TATA binding protein associated factor 0.0039 0.063 0.0907
Echinococcus granulosus aminopeptidase N 0.0372 0.6862 0.6841
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0716 0.271
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0071 0.1237 0.14
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.011 0.1956 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.011 0.1956 0.1903
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0254 0.019
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0039 0.063 0.2202
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0254 0.0359
Toxoplasma gondii aminopeptidase N protein 0.0039 0.063 0.4448
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0039 0.063 0.0713
Trypanosoma brucei aminopeptidase, putative 0.0039 0.063 0.2202
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0102 0.0136
Trypanosoma cruzi aminopeptidase, putative 0.0039 0.063 0.2202
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.011 0.1956 1
Brugia malayi MH1 domain containing protein 0.001 0.0088 0.0116
Brugia malayi intermediate filament protein 0.0032 0.0499 0.0715
Loa Loa (eye worm) hypothetical protein 0.0263 0.4816 0.7837
Echinococcus granulosus smad 0.001 0.0088 0.0022
Echinococcus granulosus intermediate filament protein 0.0032 0.0499 0.0436
Loa Loa (eye worm) hypothetical protein 0.0334 0.6143 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.063 0.1013
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0537 0.0862
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0255 0.0288
Echinococcus multilocularis cpg binding protein 0.0035 0.0572 0.051
Loa Loa (eye worm) MH2 domain-containing protein 0.001 0.0088 0.0129
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0632 0.5
Loa Loa (eye worm) hypothetical protein 0.0071 0.1237 0.2003
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0194 0.0129
Echinococcus granulosus puromycin sensitive aminopeptidase 0.011 0.1956 0.1903
Echinococcus multilocularis GPCR, family 2 0.0018 0.0254 0.019
Loa Loa (eye worm) hypothetical protein 0.004 0.0654 0.1052
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0254 0.0401
Echinococcus multilocularis lamin dm0 0.0032 0.0499 0.0436
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0255 0.019
Schistosoma mansoni aminopeptidase A (M01 family) 0.0039 0.063 0.0713
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.011 0.1956 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0104 0.0038
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.063 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0255 0.019
Schistosoma mansoni smad1 5 8 and 0.001 0.0088 0.0099
Echinococcus granulosus TGF beta signal transducer SmadC 0.001 0.0088 0.0022
Schistosoma mansoni smad1 5 8 and 0.001 0.0088 0.0099
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0254 0.019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.1097 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0716 0.271
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0039 0.063 0.1013
Onchocerca volvulus Huntingtin homolog 0.0143 0.2583 0.3276
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.011 0.1956 0.2215
Echinococcus multilocularis lamin 0.0032 0.0499 0.0436
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0039 0.063 0.2202
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0039 0.063 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.011 0.1956 0.1903
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0998 0.1613
Brugia malayi MH2 domain containing protein 0.001 0.0088 0.0116
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0039 0.063 0.3032
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0039 0.063 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0039 0.063 0.2202
Loa Loa (eye worm) peptidase family M1 containing protein 0.0301 0.5535 0.901

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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