TDR Targets

Basic information

Technical information

TDR Targets ID: 879249
Name: 1-[2-[3-(5-chloro-1,3-dimethylpyrazol-4-yl)pr op-2-enoyl]pyrazolidin-1-yl]pent-4-yn-1-one
MW: 334.801 | Formula: C16H19ClN4O2
H donors: 0 H acceptors: 3 LogP: 1.81 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: C#CCCC(=O)N1CCCN1C(=O)C=Cc1c(C)nn(c1Cl)C
InChi: 1S/C16H19ClN4O2/c1-4-5-7-14(22)20-10-6-11-21(20)15(23)9-8-13-12(2)18-19(3)16(13)17/h1,8-9H,5-7,10-11H2,2-3H3/b9-8+
InChiKey: FNXCMQZPJSJNQZ-CMDGGOBGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[2-[3-(5-chloro-1,3-dimethyl-pyrazol-4-yl)prop-2-enoyl]pyrazolidin-1-yl]pent-4-yn-1-one
1-[2-[3-(5-chloro-1,3-dimethyl-4-pyrazolyl)-1-oxoprop-2-enyl]-1-pyrazolidinyl]pent-4-yn-1-one
1-[2-[3-(5-chloro-1,3-dimethyl-pyrazol-4-yl)acryloyl]pyrazolidin-1-yl]pent-4-yn-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0172	0.0098
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0172	0.0098
Trypanosoma cruzi	casein kinase II, putative	0.0069	0.0695	1
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Schistosoma mansoni	hypothetical protein	0.0031	0.0197	0.0124
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0142	0.1672	0.161
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0197	0.0124
Trypanosoma brucei	STE group serine/threonine-protein kinase, putative	0.0044	0.0363	0.4657
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0124	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0089	0.0111
Echinococcus granulosus	sodium coupled monocarboxylate transporter 1	0.0044	0.0374	0.0302
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	CMGC family protein kinase	0.0069	0.0695	0.1588
Loa Loa (eye worm)	hypothetical protein	0.004	0.0321	0.0447
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.004	0.0321	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0172	0.0231
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0321	0.0631
Plasmodium vivax	casein kinase 2, alpha subunit, putative	0.0069	0.0695	0.2921
Loa Loa (eye worm)	MH1 domain-containing protein	0.0024	0.0107	0.0137
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Mycobacterium leprae	Possible transporter protein	0.004	0.0321	0.1024
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0089	0.0194
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0142	0.1672	0.161
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0321	0.0631
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0321	0.0631
Echinococcus granulosus	GPCR family 2	0.0031	0.0197	0.0124
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0321	0.0248
Mycobacterium ulcerans	1-deoxy-D-xylulose-5-phosphate synthase	0.0193	0.2348	0.5886
Schistosoma mansoni	transcription factor LCR-F1	0.0142	0.1672	0.161
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0321	0.0248
Brugia malayi	MH2 domain containing protein	0.0024	0.0107	0.0149
Schistosoma mansoni	protein kinase	0.0069	0.0695	0.0625
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Schistosoma mansoni	hypothetical protein	0.004	0.0321	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0403	0.5121	0.74
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.1086	0.1565
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0089	0.038
Chlamydia trachomatis	1-deoxy-D-xylulose-5-phosphate synthase	0.0193	0.2348	1
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0321	0.0631
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.2479	0.3573
Echinococcus multilocularis	sodium coupled monocarboxylate transporter 1	0.0044	0.0374	0.0302
Brugia malayi	MH2 domain containing protein	0.0356	0.4502	0.6508
Echinococcus multilocularis	sodium:myo inositol cotransporter	0.0044	0.0374	0.0302
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0107	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0321	0.0631
Trichomonas vaginalis	adenylyl cyclase type V, putative	0.004	0.0321	0.0631
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0197	0.0124
Schistosoma mansoni	hypothetical protein	0.011	0.124	0.1174
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0156	0.1848	0.2659
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	adenylate cyclase type, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	adenylate cyclase type vIII, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0089	0.0244
Brugia malayi	GH02984p	0.0403	0.5121	0.7404
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Echinococcus multilocularis	smad	0.0024	0.0107	0.0033
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0321	0.0248
Schistosoma mansoni	high-affinity choline transporter	0.0403	0.5121	0.5085
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.004	0.0321	0.0631
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.004	0.0321	0.0248
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0156	0.1848	0.1787
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0074	0.0264
Brugia malayi	Pre-SET motif family protein	0.0029	0.0172	0.0243
Schistosoma mansoni	hypothetical protein	0.0031	0.0197	0.0124
Trichomonas vaginalis	guanylate cyclase beta 1 subunit, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0321	0.0248
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0172	0.0098
Entamoeba histolytica	hypothetical protein	0.0142	0.1672	1
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Brugia malayi	Pre-SET motif family protein	0.0203	0.2479	0.3581
Echinococcus multilocularis	solute carrier family 5	0.0044	0.0374	0.0302
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0089	0.0124
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0197	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0321	0.0631
Echinococcus multilocularis	high affinity choline transporter 1	0.0403	0.5121	0.5085
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0024	0.0107	0.0033
Brugia malayi	glutaminase DH11.1	0.0317	0.3982	0.5755
Mycobacterium ulcerans	glutaminase	0.0317	0.3982	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0089	0.0194
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Entamoeba histolytica	hypothetical protein	0.0142	0.1672	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.011	0.124	0.1788
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0674	0.0959
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.004	0.0321	0.0458
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0374	0.0524
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0107	0.0033
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.1086	0.1565
Toxoplasma gondii	transporter, solute:sodium symporter (SSS) family protein	0.0044	0.0374	0.1318
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0321	0.0631
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0089	0.0194
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0089	0.0095
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0172	0.0098
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0197	0.0267
Echinococcus granulosus	single minded 2	0.004	0.0321	0.0248
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0074	0.0102
Trichomonas vaginalis	adenylate cyclase type, putative	0.004	0.0321	0.0631
Echinococcus granulosus	smad	0.0024	0.0107	0.0033
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0024	0.0107	0.0033
Trichomonas vaginalis	CMGC family protein kinase	0.0069	0.0695	0.1588
Brugia malayi	Casein kinase II, alpha chain	0.0069	0.0695	0.1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Schistosoma mansoni	hypothetical protein	0.0031	0.0197	0.0124
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0124	0.0161
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0156	0.1848	0.1787
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0321	0.0631
Toxoplasma gondii	CMGC kinase, CK2 family	0.0069	0.0695	0.2729
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0124	0.08
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	CMGC family protein kinase	0.0069	0.0695	0.1588
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0089	0.0194
Schistosoma mansoni	microtubule-associated protein tau	0.0771	1	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.004	0.0321	0.0631
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0089	0.0194
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0157	0.0084
Loa Loa (eye worm)	glutaminase	0.0317	0.3982	0.575
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0124	0.0476
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.0074	0.0315
Entamoeba histolytica	casein kinase, putative	0.0069	0.0695	0.3883
Onchocerca volvulus		0.0231	0.2851	0.5464
Schistosoma mansoni	hypothetical protein	0.0142	0.1672	0.161
Trichomonas vaginalis	CMGC family protein kinase	0.0069	0.0695	0.1588
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0172	0.0098
Trichomonas vaginalis	adenylate cyclase type, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0321	0.0631
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.0074	0.0264
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.004	0.0321	0.0631
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0012	0.0053
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate synthase	0.0193	0.2348	1
Echinococcus multilocularis	Smad4	0.0024	0.0107	0.0033
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0089	0.0111
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	CMGC family protein kinase	0.0069	0.0695	0.1588
Brugia malayi	hypothetical protein	0.0142	0.1672	0.2414
Brugia malayi	MH1 domain containing protein	0.0024	0.0107	0.0149
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0197	0.0124
Trichomonas vaginalis	glutaminase, putative	0.0317	0.3982	1
Loa Loa (eye worm)	CAMK/CAMKL/PASK protein kinase	0.0404	0.5144	0.7433
Plasmodium vivax	SET domain protein, putative	0.0029	0.0172	0.0682
Leishmania major	hypothetical protein, conserved	0.0026	0.0124	0.08
Brugia malayi	hypothetical protein	0.0026	0.0124	0.0173
Entamoeba histolytica	hypothetical protein	0.0142	0.1672	1
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Schistosoma mansoni	inositol transporter	0.0044	0.0374	0.0302
Leishmania major	casein kinase II, putative	0.0069	0.0695	1
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.004	0.0321	0.0631
Echinococcus granulosus	solute carrier family 5	0.0044	0.0374	0.0302
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0089	0.0124
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0156	0.1848	0.1787
Entamoeba histolytica	protein kinase domain containing protein	0.0069	0.0695	0.3883
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Brugia malayi	MH1 domain containing protein	0.0024	0.0107	0.0149
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.004	0.0321	0.0631
Onchocerca volvulus		0.0044	0.0374	0.0563
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0156	0.1848	0.1787
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0074	0.0089
Trichomonas vaginalis	adenylate cyclase type VI, putative	0.004	0.0321	0.0631
Loa Loa (eye worm)	MH2 domain-containing protein	0.0356	0.4502	0.6504
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0321	0.0631
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	CMGC family protein kinase	0.0069	0.0695	0.1588
Echinococcus granulosus	sodium:myo inositol cotransporter	0.0044	0.0374	0.0302
Schistosoma mansoni	hypothetical protein	0.0067	0.0674	0.0605
Loa Loa (eye worm)	MH2 domain-containing protein	0.0024	0.0107	0.0137
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0197	0.0124
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Giardia lamblia	Kinase, CMGC CK2	0.0069	0.0695	1
Echinococcus multilocularis	voltage gated potassium channel	0.004	0.0321	0.0248
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.004	0.0321	0.0631
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0197	0.0279
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.004	0.0321	0.0631
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0089	0.0244
Brugia malayi	Smad1	0.0024	0.0107	0.0149
Trichomonas vaginalis	adenylate and guanylate cyclases, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	hypothetical protein	0.004	0.0321	0.0631
Entamoeba histolytica	hypothetical protein	0.0142	0.1672	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0172	0.0429
Trypanosoma brucei	Casein kinase II	0.0069	0.0695	1
Toxoplasma gondii	1-deoxy-D-xylulose-5-phosphate synthase	0.0193	0.2348	1
Loa Loa (eye worm)	CMGC/CK2 protein kinase	0.0069	0.0695	0.0988
Schistosoma mansoni	hypothetical protein	0.0031	0.0197	0.0124
Schistosoma mansoni	sodium/solute symporter	0.0044	0.0374	0.0302
Trichomonas vaginalis	guanylate cyclase beta 2 subunit, putative	0.004	0.0321	0.0631
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0124	0.0476
Brugia malayi	Sodium:solute symporter family protein	0.0044	0.0374	0.0535
Plasmodium falciparum	casein kinase 2, alpha subunit	0.0069	0.0695	0.2921
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0089	0.0095
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0089	0.0124
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.004	0.0321	0.0631
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.0321	0.0248
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0172	0.0098
Schistosoma mansoni	smad1 5 8 and	0.0024	0.0107	0.0033
Echinococcus granulosus	Smad4	0.0024	0.0107	0.0033
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0197	0.0279
Trichomonas vaginalis	adenylate cyclase, putative	0.004	0.0321	0.0631
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0089	0.038
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0089	0.0095
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate synthase Dxs1 (1-deoxyxylulose-5-phosphate synthase) (DXP synthase) (DXPS)	0.0193	0.2348	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0024	0.0107	0.0033
Echinococcus granulosus	voltage gated potassium channel	0.004	0.0321	0.0248
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Echinococcus granulosus	sodium:glucose cotransporter 2	0.0044	0.0374	0.0302
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0089	0.0194
Echinococcus multilocularis	casein kinase ii subunit alpha	0.0069	0.0695	0.0625
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.004	0.0321	0.0631
Treponema pallidum	1-deoxy-D-xylulose-5-phosphate synthase	0.0193	0.2348	1
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.2851	0.7107
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0156	0.1848	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0538	0.6915	1
Onchocerca volvulus		0.0151	0.179	0.3366
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0156	0.1848	0.2669
Brugia malayi	hypothetical protein	0.0151	0.179	0.2585
Echinococcus granulosus	survival motor neuron protein 1	0.0538	0.6915	0.6892
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0674	0.097
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0124	0.0476
Trichomonas vaginalis	adenylate cyclase type IX, putative	0.004	0.0321	0.0631
Echinococcus granulosus	high affinity choline transporter 1	0.0403	0.5121	0.5085
Loa Loa (eye worm)	Smad1	0.0024	0.0107	0.0137
Echinococcus granulosus	sodium:glucose cotransporter	0.0044	0.0374	0.0302
Schistosoma mansoni	smad	0.0024	0.0107	0.0033
Trichomonas vaginalis	soluble guanylate cyclase gcy, putative	0.004	0.0321	0.0631
Loa Loa (eye worm)	transcription factor SMAD2	0.0356	0.4502	0.6504
Echinococcus multilocularis	microtubule associated protein 2	0.0771	1	1
Onchocerca volvulus		0.0404	0.5144	1
Brugia malayi	MH2 domain containing protein	0.0024	0.0107	0.0149
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0089	0.0194
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.1086	0.1555
Echinococcus multilocularis	survival motor neuron protein 1	0.0538	0.6915	0.6892
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0197	0.0267
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0089	0.0194
Schistosoma mansoni	inositol transporter	0.0044	0.0374	0.0302
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.0074	0.5
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE DXS1 (1-DEOXYXYLULOSE-5-PHOSPHATE SYNTHASE) (DXP SYNTHASE) (DXPS)	0.0193	0.2348	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0089	0.0244
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0124	0.08
Schistosoma mansoni	Smad4	0.0024	0.0107	0.0033
Echinococcus multilocularis	sodium:glucose cotransporter 2	0.0044	0.0374	0.0302
Trichomonas vaginalis	adenylate cyclase type III, putative	0.004	0.0321	0.0631
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0124	0.08
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate synthase, putative	0.0193	0.2348	1
Schistosoma mansoni	60S ribosomal protein L21	0.004	0.0321	0.0248
Schistosoma mansoni	survival motor neuron protein	0.011	0.124	0.1174
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.0074	0.0155
Echinococcus granulosus	casein kinase ii subunit alpha	0.0069	0.0695	0.0625
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0156	0.1848	0.1787
Onchocerca volvulus		0.0029	0.0172	0.0163
Trichomonas vaginalis	guanylate cyclase, putative	0.004	0.0321	0.0631
Loa Loa (eye worm)	glutaminase 2	0.0317	0.3982	0.575
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0156	0.1848	0.1787
Plasmodium vivax	unspecified product	0.0069	0.0695	0.2921
Schistosoma mansoni	glutaminase	0.0317	0.3982	0.3937
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0172	0.0098
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.004	0.0321	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0151	0.179	0.2576
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0089	0.0111
Brugia malayi	aryl hydrocarbon receptor nuclear translocator protein, putative	0.004	0.0321	0.0458
Trichomonas vaginalis	intestinal guanylate cyclase, putative	0.004	0.0321	0.0631
Trichomonas vaginalis	CMGC family protein kinase	0.0069	0.0695	0.1588
Loa Loa (eye worm)	hypothetical protein	0.0098	0.1086	0.1555
Onchocerca volvulus		0.011	0.124	0.2276
Brugia malayi	hypothetical protein	0.0538	0.6915	1
Echinococcus granulosus	mothers against decapentaplegic 5	0.0024	0.0107	0.0033
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0024	0.0107	0.0033
Trichomonas vaginalis	adenylate cyclase type III, putative	0.004	0.0321	0.0631

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 879249