Detailed information for compound 872456

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 376.741 | Formula: C18H11ClF2N2O3
  • H donors: 1 H acceptors: 2 LogP: 3.31 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)NC(=O)c1cn2CCOc3c2c(c1=O)c(Cl)cc3)F
  • InChi: 1S/C18H11ClF2N2O3/c19-11-2-4-14-16-15(11)17(24)10(8-23(16)5-6-26-14)18(25)22-13-7-9(20)1-3-12(13)21/h1-4,7-8H,5-6H2,(H,22,25)
  • InChiKey: DBRFMRVBPKRHOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0064 0.0251
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0203 0.1847
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0103 0.0407
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0182 0.1535 0.1534
Echinococcus granulosus expressed protein 0.0401 0.3477 0.3477
Loa Loa (eye worm) hypothetical protein 0.0118 0.0968 0.3827
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0106 0.0147
Schistosoma mansoni ATP-binding cassette transporter 0.0182 0.1535 0.2283
Entamoeba histolytica hypothetical protein 0.0039 0.0266 0.2526
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0959 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0021 0.0106 0.0105
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0959 1
Echinococcus multilocularis expressed protein 0.0401 0.3477 0.3477
Onchocerca volvulus 0.0039 0.0267 0.0451
Mycobacterium ulcerans glutaminase 0.0294 0.2526 0.6172
Echinococcus multilocularis carbonic anhydrase 0.0098 0.0792 0.0791
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0093 0.075 0.2965
Schistosoma mansoni tyrosine kinase 0.0093 0.075 0.1109
Loa Loa (eye worm) hypothetical protein 0.0093 0.075 0.2965
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0106 0.0297
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0103 0.0283
Brugia malayi intermediate filament protein 0.0029 0.018 0.0714
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0166
Echinococcus multilocularis Regulator of G protein signaling 20 0.0021 0.0106 0.0105
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0106 0.0105
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0106 0.0105
Echinococcus granulosus glutamate receptor 2 0.0275 0.2361 0.236
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0106 0.0105
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0106 0.0147
Schistosoma mansoni lipoxygenase 0.0108 0.0884 0.131
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0103 0.1214
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0417
Schistosoma mansoni hypothetical protein 0.0098 0.0792 0.1172
Echinococcus multilocularis glutamate receptor NMDA 0.0489 0.4259 0.4259
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0648 0.5664 0.5664
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0106 0.0147
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0064 0.0185
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0266 0.0265
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0103 0.0283
Echinococcus granulosus RUN 0.0039 0.0267 0.0266
Schistosoma mansoni microtubule-associated protein tau 0.0677 0.5923 0.8844
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0275 0.2361 0.236
Schistosoma mansoni glutamate receptor kainate 0.0182 0.1535 0.2283
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0103 0.0096
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0417
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0959 0.3714
Echinococcus granulosus atrial natriuretic peptide receptor 0.0093 0.075 0.0749
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0127 0.0379
Loa Loa (eye worm) matrixin family protein 0.0261 0.2239 0.8862
Loa Loa (eye worm) intermediate filament protein 0.0029 0.018 0.0711
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0106 0.0147
Loa Loa (eye worm) glutaminase 0.0294 0.2526 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0792 0.3132
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0209 0.1772 0.7013
Onchocerca volvulus 0.0029 0.018 0.0034
Schistosoma mansoni carbonic anhydrase-related 0.0098 0.0792 0.1172
Trypanosoma brucei carbonic anhydrase-like protein 0.0209 0.1772 1
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0064 0.0251
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0417
Schistosoma mansoni ap endonuclease 0.002 0.0103 0.0142
Echinococcus granulosus geminin 0.0182 0.1537 0.1536
Brugia malayi hypothetical protein 0.0039 0.0266 0.1054
Echinococcus multilocularis glutamate receptor 2 0.0093 0.075 0.0749
Onchocerca volvulus 0.0029 0.018 0.0034
Schistosoma mansoni lamin 0.0029 0.018 0.0258
Echinococcus granulosus carbonic anhydrase 0.0098 0.0792 0.0791
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0267 0.0266
Toxoplasma gondii hypothetical protein 0.0098 0.0792 1
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0143 0.1195 0.473
Loa Loa (eye worm) glutamate receptor 0.0093 0.075 0.2965
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0061 0.0243
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0266 0.0265
Echinococcus multilocularis NMDA receptor 0.0182 0.1535 0.1534
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0203 0.0686
Entamoeba histolytica hypothetical protein 0.0039 0.0266 0.2526
Loa Loa (eye worm) hypothetical protein 0.0093 0.075 0.2965
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0466 0.4053 1
Schistosoma mansoni glutamate receptor kainate 0.0182 0.1535 0.2283
Loa Loa (eye worm) glutaminase 2 0.0294 0.2526 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.018 0.0714
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0203 0.2496
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0106 0.0147
Schistosoma mansoni glutaminase 0.0294 0.2526 0.3765
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0127 0.0502
Echinococcus granulosus glutamate NMDA receptor subunit 0.0182 0.1535 0.1534
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0098 0.0792 0.3134
Schistosoma mansoni carbonic anhydrase-related 0.0098 0.0792 0.1172
Brugia malayi Receptor family ligand binding region containing protein 0.0093 0.075 0.2968
Schistosoma mansoni protein kinase 0.0093 0.075 0.1109
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0093 0.075 0.0749
Echinococcus multilocularis regulator of G protein signaling 0.0021 0.0106 0.0105
Schistosoma mansoni loxhd1 0.0039 0.0267 0.0387
Loa Loa (eye worm) hypothetical protein 0.0018 0.0086 0.0336
Schistosoma mansoni lipoxygenase 0.0039 0.0267 0.0387
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0021 0.0106 0.0105
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0959 0.3714
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.018 0.0711
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0106 0.0297
Echinococcus multilocularis axis inhibition protein axin 0.0021 0.0106 0.0105
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0108 0.0884 0.0883
Brugia malayi Guanylyl cyclase protein 23 0.0093 0.075 0.2968
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0093 0.075 0.2968
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0203 0.0686
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0106 0.0417
Schistosoma mansoni intermediate filament proteins 0.0029 0.018 0.0258
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0117 0.0959 0.2166
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0093 0.075 0.279
Loa Loa (eye worm) RGC/RGC protein kinase 0.0093 0.075 0.2965
Schistosoma mansoni hypothetical protein 0.0182 0.1535 0.2283
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0203 0.0686
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0106 0.0421
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0182 0.1535 0.1534
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0102 0.1207
Echinococcus granulosus glutamate receptor subunit protein glur 0.0182 0.1535 0.1534
Loa Loa (eye worm) hypothetical protein 0.0028 0.0176 0.0692
Echinococcus multilocularis musashi 0.0029 0.018 0.018
Brugia malayi 6-phosphofructokinase 0.0117 0.0959 0.3794
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0209 0.1772 1
Brugia malayi hypothetical protein 0.0021 0.0106 0.0421
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0466 0.4053 1
Echinococcus multilocularis glutamate receptor 2 0.0275 0.2361 0.236
Schistosoma mansoni hypothetical protein 0.0401 0.348 0.5191
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0108 0.0884 0.0883
Loa Loa (eye worm) glutamate receptor 1 0.0182 0.1535 0.6074
Loa Loa (eye worm) hypothetical protein 0.0118 0.0968 0.3827
Schistosoma mansoni hypothetical protein 0.0182 0.1537 0.2286
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0275 0.2361 0.236
Echinococcus multilocularis 6 phosphofructokinase 0.0117 0.0959 0.0958
Schistosoma mansoni hypothetical protein 0.0039 0.0266 0.0387
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0021 0.0106 0.0147
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0959 0.5326
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.00000000048702
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0021 0.0106 0.0297
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0093 0.075 0.0749
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0103 0.0405
Onchocerca volvulus Matrix metalloproteinase homolog 0.0261 0.2239 1
Loa Loa (eye worm) glutamate receptor 2 0.0182 0.1535 0.6074
Schistosoma mansoni z-protein (S1r protein) 0.0021 0.0106 0.0147
Brugia malayi Glutamate receptor 2 precursor 0.0182 0.1535 0.6076
Brugia malayi A-kinase anchor protein 10, precursor 0.0021 0.0106 0.0421
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0203 0.0686
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0021 0.0106 0.0105
Onchocerca volvulus 0.0167 0.1404 0.5957
Echinococcus granulosus carbonic anhydrase 0.0098 0.0792 0.0791
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0203 1
Echinococcus granulosus glutamate receptor 2 0.0093 0.075 0.0749
Schistosoma mansoni cpg binding protein 0.003 0.0188 0.0269
Loa Loa (eye worm) RGS-3 protein 0.0021 0.0106 0.0417
Leishmania major ATP-dependent phosphofructokinase 0.0117 0.0959 0.5326
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0209 0.1772 1
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0106 0.0147
Loa Loa (eye worm) hypothetical protein 0.0093 0.075 0.2965
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.003
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0026
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0008 0.0026
Loa Loa (eye worm) PXA domain-containing protein 0.0021 0.0106 0.0417
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0103 0.0761
Echinococcus multilocularis carbonic anhydrase 0.0098 0.0792 0.0791
Leishmania major carbonic anhydrase-like protein 0.0209 0.1772 1
Echinococcus multilocularis geminin 0.0182 0.1537 0.1536
Brugia malayi Matrixin family protein 0.0118 0.0968 0.383
Brugia malayi metabotropic glutamate receptor type 2 0.0093 0.075 0.2968
Brugia malayi Matrixin family protein 0.0118 0.0968 0.383
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0106 0.0297
Brugia malayi 6-phosphofructokinase 0.0117 0.0959 0.3794
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0093 0.075 0.2965
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0106 0.0147
Echinococcus granulosus tyrosine kinase 0.0093 0.075 0.0749
Loa Loa (eye worm) hypothetical protein 0.0093 0.075 0.2965
Loa Loa (eye worm) hypothetical protein 0.0093 0.075 0.2965
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0106 0.0147
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0048 0.0047
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0103 0.0102
Brugia malayi glutaminase DH11.1 0.0294 0.2526 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0061 0.0239
Loa Loa (eye worm) matrixin family protein 0.0285 0.2447 0.9688
Schistosoma mansoni rab6-interacting 0.0039 0.0267 0.0387
Brugia malayi hypothetical protein 0.0093 0.075 0.2968
Brugia malayi Metabotropic glutamate receptor precursor. 0.0093 0.075 0.2968
Echinococcus granulosus metabotropic glutamate receptor 5 0.0093 0.075 0.0749
Echinococcus granulosus microtubule associated protein 2 0.0677 0.5923 0.5923
Brugia malayi Glutamate receptor 1 precursor 0.0182 0.1535 0.6076
Entamoeba histolytica hypothetical protein 0.0021 0.0106 0.0798
Entamoeba histolytica hypothetical protein 0.0021 0.0106 0.0798
Onchocerca volvulus 0.0093 0.075 0.279
Echinococcus multilocularis lamin dm0 0.0029 0.018 0.018
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0959 0.1422
Echinococcus granulosus lamin dm0 0.0029 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0417
Onchocerca volvulus 0.0039 0.0267 0.0451
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0203 0.6921
Schistosoma mansoni carbonic anhydrase 0.0098 0.0792 0.1172
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0466 0.4053 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0106 0.0105
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0098 0.0792 0.3134
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0106 0.0105
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0267 0.1052
Brugia malayi CXXC zinc finger family protein 0.0028 0.0173 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0106 0.0297
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0203 0.0686
Loa Loa (eye worm) hypothetical protein 0.0093 0.075 0.2965
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0106 0.0147
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0959 0.3792
Onchocerca volvulus 0.0093 0.075 0.279
Echinococcus granulosus nmda type glutamate receptor 0.0583 0.5085 0.5085
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0275 0.2361 0.236
Schistosoma mansoni hypothetical protein 0.0167 0.1404 0.2087
Entamoeba histolytica hypothetical protein 0.0021 0.0106 0.0798
Brugia malayi hypothetical protein 0.0039 0.0267 0.1055
Echinococcus granulosus intermediate filament protein 0.0029 0.018 0.018
Schistosoma mansoni lamin 0.0029 0.018 0.0258
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0106 0.0105
Echinococcus granulosus carbonic anhydrase 0.0098 0.0792 0.0791
Trichomonas vaginalis glutaminase, putative 0.0294 0.2526 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0417
Echinococcus granulosus carbonic anhydrase II 0.0209 0.1772 0.1771
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0008 0.0007
Echinococcus multilocularis nmda type glutamate receptor 0.1137 1 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0267 0.1052
Loa Loa (eye worm) hypothetical protein 0.0093 0.075 0.2965
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0182 0.1535 0.1534
Loa Loa (eye worm) hypothetical protein 0.0098 0.0792 0.3132
Schistosoma mansoni tyrosine kinase 0.0093 0.075 0.1109
Brugia malayi Receptor family ligand binding region containing protein 0.0093 0.075 0.2968
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0117 0.0959 0.2166
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0103 0.2029
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0209 0.1772 0.2637
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0267 0.0266
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0203 0.2496
Mycobacterium ulcerans 6-phosphofructokinase 0.0117 0.0959 0.2242
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0127 0.0379
Loa Loa (eye worm) 6-phosphofructokinase 0.0117 0.0959 0.3792
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0098 0.0792 0.3132
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0355 0.3072 1
Echinococcus granulosus lamin 0.0029 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0098 0.0792 0.3132
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0203 0.2496
Brugia malayi Cytochrome P450 family protein 0.0016 0.0064 0.0255
Echinococcus granulosus cpg binding protein 0.003 0.0188 0.0187
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0266 0.0387
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0064 0.0185
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0098 0.0792 0.3134
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0021 0.0106 0.0147
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0397 0.4963
Entamoeba histolytica hypothetical protein 0.0093 0.075 0.7745
Loa Loa (eye worm) matrix metalloproteinase 0.0118 0.0968 0.3827
Schistosoma mansoni polycystin 1-related 0.007 0.0543 0.0801
Brugia malayi Matrixin family protein 0.0118 0.0968 0.383
Brugia malayi Hemopexin family protein 0.0167 0.1404 0.5557
Echinococcus granulosus glutamate receptor NMDA 0.0489 0.4259 0.4259
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0428 0.3719 0.3718
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0008 0.0007
Schistosoma mansoni glutamate receptor kainate 0.0182 0.1535 0.2283
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0093 0.075 0.2965
Schistosoma mansoni 6-phosphofructokinase 0.0117 0.0959 0.1422
Trypanosoma cruzi extracellular receptor, putative 0.0093 0.075 0.4125
Echinococcus multilocularis tyrosine kinase 0.0093 0.075 0.0749
Echinococcus granulosus regulator of G protein signaling 3 0.0021 0.0106 0.0105
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0275 0.2361 0.236
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0203 0.2496
Brugia malayi hypothetical protein 0.0039 0.0267 0.1055
Brugia malayi regulator of G-protein signaling egl-10 0.0021 0.0106 0.0421
Leishmania major extracellular receptor, putative 0.0093 0.075 0.4125
Brugia malayi PXA domain containing protein 0.0021 0.0106 0.0421
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0275 0.2361 0.236
Echinococcus granulosus dnaJ subfamily B 0.0401 0.348 0.3479
Echinococcus granulosus 6 phosphofructokinase 0.0117 0.0959 0.0958
Brugia malayi Cytochrome P450 family protein 0.0016 0.0064 0.0255
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0015 0.0059 0.0662
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0064 0.0251
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0098 0.0792 0.3134
Brugia malayi hypothetical protein 0.0021 0.0106 0.0421
Loa Loa (eye worm) hypothetical protein 0.0093 0.075 0.2965
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0203 0.6921
Toxoplasma gondii exonuclease III APE 0.002 0.0103 0.1214
Echinococcus granulosus receptor type guanylyl cyclase 0.0093 0.075 0.0749
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0959 0.3714
Loa Loa (eye worm) RGC/RGC protein kinase 0.0093 0.075 0.2965
Schistosoma mansoni hypothetical protein 0.0039 0.0267 0.0387
Schistosoma mansoni hypothetical protein 0.0182 0.1537 0.2286
Plasmodium falciparum carbonic anhydrase 0.0098 0.0792 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0275 0.2361 0.236
Schistosoma mansoni glutamate receptor NMDA 0.0182 0.1535 0.2283
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0203 0.0686
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0203 0.0254
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0267 0.0266
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0203 0.2496
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0106 0.0417
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0097 0.0786 0.1164
Brugia malayi Matrixin family protein 0.0118 0.0968 0.383
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0106 0.0105
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.348 0.3479
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0182 0.1535 0.1534
Loa Loa (eye worm) RGC/RGC protein kinase 0.0093 0.075 0.2965
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0103 0.0403
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0267 0.0266
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0203 0.0686
Schistosoma mansoni metabotropic glutamate receptor 0.0093 0.075 0.1109
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0084 0.0114
Loa Loa (eye worm) hypothetical protein 0.0029 0.018 0.0711
Echinococcus multilocularis carbonic anhydrase II 0.0209 0.1772 0.1771
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0209 0.1772 0.7012
Schistosoma mansoni metabotropic glutamate receptor 0.0093 0.075 0.1109
Trichomonas vaginalis phosphofructokinase, putative 0.0117 0.0959 0.3714
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0428 0.3719 0.3718
Entamoeba histolytica phosphofructokinase, putative 0.0117 0.0959 1
Schistosoma mansoni cpg binding protein 0.003 0.0188 0.0269
Loa Loa (eye worm) carbonic anhydrase 3 0.0209 0.1772 0.7012
Onchocerca volvulus 0.0118 0.0968 0.3845
Schistosoma mansoni regulator of G protein signaling 0.0021 0.0106 0.0147
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0466 0.4053 1
Echinococcus multilocularis carbonic anhydrase 0.0098 0.0792 0.0791
Loa Loa (eye worm) hypothetical protein 0.0118 0.0968 0.3827
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0098 0.0792 0.3134
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0117 0.0959 0.5326
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0106 0.0297
Schistosoma mansoni ap endonuclease 0.002 0.0103 0.0142
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0106 0.0421
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0093 0.075 0.2965
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0021 0.0106 0.0417
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0182 0.1535 0.1534
Schistosoma mansoni cpg binding protein 0.0028 0.0173 0.0248
Schistosoma mansoni glutamate receptor AMPA 0.0182 0.1535 0.2283
Schistosoma mansoni axis inhibition protein axin 0.0021 0.0106 0.0147
Echinococcus multilocularis cpg binding protein 0.003 0.0188 0.0187
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0103 0.0405
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0209 0.1772 0.7013
Schistosoma mansoni glutamate receptor NMDA 0.0764 0.6696 1
Schistosoma mansoni glutamate receptor AMPA 0.0182 0.1535 0.2283
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0093 0.075 0.0749
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0453 0.0666
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0267 1
Mycobacterium ulcerans hydrolase 0.0143 0.1195 0.2834
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0103 0.0405
Echinococcus multilocularis nmda type glutamate receptor 0.0583 0.5085 0.5085
Brugia malayi Regulator of G protein signaling domain containing protein 0.0021 0.0106 0.0421
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0103 0.4864
Echinococcus multilocularis receptor type guanylyl cyclase 0.0093 0.075 0.0749
Entamoeba histolytica hypothetical protein 0.0039 0.0266 0.2526
Echinococcus granulosus regulator of G protein signaling 7 0.0021 0.0106 0.0105
Echinococcus granulosus metabotropic glutamate receptor 2 0.0093 0.075 0.0749
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0267 0.0266
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0466 0.4053 1
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0106 0.0105
Brugia malayi phosphofructokinase 0.0117 0.0959 0.3794
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0143 0.1195 0.2765
Schistosoma mansoni carbonic anhydrase-related 0.0098 0.0792 0.1172
Loa Loa (eye worm) phosphofructokinase 0.0117 0.0959 0.3792
Mycobacterium leprae PROBABLE HYDROLASE 0.0143 0.1195 1
Chlamydia trachomatis glutamine binding protein 0.0466 0.4053 1
Brugia malayi Matrixin family protein 0.0285 0.2447 0.9688
Onchocerca volvulus Matrilysin homolog 0.0261 0.2239 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0106 0.0417
Brugia malayi PXA domain containing protein 0.0021 0.0106 0.0421
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0182 0.1535 0.1534
Loa Loa (eye worm) hypothetical protein 0.0039 0.0267 0.1052
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0064 0.0185
Onchocerca volvulus Matrilysin homolog 0.0118 0.0968 0.3845
Echinococcus multilocularis RUN 0.0039 0.0267 0.0266
Loa Loa (eye worm) hypothetical protein 0.0013 0.0043 0.0166
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0048 0.0047
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0182 0.1535 0.1534
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0008 0.0007
Brugia malayi regulator of G-protein signaling rgs-7 0.0021 0.0106 0.0421
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0118 0.0968 0.1435
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0267 0.0266
Loa Loa (eye worm) hypothetical protein 0.0143 0.1195 0.4728
Echinococcus multilocularis regulator of G protein signaling 3 0.0021 0.0106 0.0105
Entamoeba histolytica hypothetical protein 0.0039 0.0266 0.2526
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0103 0.0405
Echinococcus granulosus axis inhibition protein axin 0.0021 0.0106 0.0105
Brugia malayi Doublecortin family protein 0.0039 0.0267 0.1055
Schistosoma mansoni rab6-interacting 0.0039 0.0267 0.0387
Echinococcus multilocularis regulator of G protein signaling 7 0.0021 0.0106 0.0105
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0008 0.003
Echinococcus multilocularis lamin 0.0029 0.018 0.018
Leishmania major cytochrome p450-like protein 0.0016 0.0064 0.0185
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0275 0.2361 0.236
Echinococcus granulosus bloom syndrome protein 0.0023 0.0127 0.0126
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0209 0.1772 0.2637
Echinococcus multilocularis glutamate receptor 2 0.0182 0.1535 0.1534
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0127 0.0126
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0173 0.0683
Loa Loa (eye worm) hypothetical protein 0.0014 0.0048 0.0185
Loa Loa (eye worm) RecQ helicase 0.0023 0.0127 0.0499
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0103 0.0102
Echinococcus multilocularis microtubule associated protein 2 0.0677 0.5923 0.5923
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0267 0.3302
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0106 0.0297
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0275 0.2361 0.236

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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