TDR Targets

Basic information

Technical information

TDR Targets ID: 879723
Name: N-[4-[3-[(2,3-dimethoxyphenyl)methyl]-4-oxo-1 ,3-thiazolidin-2-yl]phenyl]acetamide
MW: 386.465 | Formula: C20H22N2O4S
H donors: 1 H acceptors: 2 LogP: 2.42 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(cccc1OC)CN1C(=O)CSC1c1ccc(cc1)NC(=O)C
InChi: 1S/C20H22N2O4S/c1-13(23)21-16-9-7-14(8-10-16)20-22(18(24)12-27-20)11-15-5-4-6-17(25-2)19(15)26-3/h4-10,20H,11-12H2,1-3H3,(H,21,23)
InChiKey: HMDMCHRZQSJFPU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[4-[3-[(2,3-dimethoxyphenyl)methyl]-4-oxo-thiazolidin-2-yl]phenyl]acetamide
N-[4-[3-[(2,3-dimethoxyphenyl)methyl]-4-oxo-2-thiazolidinyl]phenyl]acetamide
N-[4-[3-(2,3-dimethoxybenzyl)-4-keto-thiazolidin-2-yl]phenyl]acetamide
N-[4-[3-[(2,3-dimethoxyphenyl)methyl]-4-oxo-1,3-thiazolidin-2-yl]phenyl]ethanamide
Oprea1_568285

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0539	0.1062
Echinococcus multilocularis	cathepsin L	0.0023	0.0216	0.0208
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0023	0.0216	0.091
Plasmodium falciparum	serine repeat antigen 9	0.0023	0.0216	0.1622
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0023	0.0216	0.091
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0153	0.0312
Onchocerca volvulus	Cathepsin L homolog	0.007	0.0845	0.9476
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0058	0.0676	0.1338
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.031	0.3987	0.7964
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0044	0.0501	0.1045
Echinococcus granulosus	cathepsin b	0.031	0.3987	0.7964
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0047	0.0539	0.592
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Loa Loa (eye worm)	calpain	0.0044	0.0501	0.1191
Plasmodium falciparum	serine repeat antigen 1	0.0023	0.0216	0.1622
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0539	0.1289
Giardia lamblia	Cathepsin L-like protease	0.0023	0.0216	0.0512
Toxoplasma gondii	cathepsin CPC1	0.0023	0.0216	0.0946
Echinococcus granulosus	calpain 7 C02 family	0.0044	0.0501	0.0987
Brugia malayi	Cathepsin L-like precursor	0.007	0.0845	0.2064
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Entamoeba histolytica	cysteine protease, putative	0.0023	0.0216	0.1622
Toxoplasma gondii	aldehyde dehydrogenase	0.0057	0.0674	0.4502
Brugia malayi	calpain 5	0.0031	0.0326	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0117	0.1462	0.3619
Trypanosoma brucei	calpain-like protein, putative	0.0044	0.0501	0.316
Plasmodium falciparum	serine repeat antigen 3	0.0023	0.0216	0.1622
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0023	0.0216	0.0471
Onchocerca volvulus		0.007	0.0845	0.9476
Plasmodium vivax	unspecified product	0.0047	0.0539	0.5573
Schistosoma mansoni	calpain-7 (C02 family)	0.0044	0.0501	0.0987
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.031	0.3987	0.7964
Onchocerca volvulus		0.007	0.0845	0.9476
Echinococcus multilocularis	cysteine protease	0.007	0.0845	0.0838
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Echinococcus multilocularis	calpain	0.0044	0.0501	0.0494
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.003	0.0022
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0023	0.0216	0.0474
Leishmania major	cathepsin L-like protease	0.007	0.0845	0.583
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0023	0.0216	0.1622
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0111	0.1382	0.2751
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0539	0.3897
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0115	0.0215
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.031	0.3987	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0023	0.0216	0.1562
Giardia lamblia	Cathepsin L precursor	0.0023	0.0216	0.0512
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0023	0.0216	0.0417
Entamoeba histolytica	cysteine proteinase, putative	0.007	0.0845	1
Entamoeba histolytica	cysteine protease, putative	0.0023	0.0216	0.1622
Trypanosoma cruzi	cruzipain precursor, putative	0.007	0.0845	0.1929
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.0845	0.6114
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0023	0.0216	0.091
Echinococcus multilocularis	calpain 5	0.0044	0.0501	0.0494
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0123	0.1532	0.305
Trichomonas vaginalis	hypothetical protein	0.0013	0.0094	0.068
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0539	0.1062
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0044	0.0501	0.1045
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0057	0.0674	1
Plasmodium falciparum	serine repeat antigen 8	0.0023	0.0216	0.1622
Echinococcus multilocularis	cpg binding protein	0.0029	0.0296	0.0289
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0044	0.0501	0.1045
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0023	0.0216	0.091
Brugia malayi	Papain family cysteine protease containing protein	0.007	0.0845	0.2064
Plasmodium vivax	vivapain-2	0.007	0.0845	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0023	0.0216	0.0512
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0539	0.3451
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.0845	0.6114
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0153	0.0784
Echinococcus granulosus	cathepsin L cysteine proteinase	0.007	0.0845	0.1676
Brugia malayi	latrophilin 2 splice variant baaae	0.0032	0.0343	0.0795
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0216	0.1562
Trypanosoma brucei	antigen, putative	0.0044	0.0501	0.316
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0044	0.0501	0.0987
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0044	0.0501	0.1045
Schistosoma mansoni	cathepsin F (C01 family)	0.007	0.0845	0.1676
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.0845	0.1929
Giardia lamblia	Encystation-specific protease	0.0023	0.0216	0.0512
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0023	0.0216	0.0417
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0539	0.592
Giardia lamblia	Cathepsin L-like protease	0.0023	0.0216	0.0512
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0216	0.1562
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0013	0.0094	0.068
Schistosoma mansoni	calpain-7 (C02 family)	0.0044	0.0501	0.0987
Entamoeba histolytica	cysteine protease, putative	0.007	0.0845	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0153	0.029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0216	0.1562
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0539	0.1142
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.0845	0.6114
Schistosoma mansoni	cpg binding protein	0.0029	0.0296	0.0578
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0044	0.0501	0.316
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0117	0.1462	0.291
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0216	0.1562
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0539	0.592
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.0845	0.6114
Echinococcus multilocularis	cathepsin b	0.031	0.3987	0.3982
Loa Loa (eye worm)	calpain D	0.0013	0.0094	0.0163
Echinococcus granulosus	cathepsin b	0.031	0.3987	0.7964
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0242	0.054
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0115	0.022
Giardia lamblia	Cathepsin B precursor	0.0111	0.1382	1
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1287	0.3177
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0216	0.1562
Plasmodium vivax	calpain, putative	0.0044	0.0501	0.503
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.0845	0.1929
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.007	0.0845	0.2061
Schistosoma mansoni	calpain-2 (C02 family)	0.0013	0.0094	0.0173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Leishmania major	cathepsin L-like protease	0.007	0.0845	0.583
Echinococcus granulosus	cysteine protease	0.0047	0.0539	0.1062
Brugia malayi	Papain family cysteine protease containing protein	0.0023	0.0216	0.0474
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Trypanosoma cruzi	cruzipain precursor, putative	0.0025	0.0242	0.038
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0044	0.0501	0.1045
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0023	0.0216	0.1562
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Trypanosoma cruzi	kinesin, putative	0.0031	0.0326	0.0596
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Trypanosoma brucei	calpain-like protein, putative	0.0044	0.0501	0.316
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Echinococcus granulosus	calpain A	0.0123	0.1532	0.305
Echinococcus multilocularis	cathepsin L cysteine protease	0.007	0.0845	0.0838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Giardia lamblia	Cathepsin L precursor	0.0023	0.0216	0.0512
Schistosoma mansoni	aldehyde dehydrogenase	0.0057	0.0674	0.1333
Onchocerca volvulus		0.0027	0.0276	0.0907
Brugia malayi	Papain family cysteine protease containing protein	0.0023	0.0216	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0216	0.0471
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0343	0.0791
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0539	0.592
Entamoeba histolytica	cysteine proteinase 2	0.0047	0.0539	0.592
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0023	0.0216	0.1622
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0057	0.0674	0.0667
Brugia malayi	Cathepsin L-like precursor	0.007	0.0845	0.2064
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0216	0.0471
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0153	0.0145
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0013	0.0094	0.068
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0047	0.0539	0.1287
Trypanosoma cruzi	cysteine peptidase, putative	0.0047	0.0539	0.1142
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0044	0.0501	0.316
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0023	0.0216	0.1562
Plasmodium falciparum	serine repeat antigen 6	0.0023	0.0216	0.1622
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0153	0.0784
Echinococcus multilocularis	dnaJ subfamily B	0.0387	0.5004	0.5
Echinococcus multilocularis	calpain 7 (C02 family)	0.0044	0.0501	0.0494
Echinococcus granulosus	cathepsin l1	0.007	0.0845	0.1676
Schistosoma mansoni	hypothetical protein	0.0387	0.5004	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Entamoeba histolytica	cysteine protease, putative	0.0023	0.0216	0.1622
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0044	0.0501	0.1045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Trichomonas vaginalis	calpain, putative	0.0013	0.0094	0.068
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0046	0.0522	0.11
Brugia malayi	fibroinase precursor	0.0023	0.0216	0.0474
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0023	0.0216	0.0417
Toxoplasma gondii	cathepsin B	0.0111	0.1382	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0115	0.0216
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0123	0.1532	0.305
Schistosoma mansoni	aldehyde dehydrogenase	0.0057	0.0674	0.1333
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0051	0.0596	0.3893
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0522	0.1245
Toxoplasma gondii	cathepsin CPL	0.007	0.0845	0.583
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.0845	0.1929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0216	0.1562
Brugia malayi	calpain 7	0.0044	0.0501	0.1195
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Onchocerca volvulus		0.007	0.0845	0.9476
Brugia malayi	Cathepsin L-like precursor	0.0046	0.0522	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0073	0.088	0.2149
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Plasmodium vivax	vivapain-1	0.0047	0.0539	0.5573
Loa Loa (eye worm)	hypothetical protein	0.0086	0.1055	0.2591
Brugia malayi	CXXC zinc finger family protein	0.0027	0.0276	0.0626
Brugia malayi	cathepsin F-like cysteine proteinase	0.0023	0.0216	0.0474
Entamoeba histolytica	cysteine proteinase, putative	0.007	0.0845	1
Leishmania major	kinesin, putative	0.0031	0.0326	0.1801
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0216	0.1562
Plasmodium vivax	unspecified product	0.0025	0.0242	0.1285
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0044	0.0501	0.1045
Giardia lamblia	Cathepsin B precursor	0.0023	0.0216	0.0512
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0023	0.0216	0.091
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0216	0.0471
Echinococcus granulosus	cathepsin L cysteine protease	0.0047	0.0539	0.1062
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0111	0.1382	1
Schistosoma mansoni	ap endonuclease	0.0018	0.0153	0.029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0023	0.0216	0.1562
Echinococcus multilocularis	cathepsin L cysteine protease	0.007	0.0845	0.0838
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0215
Giardia lamblia	Cathepsin L precursor	0.0023	0.0216	0.0512
Echinococcus multilocularis	hypothetical protein	0.0044	0.0501	0.0494
Giardia lamblia	Cathepsin L precursor	0.0023	0.0216	0.0512
Leishmania major	cathepsin L-like protease	0.007	0.0845	0.583
Echinococcus granulosus	calpain 5	0.0044	0.0501	0.0987
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.0845	0.6114
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0044	0.0501	0.316
Loa Loa (eye worm)	hypothetical protein	0.007	0.0845	0.2061
Trypanosoma cruzi	cysteine peptidase, putative	0.007	0.0845	0.1929
Echinococcus multilocularis	cysteine protease	0.007	0.0845	0.0838
Loa Loa (eye worm)	cathepsin B	0.0111	0.1382	0.3418
Echinococcus multilocularis	cathepsin b	0.031	0.3987	0.3982
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0044	0.0501	0.1045
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0215
Trypanosoma cruzi	cysteine protease, putative	0.0047	0.0539	0.1142
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0216	0.1562
Brugia malayi	Cathepsin L-like precursor	0.007	0.0845	0.2064
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Schistosoma mansoni	ap endonuclease	0.0018	0.0153	0.029
Brugia malayi	Cathepsin L-like precursor	0.0046	0.0522	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0242	0.0536
Leishmania major	cysteine peptidase A (CPA)	0.007	0.0845	0.583
Onchocerca volvulus		0.0073	0.088	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0023	0.0216	0.1562
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0242	0.0536
Echinococcus granulosus	calpain	0.0044	0.0501	0.0987
Echinococcus granulosus	calpain A	0.0044	0.0501	0.0987
Leishmania major	cathepsin L-like protease	0.007	0.0845	0.583
Plasmodium falciparum	serine repeat antigen 7	0.0023	0.0216	0.1622
Echinococcus granulosus	cathepsin L	0.0047	0.0539	0.1062
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Giardia lamblia	Hypothetical protein	0.0023	0.0216	0.0512
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0023	0.0216	0.0474
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0115	0.0107
Plasmodium falciparum	serine repeat antigen 5	0.0023	0.0216	0.1622
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.031	0.3987	0.7964
Giardia lamblia	Cysteine protease	0.0023	0.0216	0.0512
Toxoplasma gondii	cathepsin CPC2	0.0023	0.0216	0.0946
Onchocerca volvulus		0.007	0.0845	0.9476
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Trichomonas vaginalis	calpain, putative	0.0013	0.0094	0.068
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0153	0.0457
Plasmodium falciparum	serine repeat antigen 2	0.0023	0.0216	0.1622
Entamoeba histolytica	protein kinase, putative	0.0031	0.0326	0.309
Giardia lamblia	Cathepsin B precursor	0.0111	0.1382	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.003	0.0044
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0023	0.0216	0.0417
Entamoeba histolytica	hypothetical protein	0.0023	0.0216	0.1622
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0025	0.0242	0.054
Plasmodium vivax	serine-repeat antigen (SERA)	0.0023	0.0216	0.091
Schistosoma mansoni	cpg binding protein	0.0027	0.0276	0.0537
Echinococcus granulosus	cathepsin l1	0.0046	0.0522	0.103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0023	0.0216	0.1562
Trypanosoma brucei	kinesin, putative	0.0031	0.0326	0.1801
Echinococcus granulosus	GPCR family 2	0.0015	0.0115	0.0215
Brugia malayi	cathepsin L-like precursor	0.0046	0.0522	0.1248
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0023	0.0216	0.091
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0057	0.0674	0.4502
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0522	0.3779
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0115	0.0216
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0115	0.022
Schistosoma mansoni	cathepsin F (C01 family)	0.007	0.0845	0.1676
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Onchocerca volvulus	Cathepsin F homolog	0.007	0.0845	0.9476
Plasmodium vivax	serine-repeat antigen (SERA)	0.0023	0.0216	0.091
Entamoeba histolytica	cysteine protease, putative	0.0023	0.0216	0.1622
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0216	0.0471
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0046	0.0522	0.3779
Loa Loa (eye worm)	calpain 5	0.0031	0.0326	0.0749
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0153	0.1106
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0023	0.0216	0.1562
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0023	0.0216	0.091
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0216	0.0471
Loa Loa (eye worm)	fibroinase	0.007	0.0845	0.2061
Brugia malayi	Papain family cysteine protease containing protein	0.0047	0.0539	0.1289
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0023	0.0216	0.0946
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0013	0.0094	0.068
Schistosoma mansoni	hypothetical protein	0.0013	0.0094	0.0173
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0023	0.0216	0.1622
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.007	0.0845	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Schistosoma mansoni	calpain (C02 family)	0.0044	0.0501	0.0987
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0057	0.0674	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.031	0.3987	1
Brugia malayi	Papain family cysteine protease containing protein	0.0023	0.0216	0.0474
Onchocerca volvulus		0.007	0.0845	0.9476
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0023	0.0216	0.1562
Schistosoma mansoni	cathepsin S (C01 family)	0.0023	0.0216	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0094	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0242	0.0536
Trypanosoma cruzi	cysteine proteinase, putative	0.0047	0.0539	0.1142
Entamoeba histolytica	cysteine proteinase, putative	0.0046	0.0522	0.5703
Giardia lamblia	Cysteine protease	0.0023	0.0216	0.0512
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0115	0.0215
Plasmodium vivax	vivapain-3	0.0047	0.0539	0.5573
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0023	0.0216	0.1622
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0057	0.0674	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0047	0.0539	0.1062
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0023	0.0216	0.0512
Entamoeba histolytica	cysteine protease, putative	0.0023	0.0216	0.1622
Brugia malayi	Cathepsin L-like precursor	0.007	0.0845	0.2064
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0522	0.1245
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0115	0.0107
Giardia lamblia	Cathepsin B precursor	0.0023	0.0216	0.0512
Schistosoma mansoni	hypothetical protein	0.0015	0.0115	0.0215
Loa Loa (eye worm)	cysteine protease	0.007	0.0845	0.2061
Giardia lamblia	Hypothetical protein	0.0023	0.0216	0.0512
Trypanosoma cruzi	major cysteine proteinase, putative	0.0023	0.0216	0.0313
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.0845	0.6114
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.007	0.0845	0.6114
Leishmania major	cathepsin L-like protease	0.007	0.0845	0.583
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.0845	0.6114
Giardia lamblia	Cathepsin L precursor	0.0023	0.0216	0.0512
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.031	0.3987	0.7964
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0153	0.0151
Plasmodium falciparum	cysteine proteinase falcipain 3	0.007	0.0845	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.0242	0.038
Brugia malayi	calpain family protein 1	0.0117	0.1462	0.3621
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0031	0.0326	0.309
Giardia lamblia	Cathepsin B precursor	0.0023	0.0216	0.0512
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0027	0.0276	0.0623
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Trichomonas vaginalis	calpain, putative	0.0013	0.0094	0.068
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0044	0.0501	0.1045
Brugia malayi	calpain family protein 1	0.0117	0.1462	0.3621
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0023	0.0216	0.0417
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0023	0.0216	0.0512
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0023	0.0216	0.0474
Schistosoma mansoni	cathepsin C	0.0023	0.0216	0.0417
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0153	0.0315
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0153	0.0457
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0013	0.0094	0.068
Plasmodium vivax	unspecified product	0.0023	0.0216	0.091
Loa Loa (eye worm)	hypothetical protein	0.031	0.3987	1
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0013	0.0094	0.068
Echinococcus granulosus	dnaJ subfamily B	0.0387	0.5004	1
Echinococcus granulosus	cpg binding protein	0.0029	0.0296	0.0578
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0057	0.0674	0.1333
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0115	0.0107
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0123	0.1532	0.1525
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0153	0.5
Onchocerca volvulus		0.007	0.0845	0.9476
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0023	0.0216	0.0417
Loa Loa (eye worm)	ctsf protein	0.007	0.0845	0.2061
Giardia lamblia	Cathepsin B precursor	0.0111	0.1382	1
Leishmania major	cathepsin L-like protease	0.007	0.0845	0.583
Trichomonas vaginalis	conserved hypothetical protein	0.0023	0.0216	0.1562
Loa Loa (eye worm)	calpain family protein 1	0.0086	0.1055	0.2591
Onchocerca volvulus	Cathepsin L homolog	0.007	0.0845	0.9476
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0047	0.0539	0.129
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0023	0.0216	0.0417
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.007	0.0845	0.0838
Giardia lamblia	Cathepsin B precursor	0.0023	0.0216	0.0512
Trypanosoma brucei	calpain-like protein, putative	0.0044	0.0501	0.316
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0123	0.1532	0.305
Loa Loa (eye worm)	calpain family protein 1	0.0117	0.1462	0.3619
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0044	0.0501	0.316
Trypanosoma brucei	calpain-like protein, putative	0.0044	0.0501	0.316
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0057	0.0674	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0047	0.0539	0.129
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0023	0.0216	0.0471
Trichomonas vaginalis	Clan CA, family C2, calpain-like cysteine peptidase	0.0013	0.0094	0.068
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0216	0.0471
Schistosoma mansoni	cpg binding protein	0.0029	0.0296	0.0578
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.0845	0.6114
Leishmania major	cathepsin L-like protease	0.007	0.0845	0.583
Giardia lamblia	Cathepsin B precursor	0.0023	0.0216	0.0512
Echinococcus multilocularis	calpain family protein 1, d	0.0086	0.1055	0.1048
Schistosoma mansoni	cathepsin s	0.0025	0.0242	0.0468
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0047	0.0539	0.3897
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0023	0.0216	0.0417
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Brugia malayi	calpain D	0.0013	0.0094	0.0166
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0047	0.0539	0.3451
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.007	0.0845	0.0838
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0047	0.0539	0.1142
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0539	0.1287
Trypanosoma cruzi	major cysteine proteinase, putative	0.0023	0.0216	0.0313
Brugia malayi	cathepsin F-like cysteine proteinase	0.0025	0.0242	0.054
Echinococcus granulosus	cathepsin l cysteine peptidase	0.007	0.0845	0.1676
Plasmodium vivax	vivapain-2	0.007	0.0845	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0023	0.0216	0.0417
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.007	0.0845	1
Echinococcus granulosus	cathepsin L	0.0023	0.0216	0.0417
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.007	0.0845	0.2061
Entamoeba histolytica	cysteine proteinase 1, putative	0.0047	0.0539	0.592
Entamoeba histolytica	cysteine proteinase, putative	0.0047	0.0539	0.592
Giardia lamblia	Cathepsin L precursor	0.0023	0.0216	0.0512
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.007	0.0845	0.583
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0046	0.0522	0.1248
Brugia malayi	Cathepsin L-like precursor	0.007	0.0845	0.2064
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.0153	0.1106
Brugia malayi	cathepsin L precursor	0.0023	0.0216	0.0474
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0094	0.068
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0023	0.0216	0.091
Leishmania major	cathepsin L-like protease	0.007	0.0845	0.583
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0111	0.1382	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0046	0.0522	0.103
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0023	0.0216	0.091
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0023	0.0216	0.0512
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0153	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0023	0.0216	0.1562
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0023	0.0216	0.1622
Toxoplasma gondii	exonuclease III APE	0.0018	0.0153	0.0457
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0044	0.0501	0.1045
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0111	0.1382	1
Plasmodium falciparum	serine repeat antigen 4	0.0023	0.0216	0.1622
Schistosoma mansoni	hypothetical protein	0.0032	0.0343	0.067
Entamoeba histolytica	cysteine protease, putative	0.0023	0.0216	0.1622
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0111	0.1382	0.3309
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.007	0.0845	0.6114
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0023	0.0216	0.091
Brugia malayi	calpain 5	0.0013	0.0094	0.0166
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.007	0.0845	0.6114
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0242	0.0536
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0153	0.0151
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0023	0.0216	0.1562
Schistosoma mansoni	calpain C (C02 family)	0.0044	0.0501	0.0987
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0023	0.0216	0.0471
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.007	0.0845	0.6114
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0023	0.0216	0.0417
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0044	0.0501	0.316
Onchocerca volvulus		0.007	0.0845	0.9476
Brugia malayi	Cathepsin L-like precursor	0.007	0.0845	0.2064
Echinococcus multilocularis	calpain A	0.0123	0.1532	0.1525
Onchocerca volvulus		0.0046	0.0522	0.4615
Giardia lamblia	Cysteine protease	0.0023	0.0216	0.0512
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0522	0.1245
Echinococcus multilocularis	cathepsin L	0.0047	0.0539	0.0531
Giardia lamblia	Cysteine protease	0.0023	0.0216	0.0512
Brugia malayi	cathepsin L-like cysteine proteinase	0.0023	0.0216	0.0474
Trypanosoma cruzi	kinesin, putative	0.0031	0.0326	0.0596
Entamoeba histolytica	cysteine protease, putative	0.0047	0.0539	0.592

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 879723