TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.513 | Formula: C17H24N2O4S2
H donors: 2 H acceptors: 4 LogP: 1.81 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCC(NC(=O)CCS(=O)(=O)c1ccc2c(c1)NC(=O)C(S2)C)(C)C
InChi: 1S/C17H24N2O4S2/c1-5-17(3,4)19-15(20)8-9-25(22,23)12-6-7-14-13(10-12)18-16(21)11(2)24-14/h6-7,10-11H,5,8-9H2,1-4H3,(H,18,21)(H,19,20)
InChiKey: GNGNZTYHBIMQIY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.009	0.1236	0.1236
Trypanosoma brucei	transcription factor BTF3, putative	0.0034	0.0253	0.1395
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0289	0.0289
Echinococcus granulosus	methionyl tRNA synthetase cytoplasmic	0.0025	0.0106	0.0106
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0124	0.1817	1
Trypanosoma cruzi	valyl-tRNA synthetase, putative	0.0042	0.0399	0.2196
Schistosoma mansoni	valine-tRNA ligase	0.0042	0.0399	0.0399
Echinococcus granulosus	geminin	0.0333	0.5447	0.5447
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0289	0.0289
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.009	0.1236	0.1986
Echinococcus granulosus	valyl tRNA synthetase	0.0042	0.0399	0.0399
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.009	0.1236	0.1236
Toxoplasma gondii	valyl-tRNA synthetase	0.0042	0.0399	0.052
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0102	0.0563
Mycobacterium ulcerans	leucyl-tRNA synthetase	0.0025	0.0106	0.038
Echinococcus multilocularis	transcription factor btf3	0.0034	0.0253	0.0253
Brugia malayi	isoleucyl-tRNA synthetase family protein	0.0119	0.1734	0.1734
Trypanosoma cruzi	hypothetical protein, conserved	0.0124	0.1817	1
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.073	0.073
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.009	0.1236	0.1236
Mycobacterium tuberculosis	Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase)	0.0042	0.0399	0.1431
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0478	0.7961	0.7961
Giardia lamblia	Rab geranylgeranyltransferase	0.0478	0.7961	1
Plasmodium vivax	valine--tRNA ligase, putative	0.0042	0.0399	0.0377
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.073	0.073
Leishmania major	basic transcription factor 3a, putative	0.0034	0.0253	0.1395
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0478	0.7961	0.7961
Mycobacterium tuberculosis	Possible DNA glycosylase	0.018	0.2788	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0289	0.0289
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.009	0.1236	0.1236
Loa Loa (eye worm)	isoleucyl-tRNA synthetase	0.0119	0.1734	0.1734
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0596	1	1
Toxoplasma gondii	hypothetical protein	0.0124	0.1817	0.3003
Giardia lamblia	Rab geranylgeranyltransferase	0.0124	0.1817	0.2282
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.009	0.1236	0.6802
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0596	1	1
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0124	0.1817	0.1817
Schistosoma mansoni	hypothetical protein	0.0333	0.5447	0.5447
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.009	0.1236	0.1236
Onchocerca volvulus		0.0124	0.1817	1
Giardia lamblia	Isoleucyl-tRNA synthetase	0.0119	0.1734	0.2178
Echinococcus granulosus	valyl tRNA synthetase	0.0042	0.0399	0.0399
Mycobacterium leprae	Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE)	0.018	0.2788	1
Echinococcus granulosus	leucyl tRNA synthetase	0.0042	0.0399	0.0399
Echinococcus multilocularis	isoleucyl tRNA synthetase, mitochondrial	0.0094	0.1293	0.1293
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0253	0.0253
Echinococcus multilocularis	valyl tRNA synthetase	0.0042	0.0399	0.0399
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.009	0.1236	0.1236
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0478	0.7961	0.7961
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0596	1	1
Trypanosoma cruzi	leucyl-tRNA synthetase, putative	0.0042	0.0399	0.2196
Toxoplasma gondii	isoleucyl-tRNA synthetase family protein	0.0119	0.1734	0.2858
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0596	1	1
Entamoeba histolytica	hypothetical protein	0.0034	0.0253	0.0253
Schistosoma mansoni	valine-tRNA ligase	0.0042	0.0399	0.0399
Brugia malayi	hypothetical protein	0.0025	0.0102	0.0102
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0478	0.7961	1
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.009	0.1236	0.1236
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.073	0.073
Trypanosoma brucei	lanosterol synthase	0.009	0.1236	0.6802
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0478	0.7961	0.7961
Echinococcus multilocularis	methionyl tRNA synthetase, cytoplasmic	0.0025	0.0106	0.0106
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0253	0.1395
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.009	0.1236	0.1986
Brugia malayi	isoleucyl-tRNA synthetase	0.0119	0.1734	0.1734
Echinococcus granulosus	isoleucyl tRNA synthetase, cytoplasmic	0.0119	0.1734	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0102	0.0102
Trypanosoma cruzi	hypothetical protein, conserved	0.009	0.1236	0.6802
Trypanosoma brucei	leucyl-tRNA synthetase, putative	0.0042	0.0399	0.2196
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0143	0.2151	0.2151
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.009	0.1236	0.1236
Loa Loa (eye worm)	hypothetical protein	0.009	0.1236	0.1236
Entamoeba histolytica	valyl tRNA synthetase, putative	0.0042	0.0399	0.0399
Mycobacterium tuberculosis	Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase)	0.018	0.2788	1
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.009	0.1236	0.1442
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1293	0.1293
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0106	0.0106
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.009	0.1236	0.1236
Trichomonas vaginalis	leucyl-tRNA synthetase, putative	0.0025	0.0106	0.0106
Leishmania major	geranylgeranyltransferase, putative	0.009	0.1236	0.6802
Wolbachia endosymbiont of Brugia malayi	isoleucyl-tRNA synthetase	0.0119	0.1734	0.5587
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.0399	0.0377
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0289	0.0289
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0124	0.1817	0.2181
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0124	0.1817	0.1817
Schistosoma mansoni	isoleucine--tRNA ligase	0.0119	0.1734	0.1734
Echinococcus multilocularis	geminin	0.0333	0.5447	0.5447
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0124	0.1817	1
Leishmania major	leucyl-tRNA synthetase, putative	0.0042	0.0399	0.2196
Loa Loa (eye worm)	hypothetical protein	0.0478	0.7961	0.7961
Schistosoma mansoni	methionine-tRNA synthetase	0.0025	0.0106	0.0106
Chlamydia trachomatis	valine--tRNA ligase	0.0042	0.0399	0.18
Entamoeba histolytica	isoleucyl-tRNA synthetase, putative	0.0119	0.1734	0.1734
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0102	0.0563
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0124	0.1817	0.1817
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1734	0.1734
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0354	0.5811	0.5811
Echinococcus granulosus	tar DNA binding protein	0.0061	0.073	0.073
Toxoplasma gondii	hypothetical protein	0.0354	0.5811	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0124	0.1817	1
Trichomonas vaginalis	isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative	0.0025	0.0106	0.0106
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.1733	0.1733
Leishmania major	valyl-tRNA synthetase, putative	0.0042	0.0399	0.2196
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0596	1	1
Giardia lamblia	Valine-tRNA ligase	0.0042	0.0399	0.0501
Plasmodium falciparum	valine--tRNA ligase, putative	0.0042	0.0399	0.0377
Loa Loa (eye worm)	TAR-binding protein	0.0061	0.073	0.073
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0061	0.073	0.073
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.009	0.1236	0.4432
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0596	1	1
Treponema pallidum	isoleucyl-tRNA synthetase	0.0119	0.1734	1
Chlamydia trachomatis	isoleucine--tRNA ligase	0.0119	0.1734	1
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0253	0.0253
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0124	0.1817	1
Trypanosoma cruzi	protein farnesyltransferase, putative	0.009	0.1236	0.6802
Trichomonas vaginalis	isoleucyl tRNA synthetase, putative	0.0119	0.1734	0.1734
Leishmania major	hypothetical protein, conserved	0.0025	0.0102	0.0563
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0124	0.1817	1
Toxoplasma gondii	isoleucyl-tRNA synthetase, putative	0.0042	0.0399	0.052
Onchocerca volvulus		0.0042	0.0399	0.1712
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0102	0.0563
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0478	0.7961	1
Trypanosoma cruzi	transcription factor btf3, putative	0.0034	0.0253	0.1395
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.009	0.1236	0.1236
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0253	0.0253
Leishmania major	farnesyltransferase beta subunit	0.009	0.1236	0.6802
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0596	1	1
Plasmodium vivax	isoleucine--tRNA ligase, putative	0.0119	0.1734	0.2076
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0124	0.1817	1
Plasmodium falciparum	basic transcription factor 3b, putative	0.0034	0.0253	0.0192
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0124	0.1817	0.1817
Echinococcus granulosus	transcription factor btf3	0.0034	0.0253	0.0253
Mycobacterium ulcerans	formamidopyrimidine-DNA glycosylase	0.018	0.2788	1
Trichomonas vaginalis	leucyl-tRNA synthetase, putative	0.0042	0.0399	0.0399
Trichomonas vaginalis	valyl-tRNA synthetase, putative	0.0025	0.0106	0.0106
Trypanosoma cruzi	valyl-tRNA synthetase, putative	0.0025	0.0106	0.0583
Echinococcus multilocularis	isoleucyl tRNA synthetase, cytoplasmic	0.0119	0.1734	0.1734
Loa Loa (eye worm)	RNA binding protein	0.0061	0.073	0.073
Trypanosoma cruzi	lanosterol synthase, putative	0.009	0.1236	0.6802
Brugia malayi	TAR-binding protein	0.0061	0.073	0.073
Plasmodium falciparum	isoleucine--tRNA ligase, putative	0.0119	0.1734	0.2076
Entamoeba histolytica	hypothetical protein	0.0036	0.0289	0.0289
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0124	0.1817	0.1817
Leishmania major	isoleucyl-tRNA synthetase, putative	0.0119	0.1734	0.9543
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.009	0.1236	0.1236
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.009	0.1236	0.6802
Toxoplasma gondii	tRNA synthetase, putative	0.0042	0.0399	0.052
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0399	0.0399
Toxoplasma gondii	leucyl-tRNA synthetase	0.0042	0.0399	0.052
Brugia malayi	Valyl-tRNA synthetase	0.0042	0.0399	0.0399
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0124	0.1817	1
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.009	0.1236	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0106	0.0106
Brugia malayi	MH2 domain containing protein	0.0119	0.1733	0.1733
Trypanosoma cruzi	lanosterol synthase, putative	0.009	0.1236	0.6802
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.073	0.073
Treponema pallidum	valyl-tRNA synthetase	0.0042	0.0399	0.18
Schistosoma mansoni	isoleucine--tRNA ligase	0.0119	0.1734	0.1734
Brugia malayi	RNA recognition motif domain containing protein	0.0061	0.073	0.073
Trypanosoma cruzi	protein farnesyltransferase, putative	0.009	0.1236	0.6802
Entamoeba histolytica	leucyl-tRNA synthetase, putative	0.0042	0.0399	0.0399
Mycobacterium leprae	isoleucyl-tRNA synthetase IleS	0.0119	0.1734	0.5587
Trypanosoma brucei	hypothetical protein, conserved	0.0124	0.1817	1
Mycobacterium ulcerans	valyl-tRNA synthetase	0.0042	0.0399	0.1431
Schistosoma mansoni	hypothetical protein	0.0036	0.0289	0.0289
Plasmodium vivax	geranylgeranyltransferase, putative	0.009	0.1236	0.1442
Echinococcus granulosus	leucyl tRNA synthetase	0.0042	0.0399	0.0399
Plasmodium vivax	basic transcription factor 3b, putative	0.0034	0.0253	0.0192
Wolbachia endosymbiont of Brugia malayi	formamidopyrimidine-DNA glycosylase	0.018	0.2788	1
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0124	0.1817	0.1817
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.009	0.1236	0.1986
Schistosoma mansoni	tar DNA-binding protein	0.0061	0.073	0.073
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0478	0.7961	0.7961
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.009	0.1236	0.1236
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0478	0.7961	0.7961
Schistosoma mansoni	hypothetical protein	0.0333	0.5447	0.5447
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.009	0.1236	0.1236
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.009	0.1236	0.1442
Mycobacterium ulcerans	formamidopyrimidine-DNA glycosylase	0.018	0.2788	1
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.009	0.1236	0.1236
Toxoplasma gondii	NAC domain-containing protein	0.0034	0.0253	0.0265
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.1733	0.1733
Brugia malayi	leucyl-tRNA synthetase	0.0042	0.0399	0.0399
Entamoeba histolytica	hypothetical protein	0.0036	0.0289	0.0289
Trypanosoma brucei	isoleucyl-tRNA synthetase, putative	0.0119	0.1734	0.9543
Trypanosoma cruzi	hypothetical protein, conserved	0.009	0.1236	0.6802
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.009	0.1236	0.1236
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0478	0.7961	0.7961
Brugia malayi	valyl-tRNA synthetase family protein	0.0042	0.0399	0.0399
Giardia lamblia	Rab geranylgeranyltransferase	0.009	0.1236	0.1552
Brugia malayi	RNA binding protein	0.0061	0.073	0.073
Entamoeba histolytica	hypothetical protein	0.0036	0.0289	0.0289
Schistosoma mansoni	transcription factor btf3	0.0034	0.0253	0.0253
Plasmodium falciparum	valine--tRNA ligase, putative	0.0042	0.0399	0.0377
Entamoeba histolytica	transcription factor BTF3, putative	0.0034	0.0253	0.0253
Entamoeba histolytica	valyl-tRNA synthetase, putative	0.0042	0.0399	0.0399
Echinococcus multilocularis	leucyl tRNA synthetase	0.0042	0.0399	0.0399
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0124	0.1817	0.1817
Mycobacterium ulcerans	isoleucyl-tRNA synthetase	0.0119	0.1734	0.6218
Mycobacterium tuberculosis	Isoleucyl-tRNA synthetase IleS	0.0077	0.1001	0.3589
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0478	0.7961	0.7961
Giardia lamblia	Prenyltransferase	0.009	0.1236	0.1552
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.009	0.1236	0.1236
Trichomonas vaginalis	leucyl-tRNA synthetase, putative	0.0042	0.0399	0.0399
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.009	0.1236	0.1442
Plasmodium falciparum	leucine--tRNA ligase, putative	0.0042	0.0399	0.0377
Loa Loa (eye worm)	ICD-1 protein	0.0034	0.0253	0.0253
Brugia malayi	beta-NAC-like protein	0.0034	0.0253	0.0253
Onchocerca volvulus		0.0094	0.1293	0.6942
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0124	0.1817	1
Trypanosoma cruzi	isoleucyl-tRNA synthetase, putative	0.0119	0.1734	0.9543
Echinococcus multilocularis	valyl tRNA synthetase	0.0042	0.0399	0.0399
Plasmodium falciparum	isoleucine--tRNA ligase, putative	0.0222	0.3521	0.435
Toxoplasma gondii	leucyl-tRNA synthetase (LeuRS2)	0.0042	0.0399	0.052
Echinococcus multilocularis	leucyl tRNA synthetase	0.0042	0.0399	0.0399
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.009	0.1236	0.6802
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.009	0.1236	0.1442
Echinococcus multilocularis	tar DNA binding protein	0.0061	0.073	0.073
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0124	0.1817	0.1817
Loa Loa (eye worm)	hypothetical protein	0.009	0.1236	0.1236
Echinococcus granulosus	isoleucyl trna synthetase mitochondrial	0.0094	0.1293	0.1293
Schistosoma mansoni	leucyl-tRNA synthetase	0.0042	0.0399	0.0399
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0124	0.1817	0.2181
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.009	0.1236	0.1236
Brugia malayi	hypothetical protein	0.0036	0.0289	0.0289
Plasmodium falciparum	geranylgeranyltransferase, putative	0.009	0.1236	0.1442
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0478	0.7961	0.7961
Trypanosoma brucei	valyl-tRNA synthetase, putative	0.0042	0.0399	0.2196

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 869313